Frequently Asked Questions

Deplin® and the Methyl-Life® range are both brands that offer L-methylfolate, the active form of folate in 7.5 mg and 15 mg "free methylfolate" dosage amounts.

However, Deplin® is a prescription medication, using Metafolin® as its active form of methylfolate. It is primarily used as an adjunctive treatment for individuals with depression or certain mental health conditions who have demonstrated a suboptimal response to antidepressant medications.

Methyl-Life® offers a range of methylfolate products which are available over-the-counter (without a prescription). Our supplements are designed to support overall health and address potential methylation issues associated with MTHFR genetic mutations. Most importantly, the form of methylfolate used in Methyl-Life® products is Magnafolate® PRO, which has been tested as one of the purest forms of methylfolate available.

Yes! But not only that, we go above and beyond the industry standard which tends to employ "skip batch" testing. This means that every time a test comes back within the approved/expected range, the manufacturer or retailer assumes that if the formula and ingredients will not change, then likely neither will the testing results of the final product formula. So they then resolve to skip a bunch of production batches and only test every 10th or 20th batch (or whatever the "skip interval number" is that they decide to use).

But not at Methyl-Life®, we want you to feel confident in every single batch we have produced, so post production we send samples from every batch to a reputable 3rd party lab that tests for us to ensure the potency is as we've formulated (and expect) it to be (as our label indicates it is). So as our customer, you know you're getting exactly what you paid for (and that we've verified it for you through an independent 3rd party).

All Methyl-Life® products are manufactured in FDA registered and audited, cGMP compliant facilities. Most of the products come out of manufacturing facilities that have gone above and beyond industry standards to become NSF certified as well (which carries an additional high set of SOPs [standard operating procedures] ensuring excellence in the final products. Extra money and time goes into carrying this level of certification, but it's designed to make customers feel more confident in the high quality standard of such facilities due to all of the additional 3rd party rigor that's designed around the production process).

Our manufacturers are FDA registered and audited, cGMP compliant and NSF certified.

Most Methyl-Life® products contain no wheat, gluten, soy, dairy, egg, fish/shellfish, yeast, nuts, starch, caffeine, artificial colorings, preservatives or artificial flavoring, bisphenol-A (BPA), or phthalate. Our multivitamin products contain small amounts of beeswax and lanolin-derived constituents so they are not considered vegan.

We do not outsource our customer support (instead we do all of our own customer support in-house). And as a family-owned business, we have discovered we are able to provide our best support to customers via chat and email. So please send us your questions in email to: support@methyl-life.com. In the rare instance that we cannot answer your question via email and need to speak over the phone, we will have a knowledgeable individual call you. We have found we can be most effective at reaching a maximum number of customers online through email, so we do not have a live-answer phone service available at this time. If you wish to pay for a 60-minute online Zoom consult with a Naturopathic Practitioner, we can facilitate that consultation for you.

If our support team has some bandwidth we can sometimes provide some basic information around testing results for MTHFR and some other related genetics here and there. This is not a comprehensive or specific service we provide, but in some cases we can offer some insights or point you in a helpful direction. If you wish to have a more comprehensive assessment, an email or zoom consultation with a Naturopathic practitioner is what we'd suggest, and we can facilitate that service and connection for you for a fee. The practitioner can help go over your genetics report with you and help you determine what's best to take based on your specific results, other blood &/or medical tests as well as your symptoms.

This depends on the supplement itself.

B vitamins are best taken in the morning as they play essential roles in energy metabolism, nerve function, and the production of neurotransmitters. This can have an energizing effect on the body, contributing to alertness.

Starting the day with your B vitamins allows you to get the most out of these vitamins throughout the day. They can help support energy levels, mental focus, and overall vitality. Alternatively, some practitioners recommend taking divided doses (e.g., morning and mid-day). This helps to maintain a steady level of folate in the bloodstream throughout the day.

