Therapeutic mood-supporting dose of bioactive L Methylfolate 7.5 mg uniquely formulated with the internationally-patented Magnafolate® PRO and bioactive vitamin B12 forms (hydroxy B12 and adenosylcobalamin) to naturally support healthy mood, cognitive function, methylation and homocysteine support.
L methylfolate is the predominant form of folate circulating in the body and used for biological processes1.
Studies show *15mg methylfolate + SSRI to be the most effective dose for improving depressive symptoms2.
L Methylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier3.
- Support for brain function4
- Supports cardiovascular health5
- Support for healthy immune function6
- Supports nerve function7 and healthy myelin formation22
- Nervous system maintenance21
- Support for preconception, pregnancy, and fetal health8
- Involved in reducing20 and maintaining healthy homocysteine levels9
- Essential nutrient required for optimal DNA methylation19 and neurotransmitter synthesis10
- Adjunctive support for serotonin selective reuptake inhibitors23
- Suitable for people with MTHFR mutations11
Key ingredients:
- Folate - 7,500 mcg (as L-5-Methyltetrahydrofolate, Calcium - Magnafolate® PRO)
- Hydroxy B12 (Vitamin B12) - 1,500 mcg
- Adenosylcobalamin (Vitamin B12) - 1,000 mcg
L Methylfolate 7.5mg is a highly bioactive form of folate made with the purest L-methylfolate available12.
- Maximum absorption and bioavailability
- No prescription required
- Available in 2.5mg, 3mg+B12, 5mg, 7.5mg+B12, 10mg, 15mg, 15mg+B12
- Rigorously tested for consistency, purity, safety, and potency
Why take L Methylfolate 7.5 mg for Mood Support?
Synthesis of mood-enhancing neurotransmitters (serotonin, dopamine, and norepinephrine) is regulated by L methylfolate, a derivative of folate10. L Methylfolate 7.5 mg has demonstrated efficacy as an adjunctive treatment for individuals who have not responded optimally to antidepressant therapy2.
Supplementing with 15mg L methylfolate alongside SSRIs may be effective in improving symptoms of depression25. L Methylfolate is absorbed more efficiently than synthetic folic acid which must be converted to active folate by the enzyme methylenetetrahydrofolate reductase (MTHFR)13.
Hydroxy B12 and adenosylcobalamin are two naturally-occurring forms of B12 shown in clinical studies to improve vitamin B12 status. They are bioidentical to the form of B12 found in the human body and vastly superior to cyanocobalamin, a synthetic form of B12 that occurs only in trace amounts in the body26.
Adenosylcobalamin is a cofactor for mitochondrial methylmalonyl-CoA mutase, which is required for the breakdown of several ketogenic amino acids and fatty acids24. It is also a cofactor in enzymatic reactions required for the synthesis of DNA, myelin, and fatty acids, which are vital for cell division and growth27.
Active B12 works closely alongside folate in converting homocysteine to methionine, which is necessary for nerve and brain health. B12’s complex metabolic pathway means that the only way to ensure proper uptake is by taking the most bioactive form of the vitamin28.
Individuals with particular mutations [single nucleotide polymorphisms (SNPs)] affecting B12 assimilation may raise their B12 status more efficiently with one or more of the specific bioavailable forms of vitamin B1226, hydroxy B12, methylcobalamin, or adenosylcobalamin.
Folate and B12 work together to produce S-adenosylmethionine (SAMe), a compound involved in immune function and mood. Studies show that bioactive B12 plays an important role in the treatment of mood disorders, particularly when combined with SSRIs29.
Who is affected by MTHFR mutations?
The MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants). Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%). Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A>C polymorphism in Hispanics and Africans is 15%14.
An increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness15. MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses16.
For these people, L methylfolate supplementation is shown to be the most effective way to provide this form of folate10.
Methyl-Life’s® L Methylfolate is an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.
Why Magnafolate® PRO?
Methyl-Life’s® L Methylfolate 7.5mg+ Support Mood is made with the internationally-patented Magnafolate® PRO, clinically tested as one of the purest methylfolate brands (Magnafolate® PRO is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic® and Extrafolate®).
Magnafolate® is made with a form of L methylfolate called L-5-MTHF-Ca, which is shown to be the most active form of folate in the plasma circulation. When compared with ordinary folate, L methylfolate was found to be absorbed faster and utilized more quickly in the body17.
A recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation18.
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1 https://pubmed.ncbi.nlm.nih.gov/20608755/
2https://pubmed.ncbi.nlm.nih.gov/23212058/
3https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687916/
4https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779227/
5https://www.ahajournals.org/doi/10.1161/hq0102.102190
6https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019735/
7https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867258/
8https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127769/
9https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832224/
10https://pubmed.ncbi.nlm.nih.gov/19193337/
11https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564482/
12https://cdn.shopify.com/s/files/1/0264/6369/9018/files/Methyl-Life_60-day_Methylfolate_Comparison.pdf?v=1595292111
13https://www.ncbi.nlm.nih.gov/books/NBK6561/
14https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630484
15https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530664/
16https://www.ahajournals.org/doi/10.1161/01.CIR.0000165142.37711.E7
17https://pubmed.ncbi.nlm.nih.gov/24032278/
18https://i.trade-cloud.com.cn/upload/6405/file/20210929/english-version-magnafolate-enhancing-immunity_524485.pdf
19https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262611/
20https://www.ahajournals.org/doi/full/10.1161/01.atv.18.3.356
21https://www.ncbi.nlm.nih.gov/books/NBK557632/#
22https://pubmed.ncbi.nlm.nih.gov/15896807/
23https://www.sciencedirect.com/science/article/abs/pii/S0924977X97004094?via%3Dihub
24https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230602/
25https://www.tandfonline.com/doi/full/10.1080/24750573.2018.1552401
26https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312744/
27https://www.ncbi.nlm.nih.gov/books/NBK559132/
28https://pubmed.ncbi.nlm.nih.gov/30693532/
29https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856388/
Dosage
WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to some dosing options.
