Methylated B12 + L-Methylfolate 3 mg in a sublingual tablet as Methyl-Life's® B-Methylated II product - one of the purest L-Methylfolate brands + Bioactive B12 as Methylcobalamin
Methyl-Life® products contain the most bioactive nutrient form of folate available today, L-Methylfolate (often denoted as L-MTHF, L-5-Methylenetretrahydrofolate, L-5-MTHF, (6S)-5-Methylfolate, etc). This is the ‘already converted’ form of the vitamin that is immediately ready for the body’s cells to use directly. It’s the only form of folate which crosses the blood-brain barrier. Those with MTHFR are also often found to be low in B12 as well as and may have significant problems absorbing it.
Every serving in Methyl-Life’s® B-Methylated II product contains a moderate dose (3 mg) of L-Methylfolate as internationally-patented Magnafolate® PRO as well as 3.75 mg of Active B12 (as Methylcobalamin B12). We specifically deliver this power-packed combination in a tasty, chewable tablet that can sit under the tongue for maximum B12 absorption.
- Methylcobalamin – Helps with methylation, brain & nerve health, circulatory & immune systems, reduces homocysteine, and positively affects anemia.
Our chewable form provides for maximum B12 absorption through the mucous membranes in the mouth. Bite the tablet into pieces and allow those to dissolve under your tongue for a sublingual delivery to maximize your body's use of the nutrient.
Did you know that recent research shows that taking B12 in a sublingual oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots? It's usually much more convenient and affordable as well - https://pubmed.ncbi.nlm.nih.gov/30632091.
In recent studies Magnafolate® PRO showed significantly greater purity, stability and potency results when compared against competing brands Quatrefolic® and Extrafolate®. This is because Magnafolate® is built on a calcium crystalline molecule structure just like the pharmaceutical brand of L-Methylfolate. So if you’re truly looking for professional strength, look no further. Read more about Magnafolate's® superiority.
Methyl-Life® remains proud that we can offer such an exceptional product line at such an affordable price point (because as a family-owned company, we know this is important to you). No other competitor sells a comparable product for less. We go above and beyond with our quality standards by investing in additional 3-year stability studies and third party lab testing to ensure our final products are the very best you can buy.
Spoiler alert ... our 5-year old products tested fully potent, but when tested against ours, the competitors' products did NOT meet the Supplement Facts claims after 5 years on the shelf.
Methyl-Life’s® B-Methylated II was formulated especially for people with genetic (MTHFR, MTR, MTRR) variants, dietary or drug-induced need. It was designed specifically to bypass genetic challenges and optimize the body’s methylation process. This means you may have more energy and motivation, get improved protection against toxins, and just plain feel better.
Moderate doses of L-Methylfolate are designed to support optimal brain and nerve health and may positively affect mood. Studies have shown methylfolate is important for peripheral neuropathy as it repairs the myelin sheath. It is often used to assist with pregnancy and fetal well-being. It can also convert homocysteine into methionine which can support cardiovascular health. L-Methylfolate can boost glutathione levels in the body (and glutathione is a great ally when it comes to detoxification, it’s your body’s strongest antioxidant). Talk to your doctor to determine, if taking moderate doses of L-Methylfolate and Methylcobalamin is right for you.
Dosage
WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to some dosing options.
How to snap the tablet in half – See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.
Dr. Amy Yasko( https://dramyyasko.com) recommends a specific form of B12 based on your genetics if you know the status of your COMT 158 and VDR Taq variants.
| COMT V158M | VDR Taq | B12 Types That Should Be Tolerated |
|---|---|---|
| – – | + + (TT) | All 3 types of B12 |
| – – | + – (Tt) | All 3 types of B12 with less Methylcobalamin |
| – – | – – (tt) | Hydroxy B12 and Adenosylcobalamin |
| + – | + + | All 3 types of B12 with less Methylcobalamin |
| + – | + – | Hydroxy B12 and Adenosylcobalamin |
| + – | – – | Hydroxy B12 and Adenosylcobalamin |
| + + | + + | Hydroxy B12 and Adenosylcobalamin |
| + + | + – | Hydroxy B12 and Adenosylcobalamin |
| + + | – – | Mostly Hydroxy B12 |
Video
SUPPLEMENT FACTS
Bite tablet into pieces, and hold under tongue or between gum and cheek until they dissolve.
Great for teeth, not for animals (contains xylitol).
| SUPPLEMENT FACTS | ||
|
Serving Size: 1 Chewable Tablet
|
||
| 90 servings per container | Amount per Serving | % Daily Value |
| Folate (as L-5-Methyltetrahydrofolate, Calcium [equal to 4,558 mcg Magnafolate® PRO]) | 6,037 DFE mcg | 1,509% |
| Vitamin B12 (as Methylcobalamin) |
3,750 mcg
|
156,250% |
PRODUCT CONTAINS NO: wheat, gluten, soy, dairy, egg, fish/shellfish, yeast, nuts, starch, ingredients of animal origin, caffeine, artificial colorings, preservatives or artificial flavoring, bisphenol-A (BPA), or phthalate.
