What is methylated folic acid?

methylated folic acid

Methylated folic acid, also more correctly referred to as methylfolate, is a nutrient that belongs to the vitamin B family. The body needs folate and cannot produce it on its own, so folate needs to be consumed in the diet or by supplementation.  Folate is primarily responsible for the easy conversion of carbohydrates into glucose in our bodies. Folate is essential in red blood cell formation, cell division, detoxification and the production of some neurotransmitters.  For this reason, folic acid is a supplement often prescribed to pregnant women to prevent certain birth defects.(2)

Why methylated folate is growing in popularity

Although folate is needed by the body and folic acid is widely used as a supplement, recent research has identified that up to 50% of the population is not able to convert folic acid—the synthetic form of B9—into absorbable folate. This genetic difference can mask vitamin B12 deficiency and lead to a host of other health problems including birth defects. As people have become more aware of the body’s need for folate and the chance that folic acid may not be an effective form of supplementation, methylated folate has increased in popularity. (2)

What are the benefits of methylated folate?

The benefits of taking methylated folic acid can be enjoyed by both men and women. The primary benefit is that you don’t have to know whether your body can convert the synthetic folic acid into natural folate: methylated folate supplements ensure that all of the following benefits are available to you. (1)

Prevention of neural tube defects

This is perhaps one of its most notable advantages. Methylated folate has been known to aid in the prevention of some birth defects. Folate is necessary for proper fetal brain and neural tube development. Increasing the intake of folate has helped to drastically reduce this problem.

Prevention of heart disease

Once methylated folate is included in your diet, the chances of suffering from a number of heart conditions is greatly reduced. Even though it has not yet been clinically proven, the presence of vitamin B complex supplements in your food can lead to reduction of homocysteine levels which can make you be less prone to heart disease and stroke.

Controlling depression

Research has shown that people who don’t get enough folate regularly and in its required form have had more problems controlling the symptoms of depression, even with the aid of antidepressants. Depression can be more effectively controlled when using the right antidepressant in combination with methylated folate in the body.

Other conditions that may be prevented with the regular consumption of folate include:

  • Cancer
  • Diarrhea
  • Periodontal disease
  • Vascular disease
  • Psoriasis
  • Epilepsy
  • Osteoporosis



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4 Responses to “What is methylated folic acid?”

  1. Monica says :

    Thanks for the information! My question is, What is your recommended dosage for nursing mothers who still take prenatal vitamins that contain folic acid?

  2. Jamie Hope says :

    Do not take prenatal vitamins with folic acid, folic acid is bad, especially for those who can’t convert it and have MTHFR defects, which is a large percentage of the population. Switch to a prescription prenatal like Neevo which has methylfolate in it, or consider Methyl-Life’s Methylated Multivitamin which was formulated to be an affordable alternative to Neevo. Most doctors are recommending between 1-3 mg of methylfolate for pregnancy and lactation (so the B-Methylated II might be a nice option as well, if you’re already taking a good multi without folic acid). If you’re suffering from postpartum depression and then your doctor might want to give you a Deplin level dose of methylfolate which is between 7.5-15 mg. Ask your doctor on this one.

  3. jerome says :

    Vitamin B benefits are amazing. Point is that most people dont read these kind of articles so they can understand the importance of eating healthy food and taking these vitamins in. Great article very well and simple written.

  4. Alexa says :

    WOW! 50% of the population can’t convert folic acid into an absorbable folate? That is huge and I can’t believe doctors are still prescribing this without doing some tests to see whether or not the person can actually convert it! I have been prescribed folic acid before and who knows if it’s good for me or not. I didn’t even hear about methylated folate. So upset at my doctor for not even mentioning this! I may even have to find a new family doctor now.

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