COVID-19 – Methyl-Life Supplements

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Furin, a potential therapeutic target for COVID-19


Canrong WU,a,1Yueying YANG,b,1Yang LIU,bPeng ZHANG,bYaliWANG,bQiqi WANG, b Yang XU,bMingxue LI,bMengzhu ZHENG,a,* Lixia CHEN,b,* &Hua LIa,b,* aHubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China bWuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China Abstract A novel coronavirus (SARS-CoV-2) infectious disease has broken out in Wuhan, Hubei Province since December 2019, and spread rapidly from Wuhan to other areas, which has been listed as an international concerning public health emergency. We compared the Spike proteins from four sources, SARS-CoV-2, SARS-CoV, MERS-CoV and Bat-CoVRaTG13, and found that the SARS-CoV-2 virus sequence had redundant PRRA sequences. Through...
Jamie Hope

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The Role of Folic Acid in the Management of Respiratory Disease Caused by COVID-19


The Role of Folic Acid in the Management of Respiratory Disease Caused by COVID-19 Zahra Sheybani, Maryam Heydari Dokoohaki, Manica Negahdaripour, Mehdi Dehdashti, Hassan Zolghadr, Mohsen Moghadami, Seyed Masoom Masoompour, Amin Reza Zolghadr Submitted date: 26/03/2020 • Posted date: 30/03/2020 Licence: CC BY-NC-ND 4.0 Citation information: Sheybani, Zahra; Dokoohaki, Maryam Heydari; Negahdaripour, Manica; Dehdashti, Mehdi; Zolghadr, Hassan; Moghadami, Mohsen; et al. (2020): The Role of Folic Acid in the Management of Respiratory Disease Caused by COVID-19. ChemRxiv. Preprint. https://doi.org/10.26434/chemrxiv.12034980.v1   Entrance of coronavirus into cells happens through the spike proteins on the virus surface, for which the spike protein should be cleaved into S1 and S2 domains. This cleavage is mediated by furin, which can specifically cleave Arg-X-X-Arg↓ sites of...
Jamie Hope

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Predictors for imaging progression on chest CT from coronavirus disease 2019 (COVID-19) patients


ABSTRACT Objective: This study aimed to investigate the potential parameters associated with imaging progression on chest CT from coronavirus disease 19 (COVID-19) patients. Results: The average age of 273 COVID-19 patients enrolled with imaging progression were older than those without imaging progression (p = 0.006). The white blood cells, platelets, neutrophils and acid glycoprotein were all decreased in imaging progression patients (all p < 0.05), and monocytes were increased (p = 0.025). The parameters including homocysteine, urea, creatinine and serum cystatin C were significantly higher in imaging progression patients (all p < 0.05), while eGFR decreased (p < 0.001). Monocyte-lymphocyte ratio (MLR) was significantly higher in imaging progression patients compared to that in imaging progression-free ones (p < 0.001). Logistic...
Jamie Hope

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How Can You Boost Your Immune System During Coronavirus?


Your immune system is your body’s defense mechanism against various different illnesses, infections, and diseases. It knows what cells are vital to the body’s function while working to eliminate anything that’s unwanted.  With the COVID-19 outbreak causing widespread panic around the world, the most effective thing we can do for our bodies during this time is to take care of it in the best ways we know how. With proper awareness and a proactive attitude, we can fight through this and return to the life we’ve grown accustomed to. If you’re like the rest of the population and are trying to find ways to boost your immune system, you’ve probably come across a wide range of conflicting arguments. We’ve noticed...
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