FAQ'S
What type of folate does Methyl-Life® use in its products?
Methyl-Life® products feature L-Methylfolate, the most bioactive form of folate available today. Also known as L-MTHF, L-5-Methylenetretrahydrofolate, or (6S)-5-Methylfolate, L-Methylfolate is the converted form of the vitamin that the body's cells can immediately utilize. It is the only form of folate capable of crossing the blood-brain barrier.
Why is L-Methylfolate important for individuals with MTHFR mutations?
What does each serving of Methyl-Life’s® B-Methylated II product contain?
What are the benefits of Methylcobalamin found in Methyl-Life’s® B-Methylated II product?
How does the chewable form of our product enhance B12 absorption?
What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?
The most important thing to realize is that blood tests for B12 are highly inaccurate at detecting actual cellular levels of B12 (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used.
What can you do if you have high B12 blood test results? Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).
What does sublingual mean and why isn’t your product labeled as “sublingual”?
My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too?
One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true.
It’s important to realize that the MTHFR status does not necessarily determine the type of B12 that’s best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).
It seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.
The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxy B12, and from there the hydroxy B12 has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.
I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?
If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well-tolerated active form of B12 for folks seems to be hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxy B12 (and this is why our methylation protocol suggests hydroxy B12 as the B12 form, to begin with):
- Folks with multiple COMT mutations tend to do very well with hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)
- Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation
- And Dr. Amy Yasko (https://dramyyasko.com) talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:
| COMT V158M | VDR Taq | B12 Types That Should Be Tolerated |
|---|---|---|
| – – | + + (TT) | All 3 types of B12 |
| – – | + – (Tt) | All 3 types of B12 with less Methylcobalamin |
| – – | – – (tt) | Hydroxy B12 and Adenosylcobalamin |
| + – | + + | All 3 types of B12 with less Methylcobalamin |
| + – | + – | Hydroxy B12 and Adenosylcobalamin |
| + – | – – | Hydroxy B12 and Adenosylcobalamin |
| + + | + + | Hydroxy B12 and Adenosylcobalamin |
| + + | + – | Hydroxy B12 and Adenosylcobalamin |
| + + | – – | Mostly Hydroxy B12 |
Methylated B12 3.75mg + L-Methylfolate 3mg as Methyl-Life®'s B-Methylated-II
Methylated B12 3.75mg + L-Methylfolate 3mg together in a sublingual tablet for max B12 absorption with bioactive Methylcobalamin B12 and 5-mthf.
Pat
I've been taking II Methylated B for several years and am very pleased with it. I had tried other methylated B12 products and none of them come close to comparing to II Methylated B. Plus I don't have to take 2 pills which is nice. Great product and company. Thank You Gratefully, Pat
hidden
Methylated B12 + L-Methylfolate 3 mg in a sublingual tablet as Methyl-Life's® B-Methylated II product - one of the purest L-Methylfolate brands + Bioactive B12 as Methylcobalamin
Methyl-Life® products contain the most bioactive nutrient form of folate available today, L-Methylfolate (often denoted as L-MTHF, L-5-Methylenetretrahydrofolate, L-5-MTHF, (6S)-5-Methylfolate, etc). This is the ‘already converted’ form of the vitamin that is immediately ready for the body’s cells to use directly. It’s the only form of folate which crosses the blood-brain barrier. Those with MTHFR are also often found to be low in B12 as well as and may have significant problems absorbing it.
Every serving in Methyl-Life’s® B-Methylated II product contains a moderate dose (3 mg) of L-Methylfolate as internationally-patented Magnafolate® PRO as well as 3.75 mg of Active B12 (as Methylcobalamin B12). We specifically deliver this power-packed combination in a tasty, chewable tablet that can sit under the tongue for maximum B12 absorption.
- Methylcobalamin – Helps with methylation, brain & nerve health, circulatory & immune systems, reduces homocysteine, and positively affects anemia.
Our chewable form provides for maximum B12 absorption through the mucous membranes in the mouth. Bite the tablet into pieces and allow those to dissolve under your tongue for a sublingual delivery to maximize your body's use of the nutrient.
Did you know that recent research shows that taking B12 in a sublingual oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots? It's usually much more convenient and affordable as well - https://pubmed.ncbi.nlm.nih.gov/30632091.
In recent studies Magnafolate® PRO showed significantly greater purity, stability and potency results when compared against competing brands Quatrefolic® and Extrafolate®. This is because Magnafolate® is built on a calcium crystalline molecule structure just like the pharmaceutical brand of L-Methylfolate. So if you’re truly looking for professional strength, look no further. Read more about Magnafolate's® superiority.
Methyl-Life® remains proud that we can offer such an exceptional product line at such an affordable price point (because as a family-owned company, we know this is important to you). No other competitor sells a comparable product for less. We go above and beyond with our quality standards by investing in additional 3-year stability studies and third party lab testing to ensure our final products are the very best you can buy.
