{"title":"Sale - All other products","description":null,"products":[{"product_id":"methylated-multivitamin","title":"Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR\/Pregnancy\/Children","description":"\u003cdiv class=\"et_pb_row et_pb_row_0\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_1_2 et_pb_column_0    et_pb_css_mix_blend_mode_passthrough\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cp\u003e\u003cstrong\u003eA delicious chewable Methylated Multivitamin with Cognitive \u0026amp; Energy promoting nutrients to support MTHFR and other genetic challenges\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cstrong\u003e\u003cspan style=\"color: #2b00ff;\"\u003eMethyl-Life’s® Methylated Multivitamin!\u003c\/span\u003e\u003c\/strong\u003e It's a Sweet 'n Tart Cherry Berry flavored chewable that tastes even better than before (your kids will love it). It holds many of the needed ingredients for methylation to occur optimally in the body. It’s been specially \u003cstrong\u003eformulated with \u003cbr\u003eL-Methylfolate and Active B12\u003c\/strong\u003e to:\u003cbr\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_1\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_4_4 et_pb_column_2    et_pb_css_mix_blend_mode_passthrough et-last-child\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_1 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003ePromote\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"\" href=\"http:\/\/www.huffingtonpost.com\/dr-mark-hyman\/glutathione-the-mother-of_b_530494.html\" rel=\"nofollow\" target=\"_blank\"\u003eglutathione, your body’s strongest antioxidant\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBoost serotonin, an important neurotransmitter\u003c\/li\u003e\n\u003cli\u003eReduce harmful homocysteine levels in the body\u003c\/li\u003e\n\u003cli\u003eSupport fertility, pregnancy and fetal health\u003c\/li\u003e\n\u003cli\u003eHelp repair the myelin sheath for nerve health\u003c\/li\u003e\n\u003cli\u003eSupport RNA\/DNA build blocks\u003c\/li\u003e\n\u003cli\u003eSupport your thyroid and liver\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cstrong\u003eThis formula is BOASTING the PUREST proven L-Methylfolate on the planet, \u003c\/strong\u003e\u003cstrong\u003eCerebrofolate® PRO\u003c\/strong\u003e. This\u003cspan\u003e \u003c\/span\u003eform of L-Methylfolate, is more identical to the pharmaceutical version of methylfolate, AND it tested 3 times more pure in a recent study. Our formula is Gluten, Dairy and Soy free.\u003c\/div\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003eThis multivitamin also contains:\u003c\/div\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eThe energy-supporting B vitamins along with their co-factors supporting the thyroid\u003c\/li\u003e\n\u003cli\u003ePatented\u003cstrong\u003e Sucrosome®\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003eVitamins A, D3, E and\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003ebioactive K2\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003eA new ATP energy formula (\u003cstrong\u003eNADH\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e+\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eCoQ10\u003c\/strong\u003e)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTMG\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eis built in for lowering homocysteine levels in the body\u003c\/li\u003e\n\u003cli\u003eA specialized, soy-free form of choline that crosses the blood brain barrier for improved cognitive health\u003c\/li\u003e\n\u003cli\u003eAnd another brain health nutrient, soy-free\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003ePhosphatidylserine\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ewhich contains essential phospholipids supporting healthy cognition\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eArtichoke extract\u003c\/strong\u003e and \u003cstrong\u003eMilk Thistle\u003c\/strong\u003e to support the liver\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\nThe Methylated Multi may reduce homocysteine levels in the body. It can be taken along with other \u003cstrong\u003e\u003cspan style=\"color: #2b00ff;\"\u003eMethyl-Life®\u003c\/span\u003e\u003c\/strong\u003e products that have methylfolate in them (if one wishes to intake higher methylfolate doses). \u003cstrong\u003e\u003cspan style=\"color: #2b00ff;\"\u003eMethyl-Life’s® Methylated Multivitamin\u003c\/span\u003e\u003c\/strong\u003e is one of the best formulas you’ll find out in the market today. You may find this multi \u003cstrong\u003ecan also act as a nice prenatal without iron or Vitamin C, as well as a great kid’s multi-vitamin \u003c\/strong\u003e(though you’ll want to consider adjusting the number of tablets given as a serving if you take it for these other purposes).\u003c\/div\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eDosage\u003c\/h2\u003e\n\u003cbr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e– How much is right for you to take? \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTalk to your doctor about what’s best for you. Check out our \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/dosage\" rel=\"noopener\" target=\"_blank\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e to learn more about what some doctors recommend.\u003c\/span\u003e\u003c\/p\u003e\n\u003cbr\u003e\n\u003ch2\u003eSUPPLEMENT FACTS\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cbr\u003e\u003cspan style=\"text-decoration: underline;\"\u003eSUGGESTED USE\u003c\/span\u003e:  Chew 1-4 tablet(s) daily with food (for best absorption), or as directed by your health care professional.\u003c\/div\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003eGreat for teeth, \u003cstrong\u003eNOT FOR ANIMALS\u003c\/strong\u003e (contains xylitol).\u003cbr\u003e\u003cbr\u003e\n\u003ctable style=\"height: 842.533px; width: 100%;\" width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\u003cstrong\u003e SUPPLEMENT FACTS \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\u003cstrong\u003e Serving Size: 4 Chewable Tablets\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cbr\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cbr\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 39.1875px;\"\u003e\u003cstrong\u003e\u003cem\u003e 30 servings per container\u003c\/em\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 39.1875px;\"\u003eAmount per Serving\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 39.1875px;\"\u003e\u003cspan\u003e% Daily Value\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003eCalories\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e14\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e*\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 39.1875px;\"\u003eTotal carbohydrate\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 39.1875px;\"\u003e3 g\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 39.1875px;\"\u003e1%*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003eTotal sugars (including added sugars)\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e3 g\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e7%*\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 39.1875px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin A\u003c\/strong\u003e (as Retinyl Palmitate)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 39.1875px;\"\u003e\u003cstrong\u003e200 mcg RAE (667 IU)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 39.1875px;\"\u003e\u003cstrong\u003e22%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 39.1875px;\"\u003e\n\u003cstrong\u003eVitamin D \u003c\/strong\u003e(as Cholecalciferol [D3]\u003cspan\u003e)\u003c\/span\u003e\u003cbr\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 39.1875px;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\u003cstrong\u003e33 mcg (1,333 IU)\u003c\/strong\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 39.1875px;\"\u003e\u003cstrong\u003e165%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 39.1875px;\"\u003e\n\u003cstrong\u003eVitamin E \u003c\/strong\u003e(as d-a-Tocopheryl Acid Succinate)\u003cbr\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 39.1875px;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\u003cstrong\u003e8 mg (12 IU)\u003c\/strong\u003e\u003c\/div\u003e\n\u003cstrong\u003e \u003c\/strong\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 39.1875px;\"\u003e\u003cstrong\u003e53%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003eThiamin \u003c\/strong\u003e(Vitamin B1)(as Thiamin HCI)\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e1 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e83%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 39.1875px;\"\u003e\n\u003cstrong\u003eRiboflavin \u003c\/strong\u003e(Vitamin B2)(as Riboflavin 5 Sodium Phosphate)\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 39.1875px;\"\u003e\u003cstrong\u003e6 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 39.1875px;\"\u003e\u003cstrong\u003e462%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\u003cstrong\u003eNiacin \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e14 mg NE\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e88%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003eVitamin B6 \u003c\/strong\u003e(as Pyridoxal 5 Phosphate)\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e3 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e176%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 39.1875px;\"\u003e\n\u003cstrong\u003eFolate\u003c\/strong\u003e (800 mcg L-Methylfolate [from 1 mg of \u003cstrong\u003eCerebrofolate®\u003c\/strong\u003e)\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 39.1875px;\"\u003e\u003cstrong\u003e1,360 mcg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 39.1875px;\"\u003e\u003cstrong\u003e340%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003eVitamin B12\u003c\/strong\u003e (as Hydroxy B12 Acetate)\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e333 mcg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cb\u003e13,875%\u003c\/b\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003eBiotin\u003c\/strong\u003e \u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e40 mcg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e133%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003ePantothenic Acid \u003c\/strong\u003e(as D-Calcium-Pantothenate)\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e5 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e100%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003eIodine \u003c\/strong\u003e(as Potassium Iodide)\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e56 mcg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e37%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003eZinc \u003c\/strong\u003e(as Liposomal Zinc Oxide)\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e12 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e109%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003eSelenium\u003c\/strong\u003e (Selenium Glycinate)\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e67 mcg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e122%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003eManganese \u003c\/strong\u003e(Manganese Bisglycinate Citrate\u003cspan\u003e)\u003c\/span\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e2 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e87%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003eChromium \u003c\/strong\u003e(Chromium Nicotinate Glycinate\u003cspan\u003e)\u003c\/span\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e23 mcg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e66%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003eMolybdenum \u003c\/strong\u003e(Molybdenum Glycinate\u003cspan\u003e)\u003c\/span\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e13 mcg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e29%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cb\u003eArtichoke \u003c\/b\u003e(Leaf - Cynara scolymus L.) Extract 5% Cynarin\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e33 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e**\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\u003cstrong\u003eCiticoline Sodium\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e33 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e**\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cb\u003eUbiquinol \u003c\/b\u003e(CoQ10 Reduced Form)\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e10 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e**\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003ePhosphatidylserine \u003c\/strong\u003e(Sunflower - Helianthus annuus)\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e7 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e** \u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003eMilk Thistle \u003c\/strong\u003e(Seed - Silybum marianum L.)\u003cstrong\u003e Extract 80% Silymarin\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e33 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e**\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\u003cb\u003ePantethine\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e14 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e**\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003ePara-Amino Benzoic Acid\u003c\/strong\u003e (PABA) (Vitamin B10)\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e7 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e**\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003eBenfotiamine\u003c\/strong\u003e (Fat Soluble Vitamin B1)\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e16 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e**\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 39.1875px;\"\u003e\n\u003cstrong\u003eNADH\u003c\/strong\u003e (Microencapsulated NADH)\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 39.1875px;\"\u003e\u003cstrong\u003e1 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 39.1875px;\"\u003e\u003cstrong\u003e**\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e\n\u003cstrong\u003eVitamin K2 \u003c\/strong\u003e(as Menaquinone-7)\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e68 mcg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e**\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 79.2612%;\"\u003e\u003cstrong\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right;\"\u003e\u003cstrong\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right;\"\u003e\u003cstrong\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e* Percent Daily Value based on a 2,000 calorie diet\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cbr\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cbr\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 79.2612%; height: 19.5938px;\"\u003e** Daily Value not established\u003c\/td\u003e\n\u003ctd style=\"width: 1.78571%; text-align: right; height: 19.5938px;\"\u003e\u003cbr\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.231%; text-align: right; height: 19.5938px;\"\u003e\u003cbr\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_0\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_0\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eOTHER INGREDIENTS\u003c\/span\u003e:  Inositol, Medium Chain Triglycerides, xylitol, natural flavors (dextrose, silicon dioxide, citric acid, propylene glycol, sugar, fruit \u0026amp; vege juice \u0026amp; concentrates, phosphoric acid, maltodextrin, potassium bitartrate, calcium lactate),  microcrystalline cellulose\u003cspan\u003e, m\u003c\/span\u003ealic acid, sodium stearyl fumarate\u003cspan\u003e, monk fruit extract. \u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_0\"\u003eTrivial source of calories. \u003cbr\u003e\u003cbr\u003e\u003cspan style=\"text-decoration: underline;\"\u003ePRODUCT CONTAINS NO\u003c\/span\u003e: wheat, gluten, dairy, egg, soy, fish, shellfish, yeast, sodium, nuts, caffeine, artificial colorings, preservatives or flavorings, bisphenol-A (BPA), or phthalate.\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_0\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2 class=\"et_pb_text_inner\"\u003eResearch\u003c\/h2\u003e\n\u003cp\u003e\u003ciframe src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/MTHFR_and_pregnancy_677.pdf?v=1591313816\" width=\"100%\" height=\"500px\"\u003e\n    \u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2\u003eFAQs\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\"\u003e What is the Chewable Methylated Multivitamin?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe Chewable Methylated Multivitamin is a comprehensive multivitamin formula containing L-Methylfolate and Active B12, specifically designed to support individuals with MTHFR mutations, pregnant women, and children.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\"\u003e What are the key features of the Chewable Methylated Multivitamin?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eThis multivitamin provides essential nutrients in a chewable form, making it convenient for individuals with MTHFR mutations, pregnant women, and children to meet their nutritional needs. With L-Methylfolate and Active B12, it offers optimal support for methylation and overall health during pregnancy and childhood.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\"\u003e What are the potential benefits of the Methylated Multi?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eThe Methylated Multi may help reduce homocysteine levels in the body, contributing to overall health and well-being. It can also be safely taken alongside other Methyl-Life® products containing methylfolate for those seeking higher doses of methylfolate.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\"\u003e How can I get more information on MTHFR?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003echeck out our Help for \u003ca href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\" rel=\"noopener\" target=\"_blank\"\u003eMTHFR Newbies page\u003c\/a\u003e.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\"\u003e Why is Methyl-Life’s® Methylated Multivitamin considered one of the best formulas available?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eMethyl-Life’s® Methylated Multivitamin stands out as an exceptional formula in the market today, offering comprehensive nutritional support with its methylated ingredients. It can serve as an excellent prenatal option without iron or Vitamin C and is also suitable as a high-quality multivitamin for children, although serving sizes may need adjustment for these specific purposes.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\"\u003e What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe most important thing to realize is that \u003cstrong\u003eblood tests for B12 are highly inaccurate at detecting actual cellular levels of B12\u003c\/strong\u003e (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used. \u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\"\u003e How should I use this product?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe suggested use for this product is to chew 1-4 tablets daily with food for optimal absorption. It is recommended to follow the dosage instructions provided by your healthcare professional.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\"\u003e How should I take this for the best results?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cspan\u003eFor maximum absorption, take your chewable tablets with a meal that contains a small amount of healthy fat.\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eThis helps your body utilize fat-soluble vitamins like \u003cstrong\u003eA, D3, E and K2.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\"\u003e My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eOne of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIt’s important to realize that the \u003cstrong\u003eMTHFR status does not necessarily determine the type of B12 that’s best for you\u003c\/strong\u003e, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIt seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.\u003c\/p\u003e\n\u003cp\u003eThe most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into \u003cspan\u003ehydroxy B12\u003c\/span\u003e, and from there the \u003cspan\u003ehydroxy B12 \u003c\/span\u003ehas to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\"\u003e I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eIf you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxy B12 (and this is why our methylation protocol suggests hydroxy B12 as the B12 form to begin with):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eFolks with multiple COMT mutations tend to do very well with \u003cspan\u003ehydroxy B12 \u003c\/span\u003e(it helps mop up excess peroxynitrites which can cause problems)\u003c\/li\u003e\n\u003cli\u003eFolks with MTR \u0026amp; MTRR mutations may do well with methylcobalamin \u0026amp; adenosylcobalamin supplementation\u003c\/li\u003e\n\u003cli\u003eAnd Dr. Amy Yasko (https:\/\/dramyyasko.com) talks about folks with a particular mutation status for COMT \u0026amp; VDR Taq as best needing the below forms of B12:\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ctable id=\"b12-table\" class=\"mytable\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eCOMT V158M\u003c\/th\u003e\n\u003cth\u003eVDR Taq\u003c\/th\u003e\n\u003cth\u003eB12 Types That Should Be Tolerated\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ + (TT)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ – (Tt)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e– – (tt)\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eMostly Hydroxy B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31134620778570,"sku":"MMulti-B1001","price":42.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methylated-Multivitamin__bottle_capsules.webp?v=1790160144"},{"product_id":"l-methylfolate-15-mg","title":"L Methylfolate 15 mg - A Mood-Boosting Supplement","description":"\u003cdiv class=\"et_pb_row et_pb_row_0\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_1_2 et_pb_column_0    et_pb_css_mix_blend_mode_passthrough\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eHigh dose L methylfolate 15 mg for healthy methylation, homocysteine and natural mood support. \u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBioactive folate uniquely formulated with the new \u0026amp; improved, internationally-branded nutrient \u003cstrong\u003eCerebrofolate®\u003csup\u003e0\u003c\/sup\u003e\u003c\/strong\u003e. \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eL-methylfolate is the predominant form of folate circulating in the body and used for biological processes\u003csup\u003e1\u003c\/sup\u003e.\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eStudies show *15mg methylfolate + SSRI to be the most effective dose for improving depressive symptoms\u003csup\u003e2\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eL Methylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier\u003csup\u003e3\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"padding-left: 30px;\"\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupport for brain function\u003csup\u003e4\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupports cardiovascular health\u003csup\u003e5\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupport for healthy immune function\u003csup\u003e6\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupports nerve function\u003csup\u003e7\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupport for preconception, pregnancy, and fetal health\u003csup\u003e8\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eInvolved in maintaining healthy homocysteine levels\u003csup\u003e9\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eEssential nutrient required for healthy DNA and neurotransmitter synthesis\u003csup\u003e10\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSuitable for people with MTHFR mutations\u003csup\u003e11\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eA 2024 animal study found that high-dose methylfolate may protect against neurodevelopmental behaviours resulting from exposure to pyrethroid, a type of pesticide. Pyrethroid exposure disrupts folate metabolism in the brain and may contribute to behavioral disorders such as autism. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMethylfolate is the biologically active form of folate and can bypass disruptions to the breakdown of folate in the body, whether caused by MTHFR or by DPE exposure. In this study, high-dose supplementation with methylfolate dramatically reduced the behavioural disorders caused by folate issues, preventing deficits in the social, communication, cognitive, and locomotor areas of the brain that are linked to autism.\u003csup\u003e21\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eProduct details\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003eKey ingredient\u003c\/span\u003e:  \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eFolate 25,500 mcg DFE (15 mg L-Methylfolate from 21 mg of \u003cstrong\u003eCerebrofolate®\u003c\/strong\u003e)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003e\u003cem\u003eL Methylfolate 15 mg\u003c\/em\u003e\u003c\/strong\u003e is a highly bioactive form of folate made with the purest \u0026amp; most potent methylfolate available\u003csup\u003e12\u003c\/sup\u003e.\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"padding-left: 30px;\"\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eMaximum absorption and bioavailability\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eNo prescription required \u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eAvailable in \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-2-5\" target=\"_blank\" rel=\"noopener\"\u003e2.5mg\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylated-b12-l-methylfolate-3mg\" target=\"_blank\" rel=\"noopener\"\u003e3mg+B12\u003c\/a\u003e\u003ca href=\"https:\/\/methyl-life.com\/products\/b-methylated-ii-chewable-tablets\" title=\"Methyl-Life® B-Methylated II product - 3mg L-methylfolate + methylcobalamin (active B12)\"\u003e\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/5-methylfolate-5-mthf-l-methylfolate-5mg\" target=\"_blank\" rel=\"noopener\"\u003e5mg\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-7-5-active-b12\" target=\"_blank\" rel=\"noopener\"\u003e7.5mg+B12\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-10\" target=\"_blank\" rel=\"noopener\"\u003e10mg\u003c\/a\u003e\u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-10\"\u003e\u003c\/a\u003e, 15mg, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-15-active-b12-30-caps\" target=\"_blank\" rel=\"noopener\"\u003e15mg+B12\u003c\/a\u003e \u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eRigorously tested for consistency, purity, safety, and potency\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eWhy take L Methylfolate?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFolate is required for numerous critical functions of the brain and nervous system. It is essential for DNA\/RNA synthesis, maintaining healthy homocysteine levels, and for proper fetal development during pregnancy. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFolic acid is a synthetic form of folate. It can only be used by the body after it has been converted to active folate by an enzyme called \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003emethylenetetrahydrofolate reductase\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e (MTHFR)\u003csup\u003e13\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWho is affected by MTHFR mutations?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants).  \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eApproximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%).  Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A\u0026gt;C polymorphism in Hispanics and Africans is 15%\u003csup\u003e14\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e.  And these are just 2 of the well-documented polymorphisms out of over 70 MTHFR possible SNPs (\u003cem\u003esingle nucleotide polymorphisms\u003c\/em\u003e) in the body.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAn increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness\u003csup\u003e15\u003c\/sup\u003e.\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e  MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses\u003csup\u003e16\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFor these people, L-methylfolate supplementation is shown to be the most effective way to provide this form of folate\u003csup\u003e10\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eMethyl-Life’s® L Methylfolate 15 mg is an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWhy CEREBROFOLATE®?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003e\u003cem\u003eMethyl-Life’s® L Methylfolate 15 mg\u003c\/em\u003e\u003c\/strong\u003e is made with the new \u0026amp; improved, internationally-branded nutrient \u003cstrong\u003eCerebrofolate®\u003c\/strong\u003e, clinically tested as the world’s purest \u0026amp; most potent methylfolate (\u003cstrong\u003eCerebrofolate®\u003c\/strong\u003e is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic®, Extrafolate®, Metafolin® \u0026amp; Magnafolate®\u003csup\u003e20\u003c\/sup\u003e).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eCerebrofolate®\u003c\/strong\u003e is made with a form of methylfolate called L-5-MTHF-Ca, which is shown to be the most active form of folate in the plasma circulation. When compared with ordinary folate, L Methylfolate was found to be absorbed faster and utilized more quickly in the body\u003csup\u003e17\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eA recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation\u003csup\u003e18\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eNot only that, it has improved production processing methods which have increased its purity and potency to exceed the USP standards.  So if you’re truly looking for professional strength, look no further, \u003cstrong\u003eCerebrofolate® \u003c\/strong\u003eis the biochemically identical version of L-methylfolate that has been used in significant clinical studies to demonstrate mood elevation.  Read more about \u003cstrong\u003eCerebrofolate's®\u003c\/strong\u003e superiority\u003csup\u003e19\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e ______________________________________\u003c\/p\u003e\n\u003cp\u003e\u003csup\u003e0\u003c\/sup\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/cerebrofolate\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/methyl-life.com\/pages\/cerebrofolate\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e1\u003c\/sup\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20608755\/\" rel=\"noopener\" target=\"_blank\"\u003e https:\/\/pubmed.ncbi.nlm.nih.gov\/20608755\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e2\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3402301\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3402301\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e3\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7687916\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7687916\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e4\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7779227\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7779227\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e5\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/hq0102.102190\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ahajournals.org\/doi\/10.1161\/hq0102.102190\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e6\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7019735\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7019735\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e7\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5867258\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5867258\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e8\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8127769\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8127769\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e9\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9832224\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9832224\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e10\u003c\/sup\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23212058\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/23212058\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e11\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7564482\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7564482\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e12\u003c\/sup\u003e\u003ca href=\"https:\/\/methyl-life.com\/blogs\/methylfolate-facts\/cerebrofolate-comparison\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/methyl-life.com\/blogs\/methylfolate-facts\/cerebrofolate-comparison\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e13\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK6561\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/books\/NBK6561\/\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e14\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6530664\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6530664\/\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e15\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6630484\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6630484\/\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e16\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.0000165142.37711.E7\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.0000165142.37711.E7\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e17\u003c\/sup\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24032278\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/24032278\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e18\u003c\/sup\u003e\u003ca href=\"https:\/\/i.trade-cloud.com.cn\/upload\/6405\/file\/20210929\/english-version-magnafolate-enhancing-immunity_524485.pdf\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/i.trade-cloud.com.cn\/upload\/6405\/file\/20210929\/english-version-magnafolate-enhancing-immunity_524485.pdf\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e19\u003c\/sup\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/methylfolate-types\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/methyl-life.com\/pages\/methylfolate-types\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e20\u003c\/sup\u003e\u003ca href=\"https:\/\/ijbpas.com\/archive\/archive-single-pdf\/6008\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/ijbpas.com\/archive\/archive-single-pdf\/6008\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e21\u003c\/sup\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11623627\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11623627\/\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003ch2\u003eDosage\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eHow much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/dosage\" rel=\"noopener\" target=\"_blank\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto learn more about what some doctors recommend. And review our suggested\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" rel=\"noopener\" target=\"_blank\"\u003emethylation protocol\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eas a potential step by step guide to some dosing options.