Active B12 Complete - 3 Fully-Bioavailable forms of B12

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Methyl-Life’s® B12 Complete product includes all active forms of B12 (even the rarer forms).  Bioactive simply means that the B12 has already been converted into a form that your body can immediately use.  With these bioactive forms, the B12 does not need to be converted by your genes/enzymes in order to be available for use by your cells (conversion can be a problem for people with MTR, MTRR, COMT as well as other gene defects).

Those with MTHFR are also often found to be low in B12 as well as folate - these are key nutrients for those with genetic challenges.

    • Methylcobalamin – Helps with methylation, brain & nerve health, circulatory & immune systems, reduces homocysteine, and positively affects anemia.
    • Hydroxocobalamin – Helps in pain sensitivity (chronic fatigue, fibromyalgia & COMT mutations may benefit), “brain fog”, detoxifying perioxynitrites or superoxides (bad guys), as well as pernicious anemia. The body converts Hydroxocobalamin into Methylcobalamin and Adenosylcobalamin.
    • Adenosylcobalamin – Helps in muscle recovery, mitochondrial support, repairing the myelin sheath, and again helps with anemia.

Our chewable form provides for maximum B12 absorption through the mucous membranes in the mouth. Bite the tablet into pieces and allow those to dissolve under your tongue for a sublingual delivery to maximize your body's use of the nutrient.

Methyl-Life’s® B-12 Complete product was the very first to combine all 3 active forms of B12 into a single tablet for effective, full-spectrum activity. Active oral B12 has been determined to be just as effective as B12 injections - so save your money and tap into the convenience of our easy-to-take tablet to avoid the problems that happen when your vitamin B12 is low.

WARNING    How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide.

Learn more about B12 and the best active forms to take.

We've spent a great deal of time on our formulations and believe they are optimal for a couple key reasons:

    • Superior formula – We chose the sublingual form specifically to ensure the best absorption of the nutrients. It’s a known fact that B12 does not absorb well through the stomach lining (and many have poor gut health complicating things even further with this delivery method). Instead, active B12 is much better absorbed through the mucosa membrane (or under the tongue – sublingually). 

    • Ideal formula – We have included all 3 of the active forms of B12 into a single product so you can have an optimum daily dose of B12 in an easy to afford product. It's also super convenient to take this tablet with your on-the-go lifestyle, it just melts in the mouth - no water needed.

Dr. Amy Yasko ( recommends a specific form of B12 based on your genetics if you know the status of your COMT 158 and VDR Taq variants.


COMT V158M VDR Taq B12 Types That Should Be Tolerated
– – + + (TT) All 3 types of B12
– – + – (Tt) All 3 types of B12 with less Methylcobalamin
– – – – (tt) Hydroxocobalamin and Adenosylcobalamin
+ – + + All 3 types of B12 with less Methylcobalamin
+ – + – Hydroxocobalamin and Adenosylcobalamin
+ – – – Hydroxocobalamin and Adenosylcobalamin
+ + + + Hydroxocobalamin and Adenosylcobalamin
+ + + – Hydroxocobalamin and Adenosylcobalamin
+ + – – Mostly Hydroxocobalamin

How to snap the tablet in half  See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.

Suggested Use: Consult with your healthcare practitioner before using this product.  See for more recommendations.
Bite tablet into pieces, and hold under tongue or between gums and cheek before ingesting.
Serving Size: 1 Chewable Tablet
90 servings per container Amount per Serving % Daily Value
 Vitamin B12 5,000 mcg (Total) 208,333% (Total)
    (as Methylcobalamin 50%) 2,500 mcg
    (as Hydroxocobalamin 25%) 1,250 mcg
    (as Adenosylcobalamin 25%) 1,250 mcg
OTHER INGREDIENTS: xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavor (dextrose, silicon dioxide, natural flavor). Not a significant source of total sugars.

Product Does NOT Contain: wheat, gluten, soy, dairy, tree nuts, animal products, GMOs.
No artificial ingredients or colorings.

Vitamin B 12 (as Hydroxocobalamin) What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?

The most important thing to realize is that blood tests for B12 are highly inaccurate at detecting actual cellular levels of B12 (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used.

Vitamin B 12 (as Hydroxocobalamin) What can you do if you have high B12 blood test results? Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).

Vitamin B 12 (as Hydroxocobalamin) What does sublingual mean and why isn’t your product labeled as “sublingual”?

