MTHFR Starter Bundle - Foundational 4 Product Pack

MTHFR Supplements: L-Methylfolate, Vitamin B12 Supplement, Multivitamin & Magnesium

Name: MTHFR Supplements: L-Methylfolate, Vitamin B12 Supplement, Multivitamin & Magnesium
Brand: Methyl-Life® Supplements
SKU: startpk-r1001
Price: 125 USD
Availability: InStock
Rating: 4.6 (12 reviews)

$125.00

MTHFR Supplements are ideal for newbies tackling MTHFR challenges. 4 unique products include: L-Methylfolate, Vitamin B12 Supplement, Multivitamin & Magnesium.

Fully Bioactive L-Methylfolate & Vitamin B12 Supplement
Cofactors Supporting Methylation, Cognition & Wellbeing
Superior-Absorbing Magnesium, Proven in Human Study
3rd-Party Tested for Purity & Safety, Non-GMO & Gluten-Free

One–Time Purchase

3 months supply

$125

$1.39 / serving

Subscription

3 months supply

Save 5% off your first order, then 7.5% off all reorders
Update or cancel anytime

Free Shipping on Orders Over $100

MTHFR Supplements are ideal for newbies tackling MTHFR challenges. 4 unique products include: L-Methylfolate, Vitamin B12 Supplement, Multivitamin & Magnesium.

Get Methyl-Life’s® four recommended starting products for those beginning with MTHFR treatment.

This comprehensive 4-product starting package contains the bioactive nutrients:

The pure & stable bioidentical L-Methylfolate for direction absorption & use within the body
Rare but most well-tolerated Vitamin B12 Supplement (as Hydroxy B12)
The optimal methylation-supporting multivitamin
High-absorption magnesium for over 600 enzymatic processes that happen in the body (including a key methylation co-factor)

Supplement Facts

Serving Size: 2 Veggie Capsules

Servings Per Container: 45 servings per container

Amount Per Serving	Daily Value
Vitamin A 300 mcg RAE (1,000 IU) (as Retinyl Palmitate)	33%
Vitamin D 50 mcg (2,000 IU) (as Cholecalciferol [D3])	250%
Vitamin E 12 mg (as d-α-Tocopheryl Acid Succinate)	80%
Thiamin 1 mg (Vitamin B1) (as Thiamin HCI)	83%
Vitamin B2 8 mg (as Riboflavin 5 Sodium Phosphate)	615%
Niacin 20 mg NE	125%
Vitamin B6 5 mg (as Pyridoxal 5 Phosphate)	294%
Biotin 60 mcg	200%
Pantothenic Acid 22 mg (as B5 - D-Calcium Pantothenate)	440%
Iodine 100 mcg (as Potassium Iodide)	67%
Zinc 15 mg (as sustained release micropellet)	136%
Selenium 100 mcg (as Sucrosomial Selenium (UltraSel®))	182%
Manganese 3 mg (Manganese Bisglycinate Citrate)	130%
Molybdenum 35 mcg (Molybdenum Glycinate (ALBION))	78%
Artichoke 50 mg (Leaf) Extract 5% Cynarin)	†
Citicoline Sodium 50 mg	†
Ubiquinol 10 mg (CoQ10 Reduced Form)	†
Phosphatidylserine 50 mg (Sunflower - Helianthus annuus)	†
Milk Thistle 50 mg ((Seed) Extract 80% Silymarin)	†
Trimethylglycine 50 mg (TMG)	†
Pantethine 50% 14 mg	†
Para-Aminobenzoic Acid 10 mg (PABA) (Vitamin B10)	†
Benfotiamine 20 mg (Fat Soluble Vitamin B1)	†
NADH 1 mg (Microencapulated NADH)	†
Vitamin K2 80 mcg (as Menaquinone-7)	†

† Daily Value not established.

Supplement Facts

Serving Size: 1 Chewable Tablet

Servings Per Container: 90

Amount Per Serving	Daily Value
Folate 4,250 mcg DFE (as L-5-Methyltetrahydrofolate, Calcium [equal to 3,400 mcg of Magnafolate® PRO])	1,063%

Supplement Facts

Serving Size: 1 Chewable Tablet

Servings Per Container: 90 servings per container

Amount Per Serving	Daily Value
Vitamin B12 2,500 mcg (as Hydroxy B12 Chloride)	104,167%

Supplement Facts

Serving Size: 2 Capsules

Servings Per Container: 45 servings per container

Amount Per Serving	Daily Value
Magnesium 320 mg (from 1,000 mg of Magnesium Sucrosomial® [as Magnesium Oxide])	76%
Inositol 100 mg	†

† Daily Value not established.

