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What are the best dosage amounts of L-Methylfolate and Methylcobalamin for me?
PLEASE NOTE: We are not doctors and cannot provide any medical advice or recommendations. We simply offer our experience and what we’ve researched and discovered from the doctors out there who are making recommendations. Check out our Methylation Protocol page which provides four different symptom-based protocols to choose from - so you can supplement based on your specific health needs.
These protocols give detailed and step-by-step instructions regarding what nutrients to take, what specific amounts need to be taken and when, what order the nutrients can best be taken in as well as particular products that can be purchased.
At the end of the day, L-Methylfolate dosage is not a one-size fits all approach, nor is it based on age, size or weight as to how much is optimal for someone to take. Instead, it's much better based on one's genetic and symptom-based needs. If you haven't already, check out the video above to learn more.
- The MD, Dr. Rawlins, talks in terms of the prescription versions of methylfolate available today, which are often considered "high dose" options (3 mg, 5.6 mg, 7.5 mg & 15 mg). There is lots of research as well as clinical trials behind these dosage levels and of course they are FDA approved.
- The Naturopath, Dr. Lynch, talks in terms of "lower dosage" options regarding methylfolate amounts, typically more like (800 mcg – 2 mg). He has found this appropriate for people unable to tolerate larger doses (due to a heavy toxic burden or over-methylation challenges related to other genetic issues).
- Starting slow and with B12 - this is a critical precursor nutrient you want onboard before you start taking L-Methylfolate (as methylfolate when taken on its own can mask a B12 deficiency - so it's recommended to start with some active B12 to prevent that). Most people both need and tolerate it very well (consider our Hydroxocobalamin or B-12 Complete products to begin with - Hydroxocobalamin is the most well-tolerated active form of B12).
- But, what if my blood tests show I have high B12 levels you ask? Note: there is no good intracellular B12 test available today, they are currently testing B12 levels in the blood, but not how much of the B12 nutrient reaches your cells and can be used by them. So, even if your levels are high, your body may not be converting the B12 and it simply swims around unused in your blood and unable to get transported to the cells for use. Try one or all of the 3 active forms of B12 to get more of the B12 nutrient into your cells (hydroxocobalamin, methylcobalamin, adenosylcobalamin – note: hydroxocobalamin converts into methylcobalamin and adenosylcobalamin within the body - so it is one of the most versatile forms to take).
- The high dose active B12 range is between 2-15 mg (with many falling in the 5-10 mg range). Some doctors recommend 10+ mg for folks with certain health issues, i.e. Parkinson's or possibly anemia. It's worth noting that some can get injections for as much as 25+ mg - of course this is not typically a 'daily' intake amount and is under a doctor's orders. If you have MTR, MTRR and/or COMT mutations, you might need significant doses of this nutrient (I personally take about 6-10 mg a day, but I also have double MTR and a few double MTRR mutations as well as some COMT mutations). Check out our Best Form of B12 page to learn more about what's right for you personally.
- After you've got the right amount of active B12 onboard (and maybe it's only 500 mcg that works for you) ... introduce methylfolate and/or just one ingredient/product/dose increase at a time and hold it for a few days to see how your body does with it (Dr. Rawlins talks about this – it allows you to understand what your body is tolerating well or unhappy with so that you can make changes accordingly) – consider our B-Methylated II or a lower dose L-Methylfolate only product like Methylfolate 2.5 to start.
- If you determine high dose Methylfolate is for you (those who suffer from depression or low serotonin find these therapeutic levels most helpful) or if you want to try to increase up to higher doses, the range for that is typically 3-15 mg daily (with many people falling into the 5-10 mg category, but some taking as much as 50 mg and I even saw a colon cancer study where they were dosed with over 100 mg a day. Of course I would NOT recommend this without being under the care of a prescribing healthcare practitioner).
- Today’s prescription level dosing for depression-level support is 7.5 mg - 15 mg of L-Methylfolate. Again, increase slowly and hold each dose change for about 3-5 days to ensure things are going fine and that you are aware of any changes taking place in your body. As you increase your dosing of methylfolate, have Nicotinic Acid or Niacin (not niacinamide) on hand so that if you feel you have taken too much methylfolate and are having an “over-methylated” reaction (heart palpitations, agitation, feeling like you've had too much caffeine, anxiety, irritability, etc.). You can counteract this 'over-methylation' experience quickly with Niacin (Dr. Lynch says 50 mg of Niacin every 30-60 minutes or so until your negative symptoms subside is the best way to neutralize over-methylation).