It’s a well-known fact that B12 does not absorb well through the gut, so taking B12 via sublingual or mouth absorption is best (holding it under the tongue or between the gums and cheek is most common). Consider some form of liquid or tablet/lozenge that can be sucked on or dissolved in the mouth. Holding the B12 in your mouth for at least 90 seconds is good and the longer you can leave it in your mouth, the better for sublingual absorption (as opposed to gut absorption).
Note: different manufacturers use different terms for tablets that are meant to dissolve sublingually in the mouth, but “sublingual” is considered a pharmaceutical term by the FDA, so dietary supplements are moving away from using that term. However, it doesn’t really matter what term you use (chewable tablet, lozenge, sublingual tablet, liquid, etc.) for maximum absorption the main idea is to hold it in your mouth for 90 seconds or more if you can (if you forget, don’t worry, since you’re taking the active form, your body will still get some benefit even if you swallow it whole). Another way to absorb B12 is muscularly through shots, however, the research tells us that sublingual (or mouth) absorption is equally as effective as muscular absorption … and shots may cost significantly more money. Also, be aware with shots (many doctors still give cyanocobalamin shots) that though you may need higher doses of active B12s (like myself), you may not do well when given higher doses of cyanocobalamin in a shot because your body may not be able to do the conversions and you could have negative side effects.

Vitamin B 12 (as Hydroxocobalamin) My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too?

One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxocobalamin, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true.

It’s important to realize that the MTHFR status does not necessarily determine the type of B12 that’s best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).

It seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.

The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxocobalamin, and from there the hydroxocobalamin has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.

Vitamin B 12 (as Hydroxocobalamin) I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?

If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be hydroxocobalamin. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxocobalamin (and this is why our methylation protocol suggests hydroxocobalamin as the B12 form to begin with):

    • Folks with multiple COMT mutations tend to do very well with hydroxocobalamin (it helps mop up excess peroxynitrites which can cause problems)
    • Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation
    • And Dr. Amy Yasko ( about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:
COMT V158M VDR Taq B12 Types That Should Be Tolerated
– – + + (TT) All 3 types of B12
– – + – (Tt) All 3 types of B12 with less Methylcobalamin
– – – – (tt) Hydroxocobalamin and Adenosylcobalamin
+ – + + All 3 types of B12 with less Methylcobalamin
+ – + – Hydroxocobalamin and Adenosylcobalamin
+ – – – Hydroxocobalamin and Adenosylcobalamin
+ + + + Hydroxocobalamin and Adenosylcobalamin
+ + + – Hydroxocobalamin and Adenosylcobalamin
+ + – – Mostly Hydroxocobalamin


Vitamin B 12 (as Hydroxocobalamin) What is Active B12 Complete?

Active B12 Complete is a supplement containing three fully-bioavailable forms of vitamin B12, providing comprehensive support for energy metabolism, cognitive function, and overall well-being in a convenient chewable form.

Vitamin B 12 (as Hydroxocobalamin) What are the three forms of B12 in Active B12 Complete?

Active B12 Complete includes methylcobalamin, adenosylcobalamin, and hydroxocobalamin, ensuring maximum absorption and utilization of vitamin B12 by the body for enhanced benefits.

Vitamin B 12 (as Hydroxocobalamin)How should Active B12 Complete be taken?

Follow the guidance of a healthcare professional when taking Active B12 Complete chewable, usually one tablet daily or as necessary to fulfill personal B12 needs. Prior to buying, explore our dosage details to understand recommendations from certain healthcare providers. Additionally, consider reviewing our suggested methylation protocol as a potential step-by-step guide.

Vitamin B 12 (as Hydroxocobalamin)How long does a supply of Active B12 Complete last?

Each purchase of Active B12 Complete provides a three-month supply, offering extended support for maintaining B12 levels and overall health.

Vitamin B 12 (as Hydroxocobalamin)Can Active B12 Complete help with fatigue and low energy levels?

Yes, Active B12 Complete supports energy metabolism and may help alleviate fatigue and low energy levels associated with B12 deficiency or inadequate B12 intake.

Please Note

Before making a purchase of any of our products, Methyl-Life® recommends consulting with a healthcare professional - especially if you have any questions. Methyl-Life® cannot assume responsibility for adverse reactions or perceived negative side effects resulting from the use of our products.

For customers who have not used Methyl-Life® products before, we recommend starting with a single bottle before considering larger orders. Additionally, we encourage you to review our dosage and methylation protocol pages and consider beginning with a lower dose product to ensure a smooth integration with the ingredients before progressing to higher dose options.

Methyl-Life® generally does not accept returns for large orders. If you choose to return three unopened bottles from a 4-pack purchase, you will receive a full refund, excluding the cost of one bottle charged at full price.


Within 45 days of your order within the United States, you can return any unopened item shipped to you by Methyl-Life® as long as all seals are intact. To initiate a return, please email us using the Contact Us form, providing your order details and tracking information for the return product shipment sent to:  P.O. Box 33606, Seattle, WA 98133. Please note that return shipping costs are the responsibility of the customer, and we recommend considering insurance for the return package. Refunds will be processed within 10 business days of receiving the returned item, and you will receive an email confirmation once the refund is complete. Please be aware that depending on your financial institution, it may take up to 10 days for the refund to appear in your account.


If you have received the wrong item, or if your product has been damaged or is defective, please email us with detailed information using the Contact us form, and our Customer Service Manager will address your concern promptly. Do not discard any items unless directed to do so.



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