Other Ingredients

Capsule (water, hypromellose).

Allergen & Safety Information

Does not contain: wheat, gluten, soy, dairy, tree nuts, animal products or GMOs
No artificial ingredients or colorings
NSF-certified manufacturing
Vegan-friendly and hypoallergenic

Suggested Use

Professional guidance:
If you are pregnant, nursing, have kidney impairment or take prescription medications (such as diuretics, antibiotics or muscle relaxants), consult your healthcare practitioner before use.

This product supports cellular magnesium balance, muscle and nerve function, energy and stress resilience, but does not replace medically necessary treatments for diagnosed magnesium deficiency or related health conditions.

Professional Guidance

If you are pregnant, breastfeeding, managing a diagnosed neurological or metabolic condition, using anti-seizure or antifolate medications, or supporting a child under a clinician-guided protocol, consult your healthcare provider before use.

Individuals using folate as part of an autism spectrum disorder or cerebral folate deficiency support plan should do so under professional supervision.

Check out the details below regarding each specific product included in the bundle using the links below:

L-Methylfolate 2.5 - Purest & most stable L-Methylfolate available on the market
Vitamin B12 Supplement - Active B12 as Hydroxy form with 2.5 mg per sublingual tablet
Non-Methylated Multivitamin - Methylation supporting multivitamin with Cognitive and Energy-promoting nutrients (designed to be taken with therapeutic levels of methylfolate & B12)
Magnesium Complete - Bioactive liposomal-like delivery form for optimal absorption in the body

Did you know that recent research shows that taking B12 in a sublingual oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots? It's usually much more convenient and affordable as well.¹

Merav Jacobson Bensky, Irit Ayalon-Dangur, Roi Ayalon-Dangur, Eviatar Naamany, Anat Gafter-Gvili, Gideon Koren, Shachaf Shiber; "Comparison of sublingual vs. intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency"; Drug delivery and translational research; 2019 Jun
https://pubmed.ncbi.nlm.nih.gov/30632091

HOW WE HAVE HELPED OUR CUSTOMERS

Deborah H.

Verified Buyer

02/19/2025

Great product

After discovering I had MRHFR and began taking this company's MethylFolate, my physical and mental condition has improved remarkably. Recently, I tried cutting back by cutting the pills in half for my daily dosage just to see how things would go. I found out I should not do that because within a week, I was stricken with two very painful conditions. I do not know if cutting back on my MethylFolate was the reason, or even part of the reason, but I will not be cutting back anymore. Once I went back to the full daily dose, everything has improved. Love this product and what it does for me. It makes me have a much sunnier disposition and have a sense of well being.

HOW WE HAVE HELPED OUR CUSTOMERS

Laura Sinski M.

Verified Buyer

01/28/2024

Excellent

I feel good. I like the way the products are grouped together. I also appreciate your customer service. Professional, intelligent, and responded quickly to my questions

HOW WE HAVE HELPED OUR CUSTOMERS

TED B.

Verified Buyer

10/12/2023

I think it's got something I definitely needed

With the MTHFR mutation, I have been trying to open up my pathways to assimilate and detoxify. I've noticed that for the first time in many years I can feel changes for the better. Thanks

HOW WE HAVE HELPED OUR CUSTOMERS

Susan R.

Verified Buyer

04/26/2023

Never felt better

When I found out I had the MTHFR mutation, I began reading everything I could about it. I ordered the beginner's bundle, and I have never felt better. I tolerate all four supplements well, I have no jitters and my energy levels are like they were 20 years ago! I will not go without these supplements ever again. Genetics are a complicated subject, so I like that they dumb it down to educate you on the why you should take certain supplements.

HOW WE HAVE HELPED OUR CUSTOMERS

Rex L.