How to snap the tablet in half – See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.
Dr. Amy Yasko (https://dramyyasko.com) recommends a specific form of B12 based on your genetics if you know the status of your COMT 158 and VDR Taq variants
| COMT V158M | VDR Taq | B12 Types That Should Be Tolerated |
|---|---|---|
| – – | + + (TT) | All 3 types of B12 |
| – – | + – (Tt) | All 3 types of B12 with less Methylcobalamin |
| – – | – – (tt) | Hydroxy B12 and Adenosylcobalamin |
| + – | + + | All 3 types of B12 with less Methylcobalamin |
| + – | + – | Hydroxy B12 and Adenosylcobalamin |
| + – | – – | Hydroxy B12 and Adenosylcobalamin |
| + + | + + | Hydroxy B12 and Adenosylcobalamin |
| + + | + – | Hydroxy B12 and Adenosylcobalamin |
| + + | – – | Mostly Hydroxy B12 |
Video
SUPPLEMENT FACTS
Bite tablet into pieces, and hold under tongue or between gum and cheek until they dissolve.
Great for teeth, not for animals (contains xylitol).
| SUPPLEMENT FACTS | ||
|
Serving Size: 1 Chewable Tablet
|
||
| 90 servings per container | Amount per Serving | % Daily Value |
| Folate | 14,567 mcg DFE | 3,642% (Total) |
| (as L-5-Methyltetrahydrofolate, Calcium [equal to 11,000 mcg Magnafolate® PRO)]) |
|
|
| Vitamin B12 | 2,500 mcg | 104,167% (Total) |
| (60% as Hydroxy B12) | 1,500 mcg | |
| (40% as Adenosylcobalamin) | 1,000 mcg |
PRODUCT CONTAINS NO: wheat, gluten, soy, dairy, egg, fish/shellfish, yeast, nuts, starch, ingredients of animal origin, caffeine, artificial colorings, preservatives or artificial flavoring, bisphenol-A (BPA), or phthalate.
Research
FAQ'S
What is L Methylfolate 7.5 mg + Vitamin B12 Tablets?
L Methylfolate 7.5 mg + Vitamin B12 Tablets is a therapeutic supplement formulated to support healthy mood, cognitive function, methylation, and homocysteine levels. It contains bioactive L methylfolate as internationally-patented Magnafolate® PRO, and sublingual vitamin B12 tablet forms (hydroxy B12 and adenosylcobalamin).
What are the key benefits of L Methylfolate 7.5 mg + Vitamin B12 Tablets?
How common is the MTHFR mutation?
Why is L-methylfolate important?
How is L Methylfolate 7.5 mg + Vitamin B12 Tablets different from other folate supplements?
What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?
The most important thing to realize is that blood tests for B12 are highly inaccurate at detecting actual cellular levels of B12 (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used.
How is the quality of L Methylfolate 7.5 mg + Vitamin B12 Tablets ensured?
Every single supplement batch undergoes rigorous 3rd-party testing for consistency, purity, safety, and potency to ensure maximum quality and efficacy.
What does sublingual mean and why isn’t your product labeled as “sublingual”?
My doctor said that because I have MTHFR, I should be taking methylcobalamin as my vitamin B12 form, why are you suggesting these other forms too?
One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true.
It’s important to realize that the MTHFR status does not necessarily determine the type of vitamin B12 tablets that are best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).
It seems there may be a general lack of education available to most doctors about the different forms of vitamin B12 tablets and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to your vitamin B12 tablets to see which you may tolerate best.
The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxy B12, and from there the hydroxy B12 has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.
I have my 23andme test results, how can I use those to know which form of vitamin B12 tablets I might best tolerate?
If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxy B12 (and this is why our methylation protocol suggests hydroxy B12 as the B12 form to begin with):
- Folks with multiple COMT mutations tend to do very well with hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)
- Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation
- And Dr. Amy Yasko (https://dramyyasko.com) talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:
| COMT V158M | VDR Taq | B12 Types That Should Be Tolerated |
|---|---|---|
| – – | + + (TT) | All 3 types of B12 |
| – – | + – (Tt) | All 3 types of B12 with less Methylcobalamin |
| – – | – – (tt) | Hydroxy B12 and Adenosylcobalamin |
| + – | + + | All 3 types of B12 with less Methylcobalamin |
| + – | + – | Hydroxy B12 and Adenosylcobalamin |
| + – | – – | Hydroxy B12 and Adenosylcobalamin |
| + + | + + | Hydroxy B12 and Adenosylcobalamin |
| + + | + – | Hydroxy B12 and Adenosylcobalamin |
| + + | – – | Mostly Hydroxy B12 |