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eHow to snap the tablet in half\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e \u003ca href=\"https:\/\/www.youtube.com\/watch?v=XOxWY-kQ8kc\u0026amp;list=PLpRy5gLP6XyP008M0ap1OqqkeDapTU-xq\u0026amp;index=12\u0026amp;t=0s\" rel=\"noopener\" target=\"_blank\"\u003eSee how its done via video\u003c\/a\u003e. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest\/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eSUPPLEMENT FACTS\u003c\/h2\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eSuggested Use\u003c\/span\u003e: Consult with your healthcare professional before using this product. See \u003ca href=\"\/dosage\" rel=\"noopener\" target=\"_blank\"\u003emethyl-life.com\/dosage\u003c\/a\u003e for more recommendations.\u003c\/div\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\n\u003cbr\u003e\u003cstrong\u003eGreat for teeth, not for animals (contains xylitol).\u003c\/strong\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cdiv class=\"supplementfactsbox\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"supplementlabel\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\u003cstrong\u003e SUPPLEMENT FACTS \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003eServing Size: 1 Chewable Tablet\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e90 servings per container\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cem\u003eAmount per Serving\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cem\u003e % Daily Value\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\u003cb\u003eFolate\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e25,500 mcg DFE\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e6,376%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e(15 mg L-Methylfolate from 21 mg of \u003cstrong\u003eCerebrofolate®\u003c\/strong\u003e)\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eOTHER INGREDIENTS\u003c\/span\u003e: xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavoring.\u003cspan style=\"font-size: 0.875rem;\"\u003e \u003c\/span\u003e\n\u003c\/div\u003e\n\u003cbr\u003e\n\u003cdiv class=\"supplementother\"\u003eNot a significant source of sugars.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cstrong\u003eProduct Does NOT Contain: \u003c\/strong\u003ewheat, gluten, soy, dairy, tree nuts, animal products, GMO’s. No artificial ingredients or colorings.\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003ch2 class=\"et_pb_text_inner\"\u003eResearch\u003c\/h2\u003e\n\u003ciframe height=\"500px\" width=\"100%\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/papakostas_2012_-_l-methylfolate_as_adjunctive_therapy_for_ssri-resistant_major_depression_-_results_of_two_randomized_double-blind_parallel-sequential_trials.pdf?v=1591251787\"\u003e\n    \u003c\/iframe\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch2\u003eFAQ'S\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What is the right dosage for me?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCheck out our \u003ca rel=\"noopener\" href=\"https:\/\/methyl-life.com\/dosage\" target=\"_blank\"\u003eDosage\u003c\/a\u003e page to learn what some \u003ca rel=\"noopener\" href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" target=\"_blank\"\u003edoctors\u003c\/a\u003e are saying. And consider reviewing our \u003ca rel=\"noopener\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\/\" target=\"_blank\"\u003eMethylation Protocol\u003c\/a\u003e page as one example of how someone could start taking the active methylation nutrients.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e Is L Methylfolate 15 mg the only thing I should take if I have an MTHFR gene mutation?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eNo, actually our recommendation is to heavily consider Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching his \u003ca rel=\"noopener\" href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" target=\"_blank\"\u003evideo seminar\u003c\/a\u003e.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou can also download one of four specific \u003ca rel=\"noopener\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" target=\"_blank\"\u003eMethylation Protocols\u003c\/a\u003e which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term. \u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou'll find our\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\" target=\"_blank\"\u003eMTHFR Newbies page\u003c\/a\u003e is very helpful as well.  It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What do doctors have to say about MTHFR and how to treat it?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eGo to \u003ca rel=\"noopener\" href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" target=\"_blank\"\u003eA Doctor Explains\u003c\/a\u003e and listen to Dr. Neil Rawlins’ seminar on MTHFR and the effects of L Methylfolate 15 mg.\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e How can I get more information on MTHFR?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003echeck out our Help for \u003ca rel=\"noopener\" href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\" target=\"_blank\"\u003eMTHFR Newbies page\u003c\/a\u003e.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium the same thing?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eBasically, yes. In the chemistry world, L stands for the “Left” isomer, which is the same as the “(6S)” isomer – the terms are synonyms (and this naming convention is used interchangeably by various companies in the industry). In the case of L-methylfolate, that L or (6S) isomer is the active isomer of 5-MTHF that the body can actually use. To learn more about the different types of methylfolate, its history, potency levels and stability details, and to see how our L Methylfolate 15 mg proves to be the purest on the planet, visit our \u003ca rel=\"noopener\" href=\"https:\/\/methyl-life.com\/pages\/methylfolate-types\" target=\"_blank\"\u003eMethylfolate Types page\u003c\/a\u003e.\u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e How can L Methylfolate 15 mg help with MTHFR mutations?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eL Methylfolate 15 mg can be beneficial for individuals with MTHFR mutations because it provides a form of folate that is already methylated, bypassing the need for the MTHFR enzyme to convert it. This supports methylation processes in the body, which may be impaired in individuals with MTHFR mutations, and helps maintain optimal folate levels necessary for various biochemical reactions. It's important to consult with a healthcare professional for personalized advice on supplementation and managing MTHFR mutation.\n\u003cdiv class=\"paragraph\"\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e How long does it take to experience the benefits of L Methylfolate 15 mg?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eIndividual responses may vary, but some users report noticing improvements in energy levels and overall well-being over just five weeks of starting L Methylfolate 15 mg supplementation.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e Why should I take L-methylfolate?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003eYou may consider taking L-methylfolate if you have certain genetic variations affecting folate metabolism, are pregnant or planning to become pregnant, or have a medical condition that requires high doses of folate supplementation. L-Methylfolate can support various bodily functions, including DNA synthesis, neurotransmitter production, and cardiovascular health, making it beneficial for individuals with specific needs or seeking optimal folate levels.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e Who can benefit from taking L Methylfolate 15 mg?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003eIndividuals with MTHFR gene mutations, those requiring high doses of folate, and pregnant women seeking prenatal support may benefit from L Methylfolate 15 mg supplementation.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e How does L Methylfolate 15 mg benefit health?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003eL Methylfolate 15 mg supports DNA synthesis, neurotransmitter production, and cardiovascular health, making it beneficial for individuals with certain genetic variations or those seeking optimal folate levels.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31134620811338,"sku":"M15-Cerebro1001","price":76.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methylfolate-15-bottle_capsules.webp?v=1773399230"},{"product_id":"5-methylfolate-5-mthf-l-methylfolate-5-mg","title":"5 Methylfolate: 5-mthf L-Methylfolate 5 mg","description":"\u003cdiv class=\"et_pb_row et_pb_row_0\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_1_2 et_pb_column_0    et_pb_css_mix_blend_mode_passthrough\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eModerate dose 5 methylfolate for healthy methylation, homocysteine and natural mood support. \u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBioactive folate (5 mthf L-Methylfolate) uniquely formulated with the fully-patented \u003cstrong\u003eCerebrofolate®\u003c\/strong\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e5 methylfolate is the predominant form of folate circulating in the body and used for biological processes\u003csup\u003e1\u003c\/sup\u003e.\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e5 Methylfolate 5.6mg shown to slow cognitive decline in patients with dementia\u003csup\u003e2\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e5 Methylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier\u003csup\u003e3\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"padding-left: 30px;\"\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupport for brain function\u003csup\u003e4\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupports cardiovascular health\u003csup\u003e5\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupport for healthy immune function\u003csup\u003e6\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupports nerve function\u003csup\u003e7\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupport for preconception, pregnancy, and fetal health\u003csup\u003e8\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eInvolved in maintaining healthy homocysteine levels\u003csup\u003e9\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eEssential nutrient required for healthy DNA and neurotransmitter synthesis\u003csup\u003e10\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSuitable for people with MTHFR mutations\u003csup\u003e11\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eA 2024 animal study found that high-dose methylfolate may protect against neurodevelopmental behaviors resulting from exposure to pyrethroid, a type of pesticide. Pyrethroid exposure disrupts folate metabolism in the brain and may contribute to behavioral disorders such as autism. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMethylfolate is the biologically active form of folate and can bypass disruptions to the breakdown of folate in the body, whether caused by MTHFR or by DPE exposure. In this study, high-dose supplementation with methylfolate dramatically reduced the behavioural disorders caused by folate issues, preventing deficits in the social, communication, cognitive, and locomotor areas of the brain that are linked to autism.\u003csup\u003e19\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eProduct details\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003eKey ingredient\u003c\/span\u003e:  \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eFolate 8,000 mcg (5 mg L-Methylfolate from 7 mg of \u003cstrong\u003eCerebrofolate®\u003c\/strong\u003e)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003e\u003cem\u003e5 Methylfolate 5 mg\u003c\/em\u003e\u003c\/strong\u003e is a highly bioactive form of folate made with the purest methylfolate available\u003csup\u003e12\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"padding-left: 30px;\"\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eMaximum absorption and bioavailability\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eNo prescription required \u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eAvailable in \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-2-5\" rel=\"noopener\" target=\"_blank\"\u003e2.5mg\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylated-b12-l-methylfolate-3mg\" rel=\"noopener\" target=\"_blank\"\u003e3mg+B12\u003c\/a\u003e\u003ca href=\"https:\/\/methyl-life.com\/products\/b-methylated-ii-chewable-tablets\" title=\"Methyl-Life® B-Methylated II product - 3mg L-methylfolate + methylcobalamin (active B12)\"\u003e\u003c\/a\u003e, 5mg, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-7-5-active-b12\" rel=\"noopener\" target=\"_blank\"\u003e7.5mg+B12\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-10\" rel=\"noopener\" target=\"_blank\"\u003e10mg\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-15\" rel=\"noopener\" target=\"_blank\"\u003e15mg\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-15-active-b12-30-caps\" rel=\"noopener\" target=\"_blank\"\u003e15mg+B12\u003c\/a\u003e \u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eRigorously tested for consistency, purity, safety, and potency\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eWhy take methylfolate?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFolate is required for numerous critical functions of the brain and nervous system. It is essential for DNA\/RNA synthesis, maintaining healthy homocysteine levels, and for proper fetal development during pregnancy. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFolic acid is a synthetic form of folate. It can only be used by the body after it has been converted to active folate by an enzyme called \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003emethylenetetrahydrofolate reductase\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e (MTHFR)\u003csup\u003e13\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWho is affected by MTHFR mutations?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants).  Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%).  Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A\u0026gt;C polymorphism in Hispanics and Africans is 15%\u003csup\u003e14\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAn increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness\u003csup\u003e15\u003c\/sup\u003e.\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e  MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses\u003csup\u003e16\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFor these people, L-methylfolate supplementation is shown to be the most effective way to provide this form of folate\u003csup\u003e10\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eMethyl-Life’s® Methylfolate is an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eA recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation\u003csup\u003e18\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e ______________________________________\u003c\/p\u003e\n\u003cp\u003e\u003csup\u003e1\u003c\/sup\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20608755\/\" rel=\"noopener\" target=\"_blank\"\u003e https:\/\/pubmed.ncbi.nlm.nih.gov\/20608755\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e2\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3402301\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3402301\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e3\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7687916\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7687916\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e4\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7779227\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7779227\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e5\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/hq0102.102190\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ahajournals.org\/doi\/10.1161\/hq0102.102190\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e6\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7019735\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7019735\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e7\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5867258\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5867258\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e8\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8127769\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8127769\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e9\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9832224\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9832224\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e10\u003c\/sup\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23212058\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/23212058\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e11\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7564482\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7564482\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e12\u003c\/sup\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methyl-Life_60-day_Methylfolate_Comparison.pdf?v=1595292111\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methyl-Life_60-day_Methylfolate_Comparison.pdf?v=1595292111\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e13\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK6561\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/books\/NBK6561\/\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e14\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6630484\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6530664\/\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e15\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6530664\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6630484\/\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e16\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.0000165142.37711.E7\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.0000165142.37711.E7\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e17\u003c\/sup\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24032278\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/24032278\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e18\u003c\/sup\u003e\u003ca href=\"https:\/\/i.trade-cloud.com.cn\/upload\/6405\/file\/20210929\/english-version-magnafolate-enhancing-immunity_524485.pdf\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/i.trade-cloud.com.cn\/upload\/6405\/file\/20210929\/english-version-magnafolate-enhancing-immunity_524485.pdf\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e19\u003c\/sup\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11623627\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11623627\/\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003ch2\u003eDosage\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eHow much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/dosage\" rel=\"noopener\" target=\"_blank\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto learn more about what some doctors recommend. And review our suggested\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\"\u003emethyla\u003c\/a\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" rel=\"noopener\" target=\"_blank\"\u003et\u003c\/a\u003e\u003ca title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\"\u003eion protocol\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eas a potential step by step guide to some dosing options.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eHow to snap the tablet in half\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e \u003ca href=\"https:\/\/www.youtube.com\/watch?v=XOxWY-kQ8kc\u0026amp;list=PLpRy5gLP6XyP008M0ap1OqqkeDapTU-xq\u0026amp;index=12\u0026amp;t=0s\" rel=\"noopener\" target=\"_blank\"\u003eSee how its done via video\u003c\/a\u003e. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest\/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eSUPPLEMENT FACTS\u003c\/h2\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eSUGGESTED USE\u003c\/span\u003e: \u003cspan\u003eConsult with your healthcare practitioner before using this product. See \u003c\/span\u003e\u003ca href=\"\/dosage\" rel=\"noopener\" target=\"_blank\"\u003emethyl-life.com\/dosage\u003c\/a\u003e\u003cspan\u003e for more recommendations.\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\u003cstrong\u003eGreat for teeth (contains xylitol).  KEEP THIS PRODUCT AWAY FROM PETS.\u003c\/strong\u003e\u003c\/div\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cdiv class=\"supplementfactsbox\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"supplementlabel\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\u003cstrong\u003e SUPPLEMENT FACTS \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003eServing Size: 1 Chewable Tablet\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cem\u003eAmount per Serving\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cem\u003e % Daily Value\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\u003cb\u003eFolate\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e8,500 mcg DFE\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e2,125%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e(5 mg L-Methylfolate from 7 mg of \u003cstrong\u003eCerebrofolate®\u003c\/strong\u003e)\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cp\u003eOTHER INGREDIENTS: \u003cspan\u003exylitol (Xylisorb\u003c\/span\u003e\u003cstrong\u003e®\u003c\/strong\u003e\u003cspan\u003e), microcrystalline cellulose (Microcel\u003c\/span\u003e\u003cstrong\u003e®\u003c\/strong\u003e\u003cspan\u003e), stearic acid, silicon dioxide, natural mint flavor (dextrose, silicon dioxide, natural flavor).\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\u003cspan\u003eNot a significant source of total sugars.\u003c\/span\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eProduct Does NOT Contain:\u003c\/strong\u003e wheat, gluten, soy, dairy, tree nuts, animal products, GMO's. No artificial ingredients or colorings. \u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 class=\"et_pb_text_inner\"\u003eResearch\u003c\/h2\u003e\n\u003cp\u003e\u003ciframe height=\"500px\" width=\"100%\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/MTHFR_alzheimer_s.pdf?v=1591312570\"\u003e\n    \u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eFAQ'S\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e \u003ca href=\"https:\/\/methyl-life.com\/blogs\/methylfolate-facts\/learn-about-the-benefits-of-l-methylfolate-supplements\" rel=\"noopener\" target=\"_blank\"\u003eWhat is the right dosage for me?\u003c\/a\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCheck out our \u003ca href=\"https:\/\/methyl-life.com\/dosage\" rel=\"noopener\" target=\"_blank\"\u003eDosage\u003c\/a\u003e page to learn what some \u003ca href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" rel=\"noopener\" target=\"_blank\"\u003edoctors\u003c\/a\u003e are saying. And consider reviewing our \u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\/\" rel=\"noopener\" target=\"_blank\"\u003eMethylation Protocol\u003c\/a\u003e page as one example of how someone could start taking the active methylation nutrients.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e Is 5 Methylfolate the only thing I should take if I have an MTHFR gene mutation?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eNo, actually our recommendation is to heavily consider following Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching parts 3 \u0026amp; 4 of his \u003ca href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" rel=\"noopener\" target=\"_blank\"\u003evideo seminar\u003c\/a\u003e.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou can also download one of four specific \u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" rel=\"noopener\" target=\"_blank\"\u003eMethylation Protocols\u003c\/a\u003e which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term. \u003cbr\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou'll find our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\" rel=\"noopener\" target=\"_blank\"\u003eMTHFR Newbies page\u003c\/a\u003e is very helpful as well.  It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What do doctors have to say about MTHFR and how to treat it?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eGo to \u003ca href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" rel=\"noopener\" target=\"_blank\"\u003eA Doctor Explains\u003c\/a\u003e and listen to Dr. Neil Rawlins’ video seminar on MTHFR and the effects of Methylfolate.\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e How can I get more information on MTHFR?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003echeck out our Help for \u003ca href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\" rel=\"noopener\" target=\"_blank\"\u003eMTHFR Newbies page\u003c\/a\u003e.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium the same thing?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cspan\u003eBasically, yes. In the chemistry world, L stands for the “Left” isomer, which is the same as the “(6S)” isomer – the terms are synonyms (and this naming convention is used interchangeably by various companies in the industry). In the case of methylfolate, that L or (6S) isomer is the active isomer of 5-MTHF that the body can actually use. To learn more about the different types of 5 methylfolate, its history, potency levels and stability details, and to see how our L-Methylfolate proves to be the purest on the planet, visit our \u003ca href=\"https:\/\/methyl-life.com\/pages\/methylfolate-types\" rel=\"noopener\" target=\"_blank\"\u003eMethylfolate Types page\u003c\/a\u003e.\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What is 5 Methylfolate 5 mg by Methyl-Life?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cspan\u003e5 Methylfolate 5 mg by Methyl-Life is a high-strength 5 methylfolate supplement, providing a bioavailable form of folate that supports methylation processes in the body, crucial for various biochemical reactions.\u003c\/span\u003e\u003cspan style=\"font-size: 0.875rem;\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e How does 5 Methylfolate 5 mg benefit health?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e5 Methylfolate 5 mg supports DNA synthesis, neurotransmitter production, and cardiovascular health, making it beneficial for individuals with certain genetic variations or those seeking optimal folate levels.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e Can 5 Methylfolate 5 mg help with depression?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e5 Methylfolate 5 mg may potentially help with depression, particularly in individuals with certain genetic variations affecting folate metabolism or those with folate deficiencies. Research suggests that 5 methylfolate supplementation may support mood regulation and mental health, although individual responses can vary. It's essential to consult with a healthcare professional for personalized advice and treatment options for depression.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e Who can benefit from taking 5 Methylfolate 5 mg?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eIndividuals with MTHFR gene mutations, those requiring high doses of folate, and pregnant women seeking prenatal support may benefit from 5 Methylfolate 5 mg supplementation.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e How long does it take to experience the benefits of 5 Methylfolate 5 mg?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eIndividual responses may vary, but some users report noticing improvements in energy levels and overall well-being over just five weeks of starting 5 Methylfolate 5 mg supplementation.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31134621302858,"sku":"Methyl5-C1001","price":44.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methylfolate-5_bottle_capsules.webp?v=1773398135"},{"product_id":"l-methylfolate-supplement-2-5-mg","title":"L Methylfolate Supplement 2.5 mg","description":"\u003cdiv class=\"et_pb_row et_pb_row_0\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_1_2 et_pb_column_0    et_pb_css_mix_blend_mode_passthrough\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eMild to Moderate dose L Methylfolate Supplement for healthy methylation, homocysteine and natural mood support. \u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBioactive folate uniquely formulated with the internationally-patented Magnafolate® PRO.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eL-methylfolate is the predominant form of folate circulating in the body and used for biological processes\u003csup\u003e1\u003c\/sup\u003e.\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAn L Methylfolate Supplement may improve symptoms of diabetic neuropathy\u003csup\u003e2\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eMethylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier\u003csup\u003e3\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"padding-left: 30px;\"\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupport for brain function\u003csup\u003e4\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupports cardiovascular health\u003csup\u003e5\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupport for healthy immune function\u003csup\u003e6\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupports nerve function\u003csup\u003e7\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupport for preconception, pregnancy, and fetal health\u003csup\u003e8\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eInvolved in maintaining healthy homocysteine levels\u003csup\u003e9\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eEssential nutrient required for healthy DNA and neurotransmitter synthesis\u003csup\u003e10\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSuitable for people with MTHFR mutations\u003csup\u003e11\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eProduct details\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003eKey ingredient\u003c\/span\u003e:  \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eFolate 2,500 mcg (L-5-Methyltetrahydrofolate, Calcium as Magnafolate® PRO)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003e\u003cem\u003eL Methylfolate Supplement 2.5 mg\u003c\/em\u003e\u003c\/strong\u003e is a highly bioactive form of folate made with the purest L-methylfolate available\u003csup\u003e12\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"padding-left: 30px;\"\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eMaximum absorption and bioavailability\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eNo prescription required \u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eAvailable in \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-2-5\" target=\"_blank\" rel=\"noopener\"\u003e2.5mg\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/b-methylated-ii-chewable-tablets\" target=\"_blank\" rel=\"noopener\"\u003e3mg+B12\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-5\"\u003e5mg\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-7-5-active-b12\" target=\"_blank\" rel=\"noopener\"\u003e7.5mg+B12\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-10\" target=\"_blank\" rel=\"noopener\"\u003e10mg\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-15\" target=\"_blank\" rel=\"noopener\"\u003e15mg\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-15-active-b12-30-caps\" target=\"_blank\" rel=\"noopener\"\u003e15mg+B12 \u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eRigorously tested for consistency, purity, safety, and potency\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eWhy take an L Methylfolate Supplement?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFolate is required for numerous critical functions of the brain and nervous system. It is essential for DNA\/RNA synthesis, maintaining healthy homocysteine levels, and for proper fetal development during pregnancy. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFolic acid is a synthetic form of folate. It can only be used by the body after it has been converted to active folate by an enzyme called \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003emethylenetetrahydrofolate reductase\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e (MTHFR)\u003csup\u003e13\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWho is affected by MTHFR mutations?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants).  Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%).  Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A\u0026gt;C polymorphism in Hispanics and Africans is 15%\u003csup\u003e14\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAn increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness\u003csup\u003e15\u003c\/sup\u003e.\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e  MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses\u003csup\u003e16\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFor these people, an L Methylfolate Supplement is shown to be the most effective way to provide this form of folate\u003csup\u003e10\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eMethyl-Life’s® L Methylfolate Supplement 2.5 mg is an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWhy Magnafolate® PRO?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003e\u003cem\u003eMethyl-Life’s® L Methylfolate Supplement 2.5 mg\u003c\/em\u003e\u003c\/strong\u003e is made with the internationally-patented Magnafolate® PRO, clinically tested as one of the world’s purest L Methylfolate Supplement brands (Magnafolate® PRO is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic® and Extrafolate®).