Methylated B12 3.75mg + L-Methylfolate 3mg as Methyl-Life®'s B-Methylated-II - Methyl-Life® Supplements
Methylated B12 3.75mg + L-Methylfolate 3mg as Methyl-Life®'s B-Methylated-II - Methyl-Life® Supplements
Methylated B12 3.75mg + L-Methylfolate 3mg as Methyl-Life®'s B-Methylated-II - Methyl-Life® Supplements
Methylated B12 3.75mg + L-Methylfolate 3mg as Methyl-Life®'s B-Methylated-II - Methyl-Life® Supplements
Methylated B12 3.75mg + L-Methylfolate 3mg as Methyl-Life®'s B-Methylated-II - Methyl-Life® Supplements
Methylated B12 3.75mg + L-Methylfolate 3mg as Methyl-Life®'s B-Methylated-II - Methyl-Life® Supplements
Methylated B12 3.75mg + L-Methylfolate 3mg as Methyl-Life®'s B-Methylated-II
Gluten-Free Dairy-Free No Artificial Additives BPA-Free Fish/Shellfish-Free Vegan-Friendly
Balanced Methylation – L-Methylfolate & Active B12

Methylated B12 3.75mg + L-Methylfolate 3mg as Methyl-Life®'s B-Methylated-II

Methylated B12 3.75mg + L-Methylfolate 3mg together in a sublingual tablet for max B12 absorption with bioactive Methylcobalamin B12 and 5-mthf.
  • Bioactive L-Methylfolate 3 Mg & Methylated B12
  • Great for Bypassing MTHFR Mutations
  • 3rd-Party Tested for Purity, Potency & Safety
  • 90 Vegan, Non-GMO, Chewable Mint Tablets

Free Shipping on Orders Over $100

Methylated B12 + L-Methylfolate 3 mg in a sublingual tablet as Methyl-Life's® B-Methylated II product - one of the purest L-Methylfolate brands + Bioactive B12 as Methylcobalamin

Supplement Facts
Serving Size: 1 Chewable Tablet
Servings Per Container: 90 servings per container
Amount Per Serving % Daily Value
Folate 6,037 DFE mcg
(as L-5-Methyltetrahydrofolate, Calcium [equal to 4,558 mcg Magnafolate® PRO]) 		1,509%
Vitamin B12 3,750 mcg
(as Methylcobalamin) 		156,250%
† Daily Value not established

Other Ingredients

Xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavor (dextrose, silicon dioxide, natural flavor, propylene glyvcol). Not a significant source of sugars.

Allergen & Safety Information

  • Does not contain: wheat, gluten, soy, dairy, tree nuts, animal products, or GMOs
  • No artificial ingredients or colorings
  • Sweetened with xylitol — do not give to pets

Suggested Use

Take 1-2 tablets after meals, or as directed by your healthcare practitioner.
May be chewed, dissolved in the mouth or swallowed.

How much should you take?

Every individual’s needs are different. Always consult your healthcare provider to determine the right dose for your specific needs.

Doctor-guided support

Visit our Dosage Information and Methylation Protocol pages to learn what some practitioners recommend, including step-by-step guidance for individuals with MTHFR gene variants.

Splitting tablets

Each chewable tablet is scored and can be split in half without a pill cutter. For best results, place your thumbs along the scored line with the tablet facing away from you, and press outward to snap. Watch the full demonstration in our tablet-splitting video.

Additional considerations

This supplement is designed to be taken daily or as recommended by your healthcare practitioner. In the absence of directions from your Healthcare Specialist, consider taking one to two tablets after meals. If you gain some relief from a single tablet, consider taking an additional tablet if you feel a second one may be beneficial.

Methylated B12 + L-Methylfolate 3 mg in a sublingual tablet as Methyl-Life's® B-Methylated II product - one of the purest L-Methylfolate brands + Bioactive B12 as Methylcobalamin

Methyl-Life® products contain the most bioactive nutrient form of folate available today, L-Methylfolate (often denoted as L-MTHF, L-5-Methylenetretrahydrofolate, L-5-MTHF, (6S)-5-Methylfolate, etc). This is the ‘already converted’ form of the vitamin that is immediately ready for the body’s cells to use directly. It’s the only form of folate which crosses the blood-brain barrier. Those with MTHFR are also often found to be low in B12 as well as and may have significant problems absorbing it.

