It is recommended that you should take an advice from a physician, or a doctor regarding the dosage quantity for yourself. The quantity of dosage differs, depending upon the degree of the MTHFR. People, those are sensitive to drugs, vitamins and supplements; should take care, and perform the research.
According to the Methyl-Life team, you should start slow, with a small quantity. Still, take the feedback from your doctor regarding the dosages, if your blood test comes out to be positive in relation to MTHFR mutation.
Folate [B-9] (as 5-Methylfolate) – This is the bioactive form of the primary enzyme needed for methylation,
especially if you have an MTHFR mutation. It by-passes vitamin processing pathways because it is the already-
converted form of the vitamin element. So your body can immediately use it. It is often recommended in daily doses of 3,000-15,000 mcg (3-15 mg) for individuals with an MTHFR defect.
B-12 (as Methylcobalamin)– This is the key form of B-12 needed by someone with an MTHFR gene defect – most often B-12 is found in the form ‘Cobalamin’ which requires additional conversions. For the body’s direct use, the methylated form of B-12 is best absorbed in the mouth’s mucous membranes (sublingual or lozenge form is best).
It’s important to note that taking L-Methylfolate (L-5-MTHF) without B-12 puts one at risk for masking a B-12
deficiency. To avoid this, just take 3,000-15,000 mcg (3-15 mg) of B-12 (Methylcobalamin) daily with your
L-Methylfolate or 5-MTHF (besides, it’s a great energy lift).
B-6 (as Pyridoxal-5-Phosphate) – This is another key piece to supporting the larger methylation process that is so inhibited in an individual who has a MTHFR gene mutation. Think of it as an important enabler of the larger methylation cycle. Note: In a small percentage of individuals, this vitamin can build up and cause a headache that feels like a tight band has been stuck on the head. It’s often recommended in daily doses between 20-35 mg to help methylation.
B-2 (as Riboflavin-5-Phosphate) – This vitamin’s need is being uncovered in studies regarding MTHFR, homocysteine,
and cardiovascular health. High homocysteine levels have often been directly correlated with low B-2 (Riboflavin)
levels (along with cardiovascular problems) in people with an MTHFR gene defect. So let’s just avoid this cardiovascular risk altogether and take B-2 every day with our L-5-MTHF supplement.
Also Read: A Suggested Methylation Protocol
B-1 (as Thiamine HCI) – This is classified as one of the essential B vitamins and therefore included to provide a complete B experience within Methyl-Life (so you don’t have to buy another B vitamin supplement in addition to your folate/methylation support).
B-3 (Niacinamide) – This is classified as one of the essential B vitamins and therefore included to provide a complete B experience within Methyl-Life (so you don’t have to buy another B vitamin supplement in addition to
your folate/methylation support).
Biotin – This is classified as one of the essential B vitamins and therefore included to provide a complete B experience within Methyl-Life (so you don’t have to buy another B vitamin supplement in addition to your
folate/methylation support)
B-5 (D-calcium pantothenate)– This is classified as one of the essential B vitamins and therefore included to provide a complete B experience within Methyl-Life (so you don’t have to buy another B vitamin supplement in
addition to your folate/methylation support).
Ask your doctor, if he or she will do a simple blood test for you (there are also cheek swab tests available through a lab in Kentucky, have your doctor fill out their form and process the test through them if you have a child and it would be easier than a blood test – https://www.pgxlab.com/mthfr/). It’s entirely possible your doctor may not know much about the MTHFR gene mutations and that you’ll have to do a little educating. In the medical field, it takes about 18 years for something to become ‘known practice’ and these two defects are a relatively recent discovery (1995 for variant 677 and 2001 for variant 1298).
A doctor can simply indicate ‘MTHFR gene’ on the lab test request sheet. Many labs around the country are able to do this test now, and many health insurance plans do cover in this test.
Also Read: Folic Acid May Reduce Age-Related Memory Problems
Your doctor may suggest, based on your symptoms, that you simply try the treatment for the MTHFR defect, and decide whether or not it makes a difference. Considering the full set of variants are not visible with the currently available blood tests and that other medical conditions and medications may be restricting methylation (see What is MTHFR? and MTHFR and Methylation), for some individuals a treatment trial is more cost-effective and beneficial. It’s a very benign treatment in terms of side effects because it is just the ‘activated forms’ of essential vitamins, so there is a big upside and not much to lose (see our dosage information if you opt to go this route).
Since you can get both Methylfolate (L-MTHF) and Methylcobalamin (B-12) over the counter, you stand to gain a lot by just trying it to see how you feel and whether it makes a difference for you or not. Because individuals are all different, you could notice a dramatic difference in as few as 3 days or you may notice a more gradual improvement over a couple of month's time.
Here’s one doctor’s opinion on testing: https://mthfr.net/mthfr-screening/2011/09/29/
Here at Methyl-Life, we are proud of the superior quality of our ingredients and our process. After all, we were born from the desire of our founder, Jamie Horn, to make products that she would want to take herself as part of her own MTHFR treatment plan!
Our products are pure. That means no junk, no fillers. Never.
So we have a rigorous manufacturing process to ensure that each supplement we produce is a product that meets our standards.
Methyl-Life looks to find the best active ingredients available in the world.
Methyl-Life only buys top ingredients from cGMP-compliant ingredient manufacturers.
The cGMP-contract, product-manufacturing facilities in the USA only accept the ingredients after using a testing lab to verify all of the below: