B-Methylated-II - Methylfolate + Methyl B12

  • Great for MTHFR
  • Best Bioactive form of folate
  • Bioactive Methyl form of B12
Regular price $39.00
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B-Methylated II - the purest L-Methylfolate (Magnafolate® PRO) + Active B12 as Methylcobalamin

 Methyl-Life® products contain the most bioactive nutrient form of folate available today, L-Methylfolate (often denoted as L-MTHF, L-5-Methylenetretrahydrofolate, L-5-MTHF, (6S)-5-Methylfolate, etc). This is the ‘already converted’ form of the vitamin that is immediately ready for the body’s cells to use directly. It’s the only form of folate which crosses the blood-brain barrier. Those with MTHFR are also often found to be low in B12 as well as and may have significant problems absorbing it.

 Every serving in Methyl-Life’s® B-Methylated II product contains a moderate dose (3 mg) of L-Methylfolate as internationally-patented Magnafolate® PRO as well as 3.75 mg of Active B12 (as Methylcobalamin).  We specifically deliver this power-packed combination in a tasty, chewable tablet that can sit under the tongue for maximum B12 absorption.

    • Methylcobalamin – Helps with methylation, brain & nerve health, circulatory & immune systems, reduces homocysteine, and positively affects anemia.

Our chewable form provides for maximum B12 absorption through the mucous membranes in the mouth. Bite the tablet into pieces and allow those to dissolve under your tongue for a sublingual delivery to maximize your body's use of the nutrient.

In recent studies Magnafolate® PRO showed significantly greater purity, stability and potency results when compared against competing brands Quatrefolic® and Extrafolate®. This is because Magnafolate® is built on a calcium crystalline molecule structure just like the pharmaceutical brand of L-Methylfolate.  So if you’re truly looking for professional strength, look no further. Read more about Magnafolate's® superiority.

Methyl-Life® is honored to have been the first company in the USA to offer this uniquely pure and superior form of L-Methylfolate, (Magnafolate®), to our customers for over 5 years now.  And we remain proud that we can offer such an exceptional product line at such an affordable price point (because as a family-owned company, we know this is important to you).  No other competitor sells a comparable product for less.  We go above and beyond with our quality standards by investing in additional 3-year stability studies and third party lab testing to ensure our final products are the very best you can buy.

Spoiler alert ... our 5-year old products tested fully potent, but when tested against ours, the competitors' products did NOT meet the Supplement Facts claims after 5 years on the shelf. 

Methyl-Life’s® B-Methylated II was formulated especially for people with genetic (MTHFR, MTR, MTRR) variants, dietary or drug-induced need. It was designed specifically to bypass genetic challenges and optimize the body’s methylation process. This means you may have more energy and motivation, get improved protection against toxins, and just plain feel better. 

Moderate doses of L-Methylfolate are designed to support optimal brain and nerve health and may positively affect mood. Studies have shown methylfolate is important for peripheral neuropathy as it repairs the myelin sheath. It is often used to assist with pregnancy and fetal well-being. It can also convert homocysteine into methionine which can support cardiovascular health. L-Methylfolate can boost glutathione levels in the body (and glutathione is a great ally when it comes to detoxification, it’s your body’s strongest antioxidant).  Talk to your doctor to determine, if taking moderate doses of L-Methylfolate and Methylcobalamin is right for you. 

WARNING  How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to some dosing options.

How to snap the tablet in half  See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more. 

Dr. Amy Yasko( recommends a specific form of B12 based on your genetics if you know the status of your COMT 158 and VDR Taq variants.