Every serving in Methyl-Life’s® B-Methylated II product contains a moderate dose (3 mg) of L-Methylfolate as internationally-patented Magnafolate® PRO as well as 3.75 mg of Active B12 (as Methylcobalamin B12).  We specifically deliver this power-packed combination in a tasty, chewable tablet that can sit under the tongue for maximum B12 absorption.

  • Methylcobalamin – Helps with methylation, brain & nerve health, circulatory & immune systems, reduces homocysteine, and positively affects anemia.

Our chewable form provides for maximum B12 absorption through the mucous membranes in the mouth. Bite the tablet into pieces and allow those to dissolve under your tongue for a sublingual delivery to maximize your body's use of the nutrient.  

Did you know that recent research shows that taking B12 in a sublingual oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots? It's usually much more convenient and affordable as well -  https://pubmed.ncbi.nlm.nih.gov/30632091.

In recent studies Magnafolate® PRO showed significantly greater purity, stability and potency results when compared against competing brands Quatrefolic® and Extrafolate®. This is because Magnafolate® is built on a calcium crystalline molecule structure just like the pharmaceutical brand of L-Methylfolate.  So if you’re truly looking for professional strength, look no further. Read more about Magnafolate's® superiority.

Methyl-Life® remains proud that we can offer such an exceptional product line at such an affordable price point (because as a family-owned company, we know this is important to you).  No other competitor sells a comparable product for less.  We go above and beyond with our quality standards by investing in additional 3-year stability studies and third party lab testing to ensure our final products are the very best you can buy.

Spoiler alert ... our 5-year old products tested fully potent, but when tested against ours, the competitors' products did NOT meet the Supplement Facts claims after 5 years on the shelf. 

Methyl-Life’s® B-Methylated II was formulated especially for people with genetic (MTHFR, MTR, MTRR) variants, dietary or drug-induced need. It was designed specifically to bypass genetic challenges and optimize the body’s methylation process. This means you may have more energy and motivation, get improved protection against toxins, and just plain feel better. 

Moderate doses of L-Methylfolate are designed to support optimal brain and nerve health and may positively affect mood. Studies have shown methylfolate is important for peripheral neuropathy as it repairs the myelin sheath. It is often used to assist with pregnancy and fetal well-being. It can also convert homocysteine into methionine which can support cardiovascular health. L-Methylfolate can boost glutathione levels in the body (and glutathione is a great ally when it comes to detoxification, it’s your body’s strongest antioxidant).  Talk to your doctor to determine, if taking moderate doses of L-Methylfolate and Methylcobalamin is right for you. 

HOW WE HAVE HELPED OUR CUSTOMERS

Bruce Daniel

Verified Buyer
01/04/2022
METHYL LIFE + B-12

I have been taking this products for several years. It has helped my memory and also my balance.

HOW WE HAVE HELPED OUR CUSTOMERS

Pat Rittenmeyer

Verified Buyer
08/27/2024
Excellent supplement

I've been taking II Methylated B for several years and am very pleased with it. I had tried other methylated B12 products and none of them come close to comparing to II Methylated B. Plus I don't have to take 2 pills which is nice. Great product and company. Thank You Gratefully, Pat

HOW WE HAVE HELPED OUR CUSTOMERS

Meagan Skaff

Verified Buyer
09/19/2023
High quality brand backed by research, standards, and good customer service!

Once I learned I had the MTHFR genetic issue and I switched to this product it has made a huge difference in my wellness. I feel that it has had a synergistic effect with all the supplements I take. I am confident that I am doing all I can do to stay on top of this at age 66 and I believe that the quality of this brand is superior. Plus as a career business strategy consultant I like to support small businesses.

HOW WE HAVE HELPED OUR CUSTOMERS

Carol

Verified Buyer
03/08/2023
I am sure that Methyl Life imp

I am sure that Methyl Life improves my memory. My electrophysiologist/MD recommended Methyl Life to improve my cognitive function.

