- Description
- Dosage
- FAQ'S
- Return Policy
Get 2 of Methyl-Life’s® key starting products bundled for those who are sensitive or wanting to start their methylation journey off slow.
This active-nutrients package contains 2 chewable products at lower to moderate dosages for those who tend to be more sensitive to supplements:
- The purest L-Methylfolate (as shown in a recent study)
- The rare but most well-tolerated form of B12 (as Hydroxocobalamin)
- Methylfolate 2.5 - Purest & most stable L-Methylfolate you can buy - 2.5 mg
- Hydroxocobalamin - Active B12 at 2.5 mg per tablet
WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to some dosing options.
How to snap the tablet in half – See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.
What is the right dosage for me?
Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.
Is Methylfolate the only thing I should take if I have an MTHFR gene mutation?
You can also download one of four specific Methylation Protocols which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term.
You'll find our MTHFR Newbies page is very helpful as well. It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.
What is included in the Actives for Sensitives Bundle?
How can I get more information on MTHFR?
How can the Actives for Sensitives Bundle benefit individuals with sensitivities?
Why is Methylfolate important in the bundle?
Methylfolate is crucial for methylation processes in the body, particularly for those who may have difficulty processing synthetic folic acid. The 2.5 mg dosage in this bundle provides a gentle introduction for sensitive individuals.
What can you do if you have high B12 blood test results?
Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).
What is the significance of Hydroxocobalamin in the bundle?
Who should consider using the Methyl-Life® Methylation Starter Bundle?
Individuals who are sensitive to supplements or those who are new to methylation support may benefit from this bundle. It offers a gentle introduction to key nutrients without overwhelming the system with high dosages.
I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?
If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be hydroxocobalamin. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxocobalamin (and this is why our methylation protocol suggests hydroxocobalamin as the B12 form to begin with):
- Folks with multiple COMT mutations tend to do very well with hydroxocobalamin (it helps mop up excess peroxynitrites which can cause problems)
- Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation
- And Dr. Amy Yasko talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:
| COMT V158M | VDR Taq | B12 Types That Should Be Tolerated |
|---|---|---|
| – – | + + (TT) | All 3 types of B12 |
| – – | + – (Tt) | All 3 types of B12 with less Methylcobalamin |
| – – | – – (tt) | Hydroxocobalamin and Adenosylcobalamin |
| + – | + + | All 3 types of B12 with less Methylcobalamin |
| + – | + – | Hydroxocobalamin and Adenosylcobalamin |
| + – | – – | Hydroxocobalamin and Adenosylcobalamin |
| + + | + + | Hydroxocobalamin and Adenosylcobalamin |
| + + | + – | Hydroxocobalamin and Adenosylcobalamin |
| + + | – – | Mostly Hydroxocobalamin |
Please Note
Before purchasing any of our products, Methyl-Life® recommends that you talk with a healthcare professional if you have any questions. Methyl-Life® cannot be held liable for adverse reactions or negative side effects that you think are the result of one of our products.
If you have not used Methyl-Life® products before, please consider ordering one bottle to start before making larger orders. We also recommend you read through our dosage and methylation protocol pages and consider starting with a lower dose product to ensure you tolerate the ingredients well before increasing your strength to a higher dose product.
It is also important to speak with your healthcare professional before purchasing. Methyl-Life® prefers not to accept returns for large orders. If you return three unopened bottles from a 4-pack purchase, you will receive a full refund minus the cost of one bottle charged at full price.
Within 45 days of your order, you can return any unopened item shipped to you by Methyl-Life® (as long as all seals are intact). Just let us know you plan to return the product by emailing us at: support@methyl-life.com or using the Contact Us form (please include the tracking information so we can be on the lookout for the package).
It will be your responsibility and cost to ensure the return parcel gets to Methyl-Life® (ship to: P.O. Box 33606, Seattle, WA 98133). We suggest you get a tracking number and consider insuring the package. After we receive your returned item, we will process your full refund within 10 business days and send you an email indicating your refund has been complete. Be aware that depending upon your institution, this may not be reflected in your account status for a few days.
If you have received the wrong item or your product has been damaged or is somehow defective, please email us at: support@methyl-life.com with detailed information or use the Contact Us form and our Customer Service Manager will address your concern(s) right away. Please do not throw any items away unless or until you are directed to do so.