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eMagnafolate® is made with a form of methylfolate called L-5-MTHF-Ca, which is shown to be the most active form of folate in the plasma circulation. When compared with ordinary folate, L-methylfolate was found to be absorbed faster and utilized more quickly in the body\u003csup\u003e17\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eA recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation\u003csup\u003e18\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e ______________________________________\u003c\/p\u003e\n\u003cp\u003e\u003csup\u003e1\u003c\/sup\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20608755\/\" target=\"_blank\" rel=\"noopener\"\u003e https:\/\/pubmed.ncbi.nlm.nih.gov\/20608755\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e2\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3402301\/\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3402301\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e3\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7687916\/\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7687916\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e4\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7779227\/\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7779227\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e5\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/hq0102.102190\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/www.ahajournals.org\/doi\/10.1161\/hq0102.102190\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e6\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7019735\/\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7019735\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e7\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5867258\/\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5867258\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e8\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8127769\/\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8127769\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e9\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9832224\/\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9832224\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e10\u003c\/sup\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23212058\/\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/23212058\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e11\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7564482\/\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7564482\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e12\u003c\/sup\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methyl-Life_60-day_Methylfolate_Comparison.pdf?v=1595292111\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methyl-Life_60-day_Methylfolate_Comparison.pdf?v=1595292111\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e13\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK6561\/\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/books\/NBK6561\/\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e14\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6530664\/\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6530664\/\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e15\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6630484\/\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6630484\/\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e16\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.0000165142.37711.E7\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.0000165142.37711.E7\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e17\u003c\/sup\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24032278\/\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/24032278\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e18\u003c\/sup\u003e\u003ca href=\"https:\/\/i.trade-cloud.com.cn\/upload\/6405\/file\/20210929\/english-version-magnafolate-enhancing-immunity_524485.pdf\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/i.trade-cloud.com.cn\/upload\/6405\/file\/20210929\/english-version-magnafolate-enhancing-immunity_524485.pdf\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003ch2\u003eDosage\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eHow much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/dosage\" target=\"_blank\" rel=\"noopener\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto learn more about what some doctors recommend. And review our suggested\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" target=\"_blank\" rel=\"noopener\"\u003emethylation protocol\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eas a potential step by step guide to some dosing options.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eHow to snap the tablet in half\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e \u003ca href=\"https:\/\/www.youtube.com\/watch?v=XOxWY-kQ8kc\u0026amp;list=PLpRy5gLP6XyP008M0ap1OqqkeDapTU-xq\u0026amp;index=12\u0026amp;t=0s\" target=\"_blank\" rel=\"noopener\"\u003eSee how its done via video\u003c\/a\u003e. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest\/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eSUPPLEMENT FACTS\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eSUGGESTED USE\u003c\/span\u003e: \u003cspan data-mce-fragment=\"1\"\u003eConsult with your healthcare practitioner before using this product. See \u003c\/span\u003e\u003ca href=\"\/dosage\" target=\"_blank\" rel=\"noopener\"\u003emethyl-life.com\/dosage\u003c\/a\u003e\u003cspan data-mce-fragment=\"1\"\u003e for more recommendations.\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\u003cstrong\u003eGreat for teeth, (contains xylitol). KEEP THIS PRODUCT AWAY FROM PETS.\u003c\/strong\u003e\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cdiv class=\"supplementfactsbox\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"supplementlabel\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\n\u003ctable style=\"height: 137.156px;\" width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 19.5938px;\"\u003e\u003cstrong\u003e SUPPLEMENT FACTS \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 19.5938px;\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003eServing Size: 1 Chewable Tablet\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 19.5938px;\"\u003e90 servings per container\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 19.5938px;\"\u003e\u003cem\u003eAmount per Serving\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 19.5938px;\"\u003e\u003cem\u003e % Daily Value\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 19.5938px;\"\u003e\u003cb\u003eFolate\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e4,250 mcg DFE\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e1,063%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 58.7812px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 58.7812px;\"\u003e(2.5 mg of L-Methylfolate from 3.4 mg of \u003cstrong\u003eMagnafolate® PRO\u003c\/strong\u003e])\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 58.7812px;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 58.7812px;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eOTHER INGREDIENTS\u003c\/span\u003e: xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavor (dextrose, silicon dioxide, natural flavor.\u003cspan style=\"font-size: 0.875rem;\"\u003e \u003c\/span\u003e\n\u003c\/div\u003e\n\u003cbr\u003e\n\u003cdiv class=\"supplementother\"\u003eNot a significant source of sugars.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cstrong\u003eProduct Does NOT Contain: \u003c\/strong\u003ewheat, gluten, soy, dairy, tree nuts, animal products, GMO’s. No artificial ingredients or colorings.\u003cbr\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003ch2\u003eFAQ'S\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e \u003ca href=\"https:\/\/methyl-life.com\/blogs\/methylfolate-facts\/methylfolate-what-s-the-right-dosage-for-me\" target=\"_blank\" rel=\"noopener\"\u003eWhat is the right dosage for me?\u003c\/a\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCheck out our \u003ca href=\"https:\/\/methyl-life.com\/dosage\" target=\"_blank\" rel=\"noopener\"\u003eDosage\u003c\/a\u003e page to learn what some \u003ca href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" target=\"_blank\" rel=\"noopener\"\u003edoctors\u003c\/a\u003e are saying. And consider reviewing our \u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\/\" target=\"_blank\" rel=\"noopener\"\u003eMethylation Protocol\u003c\/a\u003e page as one example of how someone could start taking the active methylation nutrients.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e Is an L Methylfolate Supplement the only thing I should take if I have an MTHFR gene mutation?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eNo, actually our recommendation is to heavily consider following Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching his \u003ca href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" target=\"_blank\" rel=\"noopener\"\u003evideo seminar\u003c\/a\u003e.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou can also download one of four specific \u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" target=\"_blank\" rel=\"noopener\"\u003eMethylation Protocols\u003c\/a\u003e which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term. \u003cbr\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou'll find our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\" target=\"_blank\" rel=\"noopener\"\u003eMTHFR Newbies page\u003c\/a\u003e is very helpful as well.  It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What do doctors have to say about MTHFR and how to treat it?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eGo to \u003ca href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" target=\"_blank\" rel=\"noopener\"\u003eA Doctor Explains\u003c\/a\u003e and listen to Dr. Neil Rawlins’ video seminar on MTHFR and the effects of L Methylfolate Supplementation.\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e How can I get more information on MTHFR?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003echeck out our Help for \u003ca href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\" target=\"_blank\" rel=\"noopener\"\u003eMTHFR Newbies page\u003c\/a\u003e.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium the same thing?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eBasically, yes. In the chemistry world, L stands for the “Left” isomer, which is the same as the “(6S)” isomer – the terms are synonyms (and this naming convention is used interchangeably by various companies in the industry). In the case of methylfolate, that L or (6S) isomer is the active isomer of 5-MTHF that the body can actually use. To learn more about the different types of methylfolate, its history, potency levels and stability details, and to see how our L Methylfolate Supplements prove to be the purest on the planet, visit our \u003ca href=\"https:\/\/methyl-life.com\/pages\/methylfolate-types\" target=\"_blank\" rel=\"noopener\"\u003eMethylfolate Types page\u003c\/a\u003e.\u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What is L Methylfolate Supplement 2.5 mg by Methyl-Life\u003cspan style=\"font-size: 11.0pt; line-height: 115%; font-family: 'Calibri','sans-serif'; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;\"\u003e®\u003c\/span\u003e?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eL Methylfolate Supplement 2.5 mg by Methyl-Life is a high-strength L methylfolate supplement, providing a bioavailable form of folate that supports methylation processes in the body, crucial for various biochemical reactions.\u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e How does L Methylfolate Supplement 2.5 mg benefit health?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan data-sheets-root=\"1\" data-sheets-value='{\"1\":2,\"2\":\"Methylfolate 2.5 mg supports DNA synthesis, neurotransmitter production, and cardiovascular health, making it beneficial for individuals with certain genetic variations or those seeking optimal folate levels.\"}' data-sheets-userformat='{\"2\":8961,\"3\":{\"1\":0},\"11\":3,\"12\":0,\"16\":10}'\u003eL Methylfolate Supplement 2.5 mg supports DNA synthesis, neurotransmitter production, and cardiovascular health, making it beneficial for individuals with certain genetic variations or those seeking optimal folate levels.\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003chr data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e Who can benefit from taking L Methylfolate Supplement 2.5 mg?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003eIndividuals with MTHFR gene mutations, those requiring high doses of folate, and pregnant women seeking prenatal support may benefit from the L Methylfolate Supplement 2.5 mg product.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003chr data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e Why should I take L Methylfolate Supplement 2.5 mg?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003eYou may consider taking an L methylfolate supplement if you have certain genetic variations affecting folate metabolism, are pregnant or planning to become pregnant, or have a medical condition that requires high doses of folate supplementation. L Methylfolate can support various bodily functions, including DNA synthesis, neurotransmitter production, and cardiovascular health, making it beneficial for individuals with specific needs or seeking optimal folate levels.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003chr data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e How long does it take to experience the benefits of L Methylfolate Supplement 2.5 mg?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003eIndividual responses may vary, but some users report noticing improvements in energy levels and overall well-being after just five weeks of starting the L Methylfolate Supplement 2.5 mg product.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003chr data-mce-fragment=\"1\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e How can L Methylfolate Supplement 2.5 mg help with MTHFR mutations?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"supplementboxouter\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"paragraph\" data-mce-fragment=\"1\"\u003eL Methylfolate Supplement 2.5 mg can be beneficial for individuals with MTHFR mutations because it provides a form of folate that is already methylated, bypassing the need for the MTHFR enzyme to convert it. This supports methylation processes in the body, which may be impaired in individuals with MTHFR mutations, and helps maintain optimal folate levels necessary for various biochemical reactions. It's important to consult with a healthcare professional for personalized advice on supplementation and managing MTHFR mutations.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31134621794378,"sku":"Methyl25-F1001","price":29.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methylfolate-2.5_bottle_capsules.webp?v=1773397021"},{"product_id":"methylcobalamin-b12-vitamin-b12-5000-mcg","title":"Vitamin B12 5000 mcg (Methylcobalamin B12 Complete) – 3 Bioactive Forms","description":"\u003cdiv class=\"et_pb_row et_pb_row_0\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_1_2 et_pb_column_0    et_pb_css_mix_blend_mode_passthrough\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"color: #000000;\"\u003eMethyl-Life’s® Bioactive Methylcobalamin B12 Complete - 3 Sublingual B12 Bioavailable forms - Vitamin \u003c\/span\u003eB12 5000 mcg\u003c\/strong\u003e.  Bioactive simply means that the B12 has already been converted into a form that your body can immediately use.  With these bioactive forms, the B12 does not need to be converted by your genes\/enzymes in order to be available for use by your cells (conversion can be a problem for people with MTR, MTRR, COMT as well as other gene defects).\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_1\"\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_1\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_4_4 et_pb_column_2    et_pb_css_mix_blend_mode_passthrough et-last-child\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_2 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cp\u003eThose with MTHFR are also often found to be low in B12 as well as folate - these are key nutrients for those with genetic challenges.\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMethylcobalamin B12 –\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eHelps with methylation, brain \u0026amp; nerve health, circulatory \u0026amp; immune systems, reduces homocysteine, and positively affects anemia.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHydroxy B12 –\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eHelps in pain sensitivity (chronic fatigue, fibromyalgia \u0026amp; COMT mutations may benefit), “\u003ca href=\"https:\/\/methyl-life.com\/blogs\/b-12\/benefits-of-vitamin-b12-5000-mcg-for-your-brain-cognitive-function\" rel=\"noopener\" target=\"_blank\"\u003ebrain fog\u003c\/a\u003e”, detoxifying peroxynitrites or superoxides (bad guys), as well as pernicious anemia. The body converts Hydroxy B12 into Methylcobalamin and Adenosylcobalamin.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdenosylcobalamin B12 –\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eHelps in muscle recovery, mitochondrial support, repairing the myelin sheath, and again helps with anemia.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003eOur chewable form provides for maximum B12 absorption through the mucous membranes in the mouth. Bite the tablet into pieces and allow those to dissolve under your tongue for a sublingual delivery to maximize your body's use of the nutrient.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003eMethyl-Life’s®\u003c\/strong\u003e \u003cstrong\u003eMethylcobalamin B-12 Complete Vitamin B12 5000 mcg\u003c\/strong\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003eproduct was the very first ever to combine all 3 active forms of B12 into a single tablet for effective, full-spectrum activity. \u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDid you know that \u003c\/span\u003e\u003cspan\u003erecent research shows that \u003cstrong\u003etaking B12 in a sublingual oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots\u003c\/strong\u003e? It's usually much more convenient and affordable as well -  https:\/\/pubmed.ncbi.nlm.nih.gov\/30632091. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eSo save your money and tap into the convenience of our easy-to-take tablet to avoid the \u003ca href=\"https:\/\/methyl-life.com\/blogs\/b-12\/what-happens-when-your-vitamin-b12-is-low\" rel=\"noopener\" target=\"_blank\"\u003eproblems that happen when your vitamin B12 is low\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eDosage\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e\u003cspan\u003e   \u003c\/span\u003eHow much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/dosage\" rel=\"noopener\" target=\"_blank\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto learn more about what some doctors recommend. And review our suggested\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" rel=\"noopener\" target=\"_blank\"\u003emethylation protocol\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eas a potential step by step guide.\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/best-form-of-b12\" rel=\"noopener\" target=\"_blank\"\u003eLearn more about B12 and the best active forms to take.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eWe've spent a great deal of time on our formulations and believe they are optimal for a couple key reasons:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eSuperior formula –\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eWe chose the sublingual form specifically to ensure the best absorption of the nutrients. It’s a known fact that B12 does not absorb well through the stomach lining (and many have poor gut health complicating things even further with this delivery method). Instead, active B12 is much better absorbed through the mucosa membrane (or under the tongue – sublingually). \u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdeal formula – \u003c\/strong\u003eWe have included all 3 of the active forms of B12 into a single product so you can have an optimum daily dose of B12 in an easy to afford product. It's also super convenient to take this tablet with your on-the-go lifestyle, it just melts in the mouth - no water needed.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDr. Amy Yasko \u003c\/strong\u003e(https:\/\/dramyyasko.com\/) recommends a specific form of B12 based on your genetics if you know the status of your COMT 158 and VDR Taq variants.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003ctable id=\"b12-table\" class=\"mytable\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eCOMT V158M\u003c\/th\u003e\n\u003cth\u003eVDR Taq\u003c\/th\u003e\n\u003cth\u003eB12 Types That Should Be Tolerated\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ + (TT)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ – (Tt)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e– – (tt)\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eMostly Hydroxy B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp class=\"et_pb_module et_pb_text et_pb_text_1 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\u003cstrong\u003e\u003cspan\u003e\u003cbr\u003eHow to snap the tablet in half\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.youtube.com\/watch?v=XOxWY-kQ8kc\u0026amp;list=PLpRy5gLP6XyP008M0ap1OqqkeDapTU-xq\u0026amp;index=12\u0026amp;t=0s\" target=\"_blank\"\u003eSee how its done via video\u003c\/a\u003e\u003cspan\u003e. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest\/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.\u003c\/span\u003e\u003c\/p\u003e\n\u003cdiv class=\"fluid-width-video-wrapper\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003eSUPPLEMENT FACTS\u003c\/h2\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eSuggested Use\u003c\/span\u003e: Consult with your healthcare practitioner before using this product.  See \u003ca href=\"https:\/\/methyl-life.com\/pages\/dosage\" rel=\"noopener\" target=\"_blank\"\u003emethyl-life.com\/dosage\u003c\/a\u003e for more recommendations.\u003c\/div\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\n\u003cbr\u003eBite tablet into pieces, and hold under tongue or between gums and cheek before ingesting.\u003c\/div\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\u003cstrong\u003eKEEP THIS PRODUCT AWAY FROM PETS (contains xylitol).\u003c\/strong\u003e\u003c\/div\u003e\n\u003cbr\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cdiv class=\"supplementfactsbox\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"supplementlabel\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 39%;\"\u003e\u003cstrong\u003e SUPPLEMENT FACTS \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 27.3745%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25.6255%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 39%;\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003eServing Size: 1 Chewable Tablet\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 27.3745%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25.6255%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 39%;\"\u003e\u003cem\u003e90 servings per container\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 27.3745%; text-align: right;\"\u003eAmount per Serving\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 25.6255%; text-align: right;\"\u003e\n\u003cspan\u003e% Daily Value\u003c\/span\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 39%;\"\u003e\u003cstrong\u003e Vitamin B12\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 27.3745%; text-align: right;\"\u003e\u003cstrong\u003e5,000 mcg (Total)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25.6255%; text-align: right;\"\u003e\u003cstrong\u003e208,333% (Total)\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 39%;\"\u003e    (as Methylcobalamin 50%)\u003c\/td\u003e\n\u003ctd style=\"width: 27.3745%; text-align: right;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e2,500 mcg\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 25.6255%; text-align: right;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 39%;\"\u003e    \u003cstrong\u003e\u003c\/strong\u003e(as Hydroxy B12 25%)\u003c\/td\u003e\n\u003ctd style=\"width: 27.3745%; text-align: right;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e1,250 mcg\u003c\/div\u003e\n\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 25.6255%; text-align: right;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 39%;\"\u003e    \u003cstrong\u003e\u003c\/strong\u003e(as Adenosylcobalamin 25%)\u003c\/td\u003e\n\u003ctd style=\"width: 27.3745%; text-align: right;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e1,250 mcg\u003c\/div\u003e\n\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 25.6255%; text-align: right;\"\u003e\n\u003cdiv class=\"supplementitem\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eOTHER INGREDIENTS\u003c\/span\u003e: \u003cspan\u003exylitol (Xylisorb\u003c\/span\u003e\u003cstrong\u003e®\u003c\/strong\u003e\u003cspan\u003e), microcrystalline cellulose (Microcel\u003c\/span\u003e\u003cstrong\u003e®\u003c\/strong\u003e\u003cspan\u003e), stearic acid, silicon dioxide, natural mint flavor (dextrose, silicon dioxide, natural flavor).\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\u003cspan\u003eNot a significant source of total sugars.\u003c\/span\u003e\u003c\/div\u003e\n\u003cbr\u003e\u003cbr\u003e\u003cspan style=\"text-decoration: underline;\"\u003eProduct Does NOT Contain\u003c\/span\u003e: wheat, gluten, soy, dairy, tree nuts, animal products, GMOs.\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\"\u003eNo artificial ingredients or colorings. \u003cbr\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003eFAQ'S\u003c\/strong\u003e\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe most important thing to realize is that \u003cstrong\u003eblood tests for B12 are highly inaccurate at detecting actual cellular levels of B12\u003c\/strong\u003e (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used. \u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What can you do if you have high B12 blood test results?\u003c\/span\u003e\u003c\/strong\u003e Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What does sublingual mean and why isn’t your product labeled as “sublingual”?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eIt’s a well-known fact that B12 does not absorb well through the gut, so taking B12 via sublingual or mouth absorption is best (holding it under the tongue or between the gums and cheek is most common). Consider some form of liquid or tablet\/lozenge that can be sucked on or dissolved in the mouth. Holding the B12 in your mouth for at least 90 seconds is good and the longer you can leave it in your mouth, the better for sublingual absorption (as opposed to gut absorption).\u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cbr\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003e\u003cspan style=\"text-decoration: underline;\"\u003eNote\u003c\/span\u003e: different manufacturers use different terms for tablets that are meant to dissolve sublingually in the mouth, but “sublingual” is considered a pharmaceutical term by the FDA, so dietary supplements are moving away from using that term. However, it doesn’t really matter what term you use (chewable tablet, lozenge, sublingual tablet, liquid, etc.) for maximum absorption \u003cstrong\u003ethe main idea is to hold it in your mouth for 90 seconds or more\u003c\/strong\u003e if you can (if you forget, don’t worry, since you’re taking the active form, your body will still get some benefit even if you swallow it whole).\u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eAnother way to absorb B12 is muscularly through shots, however, the research tells us that sublingual (or mouth) absorption is equally as effective as muscular absorption … and shots may cost significantly more money. Also, be aware with shots (many doctors still give cyanocobalamin shots) that though you may need higher doses of active B12s (like myself), you may not do well when given higher doses of cyanocobalamin in a shot because your body may not be able to do the conversions and you could have negative side effects.\u003cbr\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eOne of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIt’s important to realize that the \u003cstrong\u003eMTHFR status does not necessarily determine the type of B12 that’s best for you\u003c\/strong\u003e, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIt seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.\u003c\/p\u003e\n\u003cp\u003eThe most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into \u003cspan\u003ehydroxy B12\u003c\/span\u003e, and from there the \u003cspan\u003ehydroxy B12 \u003c\/span\u003ehas to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eIf you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxy B12 (and this is why our methylation protocol suggests hydroxy B12 as the B12 form to begin with):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eFolks with multiple COMT mutations tend to do very well with \u003cspan\u003ehydroxy B12 \u003c\/span\u003e(it helps mop up excess peroxynitrites which can cause problems)\u003c\/li\u003e\n\u003cli\u003eFolks with MTR \u0026amp; MTRR mutations may do well with methylcobalamin \u0026amp; adenosylcobalamin supplementation\u003c\/li\u003e\n\u003cli\u003eAnd Dr. Amy Yasko (https:\/\/dramyyasko.com)talks about folks with a particular mutation status for COMT \u0026amp; VDR Taq as best needing the below forms of B12:\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ctable style=\"height: 190px; width: 100.061%;\" id=\"b12-table\" class=\"mytable\"\u003e\n\u003cthead\u003e\n\u003ctr style=\"height: 19px;\"\u003e\n\u003cth style=\"height: 19px; width: 21.5205%;\"\u003eCOMT V158M\u003c\/th\u003e\n\u003cth style=\"height: 19px; width: 13.2434%;\"\u003eVDR Taq\u003c\/th\u003e\n\u003cth style=\"height: 19px; width: 64.3777%;\"\u003eB12 Types That Should Be Tolerated\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19px;\"\u003e\n\u003ctd style=\"height: 19px; width: 21.5205%;\"\u003e– –\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 13.2434%;\"\u003e+ + (TT)\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 64.3777%;\"\u003eAll 3 types of B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19px;\"\u003e\n\u003ctd style=\"height: 19px; width: 21.5205%;\"\u003e– –\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 13.2434%;\"\u003e+ – (Tt)\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 64.3777%;\"\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19px;\"\u003e\n\u003ctd style=\"height: 19px; width: 21.5205%;\"\u003e– –\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 13.2434%;\"\u003e– – (tt)\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 64.3777%;\"\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19px;\"\u003e\n\u003ctd style=\"height: 19px; width: 21.5205%;\"\u003e+ –\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 13.2434%;\"\u003e+ +\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 64.3777%;\"\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19px;\"\u003e\n\u003ctd style=\"height: 19px; width: 21.5205%;\"\u003e+ –\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 13.2434%;\"\u003e+ –\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 64.3777%;\"\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19px;\"\u003e\n\u003ctd style=\"height: 19px; width: 21.5205%;\"\u003e+ –\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 13.2434%;\"\u003e– –\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 64.3777%;\"\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19px;\"\u003e\n\u003ctd style=\"height: 19px; width: 21.5205%;\"\u003e+ +\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 13.2434%;\"\u003e+ +\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 64.3777%;\"\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19px;\"\u003e\n\u003ctd style=\"height: 19px; width: 21.5205%;\"\u003e+ +\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 13.2434%;\"\u003e+ –\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 64.3777%;\"\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19px;\"\u003e\n\u003ctd style=\"height: 19px; width: 21.5205%;\"\u003e+ +\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 13.2434%;\"\u003e– –\u003c\/td\u003e\n\u003ctd style=\"height: 19px; width: 64.3777%;\"\u003eMostly Hydroxy B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What is Active B12 Complete?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003eActive B12 Complete is a supplement containing three fully-bioavailable forms of vitamin B12, providing comprehensive support for energy metabolism, cognitive function, and overall well-being in a convenient chewable form.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What are the three forms of B12 in Active B12 Complete?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003eActive B12 Complete includes methylcobalamin, adenosylcobalamin, and hydroxy B12, ensuring maximum absorption and utilization of vitamin B12 by the body for enhanced benefits.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003eHow should Active B12 Complete be taken?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003eFollow the guidance of a healthcare professional when taking Active B12 Complete chewable, usually one tablet daily or as necessary to fulfill personal B12 needs. Prior to buying, explore our \u003ca class=\"in-cell-link\" href=\"https:\/\/methyl-life.com\/pages\/dosage\" rel=\"noopener\" target=\"_blank\"\u003edosage details\u003c\/a\u003e to understand recommendations from certain healthcare providers. Additionally, consider reviewing our suggested \u003ca class=\"in-cell-link\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" rel=\"noopener\" target=\"_blank\"\u003emethylation protocol\u003c\/a\u003e as a potential step-by-step guide.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003eHow long does a supply of Active B12 Complete last?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003eEach purchase of Active B12 Complete provides a three-month supply, offering extended support for maintaining B12 levels and overall health.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003eCan Active B12 Complete help with fatigue and low energy levels?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003eYes, Active B12 Complete supports energy metabolism and may help alleviate fatigue and low energy levels associated with B12 deficiency or inadequate B12 intake.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31134621892682,"sku":"B12Comp-H1001","price":32.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/B12-Complete_bottle_capsules.webp?v=1773395592"},{"product_id":"methylated-b12-l-methylfolate-3mg","title":"Methylated B12 3.75mg + L-Methylfolate 3mg as Methyl-Life®'s B-Methylated-II","description":"\u003cdiv class=\"et_pb_row et_pb_row_0\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_1_2 et_pb_column_0    et_pb_css_mix_blend_mode_passthrough\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cp\u003e\u003cstrong\u003eMethylated B12 + L-Methylfolate 3 mg in a sublingual tablet as Methyl-Life's® B-Methylated II product - one of the purest L-Methylfolate brands + Bioactive B12 as Methylcobalamin\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003eMethyl-Life®\u003c\/strong\u003e\u003c\/span\u003e products contain the most bioactive nutrient form of folate available today, L-Methylfolate (often denoted as L-MTHF, L-5-Methylenetretrahydrofolate, L-5-MTHF, (6S)-5-Methylfolate, etc). This is the ‘already converted’ form of the vitamin that is immediately ready for the body’s cells to use directly. It’s the only form of folate which crosses the blood-brain barrier. Those with MTHFR are also often found to be low in B12 as well as and may have significant problems absorbing it.