COMT V158M VDR Taq B12 Types That Should Be Tolerated
– – + + (TT) All 3 types of B12
– – + – (Tt) All 3 types of B12 with less Methylcobalamin
– – – – (tt) Hydroxocobalamin and Adenosylcobalamin
+ – + + All 3 types of B12 with less Methylcobalamin
+ – + – Hydroxocobalamin and Adenosylcobalamin
+ – – – Hydroxocobalamin and Adenosylcobalamin
+ + + + Hydroxocobalamin and Adenosylcobalamin
+ + + – Hydroxocobalamin and Adenosylcobalamin
+ + – – Mostly Hydroxocobalamin

SUGGESTED USE: Ask your doctor. Visit

Bite tablet into pieces, and hold under tongue or between gum and cheek until they dissolve.

Great for teeth, not for animals (contains xylitol).

Serving Size: 1 Chewable Tablet
90 servings per container Amount per Serving % Daily Value
Folate (as L-5-Methyltetrahydrofolate, Calcium [equal to 4,558 mcg Magnafolate® PRO]) 6,037 DFE mcg 1,509%
Vitamin B12 (as Methylcobalamin) 3,750 mcg 156,250%

OTHER INGREDIENTS: xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavor (dextrose, silicon dioxide, natural flavor, propylene glycol).
Not a significant source of total sugars.

PRODUCT CONTAINS NO: wheat, gluten, soy, dairy, egg, fish/shellfish, yeast, nuts, starch, ingredients of animal origin, caffeine, artificial colorings, preservatives or artificial flavoring, bisphenol-A (BPA), or phthalate.

Methylfolate 15 What type of folate does Methyl-Life® use in its products?

Methyl-Life® products feature L-Methylfolate, the most bioactive form of folate available today. Also known as L-MTHF, L-5-Methylenetretrahydrofolate, or (6S)-5-Methylfolate, L-Methylfolate is the converted form of the vitamin that the body's cells can immediately utilize. It is the only form of folate capable of crossing the blood-brain barrier.

Methylfolate 15 Why is L-Methylfolate important for individuals with MTHFR mutations?

Individuals with MTHFR mutations often have difficulty converting synthetic folic acid into its active form, L-Methylfolate. Therefore, using L-Methylfolate directly bypasses this conversion step, ensuring optimal folate levels in the body. Additionally, those with MTHFR mutations may also experience challenges in absorbing vitamin B12, making it crucial to address both nutrient deficiencies simultaneously.

Methylfolate 15 What does each serving of Methyl-Life’s® B-Methylated II product contain?

Each serving of Methyl-Life’s® B-Methylated II product contains a moderate dose of 3 mg of L-Methylfolate, provided as internationally-patented Magnafolate® PRO, along with 3.75 mg of Active B12 in the form of Methylcobalamin. This power-packed combination is delivered in a tasty, chewable tablet designed to sit under the tongue for maximum B12 absorption.

Methylfolate 15 What are the benefits of Methylcobalamin found in Methyl-Life’s® B-Methylated II product?

Methylcobalamin offers a range of benefits, including support for methylation, brain and nerve health, circulatory and immune systems. It also helps reduce homocysteine levels and can positively affect individuals with anemia. By including Methylcobalamin in B-Methylated II, Methyl-Life® provides a comprehensive solution for addressing various health concerns.

Methylfolate 15 How does the chewable form of our product enhance B12 absorption?

Our chewable form allows for maximum B12 absorption through the mucous membranes in the mouth. By biting the tablet into pieces and allowing them to dissolve under your tongue, you facilitate sublingual delivery, maximizing your body's utilization of this essential nutrient.

Vitamin B 12 (as Hydroxocobalamin) What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?

The most important thing to realize is that blood tests for B12 are highly inaccurate at detecting actual cellular levels of B12 (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used.

Vitamin B 12 (as Hydroxocobalamin) What can you do if you have high B12 blood test results? Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).

Vitamin B 12 (as Hydroxocobalamin) What does sublingual mean and why isn’t your product labeled as “sublingual”?

