Table of Contents
MTHFR Supplements
The Methyl-Life® MTHFR Supplements support methylation, genetic variations, and overall wellness with bioactive folate, methylated B12, and essential cofactors. Key nutrients like L-Methylfolate, Methylcobalamin, and magnesium help maintain homocysteine metabolism, neurotransmitter balance, and cellular energy. Formulated for purity and absorption, these supplements promote cardiovascular, neurological, and prenatal health. Consult a healthcare provider before use.
Potent L-Methylfolate and synergistic nutrients to optimize methylation and folate metabolism
Core MTHFR Support Supplements
This category includes targeted formulations delivering the most potent OTC L-Methylfolate combined with methylated B12 and cofactors to support efficient folate metabolism, healthy DNA/RNA replication, mood stabilization, energy production, and cognitive health. Ideal for individuals needing genetic MTHFR support or enhanced methylation pathways.
- Fully Bioactive L-Methylfolate & Vitamin B12 Supplement
- Cofactors Supporting Methylation, Cognition & Wellbeing
- Superior-Absorbing Magnesium, Proven in Human Study
- Easy Starting Dosage Levels for MTHFR Newbies
- Bioidentical L-Methylfolate for Immediate Absorption & Use
- Bioactive Vitamin B12 Sublingual, Hydroxy Form
Bioactive methylfolate and B12 combinations for mood, energy, and overall wellness
Methylated Vitamin and B12 Formulations
Formulated blends of methylated folate and B12 with cofactors to promote neurotransmitter function, cardiovascular health, and red blood cell vitality. Suitable for daily methylation support and addressing metabolic inefficiencies related to MTHFR variants.
- High-Dose Methylfolate to Lift Mood with Natural Nutrients
- Methylated-B12, 5 Mg Therapeutic Dose, to Aid B12 Sufficiency
- 3rd-Party Tested for Purity, Potency & Safety
- MTHFR Folate for Max Absorption & Improving Mood
- B12 Methylcobalamin Bioactive Sublingual for Blood Health
- 3rd-Party Tested for Purity, Potency & Safety
- Bioactive L-Methylfolate 3 Mg & Methylated B12
- Great for Bypassing MTHFR Mutations
- 3rd-Party Tested for Purity, Potency & Safety
Full-spectrum multivitamin formulas with methylfolate, B12, magnesium, and cofactors
Multivitamin Packs & Comprehensive Methylation Support
Multi-product packs and chewable multivitamins designed for broad methylation support, including energy metabolism, detoxification, and neurological health. Optimal for those seeking complete nutrient synergy to support MTHFR-related nutritional needs.
- Bioactive MTHFR Folate, Methylfolate, for Max Absorption
- Sublingual B12 to Aid B12 Sufficiency via Active Hydroxy Form
- 3rd-Party Tested for Purity, Potency & Safety
- Methylfolate, Active B12, Energy-Supporting Nutrients
- Cognition-Aiding, Methylation-Promoting Ingredients
- 3rd-Party Tested for Purity, Potency & Safety
Fast-absorbing folate and methylcobalamin to bypass digestive barriers
Targeted Sublingual Methylation Supplements
High bioavailability sublingual supplements offering direct delivery of active L-Methylfolate and methylcobalamin, fast-tracking cellular methylation processes. Perfect for users with digestive absorption challenges or those requiring rapid methylation support.
- Purest Bioactive L Methylfolate for Brain Support
- Bioidentical Active B12 Sublingual Supporting Sufficiency
- 3rd-Party Tested for Purity, Potency & Safety
- Easy Starting Dosage Levels for MTHFR Newbies
- Bioidentical L-Methylfolate for Immediate Absorption & Use
- Bioactive Vitamin B12 Sublingual, Hydroxy Form
Supplements to enhance nutrient absorption and manage stress for methylation health
Supportive Lifestyle and Digestive Health Products
Products supporting digestive enzyme function and stress modulation that indirectly benefit methylation processes and overall well-being. These supplements assist in nutrient availability and neuroimmune balance, improving outcomes in methylation-dependent health.