\u003c\/p\u003e\n\u003cp\u003eEvery serving in \u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003eMethyl-Life’s®\u003c\/strong\u003e \u003cstrong\u003eB-Methylated II\u003c\/strong\u003e\u003c\/span\u003e product contains a moderate dose \u003cstrong\u003e\u003cem\u003e(3 mg) of L-Methylfolate\u003c\/em\u003e\u003c\/strong\u003e as \u003cstrong\u003eCerebrofolate® \u003c\/strong\u003eas well as \u003cstrong\u003e\u003cem\u003e3.75 mg of\u003c\/em\u003e\u003c\/strong\u003e \u003cstrong\u003e\u003cem\u003eActive B12 \u003c\/em\u003e\u003c\/strong\u003e(as \u003cstrong\u003e\u003cem\u003eMethylcobalamin B12\u003c\/em\u003e\u003c\/strong\u003e).  We specifically deliver this power-packed combination in a tasty, chewable tablet that can sit under the tongue for maximum B12 absorption.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_1\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_4_4 et_pb_column_2    et_pb_css_mix_blend_mode_passthrough et-last-child\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_2 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMethylcobalamin –\u003c\/strong\u003e\u003cspan\u003e Helps with methylation, brain \u0026amp; nerve health, circulatory \u0026amp; immune systems, reduces homocysteine, and positively affects anemia.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003eOur chewable form provides for maximum B12 absorption through the mucous membranes in the mouth. Bite the tablet into pieces and allow those to dissolve under your tongue for a sublingual delivery to maximize your body's use of the nutrient.  \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDid you know that \u003c\/span\u003e\u003cspan\u003erecent research shows that \u003cstrong\u003etaking B12 in a sublingual oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots\u003c\/strong\u003e? It's usually much more convenient and affordable as well -  https:\/\/pubmed.ncbi.nlm.nih.gov\/30632091.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003eMethyl-Life®\u003c\/strong\u003e\u003c\/span\u003e remains proud that we can offer such an exceptional product line at such an affordable price point (because as \u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003ea family-owned company\u003c\/strong\u003e\u003c\/span\u003e, we know this is important to you).  No other competitor sells a comparable product for less.  We go above and beyond with our quality standards by investing in additional 3-year stability studies and third party lab testing to ensure our final products are the very best you can buy.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003eSpoiler alert\u003c\/span\u003e ... our 5-year old products tested fully potent, but when tested against ours, the competitors' products did NOT meet the Supplement Facts claims after 5 years on the shelf. \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003eMethyl-Life’s®\u003c\/strong\u003e \u003cstrong\u003eB-Methylated II \u003c\/strong\u003e\u003c\/span\u003ewas formulated especially for people with genetic (MTHFR, MTR, MTRR) variants, dietary or drug-induced need. It was designed specifically to bypass genetic challenges and optimize the body’s methylation process. This means you may have more energy and motivation, get improved protection against toxins, and just plain feel better. \u003c\/p\u003e\n\u003cp\u003eModerate doses of L-Methylfolate are designed to support optimal brain and nerve health and may positively affect mood. Studies have shown methylfolate is important for peripheral neuropathy as it repairs the myelin sheath. It is often used to assist with pregnancy and fetal well-being. It can also convert homocysteine into methionine which can support cardiovascular health. L-Methylfolate can boost glutathione levels in the body (and glutathione is a great ally when it comes to detoxification, it’s your body’s strongest antioxidant).  Talk to your doctor to determine, if taking moderate doses of L-Methylfolate and Methylcobalamin is right for you. \u003cbr\u003e\u003c\/p\u003e\n\u003ch2\u003eDosage\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eHow much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/dosage\" rel=\"noopener\" target=\"_blank\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto learn more about what some doctors recommend. And review our suggested\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" rel=\"noopener\" target=\"_blank\"\u003emethylation protocol\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eas a potential step by step guide to some dosing options.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eHow to snap the tablet in half\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e \u003ca href=\"https:\/\/www.youtube.com\/watch?v=XOxWY-kQ8kc\u0026amp;list=PLpRy5gLP6XyP008M0ap1OqqkeDapTU-xq\u0026amp;index=12\u0026amp;t=0s\" rel=\"noopener\" target=\"_blank\"\u003eSee how its done via video\u003c\/a\u003e. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest\/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDr. Amy Yasko\u003c\/strong\u003e(\u003cspan\u003e \u003c\/span\u003ehttps:\/\/dramyyasko.com) recommends a specific form of B12 based on your genetics if you know the status of your COMT 158 and VDR Taq variants.\u003c\/p\u003e\n\u003ctable class=\"mytable\" id=\"b12-table\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eCOMT V158M\u003c\/th\u003e\n\u003cth\u003eVDR Taq\u003c\/th\u003e\n\u003cth\u003eB12 Types That Should Be Tolerated\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ + (TT)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ – (Tt)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e– – (tt)\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eMostly Hydroxy B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eSUPPLEMENT FACTS\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eSUGGESTED USE\u003c\/span\u003e: Ask your doctor. Visit \u003ca href=\"https:\/\/methyl-life.com\/dosage\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/methyl-life.com\/dosage\u003c\/a\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cbr\u003eBite tablet into pieces, and hold under tongue or between gum and cheek until they dissolve.\u003cbr\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\n\u003cbr\u003e\u003cstrong\u003eGreat for teeth, not for animals (contains xylitol).\u003c\/strong\u003e\n\u003c\/div\u003e\n\u003cbr\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cdiv class=\"supplementfactsbox\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"supplementlabel\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\u003cstrong\u003e SUPPLEMENT FACTS \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003eServing Size: 1 Chewable Tablet\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\n\u003cspan\u003e90 servings per container\u003c\/span\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cem\u003eAmount per Serving\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cem\u003e % Daily Value\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\n\u003cb\u003eFolate \u003c\/b\u003e(3 mg L-Methylfolate from 4.2 mg of \u003cstrong\u003eCerebrofolate®\u003c\/strong\u003e)\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e5,100 DFE mcg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e1,275%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\n\u003cstrong\u003eVitamin B12 \u003c\/strong\u003e(as Methylcobalamin)\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\u003cstrong\u003e3,750 mcg\u003c\/strong\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e156,250%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eOTHER INGREDIENTS\u003c\/span\u003e: xylitol (Xylisorb\u003cb\u003e\u003cstrong\u003e®\u003c\/strong\u003e\u003c\/b\u003e), microcrystalline cellulose (Microcel\u003cb\u003e\u003cstrong\u003e®\u003c\/strong\u003e\u003c\/b\u003e), stearic acid, silicon dioxide, natural mint flavor (dextrose, \u003cspan\u003esilicon dioxide, \u003c\/span\u003enatural flavor, propylene glycol).\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003eNot a significant source of total sugars.\u003c\/div\u003e\n\u003cbr\u003e\u003cbr\u003ePRODUCT CONTAINS NO: wheat, gluten, soy, dairy, egg, fish\/shellfish, yeast, nuts, starch, ingredients of animal origin, caffeine, artificial colorings, preservatives or artificial flavoring, bisphenol-A (BPA), or phthalate.\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cbr\u003e\n\u003ch2\u003eFAQ'S\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What type of folate does Methyl-Life® use in its products?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMethyl-Life® products feature L-Methylfolate, the most bioactive form of folate available today. Also known as L-MTHF, L-5-Methylenetretrahydrofolate, or (6S)-5-Methylfolate, L-Methylfolate is the converted form of the vitamin that the body's cells can immediately utilize. It is the only form of folate capable of crossing the blood-brain barrier.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e Why is L-Methylfolate important for individuals with MTHFR mutations?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eIndividuals with MTHFR mutations often have difficulty converting synthetic folic acid into its active form, L-Methylfolate. Therefore, using L-Methylfolate directly bypasses this conversion step, ensuring optimal folate levels in the body. Additionally, those with MTHFR mutations may also experience challenges in absorbing vitamin B12, making it crucial to address both nutrient deficiencies simultaneously.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What does each serving of Methyl-Life’s® B-Methylated II product contain?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eEach serving of Methyl-Life’s® B-Methylated II product contains a moderate dose of 3 mg of L-Methylfolate, provided as internationally-patented Magnafolate® PRO, along with 3.75 mg of Active B12 in the form of Methylcobalamin. This power-packed combination is delivered in a tasty, chewable tablet designed to sit under the tongue for maximum B12 absorption.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What are the benefits of Methylcobalamin found in Methyl-Life’s® B-Methylated II product?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eMethylcobalamin offers a range of benefits, including support for methylation, brain and nerve health, circulatory and immune systems. It also helps reduce homocysteine levels and can positively affect individuals with anemia. By including Methylcobalamin in B-Methylated II, Methyl-Life® provides a comprehensive solution for addressing various health concerns.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e How does the chewable form of our product enhance B12 absorption?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eOur chewable form allows for maximum B12 absorption through the mucous membranes in the mouth. By biting the tablet into pieces and allowing them to dissolve under your tongue, you facilitate sublingual delivery, maximizing your body's utilization of this essential nutrient.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_1\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_4_4 et_pb_column_2    et_pb_css_mix_blend_mode_passthrough et-last-child\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_2 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe most important thing to realize is that \u003cstrong\u003eblood tests for B12 are highly inaccurate at detecting actual cellular levels of B12\u003c\/strong\u003e (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used. \u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What can you do if you have high B12 blood test results?\u003c\/span\u003e\u003c\/strong\u003e Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What does sublingual mean and why isn’t your product labeled as “sublingual”?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eIt’s a well-known fact that B12 does not absorb well through the gut, so taking B12 via sublingual or mouth absorption is best (holding it under the tongue or between the gums and cheek is most common). Consider some form of liquid or tablet\/lozenge that can be sucked on or dissolved in the mouth. Holding the B12 in your mouth for at least 90 seconds is good and the longer you can leave it in your mouth, the better for sublingual absorption (as opposed to gut absorption). \u003c\/span\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003e\u003cspan style=\"text-decoration: underline;\"\u003eNote\u003c\/span\u003e: different manufacturers use different terms for tablets that are meant to dissolve sublingually in the mouth, but “sublingual” is considered a pharmaceutical term by the FDA, so dietary supplements are moving away from using that term. However, it doesn’t really matter what term you use (chewable tablet, lozenge, sublingual tablet, liquid, etc.) for maximum absorption \u003cstrong\u003ethe main idea is to hold it in your mouth for 90 seconds or more\u003c\/strong\u003e if you can (if you forget, don’t worry, since you’re taking the active form, your body will still get some benefit even if you swallow it whole). \u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eAnother way to absorb B12 is muscularly through shots, however, the research tells us that sublingual (or mouth) absorption is equally as effective as muscular absorption … and shots may cost significantly more money. Also, be aware with shots (many doctors still give cyanocobalamin shots) that though you may need higher doses of active B12s (like myself), you may not do well when given higher doses of cyanocobalamin in a shot because your body may not be able to do the conversions and you could have negative side effects.\u003cbr\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eOne of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIt’s important to realize that the \u003cstrong\u003eMTHFR status does not necessarily determine the type of B12 that’s best for you\u003c\/strong\u003e, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIt seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.\u003c\/p\u003e\n\u003cp\u003eThe most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into \u003cspan\u003ehydroxy B12\u003c\/span\u003e, and from there the \u003cspan\u003ehydroxy B12 \u003c\/span\u003ehas to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eIf you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well-tolerated active form of B12 for folks seems to be hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxy B12 (and this is why our methylation protocol suggests hydroxy B12 as the B12 form, to begin with):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eFolks with multiple COMT mutations tend to do very well with \u003cspan\u003ehydroxy B12 \u003c\/span\u003e(it helps mop up excess peroxynitrites which can cause problems)\u003c\/li\u003e\n\u003cli\u003eFolks with MTR \u0026amp; MTRR mutations may do well with methylcobalamin \u0026amp; adenosylcobalamin supplementation\u003c\/li\u003e\n\u003cli\u003eAnd Dr. Amy Yasko (https:\/\/dramyyasko.com) talks about folks with a particular mutation status for COMT \u0026amp; VDR Taq as best needing the below forms of B12:\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ctable class=\"mytable\" id=\"b12-table\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eCOMT V158M\u003c\/th\u003e\n\u003cth\u003eVDR Taq\u003c\/th\u003e\n\u003cth\u003eB12 Types That Should Be Tolerated\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ + (TT)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ – (Tt)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e– – (tt)\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eMostly Hydroxy B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31134621925450,"sku":"BM2-A1001","price":39.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/B-Methylated-II_bottle_capsules.webp?v=1778831571"},{"product_id":"mthfr-supplement-methylfolate-b12-chewable","title":"MTHFR Supplement: Methylfolate + B12 Chewable Multivitamin","description":"\u003cp\u003eGet \u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003eMethyl-Life’s® MTHFR Supplement\u003c\/strong\u003e\u003c\/span\u003e bundle with 3 specialized products, a methylfolate supplement, B12 Chewable tablets as well as a multivitamin with supporting cofactor nutrients!\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eThis comprehensive starting package contains the bioactive nutrients:\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eRare but \u003cstrong\u003emost well-tolerated form of B12 Chewable\u003c\/strong\u003e (as Hydroxy B12)\u003c\/li\u003e\n\u003cli\u003eThe \u003cstrong\u003epurest Methylfolate Supplement\u003c\/strong\u003e (as shown in a recent study)\u003c\/li\u003e\n\u003cli\u003eThe optimal \u003cstrong\u003eMTHFR-supporting multivitamin\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCheck out the details below regarding each specific product included in the bundle using the links below:\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli style=\"list-style-type: none;\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cstrong\u003e\u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-2-5\"\u003eMethylfolate Supplement\u003c\/a\u003e\u003c\/strong\u003e - Purest + most stable Methylfolate Supplement (2.5 mg) you can buy\u003ca title=\"Methyl-Life's Methylated Multivitamin - 90 Chewable Tablets - 30 servings + Cognitive-enhancing Nutrients\" href=\"https:\/\/methyl-life.com\/collections\/multivitamins\/products\/methylated-multivitamin\"\u003e\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003ca href=\"https:\/\/methyl-life.com\/products\/sublingual-b12-tablets-hydroxy-b12\" title=\"Methyl-Life® Sublingual B12 as Hydroxy B12 - well-tolerated bioavailable vitamin B12 tablets - 90 ct\"\u003e\u003cstrong\u003eB12 Chewable\u003c\/strong\u003e\u003c\/a\u003e  - Active form Hydroxy B12 at 2.5 mg per tablet\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca title=\"Methyl-Life's Methylated Multivitamin - 90 Chewable Tablets - 30 servings + Cognitive-enhancing Nutrients\" href=\"https:\/\/methyl-life.com\/collections\/multivitamins\/products\/methylated-multivitamin\"\u003e\u003cstrong\u003eMethylated Multivitamin\u003c\/strong\u003e\u003c\/a\u003e - Methylation-supporting MTHFR Supplement + Cognitive and Energy-promoting nutrients for full-spectrum absorption\u003ca title=\"Methyl-Life Hydroxy B12 2.5 product - 2.5 mg of active B12 for optimal absorption\" href=\"https:\/\/methyl-life.com\/collections\/methyl-b12-and-methyl-folate\"\u003e\u003c\/a\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eDosage\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eHow much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"How much L-Methylfolate should I take? What's the right dosage level of B12 for me?\" href=\"https:\/\/methyl-life.com\/pages\/dosage\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto learn more about what some doctors recommend. And review our suggested\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\"\u003emethylation protocol\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eas a potential step by step guide to some dosing options.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eHow to snap the tablet in half\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e \u003ca title=\"How to split a Methyl-Life™ tablet in half so you can take half the dosage of a full tablet\" href=\"https:\/\/www.youtube.com\/watch?v=XOxWY-kQ8kc\u0026amp;list=PLpRy5gLP6XyP008M0ap1OqqkeDapTU-xq\u0026amp;index=12\u0026amp;t=0s\" target=\"_blank\"\u003eSee how its done via video\u003c\/a\u003e. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest\/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more. \u003c\/p\u003e\n\u003ch2 class=\"et_pb_text_inner\"\u003eResearch\u003c\/h2\u003e\n\u003cp\u003e\u003ciframe height=\"500px\" width=\"100%\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/MTHFR_and_pregnancy_677.pdf?v=1591313816\"\u003e\n    \u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eFAQ'S\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What is the right dosage for me?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCheck out our \u003ca title=\"How much L-Methylfolate should I take? What's the right dosage level of B12 for me?\" href=\"https:\/\/methyl-life.com\/dosage\"\u003eDosage\u003c\/a\u003e page to learn what some \u003ca title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, L-Methylfolate, Deplin and optimizing your health\" href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\"\u003edoctors\u003c\/a\u003e are saying. And consider reviewing our \u003ca title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\/\"\u003eMethylation Protocol\u003c\/a\u003e page as one example of how someone could start taking the active methylation nutrients.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e Are Methylfolate Supplements the only thing I should take if I have an MTHFR gene mutation?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eNo, actually our recommendation is to heavily consider following Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching parts 3 \u0026amp; 4 of his \u003ca title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, L-Methylfolate, Deplin and optimizing your health\" href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\"\u003evideo seminar\u003c\/a\u003e.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou can also download one of four specific \u003ca title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\"\u003eMethylation Protocols\u003c\/a\u003e which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term. \u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou'll find our\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"How do I treat my MTHFR? How much L-Methylfolate should I take? I'm new to MTHFR what should I do?\" href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\"\u003eMTHFR Newbies page\u003c\/a\u003e is very helpful as well.  It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What do doctors have to say about MTHFR and how to treat it?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eGo to \u003ca title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, L-Methylfolate, Deplin and optimizing your health\" href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\"\u003eA Doctor Explains\u003c\/a\u003e and listen to Dr. Neil Rawlins’ seminar on MTHFR and the effects of Methylfolate Supplements.\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e How can I get more information on MTHFR?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003echeck out our Help for \u003ca title=\"How do I treat my MTHFR? How much L-Methylfolate should I take? I'm new to MTHFR what should I do?\" href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\"\u003eMTHFR Newbies page\u003c\/a\u003e.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium the same thing?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eBasically, yes. In the chemistry world, L stands for the “Left” isomer, which is the same as the “(6S)” isomer – the terms are synonyms (and this naming convention is used interchangeably by various companies in the industry). In the case of methylfolate supplements, that L or (6S) isomer is the active isomer of 5-MTHF that the body can actually use. To learn more about the different types of methylfolate, its history, potency levels and stability details, and to see how our Methylfolate Supplements prove to be the purest on the planet, visit our \u003ca title=\"A comprehensive comparison of L-Methylfolates available on the market today. Chemical, stability, potency and purity differences studied and compared in detail.\" href=\"https:\/\/methyl-life.com\/pages\/methylfolate-types\"\u003eMethylfolate Types page\u003c\/a\u003e.\u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_1\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_4_4 et_pb_column_2    et_pb_css_mix_blend_mode_passthrough et-last-child\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_2 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What if my blood serum B12 level test comes back as high, does that mean I don’t need a B12 chewable?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe most important thing to realize is that \u003cstrong\u003eblood tests for B12 are highly inaccurate at detecting actual cellular levels of B12\u003c\/strong\u003e (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used. \u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What can you do if you have high B12 blood test results?\u003c\/span\u003e\u003c\/strong\u003e Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 chewable form in that’s most likely best for you).\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What does sublingual mean and why isn’t your product labeled as “sublingual”?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eIt’s a well-known fact that B12 does not absorb well through the gut, so taking B12 sublingual or via mouth absorption is best (holding it under the tongue or between the gums and cheek is most common). Consider some form of liquid or tablet\/lozenge that can be sucked on or dissolved in the mouth. Holding the B12 chewable in your mouth for at least 90 seconds is good and the longer you can leave it in your mouth, the better for sublingual absorption (as opposed to gut absorption).\u003c\/span\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003e\u003cspan style=\"text-decoration: underline;\"\u003eNote\u003c\/span\u003e: different manufacturers use different terms for tablets that are meant to dissolve sublingually in the mouth, but “sublingual” is considered a pharmaceutical term by the FDA, so dietary supplements are moving away from using that term. However, it doesn’t really matter what term you use (chewable tablet, lozenge, sublingual tablet, liquid, etc.) for maximum absorption \u003cstrong\u003ethe main idea is to hold it in your mouth for 90 seconds or more\u003c\/strong\u003e if you can (if you forget, don’t worry, since you’re taking the active form, your body will still get some benefit even if you swallow it whole).\u003c\/span\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eAnother way to absorb B12 is muscularly through shots, however, the research tells us that sublingual (or mouth) absorption is equally as effective as muscular absorption … and shots may cost significantly more money. Be aware with shots (many doctors still give cyanocobalamin shots) that although you may need higher doses of active B12s (like myself), you may not do well when given higher doses of cyanocobalamin in a shot because your body may not be able to do the conversions and you could have negative side effects.\u003cbr\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 Chewable form, why are you suggesting these other forms too?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eOne of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (Hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIt’s important to realize that the \u003cstrong\u003eMTHFR status does not necessarily determine the type of B12 Chewable that’s best for you\u003c\/strong\u003e, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate supplements and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate supplements well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIt seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 chewable type). So do your homework when it comes to your B12 Chewable to see which you may tolerate best.\u003c\/p\u003e\n\u003cp\u003eThe most common form of B12 Chewable that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into \u003cspan\u003eHydroxy B12\u003c\/span\u003e, and from there the \u003cspan\u003eHydroxy B12 \u003c\/span\u003ehas to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eIf you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be Hydroxy B12. All of the genetic combinations she lists below should be able to tolerate B12 in the form of Hydroxy B12 (and this is why our methylation protocol suggests Hydroxy B12 as the B12 Chewable form to begin with):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eFolks with multiple COMT mutations tend to do very well with \u003cspan\u003eHydroxy B12 \u003c\/span\u003e(it helps mop up excess peroxynitrites which can cause problems)\u003c\/li\u003e\n\u003cli\u003eFolks with MTR \u0026amp; MTRR mutations may do well with methylcobalamin \u0026amp; adenosylcobalamin supplementation\u003c\/li\u003e\n\u003cli\u003eAnd Dr. Amy Yasko (https:\/\/dramyyasko.com) talks about folks with a particular mutation status for COMT \u0026amp; VDR Taq as best needing the below forms of B12:\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ctable class=\"mytable\" id=\"b12-table\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eCOMT V158M\u003c\/th\u003e\n\u003cth\u003eVDR Taq\u003c\/th\u003e\n\u003cth\u003eB12 Types That Should Be Tolerated\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ + (TT)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ – (Tt)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e– – (tt)\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eMostly Hydroxy B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31134621958218,"sku":"M25-MMulti-Hydroxo-FBG1001","price":97.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/MethylatedMultivitamin_Methylfolate2.5_HydroxyB12-1-updated-09-22-26.webp?v=1791213265"},{"product_id":"methylfolate-2-5-vitamin-b12-sublingual","title":"MTHFR Actives - L-Methylfolate + Hydroxy B12 Sublingual","description":"\u003cp\u003eGet 2 of \u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003eMethyl-Life’s®\u003c\/strong\u003e\u003c\/span\u003e key MTHFR Active products bundled for those who are sensitive or wanting to start their methylation journey off slower. \u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eThis active-nutrients package contains 2 chewable products at lower to moderate dosages for those who tend to be more sensitive to supplements:\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eThe \u003cstrong\u003epure \u0026amp; stable L-Methylfolate\u003c\/strong\u003e for optimal absorption\u003c\/li\u003e\n\u003cli\u003eThe rare but \u003cstrong\u003emost well-tolerated form of B12\u003c\/strong\u003e (as Hydroxy B12)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCheck out the details below regarding each product included in the bundle to learn more:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli style=\"list-style-type: none;\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-2-5\" title=\"Methyl-Life's Methylfolate 2.5 mg product - purest L-Methylfolate on the planet\"\u003eL-Methylfolate 2.5\u003c\/a\u003e - Pure \u0026amp; stable L-Methylfolate - 2.5 mg\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/methyl-life.com\/products\/sublingual-b12-tablets-hydroxy-b12\" title=\"Methyl-Life® Sublingual B12 as Hydroxy B12 product - 2.5 mg of active B12 for optimal absorption\"\u003eVitamin B12 Sublingual\u003c\/a\u003e - Active Hydroxy B12 at 2.5 mg per tablet\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eDid you know that \u003c\/span\u003e\u003cspan\u003erecent research shows that \u003cstrong\u003etaking Vitamin B12 Sublingual as an oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots\u003c\/strong\u003e? It's usually much more convenient and affordable as well -  https:\/\/pubmed.ncbi.nlm.nih.gov\/30632091.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eDosage\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eHow much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/dosage\" title=\"How much L-Methylfolate should I take? What's the right dosage level of B12 for me?\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto learn more about what some doctors recommend. And review our suggested\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\"\u003emethylation protocol\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eas a potential step by step guide to some dosing options.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eHow to snap the tablet in half\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e \u003ca href=\"https:\/\/www.youtube.com\/watch?v=XOxWY-kQ8kc\u0026amp;list=PLpRy5gLP6XyP008M0ap1OqqkeDapTU-xq\u0026amp;index=12\u0026amp;t=0s\" title=\"How to split a Methyl-Life™ tablet in half so you can take half the dosage of a full tablet\" target=\"_blank\"\u003eSee how its done via video\u003c\/a\u003e. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest\/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more. \u003c\/p\u003e\n\u003ch2\u003eFAQ'S\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What is the right dosage for me?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCheck out our \u003ca href=\"https:\/\/methyl-life.com\/dosage\" title=\"How much L-Methylfolate should I take? What's the right dosage level of B12 for me?\"\u003eDosage\u003c\/a\u003e page to learn what some \u003ca href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, L-Methylfolate, Deplin and optimizing your health\"\u003edoctors\u003c\/a\u003e are saying. And consider reviewing our \u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\/\" title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\"\u003eMethylation Protocol\u003c\/a\u003e page as one example of how someone could start taking the active methylation nutrients.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e Is Methylfolate the only thing I should take if I have an MTHFR gene mutation?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eNo, actually our recommendation is to heavily consider following Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching parts 3 \u0026amp; 4 of his \u003ca href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, L-Methylfolate, Deplin and optimizing your health\"\u003evideo seminar\u003c\/a\u003e.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou can also download one of four specific \u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\"\u003eMethylation Protocols\u003c\/a\u003e which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term. \u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou'll find our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\" title=\"How do I treat my MTHFR? How much L-Methylfolate should I take? I'm new to MTHFR what should I do?\"\u003eMTHFR Newbies page\u003c\/a\u003e is very helpful as well.  It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What is included in the Actives for Sensitives Bundle?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eThe Actives for Sensitives Bundle includes 2 therapeutic products which contain L-Methylfolate and Vitamin B12 Sublingual tablets.