Verified Buyer

12/28/2021

Excellent

MTHFR Supplements: L-Methylfolate, Vitamin B12 Supplement, Multivitamin & Magnesium

$125

COMT V158M	VDR Taq	B12 Types That Should Be Tolerated
– –	+ + (TT)	All 3 types of B12
– –	+ – (Tt)	All 3 types of B12 with less Methylcobalamin
– –	– – (tt)	Hydroxy B12 and Adenosylcobalamin
+ –	+ +	All 3 types of B12 with less Methylcobalamin
+ –	+ –	Hydroxy B12 and Adenosylcobalamin
+ –	– –	Hydroxy B12 and Adenosylcobalamin
+ +	+ +	Hydroxy B12 and Adenosylcobalamin
+ +	+ –	Hydroxy B12 and Adenosylcobalamin
+ +	– –	Mostly Hydroxy B12

Traceable Ingredients You Can Trust

Every ingredient is sourced for purity, backed by clinical evidence, and rigorously tested for safety and bioavailability. Because in supplements, not all ingredients are created equal — and your body deserves only the most effective forms.

Methyl-Life® MTHFR Supplements: L-Methylfolate, Vitamin B12 Supplement, Multivitamin & Magnesium contains no unnecessary excipients, synthetic colors, artificial preservatives, or common allergens. It is 100% free from gluten, soy, dairy, GMOs, animal-derived ingredients, and the EU’s top 14 allergens.

Every batch is third-party tested for purity, potency, and safety, Manufactured in an FDA registered & NSF Certified facility, and rigorously evaluated to ensure you’re getting clean, clinical-grade nutrients — nothing more, nothing less.

Frequently Asked Questions

What is included in the MTHFR Beginner's Bundle?

The MTHFR Beginner's Bundle comprises four essential supplements: L-Methylfolate 2.5, Active B12, Non-Methylated Multi, and Magnesium Caps.

What is the importance of high-absorption magnesium?

High-absorption magnesium is essential for over 300 enzymatic processes that occur in the body, making it a critical co-factor for various physiological functions, including methylation.

Why is magnesium considered a key methylation co-factor?

Magnesium plays a crucial role in methylation, a vital biochemical process involved in numerous cellular functions, including DNA synthesis, repair, and gene expression. Therefore, ensuring adequate magnesium levels is essential for supporting optimal methylation and overall health.

What can you do if you have high B12 blood test results?

Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).

My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too?

One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true.

It’s important to realize that the MTHFR status does not necessarily determine the type of B12 that’s best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).

It seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.

The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxy B12, and from there the hydroxy B12 has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.

What are the benefits of each supplement in the bundle?

L-Methylfolate 2.5: Provides a bioactive form of folate crucial for methylation processes. Active B12: Supports neurological function, energy production, and red blood cell formation. Non-Methylated Multi: Offers a comprehensive blend of essential vitamins and minerals tailored for individuals with MTHFR mutations. Magnesium Caps: Provides magnesium, an essential mineral involved in numerous physiological processes, including nerve function, muscle contraction, and energy metabolism.

Why is Hydroxy B12 considered the most well-tolerated form of B12?

Hydroxy B12 is renowned for its exceptional tolerability, making it suitable for individuals who may experience adverse reactions to other forms of vitamin B12. This makes it an excellent choice for those seeking a gentle yet effective B12 supplement.

What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?

The most important thing to realize is that blood tests for B12 are highly inaccurate at detecting actual cellular levels of B12 (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used.

What does sublingual mean and why isn’t your product labeled as “sublingual”?

It’s a well-known fact that B12 does not absorb well through the gut, so taking B12 via sublingual or mouth absorption is best (holding it under the tongue or between the gums and cheek is most common). Consider some form of liquid or tablet/lozenge that can be sucked on or dissolved in the mouth. Holding the B12 in your mouth for at least 90 seconds is good and the longer you can leave it in your mouth, the better for sublingual absorption (as opposed to gut absorption).

Note: different manufacturers use different terms for tablets that are meant to dissolve sublingually in the mouth, but “sublingual” is considered a pharmaceutical term by the FDA, so dietary supplements are moving away from using that term. However, it doesn’t really matter what term you use (chewable tablet, lozenge, sublingual tablet, liquid, etc.) for maximum absorption the main idea is to hold it in your mouth for 90 seconds or more if you can (if you forget, don’t worry, since you’re taking the active form, your body will still get some benefit even if you swallow it whole).

Another way to absorb B12 is muscularly through shots, however, the research tells us that sublingual (or mouth) absorption is equally as effective as muscular absorption … and shots may cost significantly more money. Also, be aware with shots (many doctors still give cyanocobalamin shots) that though you may need higher doses of active B12s (like myself), you may not do well when given higher doses of cyanocobalamin in a shot because your body may not be able to do the conversions and you could have negative side effects.

I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?

