Methylfolate Side Effects and How to Prevent Them
Methylfolate is an essential nutrient required for a wide range of processes in the body. Usually, we can obtain adequate folate and folic acid from food and supplements, which the body then converts to methylfolate.
However, some people cannot process folic acid properly1 due to a MTHFR polymorphism. This typically leads to lower levels of folate in the body. In these cases, methylfolate must be restored through supplementation or medication.
Unlike folic acid, L-methylfolate can pass through the “blood-brain barrier” and enter the central nervous system. Folic acid cannot be metabolized in the body.
Prescription methylfolate is available as Deplin®, classified as a ‘medical food.’ Deplin® is commonly prescribed for treatment-resistant depression and can be used off-label for megaloblastic anemia and renal and hepatic impairment.
Methylfolate is also available over-the-counter (OTC) as a health supplement, and dozens of brands are now available for consumers.
In general, methyl folate is regarded as a harmless nutrient based on studies evaluating the safe upper limits of folate intake. In recent years, however, concerns have been raised with respect to a potential downside to folate supplementation2. As with any supplement, methylfolate can have some side effects. Most of these are mild, but it’s essential to be aware of the correct dosage ranges.
This article will cover the most common side effects associated with taking methylfolate and how to avoid them. We’ll also explain dosage requirements and the best options for taking methylfolate safely.