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e How can I get more information on MTHFR?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003echeck out our Help for \u003ca href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\" title=\"How do I treat my MTHFR? How much L-Methylfolate should I take? I'm new to MTHFR what should I do?\"\u003eMTHFR Newbies page\u003c\/a\u003e.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e How can the Actives for Sensitives Bundle benefit individuals with sensitivities?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eThis bundle is specifically curated for individuals with sensitivities to certain forms of supplements. L-Methylfolate and Vitamin B12 Sublingual provide essential nutrients in forms that are generally well-tolerated by sensitive individuals, allowing them to support their health without discomfort.\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_1\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_4_4 et_pb_column_2    et_pb_css_mix_blend_mode_passthrough et-last-child\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_2 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e Why is L-Methylfolate important in the bundle?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eL-Methylfolate is crucial for methylation processes in the body, particularly for those who may have difficulty processing synthetic folic acid. The 2.5 mg dosage in this bundle provides a gentle introduction for sensitive individuals.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What can you do if you have high B12 blood test results?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What is the significance of Vitamin B12 Sublingual in the bundle?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eVitamin B12 Sublingual is a well-tolerated form of Hydroxy B12, ideal for individuals who may experience adverse effects from other forms of B12. With a dosage of 2.5 mg per tablet, it compliments the methylation process initiated by L-methylfolate.\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e Who should consider using the Methyl-Life® Methylation Starter Bundle?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003eIndividuals who are sensitive to supplements or those who are new to methylation support may benefit from this bundle. It offers a gentle introduction to key nutrients without overwhelming the system with high dosages.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e I have my 23andme test results, how can I use those to know which form of Vitamin B12 Sublingual I might best tolerate?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eIf you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of Vitamin B12 Sublingual for folks seems to be hydroxy B12. All of the genetic combinations she lists below should be able to tolerate Vitamin B12 Sublingual in the form of hydroxy B12 (which is why our methylation protocol suggests hydroxy B12 as the Vitamin B12 Sublingual form to begin with):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eFolks with multiple COMT mutations tend to do very well with \u003cspan\u003ehydroxy B12\u003c\/span\u003e (it helps mop up excess peroxynitrites which can cause problems)\u003c\/li\u003e\n\u003cli\u003eFolks with MTR \u0026amp; MTRR mutations may do well with methylcobalamin \u0026amp; adenosylcobalamin supplementation\u003c\/li\u003e\n\u003cli\u003eAnd Dr. Amy Yasko talks about folks with a particular mutation status for COMT \u0026amp; VDR Taq as best needing the below forms of B12:\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ctable id=\"b12-table\" class=\"mytable\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eCOMT V158M\u003c\/th\u003e\n\u003cth\u003eVDR Taq\u003c\/th\u003e\n\u003cth\u003eB12 Types That Should Be Tolerated\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ + (TT)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ – (Tt)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e– – (tt)\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eMostly Hydroxy B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31134625038410,"sku":"M25-Hydroxo-FG1001","price":58.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/MethylFolate2.5_HydroxyB12-1.jpg?v=1771840379"},{"product_id":"methylated-mthfr-folate-sublingual-b12-multivitamin","title":"Methylated Multivitamin 3-Product Pack - MTHFR Folate, Sublingual B12 + Cofactors","description":"\u003cp\u003eGet 3 key \u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003eMethyl-Life®\u003c\/strong\u003e\u003c\/span\u003e products with active and supporting nutrients for the ultimate methylated multivitamin \u0026amp; MTHFR support.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eThis comprehensive starting package contains 3 bioavailable products:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli style=\"list-style-type: none;\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca title=\"Methyl-Life's® Methylfolate 2.5 mg product - purest L-Methylfolate on the planet\" href=\"https:\/\/methyl-life.com\/products\/methylfolate-2-5\"\u003eMethylfolate 2.5 mg\u003c\/a\u003e - \u003cstrong\u003ePure \u0026amp; Stable MTHFR Folate, or methylfolate,\u003c\/strong\u003e to bypass genetic challenges for optimal absorption\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/methyl-life.com\/products\/sublingual-b12-tablets-hydroxy-b12\" title=\"Methyl-Life's® Hydroxy B12 2.5 - 2.5 mg of bioavailable B12 for optimal absorption\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/methyl-life.com\/products\/sublingual-b12-tablets-hydroxy-b12\"\u003eSublingual B12\u003c\/a\u003e\u003ca href=\"https:\/\/methyl-life.com\/products\/sublingual-b12-tablets-hydroxy-b12\"\u003e - \u003c\/a\u003e\u003ca href=\"https:\/\/methyl-life.com\/collections\/multivitamins\/products\/non-methylated-multi\" title=\"Methyl-Life's Non-Methylated Multivitamin - 90 capsules - 45 servings + Cognitive-enhancing Nutrients\"\u003e2.5 mg per tablet\u003c\/a\u003e - Rare but\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003ewell-tolerated form, Hydroxy B12\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/methyl-life.com\/collections\/multivitamins\/products\/non-methylated-multi\" title=\"Methyl-Life's® Non-Methylated Multivitamin - 90 capsules - 45 servings + Cognitive-enhancing Nutrients\"\u003eNon-Methylated Multivitamin\u003c\/a\u003e - \u003cstrong\u003eMethylation supporting multivitamin\u003c\/strong\u003e + Cognitive and Energy-promoting nutrients\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eDid you know that \u003c\/span\u003e\u003cspan\u003erecent research shows that \u003cstrong\u003etaking B12 in a sublingual oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots\u003c\/strong\u003e? It's usually much more convenient and affordable as well -  https:\/\/pubmed.ncbi.nlm.nih.gov\/30632091.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDosage\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eHow much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/dosage\" title=\"How much L-Methylfolate should I take? What's the right dosage level of B12 for me?\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto learn more about what some doctors recommend. And review our suggested\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol-1\"\u003emethylation protocol\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eas a potential step by step guide to some dosing options.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eHow to snap the tablet in half\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e \u003ca href=\"https:\/\/www.youtube.com\/watch?v=XOxWY-kQ8kc\u0026amp;list=PLpRy5gLP6XyP008M0ap1OqqkeDapTU-xq\u0026amp;index=12\u0026amp;t=0s\" title=\"How to split a Methyl-Life™ tablet in half so you can take half the dosage of a full tablet\" target=\"_blank\"\u003eSee how its done via video\u003c\/a\u003e. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest\/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more. \u003c\/p\u003e\n\u003ch2\u003eFAQ'S\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What is the right dosage for me?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCheck out our \u003ca href=\"https:\/\/methyl-life.com\/dosage\" title=\"How much L-Methylfolate should I take? What's the right dosage level of B12 for me?\"\u003eDosage\u003c\/a\u003e page to learn what some \u003ca href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, L-Methylfolate, Deplin and optimizing your health\"\u003edoctors\u003c\/a\u003e are saying. And consider reviewing our \u003ca title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol-1\"\u003eMethylation Protocol\u003c\/a\u003e page as one example of how someone could start taking the active methylation nutrients.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e Is Methylfolate the only thing I should take if I have an MTHFR gene mutation?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eNo, actually our recommendation is to heavily consider following Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching parts 3 \u0026amp; 4 of his \u003ca href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, L-Methylfolate, Deplin and optimizing your health\"\u003evideo seminar\u003c\/a\u003e.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou can also download one of four specific \u003ca title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol-1\"\u003eMethylation Protocols\u003c\/a\u003e which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term. \u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou'll find our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\" title=\"How do I treat my MTHFR? How much L-Methylfolate should I take? I'm new to MTHFR what should I do?\"\u003eMTHFR Newbies page\u003c\/a\u003e is very helpful as well.  It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What do doctors have to say about MTHFR and how to treat it?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eGo to \u003ca href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, L-Methylfolate, Deplin and optimizing your health\"\u003eA Doctor Explains\u003c\/a\u003e and listen to Dr. Neil Rawlins’ 51-minute seminar on MTHFR and the effects of Methylfolate.\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e How can I get more information on MTHFR?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003echeck out our Help for \u003ca href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\" title=\"How do I treat my MTHFR? How much L-Methylfolate should I take? I'm new to MTHFR what should I do?\"\u003eMTHFR Newbies page\u003c\/a\u003e.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What is the Methyl-Life® Methylated Multivitamin Bundle?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eThe Methyl-Life® Methylated Multivitamin Bundle is a comprehensive package comprising three key active and supporting nutrient products designed to provide ultimate methylation vitamin support.\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_1\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_4_4 et_pb_column_2    et_pb_css_mix_blend_mode_passthrough et-last-child\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_2 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e Which products are included in the bundle?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan data-sheets-userformat='{\"2\":8961,\"3\":{\"1\":0},\"11\":3,\"12\":0,\"16\":10}' data-sheets-value='{\"1\":2,\"2\":\"The bundle contains:\\r\\nMethylfolate 2.5 mg: Featuring the purest and most stable form of L-Methylfolate available, supported by recent studies.\\r\\nHydroxy B12 2.5 mg per tablet: This product offers the rare but well-tolerated form of B12 as Hydroxy B12\\r\\nNon-Methylated Multivitamin: A methylation-supporting multivitamin enriched with cognitive and energy-promoting nutrients.\"}' data-sheets-root=\"1\"\u003eThe bundle contains:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan data-sheets-userformat='{\"2\":8961,\"3\":{\"1\":0},\"11\":3,\"12\":0,\"16\":10}' data-sheets-value='{\"1\":2,\"2\":\"The bundle contains:\\r\\nMethylfolate 2.5 mg: Featuring the purest and most stable form of L-Methylfolate available, supported by recent studies.\\r\\nHydroxy B12 2.5 mg per tablet: This product offers the rare but well-tolerated form of B12 as Hydroxy B12.\\r\\nNon-Methylated Multivitamin: A methylation-supporting multivitamin enriched with cognitive and energy-promoting nutrients.\"}' data-sheets-root=\"1\"\u003e \u003cbr\u003eMethylfolate 2.5 mg: Featuring an ultra-pure and stable form of MTHFR Folate, supported by recent studies. \u003cbr\u003eSublingual B12: 2.5 mg per tablet. This product offers the rare but well-tolerated form, Hydroxy B12. \u003cbr\u003eNon-Methylated Multivitamin: A methylation-supporting multivitamin enriched with cognitive and energy-promoting nutrients. Designed to be taken with active methylation cofactors.\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What can you do if you have high B12 blood test results?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the Sublingual B12 form in that’s best for you).\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e How does MTHFR Folate 2.5 mg benefit methylation support?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eMTHFR Folate, also referred to as methylfolate, plays a crucial role in supporting methylation processes in the body, particularly in individuals who may have difficulty processing synthetic folic acid. The 2.5 mg dosage provides robust support for methylation pathways.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What are the advantages of Sublingual B12 2.5 mg per tablet?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eSublingual B12, at a dosage of 2.5 mg per tablet, offers a well-tolerated form of Hydroxy B12, supporting various bodily functions including methylation processes and overall energy metabolism.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e Who can benefit from using the Methyl-Life® Methylated Multivitamin Bundle?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIndividuals seeking comprehensive methylation support, improved cognitive function, and enhanced energy levels may benefit from this bundle. It is particularly suitable for those with concerns about methylation support and overall wellness.\u003c\/span\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31134625103946,"sku":"M25-Hydroxo-NMulti-FGJ1001","price":96.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/NonMethylatedMultivitamin_Methylfolate2.5_HydroxyB12-1-updated-09-22-26.webp?v=1791209371"},{"product_id":"methylation-vitamins-methyl-b12-methylfolate-5-mthf","title":"Methylation Vitamins: Methyl B12 \u0026 Methylfolate 5 MTHF - 3 Product Pack","description":"\u003cp\u003e\u003cspan style=\"color: #ff2a00;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/span\u003eGet \u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003eMethyl-Life’s®\u003c\/strong\u003e\u003c\/span\u003e \u003cspan\u003eCognitive Health Bundle with Methylation Vitamins, Methyl B12 \u0026amp; Methylfolate 5 MTHF at 5 mg each. \u003c\/span\u003e3 solid products for full-spectrum absorption to keep your methylation biopathways supported and your brain fueled. \u003c\/p\u003e\n\u003cp\u003eThis comprehensive 3-Product Pack contains the bioactive nutrients:\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eThe \u003cstrong\u003epurest Methylfolate-5-MTHF\u003c\/strong\u003e (as shown in a recent study)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAll 3 active forms of B12\u003c\/strong\u003e (including Methyl B12, Hydroxy B12, \u0026amp; Adenosylcobalamin)\u003c\/li\u003e\n\u003cli\u003eThe optimal \u003cstrong\u003emethylation vitamins\u003c\/strong\u003e as supporting cofactor nutrients\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCheck out the details below regarding each specific product included in the bundle using the links below:\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli style=\"list-style-type: none;\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/methyl-life.com\/products\/5-methylfolate-5-mthf-l-methylfolate-5mg\" title=\"Methyl-Life's® 5 Methylfolate - 5 mthf L-Methylfolate 5mg chewable tablets\"\u003eMethylfolate 5 MTHF\u003c\/a\u003e - Pure \u0026amp; stable, bioidentical Methylfolate 5 MTHF with 5 mg \"free methylfolate\" per serving\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/methyl-life.com\/products\/methylcobalamin-b12-vitamin-b12-5000-mcg\" title=\"Methyl-Life's® Methylcobalamin B12 Complete - Vitamin B12 5000 mcg, a full-spectrum product with all 3 active B12 forms\"\u003eMethyl B12 Complete\u003c\/a\u003e - A power-packed 5 mg of 3 different bioavailable B12s (including \u003cspan\u003eMethyl B12) \u003c\/span\u003eper sublingual tablet\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/methyl-life.com\/collections\/multivitamins\/products\/non-methylated-multi\" title=\"Methyl-Life's Non-Methylated Multivitamin - 90 capsules - 45 servings + Cognitive-enhancing Nutrients\"\u003eNon-Methylated Multivitamin\u003c\/a\u003e - Methylation supporting multivitamin + Cognitive \u0026amp; Energy-promoting nutrients (formulated to be taken with high dose methylfolate 5 mthf \u0026amp; methyl b12)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eDid you know that \u003c\/span\u003e\u003cspan\u003erecent research shows that \u003cstrong\u003etaking B12 in a sublingual oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots\u003c\/strong\u003e? It's usually much more convenient and affordable as well -  https:\/\/pubmed.ncbi.nlm.nih.gov\/30632091.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDosage\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eHow much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/dosage\" title=\"How much L-Methylfolate should I take? What's the right dosage level of B12 for me?\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto learn more about what some doctors recommend. And review our suggested\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\"\u003emethylation protocol\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eas a potential step by step guide to some dosing options.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eHow to snap the tablet in half\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e \u003ca href=\"https:\/\/www.youtube.com\/watch?v=XOxWY-kQ8kc\u0026amp;list=PLpRy5gLP6XyP008M0ap1OqqkeDapTU-xq\u0026amp;index=12\u0026amp;t=0s\" title=\"How to split a Methyl-Life™ tablet in half so you can take half the dosage of a full tablet\" target=\"_blank\"\u003eSee how its done via video\u003c\/a\u003e. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest\/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more. \u003c\/p\u003e\n\u003ch2 class=\"et_pb_text_inner\"\u003eResearch\u003c\/h2\u003e\n\u003cp\u003e\u003ciframe src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/MTHFR_alzheimer_s.pdf?v=1591312570\" width=\"100%\" height=\"500px\"\u003e\n    \u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eFAQ'S\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What is the right dosage for me?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCheck out our \u003ca href=\"https:\/\/methyl-life.com\/dosage\" title=\"How much L-Methylfolate should I take? What's the right dosage level of B12 for me?\"\u003eDosage\u003c\/a\u003e page to learn what some \u003ca href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, L-Methylfolate, Deplin and optimizing your health\"\u003edoctors\u003c\/a\u003e are saying. And consider reviewing our \u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\/\" title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\"\u003eMethylation Protocol\u003c\/a\u003e page as one example of how someone could start taking the active methylation nutrients.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e Is Methylfolate the only thing I should take if I have an MTHFR gene mutation?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eNo, actually our recommendation is to heavily consider following Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching parts 3 \u0026amp; 4 of his \u003ca href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, L-Methylfolate, Deplin and optimizing your health\"\u003evideo seminar\u003c\/a\u003e.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou can also download one of four specific \u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\"\u003eMethylation Protocols\u003c\/a\u003e which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term. \u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou'll find our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\" title=\"How do I treat my MTHFR? How much L-Methylfolate should I take? I'm new to MTHFR what should I do?\"\u003eMTHFR Newbies page\u003c\/a\u003e is very helpful as well.  It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What do doctors have to say about MTHFR and how to treat it?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eGo to \u003ca href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, L-Methylfolate, Deplin and optimizing your health\"\u003eA Doctor Explains\u003c\/a\u003e and listen to Dr. Neil Rawlins’ 51-minute seminar on MTHFR and the effects of Methylfolate.\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e How can I get more information on MTHFR?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003echeck out our Help for \u003ca href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\" title=\"How do I treat my MTHFR? How much L-Methylfolate should I take? I'm new to MTHFR what should I do?\"\u003eMTHFR Newbies page\u003c\/a\u003e.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium the same thing?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eBasically, yes. In the chemistry world, L stands for the “Left” isomer, which is the same as the “(6S)” isomer – the terms are synonyms (and this naming convention is used interchangeably by various companies in the industry). In the case of methylfolate, that L or (6S) isomer is the active isomer of 5-MTHF that the body can actually use. To learn more about the different types of methylfolate, its history, potency levels and stability details, and to see how our L-Methylfolate proves to be the purest on the planet, visit our \u003ca href=\"https:\/\/methyl-life.com\/pages\/methylfolate-types\" title=\"A comprehensive comparison of L-Methylfolates available on the market today. Chemical, stability, potency and purity differences studied and compared in detail.\"\u003eMethylfolate Types page\u003c\/a\u003e.\u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_1\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_4_4 et_pb_column_2    et_pb_css_mix_blend_mode_passthrough et-last-child\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_2 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe most important thing to realize is that \u003cstrong\u003eblood tests for B12 are highly inaccurate at detecting actual cellular levels of B12\u003c\/strong\u003e (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used. \u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What can you do if you have high B12 blood test results?\u003c\/span\u003e\u003c\/strong\u003e Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What does sublingual mean and why isn’t your product labeled as “sublingual”?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eIt’s a well-known fact that B12 does not absorb well through the gut, so taking B12 via sublingual or mouth absorption is best (holding it under the tongue or between the gums and cheek is most common). Consider some form of liquid or tablet\/lozenge that can be sucked on or dissolved in the mouth. Holding the B12 in your mouth for at least 90 seconds is good and the longer you can leave it in your mouth, the better for sublingual absorption (as opposed to gut absorption).\u003c\/span\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003e\u003cspan style=\"text-decoration: underline;\"\u003eNote\u003c\/span\u003e: different manufacturers use different terms for tablets that are meant to dissolve sublingually in the mouth, but “sublingual” is considered a pharmaceutical term by the FDA, so dietary supplements are moving away from using that term. However, it doesn’t really matter what term you use (chewable tablet, lozenge, sublingual tablet, liquid, etc.) for maximum absorption \u003cstrong\u003ethe main idea is to hold it in your mouth for 90 seconds or more\u003c\/strong\u003e if you can (if you forget, don’t worry, since you’re taking the active form, your body will still get some benefit even if you swallow it whole).\u003c\/span\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eAnother way to absorb B12 is muscularly through shots, however, the research tells us that sublingual (or mouth) absorption is equally as effective as muscular absorption … and shots may cost significantly more money. Also, be aware with shots (many doctors still give cyanocobalamin shots) that though you may need higher doses of active B12s (like myself), you may not do well when given higher doses of cyanocobalamin in a shot because your body may not be able to do the conversions and you could have negative side effects.\u003cbr\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e My doctor said that because I have MTHFR, I should be taking Methyl B12 as my B12 form, why are you suggesting these other forms too?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eOne of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, Methyl B12 or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called Methyl B12, but that is simply NOT true. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIt’s important to realize that the \u003cstrong\u003eMTHFR status does not necessarily determine the type of B12 that’s best for you\u003c\/strong\u003e, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and Methyl B12 work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate Methyl B12 well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIt seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.\u003c\/p\u003e\n\u003cp\u003eThe most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxy B12, and from there the hydroxy B12 has to be converted into both adenosylcobalamin and \u003cspan\u003eMethyl B12\u003c\/span\u003e. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eIf you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxy B12 (and this is why our methylation protocol suggests hydroxy B12 as the B12 form to begin with):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eFolks with multiple COMT mutations tend to do very well with hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)\u003c\/li\u003e\n\u003cli\u003eFolks with MTR \u0026amp; MTRR mutations may do well with \u003cspan\u003eMethyl B12 \u003c\/span\u003e\u0026amp; adenosylcobalamin supplementation\u003c\/li\u003e\n\u003cli\u003eAnd Dr. Amy Yasko (https:\/\/dramyyasko.com) talks about folks with a particular mutation status for COMT \u0026amp; VDR Taq as best needing the below forms of B12:\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ctable id=\"b12-table\" class=\"mytable\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eCOMT V158M\u003c\/th\u003e\n\u003cth\u003eVDR Taq\u003c\/th\u003e\n\u003cth\u003eB12 Types That Should Be Tolerated\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ + (TT)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ – (Tt)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less \u003cspan\u003eMethyl B12\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e– – (tt)\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less \u003cspan\u003eMethyl B12\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eMostly Hydroxy B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31134625136714,"sku":"M5-B12Comp-NMulti-CHJ1001","price":114.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/NonMethylatedMultivitamin_methylfolate5_B12Complete-updated-09-22-26.webp?v=1791205123"},{"product_id":"methylation-supplements-l-methylfolate-b12-sublingual","title":"Methylation Supplements: L Methylfolate + B12 Sublingual","description":"\u003cp\u003e\u003cspan style=\"color: #ff2a00;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/span\u003eGet \u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003eMethyl-Life’s® Methylation Supplements\u003c\/strong\u003e\u003c\/span\u003e bundle with L Methylfolate and B12 Sublingual, 2 foundational products for neuro-protection. \u003c\/p\u003e\n\u003cp\u003eThis active-nutrients package contains 2 chewable products targeting improved cognition and brain health:\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eThe \u003cstrong\u003epurest bioactive L Methylfolate\u003c\/strong\u003e for direct biopathway absorption and use by the body\u003c\/li\u003e\n\u003cli\u003eThe rare but \u003cstrong\u003ewell-tolerated B12 Sublingual form, \u003c\/strong\u003eHydroxy B12\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCheck out the details below regarding each product included in the bundle to learn more:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli style=\"list-style-type: none;\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-5\" title=\"Methyl-Life's Methylfolate 5 mg product - purest L-Methylfolate on the planet\"\u003eL Methylfolate\u003c\/a\u003e\u003c\/strong\u003e - Stable \u0026amp; pure form of L Methylfolate (5 mg chewable tablet) for full absorption\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/methyl-life.com\/products\/sublingual-b12-tablets-hydroxy-b12\" title=\"Methyl-Life® Hydroxy B12 product - 2.5 mg of sublingual B12 for optimal absorption\"\u003e\u003cstrong\u003eB12 Sublingual\u003c\/strong\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/methyl-life.com\/collections\/methyl-b12-and-methyl-folate\" title=\"Methyl-Life Hydroxy B12 2.5 product - 2.5 mg of active B12 for optimal absorption\"\u003e\u003c\/a\u003e - Bioactive form at 2.5 mg of Hydroxy B12 per chewable tablet\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eDid you know that \u003c\/span\u003e\u003cspan\u003erecent research shows that \u003cstrong\u003etaking B12 in a sublingual oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots\u003c\/strong\u003e? It's usually much more convenient and affordable as well -  https:\/\/pubmed.ncbi.nlm.nih.gov\/30632091.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDosage\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eHow much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"How much L-Methylfolate should I take? What's the right dosage level of B12 for me?\" href=\"https:\/\/methyl-life.com\/pages\/dosage\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto learn more about what some doctors recommend. And review our suggested\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\"\u003emethylation protocol\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eas a potential step by step guide to some dosing options.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eHow to snap the tablet in half\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e \u003ca title=\"How to split a Methyl-Life™ tablet in half so you can take half the dosage of a full tablet\" href=\"https:\/\/www.youtube.com\/watch?v=XOxWY-kQ8kc\u0026amp;list=PLpRy5gLP6XyP008M0ap1OqqkeDapTU-xq\u0026amp;index=12\u0026amp;t=0s\" rel=\"noopener\" target=\"_blank\"\u003eSee how its done via video\u003c\/a\u003e. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest\/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more. \u003c\/p\u003e\n\u003ch2 class=\"et_pb_text_inner\"\u003eResearch\u003c\/h2\u003e\n\u003cp\u003e\u003ciframe height=\"500px\" width=\"100%\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/MTHFR_alzheimer_s.pdf?v=1591312570\"\u003e\n    \u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eFAQ'S\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What is the right dosage for me?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCheck out our \u003ca title=\"How much L-Methylfolate should I take? What's the right dosage level of B12 for me?\" href=\"https:\/\/methyl-life.com\/dosage\"\u003eDosage\u003c\/a\u003e page to learn what some \u003ca title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, L-Methylfolate, Deplin and optimizing your health\" href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\"\u003edoctors\u003c\/a\u003e are saying. And consider reviewing our \u003ca title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\/\"\u003eMethylation Protocol\u003c\/a\u003e page as one example of how someone could start taking the active methylation nutrients.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What is the Methyl-Life® Brain Protect Bundle?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eThe Methyl-Life® Brain Protect Bundle is a combination of two foundational methylation products specifically formulated for neuro-protection. It includes chewable supplements targeting improved cognition and brain health.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What do doctors have to say about MTHFR and how to treat it?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eGo to \u003ca title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, L-Methylfolate, Deplin and optimizing your health\" href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\"\u003eA Doctor Explains\u003c\/a\u003e and listen to Dr. Neil Rawlins’ 51-minute seminar on MTHFR and the effects of L Methylfolate.\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e How can I get more information on MTHFR?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003echeck out our Help for \u003ca title=\"How do I treat my MTHFR? How much L-Methylfolate should I take? I'm new to MTHFR what should I do?\" href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\"\u003eMTHFR Newbies page\u003c\/a\u003e.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e Which products are included in the bundle?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eThe bundle contains:\u003cbr\u003e\u003cbr\u003eL Methylfolate 5: This product features the most stable and pure form of L Methylfolate available for purchase, with a dosage of 5 mg per tablet.\u003cbr\u003eB12 Sublingual: This is the rare but highly tolerated form, Hydroxy B12, providing 2.5 mg of active B12 per tablet.\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_1\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_4_4 et_pb_column_2    et_pb_css_mix_blend_mode_passthrough et-last-child\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_2 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What are the benefits of Hydroxy B12 Sublingual for the brain?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eHydroxy B12 Sublingual is known for its neuroprotective properties and its ability to support healthy nerve function. With a dosage of 2.5 mg per tablet, it complements the cognitive support provided by L Methylfolate.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What can you do if you have high B12 blood test results?