Methylfolate 15 mg

  • Purest Bioactive form of folate
  • Enhance Mood*
  • 90 Chewable mint tablets
Regular price $76.00
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High dose L-methylfolate for healthy methylation, homocysteine and natural mood support.

Bioactive folate uniquely formulated with the internationally-patented Magnafolate® PRO.

L-methylfolate is the predominant form of folate circulating in the body and used for biological processes1.

Studies show *15mg methylfolate + SSRI to be the most effective dose for improving depressive symptoms2.

Methylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier3.

  • Support for brain function4
  • Supports cardiovascular health5
  • Support for healthy immune function6
  • Supports nerve function7
  • Support for preconception, pregnancy, and fetal health8
  • Involved in maintaining healthy homocysteine levels9
  • Essential nutrient required for healthy DNA and neurotransmitter synthesis10
  • Suitable for people with MTHFR mutations11

Product details

Key ingredient:  Folate 15,000 mcg (L-5-Methyltetrahydrofolate, Calcium as Magnafolate® PRO)

Methylfolate 15 mg is a highly bioactive form of folate made with the purest methylfolate available12. 

  • Maximum absorption and bioavailability
  • No prescription required 
  • Available in 2.5mg, 3mg+B125mg, 7.5mg+B1210mg, 15mg, 15mg+B12 
  • Rigorously tested for consistency, purity, safety, and potency

Why take methylfolate?

Folate is required for numerous critical functions of the brain and nervous system. It is essential for DNA/RNA synthesis, maintaining healthy homocysteine levels, and for proper fetal development during pregnancy. 

Folic acid is a synthetic form of folate. It can only be used by the body after it has been converted to active folate by an enzyme called methylenetetrahydrofolate reductase (MTHFR)13.

Who is affected by MTHFR mutations?

The MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants).  Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%).  Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A>C polymorphism in Hispanics and Africans is 15%14

An increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness15.  MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses16.

For these people, L-methylfolate supplementation is shown to be the most effective way to provide this form of folate10

Methyl-Life’s® Methylfolate is an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.

Why Magnafolate® PRO?

Methyl-Life’s® Methylfolate 15 mg is made with the internationally-patented Magnafolate® PRO, clinically tested as the world’s purest methylfolate (Magnafolate® PRO is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic® and Extrafolate®).

Magnafolate® is made with a form of methylfolate called L-5-MTHF-Ca, which is shown to be the most active form of folate in the plasma circulation. When compared with ordinary folate, L-methylfolate was found to be absorbed faster and utilized more quickly in the body17.

A recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation18



WARNING  How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to some dosing options.

How to snap the tablet in half  See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.


SUGGESTED USE: Consult with your healthcare practitioner before using this product. See for more recommendations.

Great for teeth, not for animals (contains xylitol).

Serving Size: 1 Chewable Tablet
90 servings per container Amount per Serving % Daily Value
Folate 29,135 mcg DFE 7,284%
(as L-5-Methyltetrahydrofolate, Calcium [equal to 22,000 mcg of Magnafolate® PRO])

OTHER INGREDIENTS: xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavor (dextrose, silicon dioxide, natural flavor. 

Not a significant source of sugars.

Product Does NOT Contain: wheat, gluten, soy, dairy, tree nuts, animal products, GMO’s. No artificial ingredients or colorings.

Methylfolate 15 What is the right dosage for me?

Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.

Methylfolate 15 Is Methylfolate the only thing I should take if I have an MTHFR gene mutation?

No, actually our recommendation is to heavily consider following Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching parts 3 & 4 of his video seminar.
You can also download one of four specific Methylation Protocols which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term. 

You'll find our MTHFR Newbies page is very helpful as well.  It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.

Methylfolate 15 What do doctors have to say about MTHFR and how to treat it?

Go to A Doctor Explains and listen to Dr. Neil Rawlins’ 51-minute seminar on MTHFR and the effects of Methylfolate.

Methylfolate 15 How can I get more information on MTHFR?

check out our Help for MTHFR Newbies page.

Methylfolate 15 Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium the same thing?

Basically, yes. In the chemistry world, L stands for the “Left” isomer, which is the same as the “(6S)” isomer – the terms are synonyms (and this naming convention is used interchangeably by various companies in the industry). In the case of methylfolate, that L or (6S) isomer is the active isomer of 5-MTHF that the body can actually use. To learn more about the different types of methylfolate, its history, potency levels and stability details, and to see how our L-Methylfolate proves to be the purest on the planet, visit our Methylfolate Types page.

Methylfolate 15 How can Methylfolate 15 mg help with MTHFR mutations?

Methylfolate 15 mg can be beneficial for individuals with MTHFR mutations because it provides a form of folate that is already methylated, bypassing the need for the MTHFR enzyme to convert it. This supports methylation processes in the body, which may be impaired in individuals with MTHFR mutations, and helps maintain optimal folate levels necessary for various biochemical reactions. It's important to consult with a healthcare professional for personalized advice on supplementation and managing MTHFR mutation.

Methylfolate 15 How long does it take to experience the benefits of Methylfolate 15 mg?

Individual responses may vary, but some users report noticing improvements in energy levels and overall well-being over just five weeks of starting Methylfolate 15 mg supplementation.

Methylfolate 15 Why should I take methylfolate?

You may consider taking methylfolate if you have certain genetic variations affecting folate metabolism, are pregnant or planning to become pregnant, or have a medical condition that requires high doses of folate supplementation. Methylfolate can support various bodily functions, including DNA synthesis, neurotransmitter production, and cardiovascular health, making it beneficial for individuals with specific needs or seeking optimal folate levels.

Methylfolate 15 Who can benefit from taking Methylfolate 15 mg?

Individuals with MTHFR gene mutations, those requiring high doses of folate, and pregnant women seeking prenatal support may benefit from Methylfolate 15 mg supplementation.

Methylfolate 15 How does Methylfolate 15 mg benefit health?

Methylfolate 15 mg supports DNA synthesis, neurotransmitter production, and cardiovascular health, making it beneficial for individuals with certain genetic variations or those seeking optimal folate levels.

Please Note:

Before purchasing any of our products, Methyl-Life® recommends that you talk with a healthcare professional if you have any questions. Methyl-Life® cannot be held liable for adverse reactions or negative side effects that you think are the result of one of our products.

If you have not used Methyl-Life® products before, please consider ordering one bottle to start before making larger orders. We also recommend you read through our dosage and methylation protocol pages and consider starting with a lower dose product to ensure you tolerate the ingredients well before increasing your strength to a higher dose product.

It is also important to speak with your healthcare professional before purchasing. Methyl-Life® prefers not to accept returns for large orders. If you return three unopened bottles from a 4-pack purchase, you will receive a full refund minus the cost of one bottle charged at full price.

Within 45 days of your order, you can return any unopened item shipped to you by Methyl-Life® (as long as all seals are intact). Just let us know you plan to return the product by emailing us at: or using the Contact Us form (please include the tracking information so we can be on the lookout for the package).

It will be your responsibility and cost to ensure the return parcel gets to Methyl-Life® (ship to: P.O. Box 33606, Seattle, WA 98133). We suggest you get a tracking number and consider insuring the package. After we receive your returned item, we will process your full refund within 10 business days and send you an email indicating your refund has been complete. Be aware that depending upon your institution, this may not be reflected in your account status for a few days.

If you have received the wrong item or your product has been damaged or is somehow defective, please email us at: with detailed information or use the Contact Us form and our Customer Service Manager will address your concern(s) right away. Please do not throw any items away unless or until you are directed to do so.



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