HOW WE HAVE HELPED OUR CUSTOMERS

Carolyn

Verified Buyer
09/26/2022
Rate #5. My primary care physi

Rate #5. My primary care physician recommended this supplement.
Methylated B12 3.75mg + L-Methylfolate 3mg as Methyl-Life®'s B-Methylated-II
$39

Traceable Ingredients You Can Trust

Every ingredient is sourced for purity, backed by clinical evidence, and rigorously tested for safety and bioavailability. Because in supplements, not all ingredients are created equal — and your body deserves only the most effective forms.

Methyl-Life® Methylated B12 3.75mg + L-Methylfolate 3mg as Methyl-Life®'s B-Methylated-II contains no unnecessary excipients, synthetic colors, artificial preservatives, or common allergens. It is 100% free from gluten, soy, dairy, GMOs, animal-derived ingredients, and the EU’s top 14 allergens.

Every batch is third-party tested for purity, potency, and safety, manufactured in NSF-certified, cGMP-compliant facilities, and rigorously evaluated to ensure you’re getting clean, clinical-grade nutrients — nothing more, nothing less.

EU’s top 14 allergens

  • Cereals containing gluten - wheat (such as spelt and khorasan wheat), rye, barley, oats. Note: The cereal name, e.g., 'wheat', must be declared and highlighted, not 'gluten'.
  • Crustaceans, e.g., crabs, prawns, lobsters
  • Eggs
  • Fish
  • Peanuts
  • Soybeans
  • Milk
  • Nuts (almonds, hazelnuts, walnuts, cashews, pecan nuts, brazil nuts, pistachio nuts, macadamia/Queensland nut). Note: The name of the nut, e.g., 'almond', must be declared and highlighted, not 'nuts'.
  • Celery
  • Mustard
  • Sesame seeds
  • Sulphur dioxide and sulphites (at concentrations of more than 10 mg/kg or 10 mg/L in terms of total sulphur dioxide) – used as a preservative
  • Lupin 
  • Molluscs, e.g., mussels, oysters, squid, snails

Frequently Asked Question

Methyl-Life® products feature L-Methylfolate, the most bioactive form of folate available today. Also known as L-MTHF, L-5-Methylenetretrahydrofolate, or (6S)-5-Methylfolate, L-Methylfolate is the converted form of the vitamin that the body's cells can immediately utilize. It is the only form of folate capable of crossing the blood-brain barrier.
Each serving of Methyl-Life’s® B-Methylated II product contains a moderate dose of 3 mg of L-Methylfolate, provided as internationally-patented Magnafolate® PRO, along with 3.75 mg of Active B12 in the form of Methylcobalamin. This power-packed combination is delivered in a tasty, chewable tablet designed to sit under the tongue for maximum B12 absorption.
Our chewable form allows for maximum B12 absorption through the mucous membranes in the mouth. By biting the tablet into pieces and allowing them to dissolve under your tongue, you facilitate sublingual delivery, maximizing your body's utilization of this essential nutrient.
Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).
One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true.

It’s important to realize that the MTHFR status does not necessarily determine the type of B12 that’s best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).

It seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.

The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxy B12, and from there the hydroxy B12 has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.
Individuals with MTHFR mutations often have difficulty converting synthetic folic acid into its active form, L-Methylfolate. Therefore, using L-Methylfolate directly bypasses this conversion step, ensuring optimal folate levels in the body. Additionally, those with MTHFR mutations may also experience challenges in absorbing vitamin B12, making it crucial to address both nutrient deficiencies simultaneously.
Methylcobalamin offers a range of benefits, including support for methylation, brain and nerve health, circulatory and immune systems. It also helps reduce homocysteine levels and can positively affect individuals with anemia. By including Methylcobalamin in B-Methylated II, Methyl-Life® provides a comprehensive solution for addressing various health concerns.
The most important thing to realize is that blood tests for B12 are highly inaccurate at detecting actual cellular levels of B12 (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used.
It’s a well-known fact that B12 does not absorb well through the gut, so taking B12 via sublingual or mouth absorption is best (holding it under the tongue or between the gums and cheek is most common). Consider some form of liquid or tablet/lozenge that can be sucked on or dissolved in the mouth. Holding the B12 in your mouth for at least 90 seconds is good and the longer you can leave it in your mouth, the better for sublingual absorption (as opposed to gut absorption).