\u003c\/span\u003e\u003c\/strong\u003e Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 Sublingual form in that’s most likely best for you).\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e Who can benefit from using the Methyl-Life® Brain Protect Bundle?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eIndividuals seeking to support cognitive function, enhance brain health, or protect against neurological decline may benefit from this bundle. It is particularly suitable for those with concerns about methylation support and brain health.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e How should the products in the bundle be consumed?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003eBoth \u003cstrong\u003eL Methylfolate\u003c\/strong\u003e 5 mg and \u003cstrong\u003eB12 Sublingual\u003c\/strong\u003e 2.5 mg are chewable tablets, making them convenient for daily consumption. Follow the recommended dosage instructions provided with each product or consult a healthcare professional for personalized guidance.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eIf you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 Sublingual forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 Sublingual for folks seems to be hydroxy B12 Sublingual. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxy B12 (and this is why our methylation protocol suggests hydroxy B12 as the B12 sublingual form to begin with):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eFolks with multiple COMT mutations tend to do very well with \u003cspan\u003ehydroxy B12 \u003c\/span\u003e(it helps mop up excess peroxynitrites which can cause problems)\u003c\/li\u003e\n\u003cli\u003eFolks with MTR \u0026amp; MTRR mutations may do well with methylcobalamin \u0026amp; adenosylcobalamin supplementation\u003c\/li\u003e\n\u003cli\u003eAnd Dr. Amy Yasko(https:\/\/dramyyasko.com\/)talks about folks with a particular mutation status for COMT \u0026amp; VDR Taq as best needing the below forms of B12:\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ctable class=\"mytable\" id=\"b12-table\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eCOMT V158M\u003c\/th\u003e\n\u003cth\u003eVDR Taq\u003c\/th\u003e\n\u003cth\u003eB12 Types That Should Be Tolerated\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ + (TT)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ – (Tt)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e– – (tt)\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eMostly Hydroxy B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31134625497162,"sku":"M5-Hydroxo-EG1001","price":73.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methylfolate5_HydroxyB12-1.jpg?v=1771841551"},{"product_id":"mthfr-supplements-starter-pack-methylfolate-b12-multivitamin-magnesium","title":"MTHFR Supplements: L-Methylfolate, Vitamin B12 Supplement, Multivitamin \u0026 Magnesium","description":"\u003cp\u003eGet \u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003eMethyl-Life’s®\u003c\/strong\u003e\u003c\/span\u003e four recommended starting products for those beginning with MTHFR treatment. \u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eThis comprehensive 4-product starting package contains the bioactive nutrients:\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eThe \u003cstrong\u003epure \u0026amp; stable bioidentical L-Methylfolate\u003c\/strong\u003e for direction absorption \u0026amp; use within the body\u003c\/li\u003e\n\u003cli\u003eRare but \u003cstrong\u003emost well-tolerated Vitamin B12 Supplement\u003c\/strong\u003e (as Hydroxy B12)\u003c\/li\u003e\n\u003cli\u003eThe optimal \u003cstrong\u003emethylation-supporting multivitamin\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigh-absorption magnesium\u003c\/strong\u003e for over 600 enzymatic processes that happen in the body (including a key methylation co-factor)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCheck out the details below regarding each specific product included in the bundle using the links below:\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli style=\"list-style-type: none;\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-2-5\"\u003eL-Methylfolate 2.5 \u003c\/a\u003e- Purest \u0026amp; most stable L-Methylfolate available on the market\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/methyl-life.com\/products\/sublingual-b12-tablets-hydroxy-b12\" title=\"Methyl-Life® Hydroxy B12 product - 2.5 mg of sublingual B12 for optimal absorption\"\u003eVitamin B12 Supplement\u003c\/a\u003e - Active B12 as Hydroxy form with 2.5 mg per sublingual tablet\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/methyl-life.com\/collections\/multivitamins\/products\/non-methylated-multi\" title=\"Methyl-Life's Non-Methylated Multivitamin - 90 capsules - 45 servings + Cognitive-enhancing Nutrients\"\u003eNon-Methylated Multivitamin\u003c\/a\u003e - Methylation supporting multivitamin with Cognitive and Energy-promoting nutrients (designed to be taken with therapeutic levels of methylfolate \u0026amp; B12)\u003c\/li\u003e\n\u003cli\u003e\n\u003ca title=\"Methyl-Life's Sucrosomial Magnesium 90 capsule product\" href=\"https:\/\/methyl-life.com\/collections\/superior-magnesium\/products\/superior-sucrosomial-magnesium\"\u003eMagnesium Complete\u003c\/a\u003e - Bioactive liposomal-like delivery form for optimal absorption in the body\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eDid you know that \u003c\/span\u003e\u003cspan\u003erecent research shows that \u003cstrong\u003etaking B12 in a sublingual oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots\u003c\/strong\u003e? It's usually much more convenient and affordable as well -  https:\/\/pubmed.ncbi.nlm.nih.gov\/30632091.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDosage\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eHow much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/dosage\" title=\"How much L-Methylfolate should I take? What's the right dosage level of B12 for me?\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto learn more about what some doctors recommend. And review our suggested\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\"\u003emethylation protocol\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eas a potential step by step guide to some dosing options.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eHow to snap the tablet in half\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e \u003ca href=\"https:\/\/www.youtube.com\/watch?v=XOxWY-kQ8kc\u0026amp;list=PLpRy5gLP6XyP008M0ap1OqqkeDapTU-xq\u0026amp;index=12\u0026amp;t=0s\" title=\"How to split a Methyl-Life™ tablet in half so you can take half the dosage of a full tablet\" target=\"_blank\"\u003eSee how its done via video\u003c\/a\u003e. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest\/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more. \u003c\/p\u003e\n\u003ch2\u003eFAQ'S\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What is included in the MTHFR Beginner's Bundle?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe MTHFR Beginner's Bundle comprises four essential supplements: L-Methylfolate 2.5, Active B12, Non-Methylated Multi, and Magnesium Caps.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What are the benefits of each supplement in the bundle?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eL-Methylfolate 2.5: Provides a bioactive form of folate crucial for methylation processes.\u003cbr\u003eActive B12: Supports neurological function, energy production, and red blood cell formation.\u003cbr\u003eNon-Methylated Multi: Offers a comprehensive blend of essential vitamins and minerals tailored for individuals with MTHFR mutations.\u003cbr\u003eMagnesium Caps: Provides magnesium, an essential mineral involved in numerous physiological processes, including nerve function, muscle contraction, and energy metabolism.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What is the importance of high-absorption magnesium?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eHigh-absorption magnesium is essential for over 300 enzymatic processes that occur in the body, making it a critical co-factor for various physiological functions, including methylation.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e Why is Hydroxy B12 considered the most well-tolerated form of B12?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eHydroxy B12 is renowned for its exceptional tolerability, making it suitable for individuals who may experience adverse reactions to other forms of vitamin B12. This makes it an excellent choice for those seeking a gentle yet effective B12 supplement.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e Why is magnesium considered a key methylation co-factor?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eMagnesium plays a crucial role in methylation, a vital biochemical process involved in numerous cellular functions, including DNA synthesis, repair, and gene expression. Therefore, ensuring adequate magnesium levels is essential for supporting optimal methylation and overall health.\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_1\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_4_4 et_pb_column_2    et_pb_css_mix_blend_mode_passthrough et-last-child\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_2 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe most important thing to realize is that \u003cstrong\u003eblood tests for B12 are highly inaccurate at detecting actual cellular levels of B12\u003c\/strong\u003e (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used. \u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What can you do if you have high B12 blood test results?\u003c\/span\u003e\u003c\/strong\u003e Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What does sublingual mean and why isn’t your product labeled as “sublingual”?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eIt’s a well-known fact that B12 does not absorb well through the gut, so taking B12 via sublingual or mouth absorption is best (holding it under the tongue or between the gums and cheek is most common). Consider some form of liquid or tablet\/lozenge that can be sucked on or dissolved in the mouth. Holding the B12 in your mouth for at least 90 seconds is good and the longer you can leave it in your mouth, the better for sublingual absorption (as opposed to gut absorption).\u003c\/span\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003e\u003cspan style=\"text-decoration: underline;\"\u003eNote\u003c\/span\u003e: different manufacturers use different terms for tablets that are meant to dissolve sublingually in the mouth, but “sublingual” is considered a pharmaceutical term by the FDA, so dietary supplements are moving away from using that term. However, it doesn’t really matter what term you use (chewable tablet, lozenge, sublingual tablet, liquid, etc.) for maximum absorption \u003cstrong\u003ethe main idea is to hold it in your mouth for 90 seconds or more\u003c\/strong\u003e if you can (if you forget, don’t worry, since you’re taking the active form, your body will still get some benefit even if you swallow it whole).\u003c\/span\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eAnother way to absorb B12 is muscularly through shots, however, the research tells us that sublingual (or mouth) absorption is equally as effective as muscular absorption … and shots may cost significantly more money. Also, be aware with shots (many doctors still give cyanocobalamin shots) that though you may need higher doses of active B12s (like myself), you may not do well when given higher doses of cyanocobalamin in a shot because your body may not be able to do the conversions and you could have negative side effects.\u003cbr\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eOne of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIt’s important to realize that the \u003cstrong\u003eMTHFR status does not necessarily determine the type of B12 that’s best for you\u003c\/strong\u003e, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIt seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.\u003c\/p\u003e\n\u003cp\u003eThe most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxy B12, and from there the hydroxy B12 has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eIf you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxy B12 (and this is why our methylation protocol suggests hydroxy B12 as the B12 form to begin with):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eFolks with multiple COMT mutations tend to do very well with \u003cspan\u003ehydroxy B12 \u003c\/span\u003e(it helps mop up excess peroxynitrites which can cause problems)\u003c\/li\u003e\n\u003cli\u003eFolks with MTR \u0026amp; MTRR mutations may do well with methylcobalamin \u0026amp; adenosylcobalamin supplementation\u003c\/li\u003e\n\u003cli\u003eAnd Dr. Amy Yasko talks about folks with a particular mutation status for COMT \u0026amp; VDR Taq as best needing the below forms of B12:\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ctable id=\"b12-table\" class=\"mytable\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eCOMT V158M\u003c\/th\u003e\n\u003cth\u003eVDR Taq\u003c\/th\u003e\n\u003cth\u003eB12 Types That Should Be Tolerated\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ + (TT)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ – (Tt)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e– – (tt)\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eMostly Hydroxy B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31244387156042,"sku":"StartPk-R1001","price":125.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/NonMethylatedMultivitamin_Methylfolate2.5_Hydroxy_MagnesiumComplete-updated-09-22-26.webp?v=1791206899"},{"product_id":"methylated-b-vitamins-mthfr-folate-b12-methylcobalamin","title":"Methylated B Vitamins: MTHFR Folate, B12 Methylcobalamin \u0026 Cofactors for Mood Support","description":"\u003cp\u003e\u003cspan style=\"color: #ff2a00;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/span\u003eGet \u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003eMethyl-Life’s®\u003c\/strong\u003e\u003c\/span\u003e foundational bundle - 3 solid products to keep your mood elevated and your biopathways methylated. \u003c\/p\u003e\n\u003cp\u003eThis comprehensive starting package contains the bioactive nutrients:\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eThe \u003cstrong\u003epurest L-Methylfolate\u003c\/strong\u003e (as shown in a recent study)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAll 3 active forms of B12\u003c\/strong\u003e (as Methylcobalamin, Hydroxy B12, \u0026amp; Adenosylcobalamin)\u003c\/li\u003e\n\u003cli\u003eThe optimal \u003cstrong\u003emethylation-supporting multivitamin\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCheck out the details below regarding each specific product included in the bundle using the links below:\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca title=\"Methyl-Life's Methylfolate 10 mg product - purest L-Methylfolate on the planet - high dose for depression\" href=\"https:\/\/methyl-life.com\/products\/methylfolate-10\"\u003eL-Methylfolate 10\u003c\/a\u003e - Purest \u0026amp; most stable L-Methylfolate (10 mg) you can buy\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/methyl-life.com\/products\/methylcobalamin-b12-vitamin-b12-5000-mcg\" title=\"Methyl-Life's® Methylcobalamin B12 Complete product with all 3 active B12 forms - truly a full-spectrum product\"\u003eB12 Complete\u003c\/a\u003e\u003ca href=\"https:\/\/methyl-life.com\/products\/b12-complete-tablets\" title=\"Methyl-Life's B12 Complete product with all 3 active B12 forms - truly a full-spectrum product\"\u003e\u003c\/a\u003e - A power-packed 5 mg of 3 different Active B12s per tablet\u003c\/li\u003e\n\u003cli\u003e\n\u003ca title=\"Methyl-Life's Non-Methylated Multivitamin - 90 capsules - 45 servings + Cognitive-enhancing Nutrients\" href=\"https:\/\/methyl-life.com\/collections\/multivitamins\/products\/non-methylated-multi\"\u003eNon-Methylated Multivitamin\u003c\/a\u003e - Methylation supporting multivitamin + Cognitive and Energy-promoting nutrients\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eDosage\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eHow much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"How much L-Methylfolate should I take? What's the right dosage level of B12 for me?\" href=\"https:\/\/methyl-life.com\/pages\/dosage\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto learn more about what some doctors recommend. And review our suggested\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\"\u003emethylation protocol\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eas a potential step by step guide to some dosing options.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eHow to snap the tablet in half\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e \u003ca title=\"How to split a Methyl-Life™ tablet in half so you can take half the dosage of a full tablet\" href=\"https:\/\/www.youtube.com\/watch?v=XOxWY-kQ8kc\u0026amp;list=PLpRy5gLP6XyP008M0ap1OqqkeDapTU-xq\u0026amp;index=12\u0026amp;t=0s\" target=\"_blank\"\u003eSee how its done via video\u003c\/a\u003e. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest\/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more. \u003c\/p\u003e\n\u003ch2 class=\"et_pb_text_inner\"\u003eResearch\u003c\/h2\u003e\n\u003cp\u003e\u003ciframe height=\"500px\" width=\"100%\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/papakostas_2012_-_l-methylfolate_as_adjunctive_therapy_for_ssri-resistant_major_depression_-_results_of_two_randomized_double-blind_parallel-sequential_trials.pdf?v=1591251787\"\u003e\n    \u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2\u003eFAQ'S\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What is the right dosage for me?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCheck out our \u003ca title=\"How much L-Methylfolate should I take? What's the right dosage level of B12 for me?\" href=\"https:\/\/methyl-life.com\/dosage\"\u003eDosage\u003c\/a\u003e page to learn what some \u003ca title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, L-Methylfolate, Deplin and optimizing your health\" href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\"\u003edoctors\u003c\/a\u003e are saying. And consider reviewing our \u003ca title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\/\"\u003eMethylation Protocol\u003c\/a\u003e page as one example of how someone could start taking the active methylation nutrients.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e Is Methylfolate the only thing I should take if I have an MTHFR gene mutation?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eNo, actually our recommendation is to heavily consider following Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching parts 3 \u0026amp; 4 of his \u003ca title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, L-Methylfolate, Deplin and optimizing your health\" href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\"\u003evideo seminar\u003c\/a\u003e.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou can also download one of four specific \u003ca title=\"A comprehensive methylation protocol suggested for those taking L-Methylfolate and Active B12\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\"\u003eMethylation Protocols\u003c\/a\u003e which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term. \u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eYou'll find our\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"How do I treat my MTHFR? How much L-Methylfolate should I take? I'm new to MTHFR what should I do?\" href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\"\u003eMTHFR Newbies page\u003c\/a\u003e is very helpful as well.  It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What is the Methyl-Life® Mood Support Bundle?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eThe Methyl-Life® Mood Support Bundle is a foundational package consisting of three solid products aimed at maintaining elevated mood and supporting methyl pathways within the body.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e How does Methylfolate 10 benefit mood support?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eMethylfolate is essential for neurotransmitter synthesis and methylation processes within the brain, which can directly impact mood regulation. The 10 mg dosage in this bundle provides robust support for maintaining elevated mood levels.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium the same thing?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eBasically, yes. In the chemistry world, L stands for the “Left” isomer, which is the same as the “(6S)” isomer – the terms are synonyms (and this naming convention is used interchangeably by various companies in the industry). In the case of methylfolate, that L or (6S) isomer is the active isomer of 5-MTHF that the body can actually use. To learn more about the different types of methylfolate, its history, potency levels and stability details, and to see how our L-Methylfolate proves to be the purest on the planet, visit our \u003ca title=\"A comprehensive comparison of L-Methylfolates available on the market today. Chemical, stability, potency and purity differences studied and compared in detail.\" href=\"https:\/\/methyl-life.com\/pages\/methylfolate-types\"\u003eMethylfolate Types page\u003c\/a\u003e.\u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_1\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_4_4 et_pb_column_2    et_pb_css_mix_blend_mode_passthrough et-last-child\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_2 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe most important thing to realize is that \u003cstrong\u003eblood tests for B12 are highly inaccurate at detecting actual cellular levels of B12\u003c\/strong\u003e (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used. \u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What can you do if you have high B12 blood test results?\u003c\/span\u003e\u003c\/strong\u003e Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What are the advantages of B12 Complete in the bundle?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eB12 Complete offers a unique combination of three active forms of B12, each playing a crucial role in energy metabolism and neurological function. This potent blend supports overall mood and vitality.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e How does the Non-Methylated Multivitamin contribute to mood support?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003eThe Non-Methylated Multivitamin not only supports methylation pathways but also provides cognitive and energy-promoting nutrients essential for maintaining a positive mood and overall well-being.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e How should the products in the bundle be consumed?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eFollow the recommended dosage instructions provided with each product, as they may vary based on individual needs. The supplements in this bundle are designed for daily consumption and can be taken with or without food.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31382309470282,"sku":"M10-B12Comp-NMulti-DHJ1001","price":129.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/NonMethylatedMultivitamin_methylfolate10_B12Complete-updated-09-22-26.webp?v=1791208432"},{"product_id":"l-methylfolate-7-5mg-vitamin-b12-tablets","title":"L Methylfolate 7.5 mg + Vitamin B12 Tablets","description":"\u003cdiv class=\"et_pb_row et_pb_row_0\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_1_2 et_pb_column_0    et_pb_css_mix_blend_mode_passthrough\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eTherapeutic mood-supporting dose of bioactive\u003c\/strong\u003e \u003cstrong\u003eL Methylfolate 7.5 mg\u003c\/strong\u003e\u003c\/em\u003e uniquely formulated with the fully-patented Cerebrofolate® and \u003cem\u003e\u003cstrong\u003ebioactive vitamin B12 forms \u003c\/strong\u003e(\u003cstrong\u003ehydroxy B12\u003c\/strong\u003e and \u003cstrong\u003eadenosylcobalamin\u003c\/strong\u003e)\u003c\/em\u003e to naturally support healthy mood, cognitive function, methylation and homocysteine support.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eL methylfolate is the predominant form of folate circulating in the body and used for biological processes\u003csup\u003e1\u003c\/sup\u003e.\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eStudies show *15mg methylfolate + SSRI to be the most effective dose for improving depressive symptoms\u003csup\u003e2\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eL Methylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier\u003csup\u003e3\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"padding-left: 30px;\"\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupport for brain function\u003csup\u003e4\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupports cardiovascular health\u003csup\u003e5\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupport for healthy immune function\u003csup\u003e6\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupports nerve function\u003csup\u003e7\u003c\/sup\u003e and healthy myelin formation\u003csup\u003e22\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eNervous system maintenance\u003csup\u003e21\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupport for preconception, pregnancy, and fetal health\u003csup\u003e8\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eInvolved in reducing\u003csup\u003e20\u003c\/sup\u003e and maintaining healthy homocysteine levels\u003csup\u003e9\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eEssential nutrient required for optimal DNA methylation\u003csup\u003e19\u003c\/sup\u003e and neurotransmitter synthesis\u003csup\u003e10\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eAdjunctive support for serotonin selective reuptake inhibitors\u003csup\u003e23\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSuitable for people with MTHFR mutations\u003csup\u003e11\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cb\u003eProduct details\u003c\/b\u003e (90 chewable mint tablets per container) \u003cbr\u003e\u003cspan style=\"text-decoration: underline;\"\u003eKey ingredients\u003c\/span\u003e:  \n\u003cul style=\"padding-left: 30px;\"\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eFolate\u003c\/strong\u003e - 12,750 mcg (7.5 mg L-Methylfolate from 10.5 mg of \u003cstrong\u003eCerebrofolate®\u003c\/strong\u003e)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eHydroxy B12 (Vitamin B12)\u003c\/strong\u003e - 1,500 mcg\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\n\u003cstrong\u003eAdenosylcobalamin (Vitamin B12) \u003c\/strong\u003e- 1,000 mcg\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003e\u003cem\u003eL Methylfolate 7.5mg \u003c\/em\u003e\u003c\/strong\u003eis a highly bioactive form of folate made with the purest L-methylfolate available\u003csup\u003e12\u003c\/sup\u003e.\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"padding-left: 30px;\"\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eMaximum absorption and bioavailability\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eNo prescription required \u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eAvailable in \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-2-5\" rel=\"noopener\" target=\"_blank\"\u003e2.5mg\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylated-b12-l-methylfolate-3mg\" rel=\"noopener\" target=\"_blank\"\u003e3mg+B12\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/5-methylfolate-5-mthf-l-methylfolate-5mg\" rel=\"noopener\" target=\"_blank\"\u003e5mg\u003c\/a\u003e, 7.5mg+B12, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-15\" rel=\"noopener\" target=\"_blank\"\u003e10mg\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/l-methylfolate-15-mg\" rel=\"noopener\" target=\"_blank\"\u003e15mg\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-15\" rel=\"noopener\" target=\"_blank\"\u003e15mg+B12\u003c\/a\u003e \u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eRigorously tested for consistency, purity, safety, and potency\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eWhy take L Methylfolate 7.5 mg for Mood Support?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eSynthesis of mood-enhancing neurotransmitters (serotonin, dopamine, and other) is regulated by L methylfolate, a derivative of folate\u003csup\u003e10\u003c\/sup\u003e. L Methylfolate 7.5 mg has demonstrated efficacy as an adjunctive treatment for individuals who have not responded optimally to antidepressant therapy\u003csup\u003e2\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupplementing with 15mg L methylfolate alongside SSRIs may be effective in improving symptoms of depression\u003csup\u003e25\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. L Methylfolate is absorbed more efficiently than synthetic folic acid which must be converted to active folate by the enzyme \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003emethylenetetrahydrofolate reductase\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e (MTHFR)\u003csup\u003e13\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eHydroxy B12 and adenosylcobalamin are two naturally-occurring forms of B12 shown in clinical studies to improve vitamin B12 status. They are bioidentical to the form of B12 found in the human body and vastly superior to cyanocobalamin, a synthetic form of B12 that occurs only in trace amounts in the body\u003csup\u003e26\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAdenosylcobalamin is a cofactor for mitochondrial methylmalonyl-CoA mutase, which is required for the breakdown of several ketogenic amino acids and fatty acids\u003csup\u003e24\u003c\/sup\u003e.\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e It is also a cofactor in enzymatic reactions required for the synthesis of DNA, myelin, and fatty acids, which are vital for cell division and growth\u003csup\u003e27\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eActive B12 works closely alongside folate in converting homocysteine to methionine, which is necessary for nerve and brain health. B12’s complex metabolic pathway means that the only way to ensure proper uptake is by taking the most bioactive form of the vitamin\u003csup\u003e28\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIndividuals with particular mutations [single nucleotide polymorphisms (SNPs)] affecting B12 assimilation may raise their B12 status more efficiently with one or more of the specific bioavailable forms of vitamin B12\u003csup\u003e26\u003c\/sup\u003e, hydroxy B12, methylcobalamin, or adenosylcobalamin.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFolate and B12 work together to produce S-adenosylmethionine (SAMe), a compound involved in immune function and mood. Studies show that bioactive B12 plays an important role in the treatment of mood disorders, particularly when combined with SSRIs\u003csup\u003e29\u003c\/sup\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWho is affected by MTHFR mutations?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants).  Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%).  Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A\u0026gt;C polymorphism in Hispanics and Africans is 15%\u003csup\u003e14\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAn increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness\u003csup\u003e15\u003c\/sup\u003e.\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e  MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses\u003csup\u003e16\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFor these people, L methylfolate supplementation is shown to be the most effective way to provide this form of folate\u003csup\u003e10\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eMethyl-Life’s® L Methylfolate is an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWhy Magnafolate® PRO?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003e\u003cem\u003eMethyl-Life’s® L Methylfolate 7.5mg+ Support Mood\u003c\/em\u003e\u003c\/strong\u003e is made with the fully-patented \u003cstrong\u003eCerebrofolate\u003c\/strong\u003e®, clinically tested as one of the purest methylfolate brands (\u003cstrong\u003eCerebrofolate\u003c\/strong\u003e® is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic® and Extrafolate®).