Spoiler alert ... our 5-year old products tested fully potent, but when tested against ours, the competitors' products did NOT meet the Supplement Facts claims after 5 years on the shelf.
Methyl-Life’s® B-Methylated II was formulated especially for people with genetic (MTHFR, MTR, MTRR) variants, dietary or drug-induced need. It was designed specifically to bypass genetic challenges and optimize the body’s methylation process. This means you may have more energy and motivation, get improved protection against toxins, and just plain feel better.
Moderate doses of L-Methylfolate are designed to support optimal brain and nerve health and may positively affect mood. Studies have shown methylfolate is important for peripheral neuropathy as it repairs the myelin sheath. It is often used to assist with pregnancy and fetal well-being. It can also convert homocysteine into methionine which can support cardiovascular health. L-Methylfolate can boost glutathione levels in the body (and glutathione is a great ally when it comes to detoxification, it’s your body’s strongest antioxidant). Talk to your doctor to determine, if taking moderate doses of L-Methylfolate and Methylcobalamin is right for you.
Dosage
WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to some dosing options.
How to snap the tablet in half – See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.
Dr. Amy Yasko( https://dramyyasko.com) recommends a specific form of B12 based on your genetics if you know the status of your COMT 158 and VDR Taq variants.
| COMT V158M | VDR Taq | B12 Types That Should Be Tolerated |
|---|---|---|
| – – | + + (TT) | All 3 types of B12 |
| – – | + – (Tt) | All 3 types of B12 with less Methylcobalamin |
| – – | – – (tt) | Hydroxy B12 and Adenosylcobalamin |
| + – | + + | All 3 types of B12 with less Methylcobalamin |
| + – | + – | Hydroxy B12 and Adenosylcobalamin |
| + – | – – | Hydroxy B12 and Adenosylcobalamin |
| + + | + + | Hydroxy B12 and Adenosylcobalamin |
| + + | + – | Hydroxy B12 and Adenosylcobalamin |
| + + | – – | Mostly Hydroxy B12 |
Video
SUPPLEMENT FACTS
Bite tablet into pieces, and hold under tongue or between gum and cheek until they dissolve.
Great for teeth, not for animals (contains xylitol).
| SUPPLEMENT FACTS | ||
|
Serving Size: 1 Chewable Tablet
|
||
| 90 servings per container | Amount per Serving | % Daily Value |
| Folate (as L-5-Methyltetrahydrofolate, Calcium [equal to 4,558 mcg Magnafolate® PRO]) | 6,037 DFE mcg | 1,509% |
| Vitamin B12 (as Methylcobalamin) |
3,750 mcg
|
156,250% |
PRODUCT CONTAINS NO: wheat, gluten, soy, dairy, egg, fish/shellfish, yeast, nuts, starch, ingredients of animal origin, caffeine, artificial colorings, preservatives or artificial flavoring, bisphenol-A (BPA), or phthalate.
FAQ'S
What type of folate does Methyl-Life® use in its products?
Methyl-Life® products feature L-Methylfolate, the most bioactive form of folate available today. Also known as L-MTHF, L-5-Methylenetretrahydrofolate, or (6S)-5-Methylfolate, L-Methylfolate is the converted form of the vitamin that the body's cells can immediately utilize. It is the only form of folate capable of crossing the blood-brain barrier.
Why is L-Methylfolate important for individuals with MTHFR mutations?
What does each serving of Methyl-Life’s® B-Methylated II product contain?
What are the benefits of Methylcobalamin found in Methyl-Life’s® B-Methylated II product?
How does the chewable form of our product enhance B12 absorption?
What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?
The most important thing to realize is that blood tests for B12 are highly inaccurate at detecting actual cellular levels of B12 (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used.
What can you do if you have high B12 blood test results? Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).
What does sublingual mean and why isn’t your product labeled as “sublingual”?
My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too?
One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true.
It’s important to realize that the MTHFR status does not necessarily determine the type of B12 that’s best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).
It seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.
The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxy B12, and from there the hydroxy B12 has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.
I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?
If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well-tolerated active form of B12 for folks seems to be hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxy B12 (and this is why our methylation protocol suggests hydroxy B12 as the B12 form, to begin with):
- Folks with multiple COMT mutations tend to do very well with hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)
- Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation
- And Dr. Amy Yasko (https://dramyyasko.com) talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:
| COMT V158M | VDR Taq | B12 Types That Should Be Tolerated |
|---|---|---|
| – – | + + (TT) | All 3 types of B12 |
| – – | + – (Tt) | All 3 types of B12 with less Methylcobalamin |
| – – | – – (tt) | Hydroxy B12 and Adenosylcobalamin |
| + – | + + | All 3 types of B12 with less Methylcobalamin |
| + – | + – | Hydroxy B12 and Adenosylcobalamin |
| + – | – – | Hydroxy B12 and Adenosylcobalamin |
| + + | + + | Hydroxy B12 and Adenosylcobalamin |
| + + | + – | Hydroxy B12 and Adenosylcobalamin |
| + + | – – | Mostly Hydroxy B12 |