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What Should I Be Taking? – A Suggested Methylation Protocol


  • Read the Dosage page before you start here, so you can understand what certain doctors might suggest (low dose or high dose methylfolate protocols) and what you decide you might want to try for yourself.
  • Since every person has different genetics, symptoms and toxic exposure, no one protocol will fit us all.
  • This is simply one specific suggestion to help people experiment with dosage levels slowly and safely based on their goals.
  • Start on the step that you think fits you best (if you don’t know, start at the beginning).
  • Stop at the step where you feel best (stop &/or go back a step if you experience negative reactions, maybe you’ve gone beyond a good therapeutic dose for you or introduced a new nutrient that your body doesn’t like).
  • Each step could be defined as 1 day or as many as 7 days (depending upon how sensitive you are to supplement changes, and how carefully you want to track your body’s reactions – positive or negative).  I suspect many will comfortably define a step as 2-5 days.
  • For those not following a doctor’s orders with specific products or dosages, you might consider our starter pack which can be purchased here.

 

Who Starts Where? Steps Active Daily Amount What To Take How Much When Comments
Kids, those very sick or sensitive to vitamins or medications, or folks targeting low dose start here 1 1,250 mcg (1.25 mg) of B-12 Hydroxocobalamin 1/2 tablet Morning People very sick (i.e. Chronic Fatigue, Fibromyalgia, Lyme, Autism, etc.) &/or sensitive to vitamins, supplements, or medications might start here.
Note: If you have high B12 serum levels, you may need some low-dose lithium orotate to help drive that B12 into the cells. You may want to start with that before adding the B12/hydroxocobalamin to your routine – talk to your doctor.
2 2,500 mcg (2.5 mg) of B-12 Hydroxocobalamin 1 tablet 1/2 Morning & 1/2 Afternoon For those who are significantly sick (i.e. Chronic Fatigue, Fibromyalgia, Lyme, Autism, Pernicious Anemia, etc.) or have a number of COMT mutations, they may want to add more Hydroxocobalamin daily to tolerance, I personally take ~5 mg a day.
3 2,500 mcg (2.5 mg) of B-12 Hydroxocobalamin 1 tablet 1/2 Morning & 1/2 Afternoon Some have a need for more B12 than others (especially if they’re significantly sick), if that’s you, then taking B-12 Complete may really help. MTR & MTRR mutations require more B12 in active forms (methylcobalamin & adenosylcobalamin) – I personally take 1-2 of the B-12 Complete a day. But more B12 can always be added in at a later step too.
500 mcg (0.5 mg) of Methylfolate + essential vitamins Methylated Multi 2 tablets Morning with food Here we introduce methylcobalamin (B12 @ 250 mcg or 0.25 mg) and methylfolate (@ 500 mcg or 0.5 mg), so pay attention to your body and notice if there are any negative reactions you have (possibly over-methylation or detox symptoms for the super sensitive). Most won’t notice anything at these small doses, but some will (pay attention to your body).
4 2,500 mcg (2.5 mg) of B-12 Hydroxocobalamin 1 tablet 1/2 Morning & 1/2 Afternoon
750 mcg (0.75 mg) of Methylfolate + essential vitamins Methylated Multi 3 tablets 2 Morning & 1 Afternoon with food
General MTHFR, those w/out significant symptoms or desiring more energy/health might start here 5 2,500 mcg (2.5 mg) of B-12 Hydroxocobalamin 1 tablet 1/2 Morning & 1/2 Afternoon People not paricularly sensitive to vitamins/medications might be able to start here.
1,000 mcg (1 mg) of Methylfolate + essential vitamins Methylated Multi 4 tablets 2 Morning & 2 Afternoon with food