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eA recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation\u003csup\u003e17\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e ______________________________________\u003c\/p\u003e\n\u003cp\u003e\u003csup\u003e1\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20608755\/\" target=\"_blank\"\u003e https:\/\/pubmed.ncbi.nlm.nih.gov\/20608755\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e2\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23212058\/\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/23212058\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e3\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7687916\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7687916\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e4\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7779227\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7779227\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e5\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/hq0102.102190\" target=\"_blank\"\u003ehttps:\/\/www.ahajournals.org\/doi\/10.1161\/hq0102.102190\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e6\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7019735\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7019735\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e7\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5867258\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5867258\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e8\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8127769\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8127769\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e9\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9832224\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9832224\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e10\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19193337\/\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/19193337\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e11\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7564482\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7564482\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e12\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methyl-Life_60-day_Methylfolate_Comparison.pdf?v=1595292111\" target=\"_blank\"\u003ehttps:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methyl-Life_60-day_Methylfolate_Comparison.pdf?v=1595292111\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e13\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK6561\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/books\/NBK6561\/\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e14\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6630484\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6630484\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e15\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6530664\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6530664\/\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e16\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.0000165142.37711.E7\" target=\"_blank\"\u003ehttps:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.0000165142.37711.E7\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e17\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24032278\/\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/24032278\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e18\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/i.trade-cloud.com.cn\/upload\/6405\/file\/20210929\/english-version-magnafolate-enhancing-immunity_524485.pdf\" target=\"_blank\"\u003ehttps:\/\/i.trade-cloud.com.cn\/upload\/6405\/file\/20210929\/english-version-magnafolate-enhancing-immunity_524485.pdf\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e19\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3262611\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3262611\/ \u003c\/a\u003e\u003cbr\u003e\u003csup\u003e20\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.atv.18.3.356\" target=\"_blank\"\u003ehttps:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.atv.18.3.356\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e21\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557632\/#\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557632\/#\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e22\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15896807\/\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/15896807\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e23\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0924977X97004094?via%3Dihub\" target=\"_blank\"\u003ehttps:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0924977X97004094?via%3Dihub\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e24\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7230602\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7230602\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e25\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/24750573.2018.1552401\" target=\"_blank\"\u003ehttps:\/\/www.tandfonline.com\/doi\/full\/10.1080\/24750573.2018.1552401\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e26\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5312744\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5312744\/\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e27\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559132\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559132\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e28\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30693532\/\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/30693532\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e29\u003c\/sup\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3856388\/\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3856388\/\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003ch2\u003eDosage\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/blogs\/methylfolate-facts\/methylfolate-what-s-the-right-dosage-for-me\" rel=\"noopener\" target=\"_blank\"\u003eHow much is right for you to take?\u003c\/a\u003e Talk to your doctor about what’s best for you. Before you purchase check out our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/dosage\" rel=\"noopener\" target=\"_blank\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto learn more about what some doctors recommend. And review our suggested\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" rel=\"noopener\" target=\"_blank\"\u003emethylation protocol\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eas a potential step by step guide to some dosing options.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eHow to snap the tablet in half\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e \u003ca rel=\"noopener\" href=\"https:\/\/www.youtube.com\/watch?v=XOxWY-kQ8kc\u0026amp;list=PLpRy5gLP6XyP008M0ap1OqqkeDapTU-xq\u0026amp;index=12\u0026amp;t=0s\" target=\"_blank\"\u003eSee how its done via video\u003c\/a\u003e. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest\/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDr. Amy Yasko\u003c\/strong\u003e\u003cspan\u003e (\u003c\/span\u003ehttps:\/\/dramyyasko.com) recommends a specific form of B12 based on your genetics if you know the status of your COMT 158 and VDR Taq variants\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable id=\"b12-table\" class=\"mytable\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eCOMT V158M\u003c\/th\u003e\n\u003cth\u003eVDR Taq\u003c\/th\u003e\n\u003cth\u003eB12 Types That Should Be Tolerated\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ + (TT)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ – (Tt)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e– – (tt)\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eMostly Hydroxy B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp class=\"et_pb_module et_pb_text et_pb_text_1 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e \u003c\/p\u003e\n\u003cdiv class=\"col-lg-6\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"col-lg-6\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003eSUPPLEMENT FACTS\u003c\/h2\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eSUGGESTED USE\u003c\/span\u003e: Ask your doctor. Visit \u003ca href=\"https:\/\/methyl-life.com\/dosage\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/methyl-life.com\/dosage\u003c\/a\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cbr\u003eBite tablet into pieces, and hold under tongue or between gum and cheek until they dissolve.\u003c\/p\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\n\u003cbr\u003e\u003cstrong\u003eGreat for teeth, not for animals (contains xylitol).\u003c\/strong\u003e\n\u003c\/div\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cdiv class=\"supplementfactsbox\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"supplementlabel\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\u003cstrong\u003e SUPPLEMENT FACTS \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003eServing Size: 1 Chewable Tablet\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e90 servings per container\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cem\u003eAmount per Serving\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cem\u003e % Daily Value\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\u003cb\u003eFolate\u003c\/b\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e14,567 mcg DFE\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e3,642% (Total)\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e(as L-5-Methyltetrahydrofolate, Calcium [equal to 11,000 mcg \u003cstrong\u003eMagnafolate® PRO\u003c\/strong\u003e)])\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\u003cstrong\u003eVitamin B12\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e2,500 mcg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e104,167% (Total)\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e    (60% as H\u003cspan\u003eydroxy B12\u003c\/span\u003e)\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e1,500 mcg\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e    (40% as Adenosylcobalamin)\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e1,000 mcg\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eOTHER INGREDIENTS\u003c\/span\u003e: \u003cspan\u003exylitol (Xylisorb\u003c\/span\u003e\u003cstrong\u003e®\u003c\/strong\u003e\u003cspan\u003e), microcrystalline cellulose (Microcel\u003c\/span\u003e\u003cstrong\u003e®\u003c\/strong\u003e\u003cspan\u003e), stearic acid, silicon dioxide, natural mint flavor (dextrose, silicon dioxide, natural flavor).\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\u003cspan\u003eNot a significant source of total sugars.\u003c\/span\u003e\u003c\/div\u003e\n\u003cbr\u003e\u003cbr\u003ePRODUCT CONTAINS NO: wheat, gluten, soy, dairy, egg, fish\/shellfish, yeast, nuts, starch, ingredients of animal origin, caffeine, artificial colorings, preservatives or artificial flavoring, bisphenol-A (BPA), or phthalate.\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cbr\u003e\n\u003ch2 class=\"et_pb_text_inner\"\u003eResearch\u003c\/h2\u003e\n\u003ciframe loading=\"lazy\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/papakostas_2012_-_l-methylfolate_as_adjunctive_therapy_for_ssri-resistant_major_depression_-_results_of_two_randomized_double-blind_parallel-sequential_trials.pdf?v=1591251787\" width=\"100%\" height=\"500px\"\u003e\n    \u003c\/iframe\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch2\u003eFAQ'S\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" width=\"16\" height=\"16\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What is L Methylfolate 7.5 mg + Vitamin B12 Tablets?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eL Methylfolate 7.5 mg + Vitamin B12 Tablets is a therapeutic supplement formulated to support healthy mood, cognitive function, methylation, and homocysteine levels. It contains bioactive L methylfolate as internationally-patented Magnafolate® PRO, and sublingual vitamin B12 tablet forms (hydroxy B12 and adenosylcobalamin).\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" width=\"16\" height=\"16\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What are the key benefits of L Methylfolate 7.5 mg + Vitamin B12 Tablets?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eThis supplement provides support for brain function, cardiovascular health, immune function, nerve function, nervous system maintenance, preconception, pregnancy, and fetal health. It also aids in reducing and maintaining healthy homocysteine levels, supports optimal DNA methylation, neurotransmitter synthesis, and can be adjunctive support for serotonin selective reuptake inhibitors.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" width=\"16\" height=\"16\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e How common is the MTHFR mutation?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eThe MTHFR mutation is more widespread than commonly realized, with approximately 50% of the global population estimated to have at least one of two common variants. Around 25% of the global population carries the MTHFR mutation C677T, with Hispanics having the highest proportion at 47%.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" width=\"16\" height=\"16\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e Why is L-methylfolate important?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eL-methylfolate is the biologically activated form of folate, which is essential for various biological processes, including crossing the blood-brain barrier, supporting brain function, and DNA methylation.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" width=\"16\" height=\"16\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e How is L Methylfolate 7.5 mg + Vitamin B12 Tablets different from other folate supplements?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eIt is uniquely formulated with Magnafolate® PRO, ensuring maximum absorption and bioavailability. Additionally, it contains active vitamin B12 sublingual tablet forms for comprehensive mood support.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" height=\"16\" width=\"16\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe most important thing to realize is that \u003cstrong\u003eblood tests for B12 are highly inaccurate at detecting actual cellular levels of B12\u003c\/strong\u003e (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used. \u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" height=\"16\" width=\"16\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e How is the quality of L Methylfolate 7.5 mg + Vitamin B12 Tablets ensured?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eEvery single supplement batch undergoes rigorous 3rd-party testing for consistency, purity, safety, and potency to ensure maximum quality and efficacy.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" height=\"16\" width=\"16\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What does sublingual mean and why isn’t your product labeled as “sublingual”?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eIt’s a well-known fact that vitamin B12 does not absorb well through the gut, so taking B12 via sublingual or mouth absorption is best (holding it under the tongue or between the gums and cheek is most common). Consider some form of liquid or vitamin B12 tablets or lozenges that can be sucked on or dissolved in the mouth. Holding the vitamin B12 tablets in your mouth for at least 90 seconds is good and the longer you can leave it in your mouth, the better for sublingual absorption (as opposed to gut absorption).\u003c\/span\u003e\u003c\/div\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003e\u003cspan style=\"text-decoration: underline;\"\u003eNote\u003c\/span\u003e: different manufacturers use different terms for tablets that are meant to dissolve sublingually in the mouth, but “sublingual” is considered a pharmaceutical term by the FDA, so dietary supplements are moving away from using that term. However, it doesn’t really matter what term you use (chewable tablet, lozenge, sublingual tablet, liquid, etc.) for maximum absorption \u003cstrong\u003ethe main idea is to hold it in your mouth for 90 seconds or more\u003c\/strong\u003e if you can (if you forget, don’t worry, since you’re taking the active form, your body will still get some benefit even if you swallow it whole).\u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eAnother way to absorb B12 is muscularly through shots, however, the research tells us that sublingual (or mouth) absorption is equally as effective as muscular absorption … and shots may cost significantly more money. Also, be aware with shots (many doctors still give cyanocobalamin shots) that though you may need higher doses of active B12s (like myself), you may not do well when given higher doses of cyanocobalamin in a shot because your body may not be able to do the conversions and you could have negative side effects.\u003cbr\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" height=\"16\" width=\"16\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e My doctor said that because I have MTHFR, I should be taking methylcobalamin as my vitamin B12 form, why are you suggesting these other forms too?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eOne of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIt’s important to realize that the \u003cstrong\u003eMTHFR status does not necessarily determine the type of vitamin B12 tablets that are best for you\u003c\/strong\u003e, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIt seems there may be a general lack of education available to most doctors about the different forms of vitamin B12 tablets and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to your vitamin B12 tablets to see which you may tolerate best.\u003c\/p\u003e\n\u003cp\u003eThe most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxy B12, and from there the hydroxy B12 has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" height=\"16\" width=\"16\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e I have my 23andme test results, how can I use those to know which form of vitamin B12 tablets I might best tolerate?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eIf you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxy B12 (and this is why our methylation protocol suggests hydroxy B12 as the B12 form to begin with):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eFolks with multiple COMT mutations tend to do very well with hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)\u003c\/li\u003e\n\u003cli\u003eFolks with MTR \u0026amp; MTRR mutations may do well with methylcobalamin \u0026amp; adenosylcobalamin supplementation\u003c\/li\u003e\n\u003cli\u003eAnd Dr. Amy Yasko (https:\/\/dramyyasko.com) talks about folks with a particular mutation status for COMT \u0026amp; VDR Taq as best needing the below forms of B12:\n\u003cp\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ctable id=\"b12-table\" class=\"mytable\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eCOMT V158M\u003c\/th\u003e\n\u003cth\u003eVDR Taq\u003c\/th\u003e\n\u003cth\u003eB12 Types That Should Be Tolerated\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ + (TT)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ – (Tt)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e– – (tt)\u003c\/td\u003e\n\u003ctd\u003e\n\u003cspan\u003eHydroxy B12 \u003c\/span\u003eand Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e\n\u003cspan\u003eHydroxy B12 \u003c\/span\u003eand Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e\n\u003cspan\u003eHydroxy B12 \u003c\/span\u003eand Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e\n\u003cspan\u003eHydroxy B12 \u003c\/span\u003eand Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e\n\u003cspan\u003eHydroxy B12 \u003c\/span\u003eand Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eMostly \u003cspan\u003eHydroxy B12 \u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31482280640586,"sku":"Methyl75-S1001","price":56.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methylfolate-7.5__bottle_capsules.webp?v=1773395154"},{"product_id":"methylated-vitamins-methylfolate-methylated-b12","title":"Methylated Vitamins: Professional Strength Methylfolate \u0026 Methylated-B12","description":"\u003cp\u003e\u003cspan style=\"color: #ff2a00;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/span\u003eGet \u003cspan style=\"color: #2b00ff;\"\u003e\u003cstrong\u003eMethyl-Life’s®\u003c\/strong\u003e\u003c\/span\u003e most popular professional-strength, Mood-Elevating Bundle \u0026amp; experience full-spectrum absorption as well as therapeutic benefits.\u003c\/p\u003e\n\u003cp\u003eThese 2 products bundled contain the most bioavailable nutrients which target uplifting your Mood. Talk with your healthcare professional to ensure \"professional strength\" is right for you.  This methylation 2-product pack contains the bioactive nutrients:\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eThe \u003cstrong\u003epurest bioactive Methylfolate\u003c\/strong\u003e designed to get around genetic \u0026amp; absorption challenges\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAll 3 active forms of B12\u003c\/strong\u003e (as Methylated-B12, Hydroxy B12, \u0026amp; Adenosylcobalamin) for a full-spectrum mechanism of action\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCheck out the details below regarding each specific product included in the bundle using the links below:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli style=\"list-style-type: none;\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/methyl-life.com\/products\/l-methylfolate-15-mg\" title=\"Methylfolate - Methylfolate 15 mg - A Mood-Boosting Methyl-Life® Supplement - high dose for therapeutic benefit\"\u003eMethylfolate\u003c\/a\u003e - Most stable \u0026amp; pure Methylfolate (15 mg) you can find\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/methyl-life.com\/products\/b12-complete-tablets\" title=\"Methyl-Life's B12 Complete product with all 3 active B12 forms - truly a full-spectrum product\"\u003eMethylated-B12\u003c\/a\u003e - A power-packed 5 mg of 3 different Bioactive B12s per tablet\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eDid you know that \u003c\/span\u003e\u003cspan\u003erecent research shows that \u003cstrong\u003etaking B12 in a sublingual oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots\u003c\/strong\u003e? It's usually much more convenient and affordable as well -  https:\/\/pubmed.ncbi.nlm.nih.gov\/30632091.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDosage\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eHow much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"How much Methylfolate should I take? What's the right dosage level of B12 for me?\" href=\"https:\/\/methyl-life.com\/pages\/dosage\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto learn more about what some doctors recommend. And review our suggested\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"A comprehensive methylation protocol suggested for those taking Methylfolate and Active B12\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\"\u003emethylation protocol\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eas a potential step by step guide to some dosing options.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eHow to snap the tablet in half\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e–\u003c\/strong\u003e \u003ca title=\"How to split a Methyl-Life™ tablet in half so you can take half the dosage of a full tablet\" href=\"https:\/\/www.youtube.com\/watch?v=XOxWY-kQ8kc\u0026amp;list=PLpRy5gLP6XyP008M0ap1OqqkeDapTU-xq\u0026amp;index=12\u0026amp;t=0s\" target=\"_blank\"\u003eSee how its done via video\u003c\/a\u003e. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest\/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more. \u003c\/p\u003e\n\u003ch2 class=\"et_pb_text_inner\"\u003eResearch\u003c\/h2\u003e\n\u003cp\u003e\u003ciframe height=\"500px\" width=\"100%\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/papakostas_2012_-_l-methylfolate_as_adjunctive_therapy_for_ssri-resistant_major_depression_-_results_of_two_randomized_double-blind_parallel-sequential_trials.pdf?v=1591251787\"\u003e\n    \u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2\u003eFAQ'S\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What is the right dosage for me?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCheck out our \u003ca title=\"How much Methylfolate should I take? What's the right dosage level of B12 for me?\" href=\"https:\/\/methyl-life.com\/dosage\"\u003eDosage\u003c\/a\u003e page to learn what some \u003ca title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, Methylfolate, Deplin and optimizing your health\" href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\"\u003edoctors\u003c\/a\u003e are saying. And consider reviewing our \u003ca title=\"A comprehensive methylation protocol suggested for those taking Methylfolate and Active Methylated-B12\" href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\/\"\u003eMethylation Protocol\u003c\/a\u003e page as one example of how someone could start taking the active methylation nutrients.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What is included in the Mood Elevating Bundle?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eThe Mood Elevating Bundle consists of Methylfolate 15 mg and 3 Active B12s (including Methylated-B12) 5 mg. This bundle provides a 3-month supply of chewable tablets.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What do doctors have to say about MTHFR and how to treat it?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan\u003eGo to \u003ca title=\"Dr. Neil Rawlins talks about MTHFR, Methylation, Methylfolate, Deplin and optimizing your health\" href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\"\u003eA Doctor Explains\u003c\/a\u003e and listen to Dr. Neil Rawlins’ 51-minute seminar on MTHFR and the effects of Methylfolate.\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e How can the Mood Elevating Bundle benefit me?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eThis bundle is designed to support mood elevation and overall well-being. Methylfolate and Active B12s work synergistically to promote healthy mood balance. With a 3-month supply of chewable tablets, it offers convenience and ease of use.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e What does this methylation package contain?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eThis methylation package includes the following bioactive nutrients:\u003cbr\u003e\u003cbr\u003eThe purest Methylfolate, as demonstrated in a recent study.\u003cbr\u003eAll three active forms of B12, including Methylated-B12, Hydroxy B12, and Adenosylcobalamin.\u003c\/div\u003e\n\u003cdiv class=\"et_pb_row et_pb_row_1\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_4_4 et_pb_column_2    et_pb_css_mix_blend_mode_passthrough et-last-child\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_2 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e How can these nutrients benefit me?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThese bioactive nutrients are essential for supporting optimal methylation processes in the body, which play a crucial role in various physiological functions. Methylfolate and the active forms of B12 work together synergistically to promote overall health and well-being.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What can you do if you have high B12 blood test results?\u003c\/span\u003e\u003c\/strong\u003e Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e How does Methylfolate adjunctive therapy benefit individuals with SSRI-resistant major depression?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eHow does Methylfolate adjunctive therapy benefit individuals with SSRI-resistant major depression?\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e My doctor said that because I have MTHFR, I should be taking Methylated-B12 as my B12 form, why are you suggesting these other forms too?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eOne of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, Methylated-B12 or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called Methylated-B12, but that is simply NOT true. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIt’s important to realize that the \u003cstrong\u003eMTHFR status does not necessarily determine the type of B12 that’s best for you\u003c\/strong\u003e, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and Methylated-B12 work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate Methylated-B12 well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIt seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.\u003c\/p\u003e\n\u003cp\u003eThe most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into Hydroxy B12, and from there the Hydroxy B12 has to be converted into both adenosylcobalamin and Methylated-B12. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eIf you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be Hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of Hydroxy B12 (and this is why our methylation protocol suggests Hydroxy B12 as the B12 form to begin with):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eFolks with multiple COMT mutations tend to do very well with Hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)\u003c\/li\u003e\n\u003cli\u003eFolks with MTR \u0026amp; MTRR mutations may do well with Methylated-B12 \u0026amp; adenosylcobalamin supplementation\u003c\/li\u003e\n\u003cli\u003eAnd Dr. Amy Yasko (https:\/\/dramyyasko.com) \u003cmeta charset=\"utf-8\"\u003etalks about folks with a particular mutation status for COMT \u0026amp; VDR Taq as best needing the below forms of B12:\u003cstrong data-mce-fragment=\"1\"\u003e \u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ctable class=\"mytable\" id=\"b12-table\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eCOMT V158M\u003c\/th\u003e\n\u003cth\u003eVDR Taq\u003c\/th\u003e\n\u003cth\u003eB12 Types That Should Be Tolerated\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ + (TT)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ – (Tt)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylated-B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e– – (tt)\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less Methylated-B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eMostly Hydroxy B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31487668944970,"sku":"M15-B12Comp-EH1001","price":108.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methylfolate15_B12Compete-1.jpg?v=1771841656"},{"product_id":"l-methylfolate-15mg-vitamin-b12-with-methyl","title":"L Methylfolate 15mg + Vitamin B12 with Methyl","description":"\u003cdiv class=\"et_pb_row et_pb_row_0\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_1_2 et_pb_column_0    et_pb_css_mix_blend_mode_passthrough\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eTherapeutic high-dose of bioactive\u003c\/strong\u003e \u003cstrong\u003eL Methylfolate 15mg\u003c\/strong\u003e\u003c\/em\u003e uniquely formulated with the ultra-pure bioidentical methylfolate Cerebrofolate® and \u003cem\u003e\u003cstrong\u003eVitamin B12 with Methyl\u003c\/strong\u003e\u003c\/em\u003e, as well as \u003cem\u003e\u003cstrong\u003einositol\u003c\/strong\u003e\u003c\/em\u003e to naturally support healthy mood, cognitive function, methylation and homocysteine support.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eL-methylfolate is the predominant form of folate circulating in the body and used for biological processes\u003csup\u003e1\u003c\/sup\u003e.\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eStudies show *L methylfolate 15mg + SSRI to be the most effective dose for improving depressive symptoms\u003csup\u003e2\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eL Methylfolate 15 mg is the biologically activated form of folate and the only form that can cross the blood-brain barrier\u003csup\u003e3\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"padding-left: 30px;\"\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupport for brain function\u003csup\u003e4\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupports cardiovascular health\u003csup\u003e5\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupport for healthy immune function\u003csup\u003e6\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupports nerve function\u003csup\u003e7\u003c\/sup\u003e and healthy myelin formation\u003csup\u003e22\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eNervous system maintenance\u003csup\u003e21\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupport for preconception, pregnancy, and fetal health\u003csup\u003e8\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eInvolved in reducing\u003csup\u003e20\u003c\/sup\u003e and maintaining healthy homocysteine levels\u003csup\u003e9\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eEssential nutrient required for optimal DNA methylation\u003csup\u003e19\u003c\/sup\u003e and neurotransmitter synthesis\u003csup\u003e10\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eAdjunctive support for serotonin selective reuptake inhibitors\u003csup\u003e23\u003c\/sup\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\n\u003cspan style=\"font-weight: 400;\"\u003eSuitable for people with MTHFR mutations\u003csup\u003e11\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003csup\u003e\u003c\/sup\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cb\u003eProduct details\u003c\/b\u003e (30 capsule servings per container) \u003cbr\u003e\u003cspan style=\"text-decoration: underline;\"\u003eKey ingredients\u003c\/span\u003e:  \n\u003cul style=\"padding-left: 30px;\"\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eFolate\u003c\/strong\u003e - 15,000 mcg (as L-5-Methyltetrahydrofolate, Calcium - Magnafolate® PRO)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eVitamin B12\u003c\/strong\u003e - 1,000 mcg (as Hydroxy B12)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eInositol\u003c\/strong\u003e - 180 mg\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003e\u003cem\u003eL Methylfolate 15mg + Vitamin B12 with Methyl\u003c\/em\u003e\u003c\/strong\u003e is a highly bioactive form of folate made with the purest L methylfolate available\u003csup\u003e12\u003c\/sup\u003e.\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cul style=\"padding-left: 30px;\"\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eMaximum absorption and bioavailability\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eNo prescription required \u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eAvailable in \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-2-5\" target=\"_blank\" rel=\"noopener\"\u003e2.5mg\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylated-b12-l-methylfolate-3mg\" target=\"_blank\" rel=\"noopener\"\u003e3mg+B12\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/5-methylfolate-5-mthf-l-methylfolate-5mg\" target=\"_blank\" rel=\"noopener\"\u003e5mg\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/l-methylfolate-7-5mg-vitamin-b12-tablets\" target=\"_blank\" rel=\"noopener\"\u003e7.5mg+B12\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/methylfolate-15\" target=\"_blank\" rel=\"noopener\"\u003e10mg\u003c\/a\u003e, \u003ca href=\"https:\/\/methyl-life.com\/products\/l-methylfolate-15-mg\" target=\"_blank\" rel=\"noopener\"\u003e15mg\u003c\/a\u003e, 15mg+B12 \u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eRigorously tested for consistency, purity, safety, and potency\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eAbsolutely no fillers or additives of any kind\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eWhy take L Methylfolate 15mg + Vitamin B12 with Methyl?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eSynthesis of mood-enhancing neurotransmitters (serotonin, dopamine, and more) is regulated by L methylfolate, a derivative of folate\u003csup\u003e10\u003c\/sup\u003e. L Methylfolate has demonstrated efficacy as an adjunctive treatment for individuals who have not responded optimally to antidepressant therapy\u003csup\u003e2\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eSupplementing with 15mg L methylfolate alongside SSRIs may be effective in improving symptoms of depression\u003csup\u003e25\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. L Methylfolate is absorbed more efficiently than synthetic folic acid which must be converted to active folate by the enzyme \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003emethylenetetrahydrofolate reductase\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e (MTHFR)\u003csup\u003e13\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eHydroxy B12 works closely alongside folate in converting homocysteine to methionine to support mood and nervous system health. Individuals with MTHFR mutations may raise their nutrient status more efficiently with methylfolate\u003csup\u003e11\u003c\/sup\u003e and Hydroxy B12\u003csup\u003e26\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eInositol may be effective in treating disorders responsive to selective serotonin reuptake inhibitors, including depression, panic disorders, and obsessive-compulsive disorder\u003csup\u003e24\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eL Methylfolate 15mg + Vitamin B12 with Methyl is 100% free from all fillers and additives.