- Ease Your Belly from Post Meal Discomfort
- Assists Breakdown of Proteins, Carbohydrates, Lipids, Gluten & Dairy
- Tastes like a natural, after-dinner mint
- GABA Provides a Sense of Calm & Helps Manage Cortisol
- GABA Promotes Restful Sleep & Supports Cognitive Function
- 3rd-Party Tested For Purity, Potency & Safety
Methyl-Life® MTHFR Supplements Collection: Comprehensive and Science-Backed Support for Methylation, Genetic Variations, and Overall Wellness
The Methyl-Life® MTHFR Supplements collection offers a precisely formulated range of bioactive methylfolate products with synergistic nutrients designed to optimize methylation and support individuals with MTHFR gene variations. These supplements target critical biochemical pathways for DNA/RNA synthesis, neurotransmitter production, cardiovascular wellness, energy metabolism, and mood balance.
With L-Methylfolate and methylcobalamin/hydroxycobalamin in clinically validated active forms, plus cofactors like magnesium, this collection helps the body perform essential methylation functions efficiently.
Understanding MTHFR and Methylfolate
The MTHFR gene produces an enzyme that converts folic acid into L-Methylfolate, the active folate form. Common MTHFR variants (C677T, A1298C) can reduce enzyme efficiency, leading to impaired folate metabolism, elevated homocysteine, and increased risk for cardiovascular, neurological, and detoxification challenges.*
Supplementing with L-Methylfolate bypasses this genetic bottleneck, supporting:
- DNA/RNA synthesis for cell growth and repair
- Neurotransmitter production (serotonin, dopamine, and more)
- Homocysteine conversion to methionine for cardiovascular health
- Healthy fetal neural development during pregnancy
Key Benefits of the MTHFR Collection
- Optimizes Methylation – Active L-Methylfolate and methylated B12 for efficient methylation cycles
- Supports Cardiovascular Health – Helps maintain healthy homocysteine levels
- Enhances Neurological & Mental Function – Supports mood, cognition, and neurotransmitter synthesis
- Promotes Detox & Cellular Repair – Assists in DNA integrity and toxin clearance
- Supports Pregnancy – Provides critical nutrients for healthy prenatal development*
Product Categories in the Collection
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Monday-Friday (8:00 am - 7:00 pm)
support@methyl-life.com
Phone: (571) 308-2172
Methylation & Nutritional support for MTHFR since 2011.
Every batch is third-party tested for purity, potency, and safety, manufactured in NSF-certified, cGMP-compliant facilities, and rigorously evaluated to ensure you’re getting clean, clinical-grade nutrients — nothing more, nothing less.
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Let customers speak for us
from 1202 reviewsGreat
My GP recommended that I take this supplement about 10 years ago. I'm not sure how much effect it has had on my heath but my yearly blood work has always returned stellar results. The chewable tablets taste great and are easy to digest.
I have been taking this for 4 years. It really makes a difference and I always make sure I don't run out. Awesome product at a great price!
Just 2 a day and my mental state is vastly improved. Took a few weeks but now back to myself. The anger and roller coaster moods are gone. BTW, I have the MTHFR mutations and chronic Lyme disease.
i’be taking methylfolate for quite a few years at the suggestion of my doctor. I love the convenience of ordering by mail, automatically renewed, and having it delivered. Thanks for all your help when I had some problems ordering; the automatic renewal solved everything!
Pure. Works perfectly. I would never want to switch brands.
Absolutely wonderful ! My mental clarity and physical energy is back. I sleep well and like never before in years .
Can't tell energy affects yet but my kids all have the mthfr c677t homozygous mutation, lyme disease, Morgellons disease, and 2 of my 3 kids also have Bartonella. Top it off-- we have mold in our home and can't do construction for several months to remove mold.
This is a keeper - perfect for my son (who hates swallowing capsules)!!
It feels like it’s starting to help work.
Es super bueno, recomendado 100% a mi niña le hace muy bien
Seems to really balance my mood.
All Methyl-Life Supplements have been far superior to any other supplements I’ve taken for the last 10 years. I fully trust Methyl-Life for all my supplements..
5 mgmethylfolate helps me out a lot. I feel like I cone alive when i take it.
Love it! I can actually feel my energy has improved!!!!
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