What is Cerebrofolate™?

Cerebrofolate™ is a calcium salt form of (65)-5-methyltetrahydrofolate (or L-5-MTHF). L-5-MTHF is the predominant micronutrient form of folate that circulates in plasma and is involved in biological processes.

Cerebrofolate™ is readily metabolized by Ca2+ and L-5-MTHF ions for absorption by intestinal cells.(1) It is then transferred to the liver, where it is either stored or released back into circulation for distribution to other tissues.

Benefits of Cerebrofolate™

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May Reduce Neural Tube Defects

Supplemental methylfolate is recommended over folic acid during pregnancy due to its superior absorption and reduced risk of UMFA. Methylfolate can effectively improve folate biomarkers during pregnancy to prevent Neural Tube Defects.(3)
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Supports Healthy Mood

Low levels of active folate are associated with treatment-resistant depression(TRD). Clinical studies indicate that L-5-MTHF Calcium 15mg can enhance antidepressant response in those with TRD as well as supporting healthy mood.(4)
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Supports Brain Health

L-5-MTHF is the only folate form that can cross the blood brain barrier to support brain health naturally. L-methylfolate is essential in the brain for making neurotransmitters and DNA.
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Supports Cardiovascular Health

Homocysteine is an amino acid that can severely impact cardiovascular health. Elevated homocysteine occurs when the body is unable to convert homocysteine to methionine. This is triggered by genetic mutations or insufficient body stores of active vitamins B6, B12, and folate, causing vasoconstriction in the central nervous system(5). Chronically elevated homocysteine is associated with numerous major medical conditions, including heart disease, stroke, Parkinson’s disease, and Alzheimer’s disease.(6)

Cerebrofolate™ is a stabilized crystalline molecule type form of L-5-MTHF Calcium. It will retain its stability for up to 2 years when stored at room temperature.

Compare Cerebrofolate™
to Other L-5-MTFH Calcium Methylfolates

L-5-MTHF calcium supplements are available in two forms:


Unstable amorphous type


Stabilized crystalline type
(key for maintaining stability and ensuring potency over time)

Cerebrofolate™ quality control is superior
to other L-5-MTHF calcium supplements in several ways.


Minimal solvents

Many brands use acetone or isopropyl alcohol during their manufacturing process, which can affect the purity of the finished product. Only ethanol is used during production to ensure that Cerebrofolate™ is as pure as possible.

No risk of contamination

Cerebrofolate™ is manufactured in its own production line to eliminate the risk of cross-contamination.


Most competitors test only one out of every five batches. EVERY SINGLE BATCH of Cerebrofolate™ gets tested. Our comprehensive testing for heavy metals and impurities (such as platinum, arsenic, cadmium, lead and mercury) ensures the purity and stability of our product. Regular test results show “Not Detected” for the heavy metals and inactive isomer type impurities (D-5-Methylfolate, Ca) batch over batch.

Interested in Learning More About Cerebrofolate™

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