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Cerebral Folate Deficiency (CFD) is a recently identified neurometabolic disorder showing low concentrations of 5-MTHF (5-methyltetrahydrofolate) in the cerebrospinal fluid (CSF); however, in these cases, the folate levels in the bloodstream may remain unaffected. This implies that the 5-MTHF may not be getting converted/generated from folate for proper absorption into the cells. (1)(2) It is

  Cerebral folate deficiency usually develops in the first year of a baby’s life. The causes for this serious medical condition are not yet determined, but it is very likely that the immune system is involved. We absorb folates through food but the problem occurs when the folates need to be transported from the blood

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