L Methylfolate 15 mg - A Mood-Boosting Supplement

*DFE = Dietary Folate Equivalents. 25,500 mcg DFE (15 mg L-Methylfolate from 21 mg of Cerebrofolate™

Other Ingredients

Xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavoring. Not a significant source of sugars.

Allergen & Safety Information

• Does not contain: wheat, gluten, soy, dairy, tree nuts, animal products, or GMOs
• No artificial ingredients or colorings
• Sweetened with xylitol — do not give to pets

Suggested Use

Take 1 chewable tablet daily, or as directed by your healthcare practitioner.
May be chewed, dissolved in the mouth or swallowed.

How much should you take?

Every individual’s needs are different. Always consult your healthcare provider to determine the right dose for your specific needs.

Doctor-guided support

Visit our Dosage Information and Methylation Protocol pages to learn what some practitioners recommend, including step-by-step guidance for individuals with MTHFR gene variants.

Splitting tablets

Each chewable tablet is scored and can be split in half without a pill cutter. For best results, place your thumbs along the scored line with the tablet facing away from you, and press outward to snap. Watch the full demonstration in our tablet-splitting video.

Additional considerations

This supplement is designed to be taken daily or as recommended by your healthcare practitioner. Some individuals start with lower doses and increase gradually, based on tolerance and need.

High dose L methylfolate 15 mg for healthy methylation, homocysteine and natural mood support. 

Bioactive folate uniquely formulated with the new & improved, internationally-branded nutrient Cerebrofolate™¹.

L-methylfolate is the predominant form of folate circulating in the body and used for biological processes¹.

Studies show *15mg methylfolate + SSRI to be the most effective dose for improving depressive symptoms².

L Methylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier³.

• Support for brain function⁴
• Supports cardiovascular health⁵
• Support for healthy immune function⁶
• Supports nerve function⁷
• Support for preconception, pregnancy, and fetal health⁸
• Involved in maintaining healthy homocysteine levels⁹
• Essential nutrient required for healthy DNA and neurotransmitter synthesis¹⁰
• Suitable for people with MTHFR mutations¹¹

A 2024 animal study found that high-dose methylfolate may protect against neurodevelopmental behaviours resulting from exposure to pyrethroid, a type of pesticide. Pyrethroid exposure disrupts folate metabolism in the brain and may contribute to behavioral disorders such as autism.

Methylfolate is the biologically active form of folate and can bypass disruptions to the breakdown of folate in the body, whether caused by MTHFR or by DPE exposure. In this study, high-dose supplementation with methylfolate dramatically reduced the behavioural disorders caused by folate issues, preventing deficits in the social, communication, cognitive, and locomotor areas of the brain that are linked to autism.²¹

Product details

Key ingredient:  Folate 25,500 mcg DFE (15 mg L-Methylfolate from 21 mg of Cerebrofolate™)

L Methylfolate 15 mg is a highly bioactive form of folate made with the purest & most potent methylfolate available¹². 

• Maximum absorption and bioavailability
• No prescription required 
• Available in 2.5mg, 3mg+B12, 5mg, 7.5mg+B12, 10mg, 15mg, 15mg+B12 
• Rigorously tested for consistency, purity, safety, and potency

Why take L Methylfolate?

Folate is required for numerous critical functions of the brain and nervous system. It is essential for DNA/RNA synthesis, maintaining healthy homocysteine levels, and for proper fetal development during pregnancy. 

Folic acid is a synthetic form of folate. It can only be used by the body after it has been converted to active folate by an enzyme called methylenetetrahydrofolate reductase (MTHFR)¹³.

Who is affected by MTHFR mutations?

The MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants). 

Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%).  Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A>C polymorphism in Hispanics and Africans is 15%¹⁴.  And these are just 2 of the well-documented polymorphisms out of over 70 MTHFR possible SNPs (single nucleotide polymorphisms) in the body.

An increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness¹⁵.  MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses¹⁶.

For these people, L-methylfolate supplementation is shown to be the most effective way to provide this form of folate¹⁰. 

Methyl-Life’s® L Methylfolate 15 mg is an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.

Why CEREBROFOLATE™?

Methyl-Life’s® L Methylfolate 15 mg is made with the new & improved, internationally-branded nutrient Cerebrofolate™, clinically tested as the world’s purest & most potent methylfolate (Cerebrofolate™ is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic®, Extrafolate®, Metafolin® & Magnafolate®²⁰).

Cerebrofolate™ is made with a form of methylfolate called L-5-MTHF-Ca, which is shown to be the most active form of folate in the plasma circulation. When compared with ordinary folate, L Methylfolate was found to be absorbed faster and utilized more quickly in the body¹⁷.

A recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation¹⁸. 

Not only that, it has improved production processing methods which have increased its purity and potency to exceed the USP standards.  So if you’re truly looking for professional strength, look no further, Cerebrofolate™ is the biochemically identical version of L-methylfolate that has been used in significant clinical studies to demonstrate mood elevation.  Read more about Cerebrofolate's™ superiority¹⁹.