If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be Hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of Hydroxy B12 (and this is why our methylation protocol suggests Hydroxy B12 as the B12 form to begin with):

↦ Folks with multiple COMT mutations tend to do very well with Hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)

↦ Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation

↦ And Dr. Amy Yasko talks (https://dramyyasko.com) about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12

Very disappointed still have not received my order. Customer service has been disappointing as well. I will rate if I ever receive my order.

Thank you for your feedback, and we’re very sorry to hear this.

We understand how frustrating it is not to receive your order yet, especially when you’ve also had a poor experience with customer service. That’s not the standard we aim to provide, and we agree this needs to be addressed properly.

Please contact our support team with your order details so we can prioritise this and work toward a resolution for you as quickly as possible.

We appreciate your patience, and we hope we can still resolve this for you.

Best of health to you

"Excellent product"

"I could only take one of the multi vitamins. But love all the other ones and have not had any reaction to the others."

Thank you for your honest feedback! We're glad to hear that you’ve had a good experience with our other products, even if the multivitamin didn’t fully agree with you. Your experience helps us continue improving and supporting our customers' unique needs.

Best of health to you.

Love!

Thank you for your feedback! We’re so glad to hear you’re loving it!

Best of health to you,
The Methyl-Life® Team

Too soon to tell but feel less achy - is it a coincidence?

Thank you for your feedback! We’re glad to hear you’re already noticing some positive changes and hope it continues to support your well-being over time.

Best of health to you,
The Methyl-Life® Team

No review title

No review content

5 stars: 10 (83%)
4 stars: 1 (8%)
3 stars: 0 (0%)
2 stars: 0 (0%)
1 star: 1 (8%)

"Great product"

"After discovering I had MRHFR and began taking this company's MethylFolate, my physical and mental condition has improved remarkably. Recently, I tried cutting back by cutting the pills in half for my daily dosage just to see how things would go. I found out I should not do that because within a week, I was stricken with two very painful conditions. I do not know if cutting back on my MethylFolate was the reason, or even part of the reason, but I will not be cutting back anymore. Once I went back to the full daily dose, everything has improved. Love this product and what it does for me. It makes me have a much sunnier disposition and have a sense of well being."

Thank you for sharing your experience with MethylFolate and how it has positively impacted your health. It’s great to hear that returning to your full dose helped restore your wellbeing and mood.

We appreciate your trust in our product and are honored to be part of your health journey.

Best of Health to you.

Love!

Thank you for your feedback! We’re so glad to hear you’re loving it!

Best of health to you,
The Methyl-Life® Team

Too soon to tell but feel less achy - is it a coincidence?

Thank you for your feedback! We’re glad to hear you’re already noticing some positive changes and hope it continues to support your well-being over time.

Best of health to you,
The Methyl-Life® Team

Very disappointed still have not received my order. Customer service has been disappointing as well. I will rate if I ever receive my order.

Thank you for your feedback, and we’re very sorry to hear this.

Please contact our support team with your order details so we can prioritise this and work toward a resolution for you as quickly as possible.

We appreciate your patience, and we hope we can still resolve this for you.

Best of health to you

"Excellent product"

"I could only take one of the multi vitamins. But love all the other ones and have not had any reaction to the others."

Best of health to you.

No review title

No review content

"Excellent"

"I feel good. I like the way the products are grouped together. I also appreciate your customer service. Professional, intelligent, and responded quickly to my questions"

Thank you so much for these very kind words Laura; we are so happy to hear you are doing well with this bundle. Best of health to you!

"I think it's got something I definitely needed"

"With the MTHFR mutation, I have been trying to open up my pathways to assimilate and detoxify. I've noticed that for the first time in many years I can feel changes for the better.
Thanks,"

Wow Ted! Thank you so much for sharing your experience; we are over the moon to hear this news! We appreciate your support; best of health to you!

No review title

No review content

We are so thankful for your support Nancy! Thank you so much for taking the time to submit this review! Best of health to you!

"Never felt better"

"When I found out I had the MTHFR mutation, I began reading everything I could about it. I ordered the beginner's bundle, and I have never felt better. I tolerate all four supplements well, I have no jitters and my energy levels are like they were 20 years ago! I will not go without these supplements ever again. Genetics are a complicated subject, so I like that they dumb it down to educate you on the why you should take certain supplements."

Thank you so much for sharing your story! We're thrilled to hear that the Beginner’s Bundle has made such a significant difference in your energy and overall well-being. It’s especially rewarding to know that you're tolerating the supplements well and feeling better than you have in years. We understand how overwhelming genetic information can be, and we’re glad our educational resources helped make things clearer and more approachable.

