MTHFR Supplements: L-Methylfolate, Vitamin B12 Supplement, Multivitamin & Magnesium
- Fully Bioactive L-Methylfolate & Vitamin B12 Supplement
- Cofactors Supporting Methylation, Cognition & Wellbeing
- Superior-Absorbing Magnesium, Proven in Human Study
- 3rd-party tested for Purity & Safety, Non-GMO, Gluten-Free
- Description
- Dosage
- FAQ'S
- Return Policy
Get Methyl-Life’s® four recommended starting products for those beginning with MTHFR treatment.
This comprehensive 4-product starting package contains the bioactive nutrients:
- The pure & stable bioidentical L-Methylfolate for direction absorption & use within the body
- Rare but most well-tolerated Vitamin B12 Supplement (as Hydroxy B12)
- The optimal methylation-supporting multivitamin
- High-absorption magnesium for over 600 enzymatic processes that happen in the body (including a key methylation co-factor)
Check out the details below regarding each specific product included in the bundle using the links below:
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- L-Methylfolate 2.5 - Purest & most stable L-Methylfolate available on the market
- Vitamin B12 Supplement - Active B12 as Hydroxy form with 2.5 mg per sublingual tablet
- Non-Methylated Multivitamin - Methylation supporting multivitamin with Cognitive and Energy-promoting nutrients (designed to be taken with therapeutic levels of methylfolate & B12)
- Magnesium Complete - Bioactive liposomal-like delivery form for optimal absorption in the body
Did you know that recent research shows that taking B12 in a sublingual oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots? It's usually much more convenient and affordable as well - https://pubmed.ncbi.nlm.nih.gov/30632091.
WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to some dosing options.
How to snap the tablet in half – See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.
What is included in the MTHFR Beginner's Bundle?
The MTHFR Beginner's Bundle comprises four essential supplements: L-Methylfolate 2.5, Active B12, Non-Methylated Multi, and Magnesium Caps.
What are the benefits of each supplement in the bundle?
Active B12: Supports neurological function, energy production, and red blood cell formation.
Non-Methylated Multi: Offers a comprehensive blend of essential vitamins and minerals tailored for individuals with MTHFR mutations.
Magnesium Caps: Provides magnesium, an essential mineral involved in numerous physiological processes, including nerve function, muscle contraction, and energy metabolism.
What is the importance of high-absorption magnesium?
High-absorption magnesium is essential for over 300 enzymatic processes that occur in the body, making it a critical co-factor for various physiological functions, including methylation.Why is Hydroxy B12 considered the most well-tolerated form of B12?
Hydroxy B12 is renowned for its exceptional tolerability, making it suitable for individuals who may experience adverse reactions to other forms of vitamin B12. This makes it an excellent choice for those seeking a gentle yet effective B12 supplement.Why is magnesium considered a key methylation co-factor?
Magnesium plays a crucial role in methylation, a vital biochemical process involved in numerous cellular functions, including DNA synthesis, repair, and gene expression. Therefore, ensuring adequate magnesium levels is essential for supporting optimal methylation and overall health. What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?
The most important thing to realize is that blood tests for B12 are highly inaccurate at detecting actual cellular levels of B12 (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used.
What can you do if you have high B12 blood test results? Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).
What does sublingual mean and why isn’t your product labeled as “sublingual”?
Another way to absorb B12 is muscularly through shots, however, the research tells us that sublingual (or mouth) absorption is equally as effective as muscular absorption … and shots may cost significantly more money. Also, be aware with shots (many doctors still give cyanocobalamin shots) that though you may need higher doses of active B12s (like myself), you may not do well when given higher doses of cyanocobalamin in a shot because your body may not be able to do the conversions and you could have negative side effects.
My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too?
One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true.
It’s important to realize that the MTHFR status does not necessarily determine the type of B12 that’s best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).
It seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.
The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxy B12, and from there the hydroxy B12 has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.
I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?
If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxy B12 (and this is why our methylation protocol suggests hydroxy B12 as the B12 form to begin with):
- Folks with multiple COMT mutations tend to do very well with hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)
- Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation
- And Dr. Amy Yasko talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:
COMT V158M | VDR Taq | B12 Types That Should Be Tolerated |
---|---|---|
– – | + + (TT) | All 3 types of B12 |
– – | + – (Tt) | All 3 types of B12 with less Methylcobalamin |
– – | – – (tt) | Hydroxy B12 and Adenosylcobalamin |
+ – | + + | All 3 types of B12 with less Methylcobalamin |
+ – | + – | Hydroxy B12 and Adenosylcobalamin |
+ – | – – | Hydroxy B12 and Adenosylcobalamin |
+ + | + + | Hydroxy B12 and Adenosylcobalamin |
+ + | + – | Hydroxy B12 and Adenosylcobalamin |
+ + | – – | Mostly Hydroxy B12 |
Please Note
Before making a purchase of any of our products, Methyl-Life® recommends consulting with a healthcare professional - especially if you have any questions. Methyl-Life® cannot assume responsibility for adverse reactions or perceived negative side effects resulting from the use of our products.
For customers who have not used Methyl-Life® products before, we recommend starting with a single bottle before considering larger orders. Additionally, we encourage you to review our dosage and methylation protocol pages and consider beginning with a lower dose product to ensure a smooth integration with the ingredients before progressing to higher dose options.
Methyl-Life® generally does not accept returns for large orders. If you choose to return three unopened bottles from a 4-pack purchase, you will receive a full refund, excluding the cost of one bottle charged at full price.
RETURN PROCESS
Within 45 days of your order within the United States, you can return any unopened item shipped to you by Methyl-Life® as long as all seals are intact. To initiate a return, please email us using the Contact Us form, providing your order details and tracking information for the return product shipment sent to: P.O. Box 33606, Seattle, WA 98133. Please note that return shipping costs are the responsibility of the customer, and we recommend considering insurance for the return package. Refunds will be processed within 10 business days of receiving the returned item, and you will receive an email confirmation once the refund is complete. Please be aware that depending on your financial institution, it may take up to 10 days for the refund to appear in your account.
DAMAGED OR INCORRECT ITEMS
If you have received the wrong item, or if your product has been damaged or is defective, please email us with detailed information using the Contact us form, and our Customer Service Manager will address your concern promptly. Do not discard any items unless directed to do so.