It’s a well-known fact that B12 does not absorb well through the gut, so taking B12 via sublingual or mouth absorption is best (holding it under the tongue or between the gums and cheek is most common). Consider some form of liquid or tablet/lozenge that can be sucked on or dissolved in the mouth. Holding the B12 in your mouth for at least 90 seconds is good and the longer you can leave it in your mouth, the better for sublingual absorption (as opposed to gut absorption).
Note: different manufacturers use different terms for tablets that are meant to dissolve sublingually in the mouth, but “sublingual” is considered a pharmaceutical term by the FDA, so dietary supplements are moving away from using that term. However, it doesn’t really matter what term you use (chewable tablet, lozenge, sublingual tablet, liquid, etc.) for maximum absorption the main idea is to hold it in your mouth for 90 seconds or more if you can (if you forget, don’t worry, since you’re taking the active form, your body will still get some benefit even if you swallow it whole). Another way to absorb B12 is muscularly through shots, however, the research tells us that sublingual (or mouth) absorption is equally as effective as muscular absorption … and shots may cost significantly more money. Also, be aware with shots (many doctors still give cyanocobalamin shots) that though you may need higher doses of active B12s (like myself), you may not do well when given higher doses of cyanocobalamin in a shot because your body may not be able to do the conversions and you could have negative side effects.

Vitamin B 12 (as Hydroxocobalamin) My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too?

One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxocobalamin, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true.

It’s important to realize that the MTHFR status does not necessarily determine the type of B12 that’s best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).

It seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.

The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxocobalamin, and from there the hydroxocobalamin has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.

Vitamin B 12 (as Hydroxocobalamin) I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?

If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well-tolerated active form of B12 for folks seems to be hydroxocobalamin. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxocobalamin (and this is why our methylation protocol suggests hydroxocobalamin as the B12 form, to begin with):

    • Folks with multiple COMT mutations tend to do very well with hydroxocobalamin (it helps mop up excess peroxynitrites which can cause problems)
    • Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation
    • And Dr. Amy Yasko ( talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:
COMT V158M VDR Taq B12 Types That Should Be Tolerated
– – + + (TT) All 3 types of B12
– – + – (Tt) All 3 types of B12 with less Methylcobalamin
– – – – (tt) Hydroxocobalamin and Adenosylcobalamin
+ – + + All 3 types of B12 with less Methylcobalamin
+ – + – Hydroxocobalamin and Adenosylcobalamin
+ – – – Hydroxocobalamin and Adenosylcobalamin
+ + + + Hydroxocobalamin and Adenosylcobalamin
+ + + – Hydroxocobalamin and Adenosylcobalamin
+ + – – Mostly Hydroxocobalamin

Please Note

Before making a purchase of any of our products, Methyl-Life® recommends consulting with a healthcare professional - especially if you have any questions. Methyl-Life® cannot assume responsibility for adverse reactions or perceived negative side effects resulting from the use of our products.

For customers who have not used Methyl-Life® products before, we recommend starting with a single bottle before considering larger orders. Additionally, we encourage you to review our dosage and methylation protocol pages and consider beginning with a lower dose product to ensure a smooth integration with the ingredients before progressing to higher dose options.

Methyl-Life® generally does not accept returns for large orders. If you choose to return three unopened bottles from a 4-pack purchase, you will receive a full refund, excluding the cost of one bottle charged at full price.


Within 45 days of your order within the United States, you can return any unopened item shipped to you by Methyl-Life® as long as all seals are intact. To initiate a return, please email us using the Contact Us form, providing your order details and tracking information for the return product shipment sent to:  P.O. Box 33606, Seattle, WA 98133. Please note that return shipping costs are the responsibility of the customer, and we recommend considering insurance for the return package. Refunds will be processed within 10 business days of receiving the returned item, and you will receive an email confirmation once the refund is complete. Please be aware that depending on your financial institution, it may take up to 10 days for the refund to appear in your account.


If you have received the wrong item, or if your product has been damaged or is defective, please email us with detailed information using the Contact us form, and our Customer Service Manager will address your concern promptly. Do not discard any items unless directed to do so.



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