Your trust means everything to us, thank you for letting Methyl-Life be a part of your journey.

Best of Health to you.

"Excellent"

"Excellent"

Thank you! We’re so happy to hear that.

Best of Health to you.

"Execellent"

"Execellent"

Thank you! We’re so happy to hear that.

Best of Health to you.

How long does this bundle last

Why are the non-methylated multivitamins offered in this bundle and not the methylated multivitamins? If methylated multivitamins are more easily absorbed what is the reason for offering non-methylated multivitamins?

Alexander Sullivan

Great question! In our product lineup, we offer a Non-Methylated Multivitamin specifically designed for individuals who may have difficulty tolerating methylated nutrients. Our approach focuses on providing customized methylation support by removing methylated nutrients from the multivitamin. This allows our customers to tailor their intake of methylfolate and other methylated nutrients to meet their individual needs.

For example, some individuals may require lower doses of methylfolate, such as those found in our Methylfolate 2.5 mg product. Others may benefit from higher doses, ranging from 7.5 mg to 15 mg, to support mood enhancement. By separating the methylated nutrients from the multivitamin, both groups can use the same base multivitamin and adjust their intake of active methylated nutrients accordingly.

This flexibility is crucial because our methylation needs can vary throughout our lives. By allowing users to titrate bioidentical nutrients up or down as needed, our approach enables more precise customization of dosage to suit individual requirements. The Non-Methylated vitamins are just as easily absorbed as long as Methylfolate is taken with it.

Best of health to you!

Can these products be taken post C-Diff and various forms of e-coli

Alexander Sullivan

Hi Kat,
Thank you for reaching out.
Methylation products, such as methylated vitamins or compounds involved in methylation processes like methylcobalamin (vitamin B12), are generally safe to take post-infection with C. diff or various forms of E. coli.

We still recommend to talk to your doctor or healthcare provider as after an infection like C. diff or E. coli, your immune system may be compromised or in recovery mode. Your overall health and any pre-existing conditions should be considered before starting any new supplements. Since C. diff and some forms of E. coli can disrupt the gut microbiome, which plays a role in vitamin absorption and overall health, it's crucial to support gut health during recovery. This may include consuming probiotics or prebiotics to restore balance in the gut flora.

If you have had a severe infection or if you're uncertain about how your body is recovering, consulting with a healthcare professional for guidance tailored to your situation is recommended as we are not doctors and can only provide you with information that is available to us.

Best of health to you.

I have just come across your product. Can you please tell me more about the b 12 with a low dose of 2.5mg. My PA thinks that I am suffering from MTFHR. I am currently anemic since I have become vegetarian due to many food sensitivities, and I also cannot tolerate b12. Currently I started taking a multivitamin, but I can only do one capsule split in half to a quarter due to the B12. Would the B 12 at 2.5 mg work for me? Or would I be better off with the non - B 12 vitamin for now? I just about cried when I saw your website caters to those with MTFR. Since I have struggled with so many intolerances for years and they have progressively gotten worse. My current vitamin has 24 mg B 12 It is made by Garden for Life and it's a women's multi for age 40 and over. It also whole food so its tolerable on my digestion. I am assuming these are well tolerable for that also. Can you please advise me on these things? Thank you, Kim H.

Alexander Sullivan

Hello there,
I will follow up with you via email; however, I do want to highlight our Naturopathic Doctor Consultation option here for you: https://methyl-life.com/pages/naturopathic-consultations

Asking here because I don't know where else to ask this question.. in the 6 tips section regarding 'priming the pump" with NAC for 1 to 2 weeks prior to starting a protocol, do you stop the nac after that or continue?

Alexander Sullivan

Great question, NAC is a valuable nutrient for methylation and health in general, it plays a big role in ensuring our intracellular glutathione levels are in a good range and able to be utilized by the methylfolate when we introduce that important nutrient. So taking glutathione regularly is the typically recommended practice as it will help you detoxify the many toxic burdens we pick up along the way throughout our life's journey. Life has us collecting toxic burdens along the way, so we always want to be detoxifying those things we get exposed to regularly. The main issue to weigh here is how fast you're detoxing vs. how fast your body can keep up with that process. Some need significant liver support if they're doing a lot of antioxidant support (which is what NAC supplementation falls under). Short answer, if you tolerate it well, YES, take NAC regularly, even and especially after you begin the methylfolate. Best - Jamie

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