Methyl-Life’s product, B-Methylated-II is a lozenge meant to be taken sublingually (or absorbed through the mouth). It has the most biologically active forms of B-9 Methylfolate (often denoted as L-MTHF, 5-MTHF, or L-5-MTHF) and B-12 (as Methylcobalamin) that you can get. They are the ‘already converted’ forms of the vitamins that are immediately ready for the body’s cells to use directly. The lozenge is most effective when absorbed through the mouth because B12 does not absorb well via the gut. B12 absorption is maximized when taken sublingually. Methyl-Life’s B-Methylated II bottle of 90 tablets is one of the most cost-effective versions of lozenge Methylfolate/Methylcobalamin available over-the-counter today.
Please Note: We have gone back to our original formula with the smaller tablet size, the xylitol sweetener and the nice hint of peppermint flavor. The tablets dissolve well in the mouth again. For faster dissolving results, bite the tablet into pieces and place the pieces under your tongue or between your gums and cheeks.
WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase, check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to one dosing option.
We spent a great deal of time on our formulations and believe they are optimal for three key reasons:
- Superior formula – We chose the sublingual form specifically to ensure the best absorption of the ingredients, it’s a known fact that B-12 does not absorb well through the stomach lining, but much better through the mucosa (or under the tongue – sublingually).
- Perfect dosage – Our formulation allows you to take the higher doses of Methylfolate you need with less pills per day, and more cost effectively. It also allows for more flexible dosing, for example, one family member may only need one pill per day and another may require 3 pills per day.
- Ideal formula – We included the primary B vitamins needed to promote methylation in individuals with an MTHFR gene defect (Folate as Methylfolate and B-12 as Methylcobalamin) so you can have an optimum daily dose of these essential bioactive Bs in one easy tablet!
Bite tablet into pieces, & hold in mouth for 90+ seconds prior to ingestion. Great for teeth, not for animals (contains xylitol).
Serving Size: 1 Chewable Tablet
Amount per Serving
% Daily Value
(as (6S)-5-Methyltetrahydrofolate, glucosamine salt) – (Quatrefolic®)
$34.00 – OTHER INGREDIENTS: xylitol (from non-GMO hardwoods), microcrystalline, cellulose, stearic, acid, silicon dioxide, less than 1% dextrose, peppermint oil, natural FEMA GRAS aromatics.
What is the right dosage for me?
Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.
Is Methylfolate the only thing I should take if I have an MTHFR gene mutation?
No, actually our recommendation is to heavily consider following Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching parts 3 & 4 of his video seminar, or downloading his protocol document found on the A Doctor Explains page.
What do doctors have to say about MTHFR and how to treat it?
Go to A Doctor Explains and listen to Dr. Neil Rawlins’ 51-minute seminar on MTHFR and the effects of Methylfolate.
How can I get more information on MTHFR?
Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium or (6S)-5-Methylfolate, glucosamine salt the same thing?
Basically, yes. In the chemistry world, L stands for the “Left” isomer, which is the same as the “(6S)” isomer – the terms are synonyms (and this naming convention is used interchangeably by various companies in the industry). In the case of methylfolate, that L or (6S) isomer is the active isomer of 5-MTHF that the body can actually use. The L-5-MTHF [or (6S)-5-MTHF] enzyme is bound to a salt molecule and in the case of one ingredient (Magnafolate-C™), it’s bound to a calcium salt molecule for delivery to the body, and in the case of another ingredient (Quatrefolic®), it’s bound to a glucosamine salt molecule for delivery to the body. To learn more about the different types of methylfolate, its history, potency levels and stability details, visit our Methylfolate Types page.
Before purchasing any of our products, Methyl-Life recommends that you talk with a healthcare professional if you have any questions. Methyl-Life cannot be held liable for adverse reactions or negative side effects that you think are the result of one of our products.
If you have not used Methyl-Life products before, please consider ordering one bottle to start before making larger orders. We also recommend you read through our dosage and methylation protocol pages and consider starting with a lower dose product to ensure you tolerate the ingredients well before increasing your strength to a higher dose product.
It is also important to speak with your healthcare professional before purchasing. Methyl-Life prefers not to accept returns for large orders. If you return three unopened bottles from a 4-pack purchase, you will receive a full refund minus the cost of one bottle charged at full price.
Within 45 days of your order, you can return any unopened item shipped to you by Methyl-Life (as long as all seals are intact). Just let us know you plan to return the product by emailing us using the Contact Us form (please include the tracking information so we can be on the lookout for the package).
It will be your responsibility and cost to ensure the return parcel gets to Methyl-Life (ship to: P.O. Box 1484, Renton, WA 98057). We suggest you get a tracking number and consider insuring the package. After we receive your returned item, we will process your full refund within 10 business days and send you an email indicating your refund has been complete. Be aware that depending upon your institution, this may not be reflected in your account status for a few days.
If you have received the wrong item or your product has been damaged or is somehow defective, please email us with detailed information using the Contact us form and our Customer Service Manager will address your concern right away. Please do not throw any items away unless or until you are directed to do so.
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