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWho is affected by MTHFR mutations?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants).  Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%).  Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A\u0026gt;C polymorphism in Hispanics and Africans is 15%\u003csup\u003e14\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAn increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness\u003csup\u003e15\u003c\/sup\u003e.\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e  MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses\u003csup\u003e16\u003c\/sup\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFor these people, L Methylfolate supplementation is shown to be the most effective way to provide this form of folate\u003csup\u003e10\u003c\/sup\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eMethyl-Life’s® L Methylfolate 15mg is an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e ______________________________________\u003c\/p\u003e\n\u003cp\u003e\u003csup\u003e1\u003c\/sup\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20608755\/\" rel=\"noopener\" target=\"_blank\"\u003e https:\/\/pubmed.ncbi.nlm.nih.gov\/20608755\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e2\u003c\/sup\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23212058\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/23212058\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e3\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7687916\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7687916\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e4\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7779227\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7779227\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e5\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/hq0102.102190\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ahajournals.org\/doi\/10.1161\/hq0102.102190\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e6\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7019735\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7019735\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e7\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5867258\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5867258\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e8\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8127769\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8127769\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e9\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9832224\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9832224\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e10\u003c\/sup\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19193337\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/19193337\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e11\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7564482\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7564482\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e12\u003c\/sup\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methyl-Life_60-day_Methylfolate_Comparison.pdf?v=1595292111\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methyl-Life_60-day_Methylfolate_Comparison.pdf?v=1595292111\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e13\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK6561\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/books\/NBK6561\/\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e14\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6630484\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6630484\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e15\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6530664\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6530664\/\u003c\/a\u003e\u003cbr\u003e\u003csup\u003e16\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.0000165142.37711.E7\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ahajournals.org\/doi\/10.1161\/01.CIR.0000165142.37711.E7\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e17\u003c\/sup\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24032278\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/24032278\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e18\u003c\/sup\u003e\u003ca href=\"https:\/\/i.trade-cloud.com.cn\/upload\/6405\/file\/20210929\/english-version-magnafolate-enhancing-immunity_524485.pdf\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/i.trade-cloud.com.cn\/upload\/6405\/file\/20210929\/english-version-magnafolate-enhancing-immunity_524485.pdf\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e19\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3262611\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3262611\/ \u003c\/a\u003e\u003cbr\u003e\u003csup\u003e20\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.atv.18.3.356\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.atv.18.3.356\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e21\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557632\/#\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557632\/#\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e22\u003c\/sup\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15896807\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/15896807\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e23\u003c\/sup\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0924977X97004094?via%3Dihub\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0924977X97004094?via%3Dihub\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e24\u003c\/sup\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8780431\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/8780431\/\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e25\u003c\/sup\u003e\u003ca href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/24750573.2018.1552401\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.tandfonline.com\/doi\/full\/10.1080\/24750573.2018.1552401\u003c\/a\u003e \u003cbr\u003e\u003csup\u003e26\u003c\/sup\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5312744\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5312744\/\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003ch2\u003eCofA\u003c\/h2\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eCERTIFICATE OF ANALYSIS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ciframe src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/M15__CofA-Redact_Mfg_Date-03-2023.pdf?v=1735410440\" width=\"100%\" height=\"500px\"\u003e\n    \u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2\u003eDosage\u003c\/h2\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWARNING\u003c\/span\u003e – How much is right for you to take? \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTalk to your doctor about what’s best for you. Before you purchase check out our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/dosage\" target=\"_blank\" rel=\"noopener\"\u003edosage information\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto learn more about what some doctors recommend. And review our suggested\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\" target=\"_blank\" rel=\"noopener\"\u003emethylation protocol\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eas a potential step-by-step guide to some dosing options.\u003c\/p\u003e\n\u003cp\u003eFor optimal absorption, open the capsule and empty it under the tongue (hold it there and let it dissolve) – B12 is best absorbed via the mucous membrane in the mouth.\u003c\/p\u003e\n\u003cp\u003e \u003cstrong\u003eDr. Amy Yasko \u003c\/strong\u003e(https:\/\/dramyyasko.com) recommends a specific form of B12 based on your genetics if you know the status of your COMT 158 and VDR Taq variants.\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable id=\"b12-table\" class=\"mytable\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eCOMT V158M\u003c\/th\u003e\n\u003cth\u003eVDR Taq\u003c\/th\u003e\n\u003cth\u003eB12 Types That Should Be Tolerated\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ + (TT)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ – (Tt)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less vitamin B12 with methyl\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e– – (tt)\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less vitamin B12 with methyl\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eMostly Hydroxy B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp class=\"et_pb_module et_pb_text et_pb_text_1 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e \u003c\/p\u003e\n\u003ch2\u003eVideo\u003c\/h2\u003e\n\u003cdiv class=\"col-lg-6\"\u003e\n\u003cdiv class=\"fluid-width-video-wrapper\"\u003e\u003ciframe src=\"https:\/\/www.youtube.com\/embed\/I3e2K6OKdMI\" id=\"fitvid0\"\u003e\u003c\/iframe\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"col-lg-6\"\u003e\n\u003cdiv class=\"fluid-width-video-wrapper\"\u003e\n\u003cbr\u003e\u003ciframe src=\"https:\/\/www.youtube.com\/embed\/-hW1yt1dPzg\" id=\"fitvid0\"\u003e\u003c\/iframe\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2\u003eSUPPLEMENT FACTS\u003c\/h2\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eSUGGESTED USE\u003c\/span\u003e:  \u003cspan class=\"suggesteduse\"\u003e\u003cspan\u003eConsult with your healthcare practitioner before using this product. See \u003c\/span\u003e\u003ca class=\"text-link\" href=\"https:\/\/methyl-life.com\/dosage\" target=\"_blank\" rel=\"noopener\"\u003ehttps:\/\/methyl-life.com\/dosage\u003c\/a\u003e\u003cspan\u003e for more recommendations.\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cdiv class=\"supplementfactsbox\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"supplementlabel\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\u003cstrong\u003e SUPPLEMENT FACTS \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003eServing Size: 1 Veggie Capsule\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\u003cem\u003e30 servings per container\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cem\u003eAmount per Serving\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cem\u003e % Daily Value\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\n\u003cb\u003eFolate \u003c\/b\u003e(as L-5-Methyltetrahydrofolate, Calcium [equal to 20,000 mcg of\u003cb\u003e \u003cstrong\u003eMagnafolate PRO®\u003c\/strong\u003e\u003c\/b\u003e])\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e26,883 mcg DFE\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e6,721% (Total)\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\n\u003cstrong\u003eVitamin B12 \u003c\/strong\u003e(as Hydroxy B12)\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e1,000 mcg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e41,667% (Total)\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 41.9963%;\"\u003e\u003cstrong\u003eInositol\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right;\"\u003e\u003cstrong\u003e180 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right;\"\u003e\u003cstrong\u003e**\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eOTHER INGREDIENTS\u003c\/span\u003e:  Capsule (water, hypromellose).\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003ePRODUCT CONTAINS NO\u003c\/span\u003e:  wheat, gluten, soy, dairy, egg, fish\/shellfish, corn, yeast, nuts, starch, ingredients of animal origin, caffeine, artificial colorings, preservatives or artificial flavoring, bisphenol-A (BPA), or phthalate.\u003c\/p\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 class=\"et_pb_text_inner\"\u003eResearch\u003c\/h2\u003e\n\u003ciframe src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/papakostas_2012_-_l-methylfolate_as_adjunctive_therapy_for_ssri-resistant_major_depression_-_results_of_two_randomized_double-blind_parallel-sequential_trials.pdf?v=1591251787\" width=\"100%\" height=\"500px\"\u003e\n    \u003c\/iframe\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch2\u003eFAQ'S\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What is the right dosage for me?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCheck out our \u003ca href=\"https:\/\/methyl-life.com\/dosage\" target=\"_blank\" rel=\"noopener\"\u003eDosage\u003c\/a\u003e page to learn what some \u003ca href=\"https:\/\/methyl-life.com\/pages\/a-doctor-explains\" target=\"_blank\" rel=\"noopener\"\u003edoctors\u003c\/a\u003e are saying. And consider reviewing our \u003ca href=\"https:\/\/methyl-life.com\/pages\/methylation-protocol\/\" target=\"_blank\" rel=\"noopener\"\u003eMethylation Protocol\u003c\/a\u003e page as one example of how someone could start taking the active methylation nutrients.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What is L Methylfolate 15mg + Vitamin B12 with Methyl?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eL Methylfolate 15mg + Vitamin B12 with Methyl is a supplement that combines L Methylfolate, the active form of folate, with an active form of vitamin B12 for a professional-strength, mood-enhancing supplement.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003eWhat are the benefits of L Methylfolate 15mg + Vitamin B12 with Methyl?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eThis natural, mood-enhancing supplement provides a high dose of L Methylfolate 15mg along with vitamin B12 with methyl at 1000 mcg, which supports methylation processes in the body. It may be beneficial for individuals with specific health concerns, genetic challenges or nutritional needs requiring higher levels of these nutrients.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e How can I get more information on MTHFR?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003echeck out our Help for \u003ca href=\"https:\/\/methyl-life.com\/pages\/mthfr-newbies\" target=\"_blank\" rel=\"noopener\"\u003eMTHFR Newbies page\u003c\/a\u003e.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What is the Therapeutic high-dose of bioactive L-methylfolate?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eA therapeutic high-dose of bioactive L-methylfolate is often considered 7.5 mg - 15mg in a supplement uniquely formulated with an internationally-patented methylfolate brand. L Methylfolate 15mg + active vitamin B12 with methyl 1000 mcg \u0026amp; inositol.\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe most important thing to realize is that \u003cstrong\u003eblood tests for B12 are highly inaccurate at detecting actual cellular levels of B12\u003c\/strong\u003e (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used. \u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What is L Methylfolate 15mg + Enhance Mood?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMethylfolate 15mg+ Enhance Mood is a highly bioactive form of folate made with the purest methylfolate available.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e What are the key features of L Methylfolate 15mg + Enhance Mood?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cspan data-sheets-userformat='{\"2\":8961,\"3\":{\"1\":0},\"11\":3,\"12\":0,\"16\":10}' data-sheets-value='{\"1\":2,\"2\":\"This supplement offers maximum absorption and bioavailability, does not require a prescription, and is available in various strengths ranging from 2.5mg to 15mg+B12. It undergoes rigorous testing for consistency, purity, safety, and potency and contains absolutely no fillers or additives of any kind.\"}' data-sheets-root=\"1\"\u003eThis supplement offers maximum absorption and bioavailability, does not require a prescription, and is available in various strengths ranging from 2.5mg to 15mg+B12. It undergoes rigorous testing for consistency, purity, safety, and potency and contains absolutely no fillers or additives of any kind.\u003c\/span\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e My doctor said that because I have MTHFR, I should be taking vitamin B12 with methyl as my B12 form, why are you suggesting these other forms too?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eOne of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, vitamin B12 with methyl or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called vitamin B12 with methyl, but that is simply NOT true. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIt’s important to realize that the \u003cstrong\u003eMTHFR status does not necessarily determine the type of B12 that’s best for you\u003c\/strong\u003e, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that L methylfolate and vitamin B12 with methyl work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate L methylfolate well you’ll also need, want or tolerate vitamin B12 with methyl well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIt seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.\u003c\/p\u003e\n\u003cp\u003eThe most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxy B12, and from there the hydroxy B12 has to be converted into both adenosylcobalamin and \u003cspan\u003evitamin B12 with methyl\u003c\/span\u003e. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Vitamin B 12 (as Hydroxy B12)\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Vitamin B 12 (as Hydroxy B12)\"\u003e\u003cspan\u003e I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cp\u003e\u003cspan\u003eIf you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be Hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of Hydroxy B12 (and this is why our methylation protocol suggests Hydroxy B12 as the B12 form to begin with):\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\n\u003cli\u003eFolks with multiple COMT mutations tend to do very well with Hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)\u003c\/li\u003e\n\u003cli\u003eFolks with MTR \u0026amp; MTRR mutations may do well with \u003cspan\u003evitamin B12 with methyl\u003c\/span\u003e \u0026amp; adenosylcobalamin supplementation\u003c\/li\u003e\n\u003cli\u003eAnd Dr. Amy Yasko (https:\/\/dramyyasko.com) talks about folks with a particular mutation status for COMT \u0026amp; VDR Taq as best needing the below forms of B12:\n\u003cp\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ctable id=\"b12-table\" class=\"mytable\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eCOMT V158M\u003c\/th\u003e\n\u003cth\u003eVDR Taq\u003c\/th\u003e\n\u003cth\u003eB12 Types That Should Be Tolerated\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ + (TT)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e+ – (Tt)\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less \u003cspan\u003evitamin B12 with methyl\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003e– – (tt)\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eAll 3 types of B12 with less \u003cspan\u003evitamin B12 with methyl\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e+ –\u003c\/td\u003e\n\u003ctd\u003eHydroxy B12 and Adenosylcobalamin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e+ +\u003c\/td\u003e\n\u003ctd\u003e– –\u003c\/td\u003e\n\u003ctd\u003eMostly Hydroxy B12\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cstyle\u003e\n  .subscription {display:none}\n  \u003c\/style\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":31868889038922,"sku":"Methyl15+-T1001","price":47.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Methylfolate-15__bottlecapsules.webp?v=1773941028"},{"product_id":"calming-your-stress-with-the-best-gaba-supplement","title":"CALMING Your Stress Naturally with the Best GABA Supplement","description":"\u003cdiv class=\"et_pb_row et_pb_row_0\"\u003e\n\u003cdiv class=\"et_pb_column et_pb_column_1_2 et_pb_column_0    et_pb_css_mix_blend_mode_passthrough\"\u003e\n\u003cdiv class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_bg_layout_light  et_pb_text_align_left\"\u003e\n\u003cdiv class=\"et_pb_text_inner\"\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eDoes anxiousness overwhelm you sometimes? Do you want to manage it with an effective natural remedy instead of taking medications?\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThen you're in the right place! For many, getting hit by life's crazy curveballs can sometimes crowd out the ability to function with ease. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIf you suffer from an over-active nervous system, you may benefit from our ultra-CALMING product which contains natural forms of Gaba \u0026amp; Saffron as well as NAC, Zinc, Phosphatidylserine, and a bioavailable version of choline - all to support your stress response. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIt's been specifically formulated to help both the mind \u0026amp; body settle down almost immediately into a more relaxed state of being. This will allow you to get back to doing what's most important to you. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eBuilding resilience to stress is crucial for maintaining both mental and physical well-being in today's fast-paced and unpredictable world. Resilience acts as a psychological armor, enabling individuals to navigate challenges with greater ease and adaptability. In the face of stressors, resilient individuals exhibit a capacity to bounce back, learn from adversity, and grow stronger. Methyl-Life’s® product “\u003cem\u003e\u003cstrong\u003eCALMING for Mind and Body Balance\u003c\/strong\u003e\u003c\/em\u003e” has been formulated with key nutrients that work together for building and supporting resilience and CALM. It is all natural, free of gluten, dairy, and soy, and does not contain preservatives that could exacerbate symptoms of anxiety. Let’s take a closer look at our formulation.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFirst, we have GABA, which fosters emotional well-being by slowing down neurotransmitter hyperactivity which benefits individuals in managing and regulating their responses to stress.\u003c\/li\u003e\n\u003cli\u003eNext, we have Saffron, a nutrient that not only comes from a beautiful flower, but has been shown to provide positive effects on MOOD and SLEEP by supporting healthy levels of neurotransmitters like dopamine, and serotonin while lowering high levels of homocysteine.\u003c\/li\u003e\n\u003cli\u003eThe wonder nutrient NAC is known for its supportive role in reducing the risk of chronic psychological issues such as anxiety and depression by modulating the release of dopamine, it’s anti-inflammatory, promotes detoxification, and functions as a powerful antioxidant through stimulating the synthesis and increase of intracellular glutathione.\u003c\/li\u003e\n\u003cli\u003ePhosphatidylserine is pivotal in enhancing cognitive function, enabling better problem-solving and decision-making under pressure, in addition to helping regulate cortisol levels (the hormone that produces the “fight or flight” response).\u003c\/li\u003e\n\u003cli\u003eOther accompanying nutrients (Zinc and \u003cspan style=\"font-weight: 400;\"\u003ebioavailable choline\u003c\/span\u003e) work in supporting healthy cognitive function by reducing inflammation which promotes healthy brain cell membranes, synapses, and the ability to focus.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eYou may find our formula helps improve your sleep - especially if you take it along with an absorptive form of magnesium in the evening.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cem\u003e\u003cstrong\u003eCALMING for Mind and Body Balance\u003c\/strong\u003e\u003c\/em\u003e can contribute to a healthier and more resilient lifestyle by reducing symptoms of stress, which is associated with detrimental effects on the body, including depression, cardiovascular problems and weakened immune function. By building resilience through strategies like supportive nutrition, mindfulness, positive thinking, and social support you can mitigate some of these negative impacts.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cem data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eCALMING for Mind and Body Balance\u003c\/strong\u003e\u003c\/em\u003e empowers individuals to face life's inevitable stressors with grace and fortitude, ultimately leading to a more fulfilling, CALM, and balanced life.\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003ch2\u003eDosage\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eFor best results always consult your Healthcare Practitioner when you add new nutrients to your routine.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn the absence of directions from your Healthcare Specialist, consider taking one capsule when you are especially activated and wish to \"CALM down\" quickly\u003c\/span\u003e. Consider taking an additional capsule if you gain some relief from a single capsule, but feel a second one may be beneficial.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eBe aware that the product could make some folks sleepy.\u003c\/span\u003e\u003c\/strong\u003e \u003ca href=\"https:\/\/www.youtube.com\/watch?v=XOxWY-kQ8kc\u0026amp;list=PLpRy5gLP6XyP008M0ap1OqqkeDapTU-xq\u0026amp;index=12\u0026amp;t=0s\" title=\"How to split a Methyl-Life™ tablet in half so you can take half the dosage of a full tablet\" rel=\"noopener\" target=\"_blank\"\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003cdiv class=\"col-lg-6\"\u003e\n\u003cdiv class=\"fluid-width-video-wrapper\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003ch2\u003eSUPPLEMENT FACTS\u003c\/h2\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eSUGGESTED USE\u003c\/span\u003e: Consult with your healthcare practitioner before using this product. \u003c\/div\u003e\n\u003cdiv class=\"suggesteduse\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cdiv class=\"supplementfactsbox\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"supplementlabel\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\n\u003ctable width=\"100%\" style=\"height: 235.125px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 19.5938px;\"\u003e\u003cstrong\u003e SUPPLEMENT FACTS \u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 19.5938px;\"\u003e\n\u003cdiv class=\"supplementservingsize\"\u003eServing Size: 1 Capsule\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 19.5938px;\"\u003e60 servings per container\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 19.5938px;\"\u003e\u003cem\u003eAmount per Serving\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 19.5938px;\"\u003e\u003cem\u003e % Daily Value\u003cstrong\u003e\u003c\/strong\u003e \u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 39.1875px;\"\u003e\n\u003cb\u003eZinc \u003c\/b\u003e(encapsulaated zinc oxide micro-release pellet)\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 39.1875px;\"\u003e\u003cstrong\u003e11 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 39.1875px;\"\u003e\u003cstrong\u003e100%\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 19.5938px;\"\u003e\u003cstrong\u003eNACET\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 19.5938px;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\u003cstrong\u003e60 mg\u003c\/strong\u003e\u003c\/div\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 19.5938px;\"\u003e\n\u003cdiv class=\"supplementcol2\"\u003e\n\u003cstrong\u003e* \u003c\/strong\u003e  \u003c\/div\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 19.5938px;\"\u003e\u003cstrong\u003eGamma Amino Butyric Acid\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e72 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 19.5938px;\"\u003e\n\u003cstrong\u003e* \u003c\/strong\u003e\u003cspan\u003e  \u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 19.5938px;\"\u003e\u003cstrong\u003eCiticone (Sodium Citicoline)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e45 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 19.5938px;\"\u003e\n\u003cstrong\u003e* \u003c\/strong\u003e\u003cspan\u003e  \u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 19.5938px;\"\u003e\u003cstrong\u003ePhosphatidylserine 70%\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 19.5938px;\"\u003e\u003cstrong\u003e45 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 19.5938px;\"\u003e\n\u003cstrong\u003e* \u003c\/strong\u003e\u003cspan\u003e  \u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.1875px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 39.1875px;\"\u003e\n\u003cstrong\u003eSaffron \u003c\/strong\u003e(Stigma)\u003cstrong\u003e\u003cbr\u003e\u003c\/strong\u003e(Crocus sativus) Extract 3% Crocins\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 39.1875px;\"\u003e\u003cstrong\u003e10 mg\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 39.1875px;\"\u003e\u003cstrong\u003e*   \u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 0px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 0px;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 0px;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 0px;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.5938px;\"\u003e\n\u003ctd style=\"width: 41.9963%; height: 19.5938px;\"\u003e\n\u003cstrong\u003e   *  \u003c\/strong\u003eDaily value not established\u003c\/td\u003e\n\u003ctd style=\"width: 24.0037%; text-align: right; height: 19.5938px;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 25%; text-align: right; height: 19.5938px;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cbr\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\n\u003cspan style=\"text-decoration: underline;\"\u003eOTHER INGREDIENTS\u003c\/span\u003e: capsule (water, hypromellose).\u003cspan style=\"font-size: 0.875rem;\"\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementother\"\u003e\u003cspan style=\"font-size: 0.875rem;\"\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003cstrong\u003eProduct Does NOT Contain: \u003c\/strong\u003ewheat, gluten, soy, dairy, tree nuts, animal products, GMO’s. No artificial ingredients or colorings.\u003c\/div\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv class=\"supplementboxouter\"\u003e\n\u003ch2 class=\"et_pb_text_inner\"\u003eResearch\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eCholine\u003c\/span\u003e: pharmacological and clinical review, 2022 update (https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10548481)\u003c\/p\u003e\n\u003cp\u003eApplication of \u003cspan style=\"font-weight: 400;\"\u003eCholine \u003c\/span\u003ein Neurological Disorders: A Systematic Review (https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7601330)\u003c\/p\u003e\n\u003ch2\u003eFAQ'S\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e How does Gaba help with stress or anxiety?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGABA is a neurotransmitter that plays a crucial role in regulating mood and reducing anxiety by improving the gaba\/glutamate balance. Supplementation with GABA may help in calming the nervous system and therefore reducing stress and anxiety levels. Individuals with MTHFR mutations may have impaired neurotransmitter function, including GABA.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e How does Saffron help with stress or anxiety?\u003cbr\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eSaffron contains compounds like safranal and crocin, which have been shown to have antidepressant and anxiolytic effects. These compounds may modulate neurotransmitter levels in the brain, including serotonin, dopamine and GABA, which could help alleviate stress and improve mood.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e What does Zinc have to do with mental health?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eZinc is an essential mineral that plays a role in numerous biochemical processes in the body, including neurotransmitter function and immune system regulation.\u003cbr\u003eZinc deficiency is associated with increased stress, anxiety, and depression.\u003cbr\u003eIndividuals with MTHFR mutations may have impaired absorption or utilization of zinc, leading to deficiency.\u003cbr\u003eSupplementation with zinc may help correct deficiencies and support overall mental well-being.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e How does NAC protect cognition and improve mental health?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003eNAC has the capability of modulating neurological pathways like glutamate dysregulation, oxidative stress, and inflammation - all of which can affect how the brain functions. N-acetylcysteine is being explored and has been used as an added therapy for some psychiatric conditions. NAC is a precursor to glutathione, the body's most powerful antioxidant.\u003cbr\u003eMTHFR mutations can lead to reduced glutathione levels, which may result in oxidative stress and inflammation.\u003cbr\u003eNAC can replenish intracellular glutathione levels which support methylation and detoxification. NAC can help reduce oxidative stress and inflammation, which are often elevated in individuals with MTHFR mutations and may contribute to stress and anxiety.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg title=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" alt=\"Methylfolate 15\"\u003e\u003cspan\u003e Can Phosphatidylserine improve my brain function?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003ePhosphatidylserine is a phospholipid that is a component of cell membranes, particularly in brain cells.\u003cbr\u003eIt plays a role in neurotransmitter release and receptor function, including those involved in stress response and mood regulation.\u003cbr\u003eSupplementation with phosphatidylserine may help support cognitive function, reduce cortisol levels, and alleviate stress.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg alt=\"Methylfolate 15\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/check_mark_gray.png?v=1613535892\" title=\"Methylfolate 15\"\u003e\u003cspan\u003e How does Choline help with brain health?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"paragraph\"\u003e\n\u003cspan style=\"font-weight: 400;\"\u003eCholine \u003c\/span\u003eis a nutrient that is foundational for brain health and neurotransmitter synthesis. It plays a role in the protection and health of brain cells. A systematic review found that \u003cspan style=\"font-weight: 400;\"\u003eCholine \u003c\/span\u003ehas a positive impact on learning and cognition (it improves memory and attention) among the healthy population. In that same study, it was also determined that \u003cspan style=\"font-weight: 400;\"\u003eCholine \u003c\/span\u003ecould be considered an important nutrient for treating many neurological diseases.\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"paragraph\"\u003eApplication of \u003cspan style=\"font-weight: 400;\"\u003eCholine \u003c\/span\u003ein Neurological Disorders: A Systematic Review (https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7601330)\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Methyl-Life® Supplements","offers":[{"title":"Default Title","offer_id":43170325725359,"sku":"CALM-V1001","price":49.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0264\/6369\/9018\/files\/Calming-bottle_capsules.webp?v=1773394655"}],"url":"https:\/\/methyl-life.com\/collections\/sale-all-other-products.oembed","provider":"Methyl-Life® Supplements","version":"1.0","type":"link"}