Your Recommendation:

Your suggested daily methylfolate target might be around 7.5-15 mg of L-Methylfolate (we base this on the prescription product, Deplin, prescribed specifically for depression. Deplin has clinical data demonstrating its effectiveness in improving depression).

Deplin contains a 7.5 mg or 15 mg therapeutic dose of L-Methylfolate - Dr. Rawlins’ generally recommends his depressed patients take 15 mg for up to 4 months before deciding it is not helping the depression (some folks respond quickly – within weeks and others may take a full 4 months before they respond favorably to the higher therapeutic methylfolate dose). 

Download and follow our FREE step-by-step Central Nervous System Methylation Protocol which lists specific products and dosages. Start where you feel comfortable with your initial dose and increase slowly (as/if you tolerate it) until you get to your mg goal or the amount you best tolerate. Not everyone can tolerate these higher level therapeutic doses of methylfolate. You may only be able to take 1/2 of the suggested dosage level, but that may be just right for you personally. Listen to your body as you adjust dosing! 

CAVEAT: It’s very important that you do not take methylfolate without also taking an active form of B12 with it, otherwise you could mask a B12 deficiency issue and incur other complications. Methyl-Life™ has many product combinations which cover both of these key nutrients (and you'll find them on your FREE Methylation Protocol sheet).

Click to determine what form of B12 is best for you personally to take.

POTENTIAL SIDE EFFECTS:  Lastly, please review our dosage page/video for more information on dosing with methylfolate and its potential side effects.