Water-soluble vitamins - folate, thiamine, riboflavin, niacin, pantothenic acid, biotin, vitamin B6, and vitamin B12, and vitamin C - can be taken with or without food.

Fat-soluble vitamins - A, D, E, and K - are absorbed and transported in a manner similar to that of fats, so they should be taken with a meal.

Some people find that certain nutrients can cause stomach upset when taken on an empty stomach (i.e. zinc), so if you notice stomach upset when you take a nutrient on an empty stomach, consider trying it with food before you give up on it entirely.

Yes mostly, and no. Most Methyl-Life® products contain NO animal-derived substances, however, our multivitamins contain small amounts of beeswax and lanolin-derived constituents, so they are not considered 100% vegan. They are vegetarian, gluten free, and dairy free.

Magnafolate® PRO, Magnafolate® C, and Cerebrofolate™ are all patented, crystallized forms of L-5-Methyltetrahydrofolate Calcium Salt.

Magnafolate® is a ~98-99% pure form of L-methylfolate (only the (6S)/L isomer in the ingredient). It is also a calcium salt-based crystalline form and is extremely stable. It has a ~78% “free methylfolate” absorption rate, which means that 1 mg of raw Magnafolate® equals approximately 0.78 mg of the active L-methylfolate (bioactive “free methylfolate”) that can be absorbed by your body.

Cerebrofolate™, on the other hand, is a crystalline calcium salt form of L-methylfolate. It comprises >=80% “free methylfolate”, while L-5-MTHF glucosamine comprises only ~52% “free methylfolate”. This makes Cerebrofolate™ the most potent L-methylfolate on the market today. Ingesting just 1 mg of the raw ingredient provides at least 0.80 mg of absorbable L-methylfolate.

Methyl-Life’s® Non-Methylated Multivitamin with Cognitive Nutrients contains no methylated nutrients. It is designed to be taken alongside a customized dose of methylfolate and/or prescribed Vitamin B12. See our available products

Methyl-Life’s® methylfolate products are chewable, including the Chewable Methylated Multi, most of the methylfolate tablets as well as the Active B12 products.

The Gut Health 4 in 1, Sucrosomial Magnesium®, MitoQ, Focus and Recall, Methylfolate 15+ and probiotics are all capsules.

Methyl-Life’s® Chewable Multivitamin contains methylated folate and B12 (as methylcobalamin). This multi is designed to assist with methylation processes in the body and is ideal for those with MTHFR genetic mutations who require active nutrients.

The Non-Methylated Multivitamin with Cognitive Nutrients contains no methylated nutrients. It is designed to be taken alongside a customized dose of methylfolate and/or prescribed Vitamin B12. It acts as a methylation-support multivitamin, but it does not contain any methylated nutrients.

The Chewable Methylated Multi contains a B-complex alongside other vitamins, minerals, antioxidants, and cognitive nutrients.

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Signing up on our email list (you get education + promotions)
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Select one of our discounted bundles
Purchasing a “Frequently Bought Together” bundle
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Write a special review for us
Purchase 4 products (and input the discount code ML-SAVE6 at checkout)

Testing options for MTHFR include:

Healthcare provider: Consult with your doctor/primary care physician, or a local hospitals or clinical genetics center. They can assess your medical history, symptoms, and family history to determine if genetic testing for MTHFR mutations is appropriate. They can also guide you through the testing process and sometimes help you interpret the results.

Genetic testing laboratories: Many reputable genetic testing laboratories offer MTHFR genetic testing directly to consumers. These companies provide test kits that can be ordered online, which involves sending a sample (usually saliva or cheek swab) to the laboratory for analysis. Some options include 23andMe, AncestryDNA, Genetic Genie, Doctor's Data, MyHeritage DNA, etc. Google may be able to help you determine which test is best for you based on some comparison data between the various companies.

Of course. Methyl-Life’s® supplement range is designed to optimize overall health and wellbeing for anyone, whether you have MTHFR or simply require some extra nutritional support.