Cerebral Folate Deficiency (CFD) is a recently identified neurometabolic disorder showing low concentrations of 5-MTHF (5-methyltetrahydrofolate) in the cerebrospinal fluid (CSF); however, in these cases, the folate levels in the bloodstream may remain unaffected. This implies that the 5-MTHF may not be getting converted/generated from folate for proper absorption into the cells. (1)(2) It is
Methylation defects are relatively new genetic disorders and they are thoroughly being studied and treated around the world. Methylation is a vital part of our bodies’ natural process of detoxification. Methylation also regulates neurotransmitters and hormones. Individuals with a methylenetetrahydrofolate reductase (MTHFR) mutation have a decreased ability to convert folate–or folic acid–into a usable form.