6 2,500 mcg (2.5 mg) of B-12 Hydroxocobalamin 1 tablet 1/2 Morning & 1/2 Afternoon Those without MTHFR defects or methylation needs who just want a nice energy/healthy vitamin regimen may choose to stop somewhere between steps 5-6 (using this as their daily routine).
Note: Adding an NADH + CoQ10 tablet might really boost energy if you choose to stop here (it’s more mitochondrial function focused, as opposed to methylation focused).
1,250 mcg (1.25 mg) of Methylfolate Methylfolate 2.5 1/2 tablet Morning
1,000 mcg (1 mg) of Methylfolate + essential vitamins Methylated Multi 4 tablets 2 Morning & 2 Afternoon with food
7 2,500 mcg (2.5 mg) of B-12 Hydroxocobalamin 1 tablet 1/2 Morning & 1/2 Afternoon
2,500 mcg (2.5 mg) of Methylfolate Methylfolate 2.5 1 tablet 1/2 Morning & 1/2 Afternoon Some folks may find they have a higher need for more methylcobalamin B12 (if you have MTR & MTRR mutations and find you do well when taking higher doses of methylcobalamin), then the B-Methylated II product might be a better fit for you than the Methylfolate 2.5 as the B-Methylated II has both the Methylfolate & Methylcobalamin in it (and costs less money than the Methylfolate 2.5 + the B-12 Complete products combined). You may not need the B-12 Complete if you tolerate the B-Methylated II just fine.
1,000 mcg (1 mg) of Methylfolate + essential vitamins Methylated Multi 4 tablets 2 Morning & 2 Afternoon with food
2,500 mcg (2.5 mg) of B-12 B-12 Complete 1/2 tablet Afternoon
8 2,500 mcg (2.5 mg) of B-12 Hydroxocobalamin 1 tablet 1/2 Morning & 1/2 Afternoon
5,000 mcg (5 mg) of Methylfolate Methylfolate 2.5 2 tablets 1 Morning & 1 Afternoon
1,000 mcg (1 mg) of Methylfolate + essential vitamins Methylated Multi 4 tablets 2 Morning & 2 Afternoon with food
5,000 mcg (5 mg) of B-12 B-12 Complete 1 tablet 1/2 Morning & 1/2 Afternoon
9 5,000 mcg (5 mg) of B-12 B-12 Complete 1 tablet 1 Morning
7,500 mcg (7.5 mg) of Methylfolate Methylfolate 2.5 3 tablets 2 Morning & 1 Afternoon If someone wishes to dose higher levels of methylfolate, when the 2.5 mg tablets are gone, 5 mg, 10 mg or 15 mg tablet products can be purchased for less money per mg (but it’s nice to start out with the smaller mg tablets since you won’t know where your best range is until you slowly add and work your way up to get to your target).
1,000 mcg (1 mg) of Methylfolate + essential vitamins Methylated Multi 4 tablets 2 Morning & 2 Afternoon with food
2,500 mcg (2.5 mg) of B-12 Hydroxocobalamin 1 tablet 1 Afternoon
10 5,000 mcg (5 mg) of B-12 B-12 Complete 1 tablet 1 Morning
10,000 mcg (10 mg) of Methylfolate Methylfolate 2.5 4 tablets 2 Morning & 2 Afternoon At this point some may choose to use the Methylfolate 10 product and cut the pills in half for a cost savings (to replace the Methylfolate 2.5 tablets – 1/2 morning & 1/2 afternoon).
1,000 mcg (1 mg) of Methylfolate + essential vitamins Methylated Multi 4 tablets 2 Morning & 2 Afternoon with food
2,500 mcg (2.5 mg) of B-12 Hydroxocobalamin 1 tablet 1 Afternoon
11 5,000 mcg (5 mg) of B-12 B-12 Complete 1 tablet 1 Morning
12,500 mcg (12.5 mg) of Methylfolate Methylfolate 2.5 5 tablets 3 Morning & 2 Afternoon
1,000 mcg (1 mg) of Methylfolate + essential vitamins Methylated Multi 4 tablets 2 Morning & 2 Afternoon with food
2,500 mcg (2.5 mg) of B-12 Hydroxocobalamin 1 tablet 1 Afternoon
12 5,000 mcg (5 mg) of B12 B-12 Complete 1 tablet 1 Morning
15,000 mcg (15 mg) of Methylfolate Methylfolate 2.5 6 tablets 3 Morning & 3 Afternoon There is a Methylfolate 15 product that can be cut in half to create a 7.5 mg dose.
1,000 mcg (1 mg) of Methylfolate + essential vitamins Methylated Multi 4 tablets 2 Morning & 2 Afternoon with food
2,500 mcg (2.5 mg) of B-12 Hydroxocobalamin 1 tablet 1 Afternoon

 

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