Cerebrofolate™ is a calcium salt form of (65)-5-methyltetrahydrofolate (or L-5-MTHF). L-5-MTHF is the predominant micronutrient form of folate that circulates in plasma and is involved in biological processes.
Cerebrofolate™ is readily metabolized by Ca2+ and L-5-MTHF ions for absorption by intestinal cells.(1) It is then transferred to the liver, where it is either stored or released back into circulation for distribution to other tissues.
Cerebrofolate™ is metabolically active. It requires no further conversion in the body. Unlike folic acid, Cerebrofolate™ bypasses folate metabolism and is immediately available for numerous biological processes.
An estimated 40% of the world’s population are unable to metabolize folic acid due to a mutation on the MTHFR gene. This gene instructs the body to create the MTHFR enzyme, which is required to metabolize folic acid.
Ingesting >200 mcg folic acid from supplements and/or fortified foods can lead to a buildup of unmetabolized folic acid (UMFA) in the body. UMFA has been associated with numerous health concerns, including masking a B12 deficiency, impaired immune function, and an increased risk of cancer. (2)
L-5-MTHF calcium supplements are available in two forms:
Unstable amorphous type
(key for maintaining stability and ensuring potency over time)