The Gold Standard in L-Methylfolate Therapy
A research-backed, medical-grade form of L-methylfolate designed to:
Folate deficiency affects millions worldwide, often going undiagnosed
Unmetabolized folic acid can accumulate in blood, potentially masking B12 deficiency
MTHFR mutations reduce conversion efficiency by 30–70%, limiting bioavailability
Synthetic folic acid doesn’t directly address cellular folate needs
Understanding the MTHFR gene problem and why active folate is essential
~12% of population (homozygous)
65–70% enzyme reduction
~7% of population (homozygous)
20–30% enzyme reduction
Heterozygous (1 copy)
25–30% enzyme reduction
Homozygous (2 copies)
65–70% enzyme reduction
Compound Heterozygous
40–50% enzyme reduction
Cerebrofolate® is a clinically advanced form of L-methylfolate designed for superior absorption and bioavailability.
It is a crystalline Type I calcium salt form of L-5-MTHF, identical to the bioactive form of folate used by the body.
L-methylfolate is the only form of folate capable of crossing the blood-brain barrier. Once inside the brain, it participates in key biological processes such as:
Neurotransmitter synthesis
(serotonin, dopamine, epinephrine & norepinephrine)
Folate deficiency and poor methylation are correlated with mood imbalances and poor response to standard mental health therapy. For individuals with MTHFR polymorphisms, active L-methylfolate supplementation is essential to:
Promote balanced methylation in the brain
Support mood regulation through optimized neurotransmitter activity
Homocysteine is a byproduct of amino acid metabolism, and elevated levels are a known risk factor for cardiovascular issues. L-methylfolate plays a key role in converting homocysteine into methionine through the methylation cycle.
Homocysteine Regulation
Supports healthy homocysteine levels through efficient methylation
Endothelial Function
Supports healthy blood vessel function and circulation
Cardiovascular Protection
May help reduce cardiovascular risk factors
Neural tube development begins in the early stages of pregnancy—often before many women are aware they are expecting. The use of L-methylfolate rather than folic acid provides:
Faster, more efficient folate delivery
Avoidance of unmetabolized folic acid (UMFA) buildup
Improved maternal folate biomarkers
Why methylfolate formulation matters – 90-day post-market surveillance study results
While several forms of L-methylfolate are available, they vary drastically in their:
To identify the most effective form, a 90-day post-market surveillance study (Cyntax Health Projects) compared four leading L-methylfolate formulations:
Conditions: open-air, 25°C, 65% RH. Assessed: total impurities, water content, free folate %, stability (color).
| Metric / Attribute | USP 2040 Standard | Cerebrofolate® | Metafolin® | Quatrefolic® | Generic Amorphous |
|---|---|---|---|---|---|
| Free Folate (%) | — | 78.5% | 76.8% | 42.1% | 43.8% |
| Total Impurities (%) | ≤ 2.5% | 1.5% | 2.6% | 13.6% | 25.3% |
| Stability (Before/After) | — |
|
|
|
|
| Structural Type | — | Crystalline Calcium Salt, Type I | Crystalline Calcium Salt, Type I | Amorphous | Amorphous |
Cerebrofolate® and Metafolin® both maintained high potency and stability, with only minor changes over 90 days.
Quatrefolic® and the generic amorphous form exceeded the USP NF2022 impurity limit (≤2.5%), showing significant degradation in structure, potency, and color stability within 30–60 days.
Cerebrofolate® had the highest free-folate content and the lowest impurity load — the only formula to meet/exceed USP standards across all areas at day 90.
The crystalline calcium salt structure of Cerebrofolate®, plus ultra-pure manufacturing, delivers a significant clinical advantage: durable integrity and the highest active folate yield for therapeutic use.
Higher is better – shows bioavailable folate content
Lower is better – USP standard is ≤2.5%
Independent 90-day post-market surveillance study showing consistent performance
“Cerebrofolate® retained well over 78% active folate after 90 days — with the lowest total impurity load of any tested brand.”
Purity, Safety & Manufacturing Integrity
Manufactured under the highest pharmaceutical-grade conditions to ensure quality, safety, and consistency.
Zero-compromise approach with every single batch tested for complete quality assurance.
Crystalline calcium salt structure proven superior to amorphous forms in stability and bioavailability.
Products & Clinical Dosing for Your Health Goals
Individuals seeking advanced methylation and brain health support—especially those with MTHFR variants or looking to promote healthy neurotransmitter function and emotional well-being.
Women seeking UMFA-free prenatal folate, especially those with MTHFR mutations.
Anyone with elevated homocysteine levels or family history of heart disease.
Individuals new to methylation support, those with mild MTHFR polymorphisms, or anyone seeking a gentle, well-rounded foundation for methylation, energy, and detox support.
Why It Works:L-methylfolate bypasses the reduced enzyme activity caused by MTHFR variants, supporting methylation needed for producing mental health regulating neurotransmitters like serotonin and dopamine. It also aids melatonin synthesis, which controls sleep cycles. Combined with hydroxy B12 and magnesium, it enhances nervous system health and detoxification. This targeted support helps improve sleep quality, especially in individuals with MTHFR polymorphisms or those new to methylation supplementation.
Ideal for those experiencing mood imbalances, light sleep, or insomnia—especially individuals with MTHFR variants (C677T and/or A1298C) who may be sensitive to higher dosing. This bundle supports neurotransmitter balance and restorative sleep without overstimulation.
Why It Works:Recent clinical studies have shown that 5 mg of L-Methylfolate may significantly improve sleep patterns in individuals with MTHFR gene variants. In one 2024 study, participants experienced better sleep quality within just two weeks, with full improvements by eight weeks. Additional research supports L-Methylfolate’s role in managing sleep duration, latency, and insomnia symptoms in this population.
Those experiencing brain fog, age-related memory decline, low mental stamina, or neurotransmitter imbalances often seen in MTHFR-related cognitive issues.
Experience the power of Cerebrofolate®. Shop clinically formulated products featuring this breakthrough ingredient—only from Methyl-Life®.