Note: different manufacturers use different terms for tablets that are meant to dissolve sublingually in the mouth, but “sublingual” is considered a pharmaceutical term by the FDA, so dietary supplements are moving away from using that term. However, it doesn’t really matter what term you use (chewable tablet, lozenge, sublingual tablet, liquid, etc.) for maximum absorption the main idea is to hold it in your mouth for 90 seconds or more if you can (if you forget, don’t worry, since you’re taking the active form, your body will still get some benefit even if you swallow it whole).

Another way to absorb B12 is muscularly through shots, however, the research tells us that sublingual (or mouth) absorption is equally as effective as muscular absorption … and shots may cost significantly more money. Also, be aware with shots (many doctors still give cyanocobalamin shots) that though you may need higher doses of active B12s (like myself), you may not do well when given higher doses of cyanocobalamin in a shot because your body may not be able to do the conversions and you could have negative side effects.
If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well-tolerated active form of B12 for folks seems to be hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxy B12 (and this is why our methylation protocol suggests hydroxy B12 as the B12 form, to begin with):

↦ Folks with multiple COMT mutations tend to do very well with hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)

↦ Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation

↦ And Dr. Amy Yasko (https://dramyyasko.com) talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12

The Science Behind

Understanding DFE Labeling for Methylfolate

What the New Numbers on Your Label Mean Now — and Why the Label Change Hasn’t Changed Your Dose

When it comes to folate supplements, labels can be misleading — not because the formulas are different, but because the rules have changed. In this video, Jamie from Methyl-Life® explains the FDA’s new requirement to use Dietary Folate Equivalents (DFE) and what that means for how folate is reported on supplement labels.

What’s this video about?: How the new FDA labeling standards affect folate supplements — and why your formula hasn’t changed, even if the number on the label looks much higher.

B-Methylated II: Pure B12 & Bioactive B9 for MTHFR & Neuropathy | Methyl-Life® Explained

The benefits of using already-converted, bioactive B9 and B12—ready for your cells to use immediately

Unlock better methylation support with B-Methylated II from Methyl-Life®, introduced by founder Jamie Hope. In this video, Jamie explains how B-Methylated II is specially formulated for people with MTHFR and methylation challenges, delivering the most biologically active forms of B9 (methylfolate) and B12 (methylcobalamin) for maximum effectiveness.

B-Methylated II offers a cost-effective, over-the-counter alternative to prescription products like Metanx, but without the risk of high-dose B6 toxicity

Why Folate Labels Now Use DFE

The FDA now requires that all folate-containing supplements list folate content in mcg DFE to account for how much folate is actually absorbed by the body, based on source.

  • Folic acid × 1.7 = mcg DFE
  • Methylfolate × 1.7 = mcg DFE

This change reflects differences in bioavailability. The folic acid nutrient, for example, has ~85% bioavailability when taken with food. However, natural food folate has only ~50% bioavailability. The DFE unit helps consumers understand how much “usable folate” they’re getting as if it were compared to eating folate from whole foods.

Example:

  • A supplement with 1,000 mcg folic acid will now be labeled as 1,700 mcg DFE.
  • A supplement with 15,000 mcg L-Methylfolate will now show 25,500 mcg DFE (or could show more, depending on the salt form used and its potency calculation).

NOTE:  this is not an increase in the dosage amount — just new math to reflect usable folate content from the same formula.

Why This Matters for Methyl-Life® Users

Methyl-Life® uses L-5-Methyltetrahydrofolate (L-Methylfolate) — a bioactive form of folate that does not require MTHFR conversion. Even though it’s more effective and better absorbed than folic acid, the FDA still requires methylfolate products to use the same 1.7x multiplier for DFE.

So if your bottle used to say 15,000 mcg of L-Methylfolate, and now it says 25,000-30,000 mcg DFE, just know that neither the formula nor the dose has changed — only the math has. You're still receiving 15 mg of pure L-Methylfolate, now labeled using the updated DFE format.

Why the DFE Conversion Matters Less Than the Form

DFE was designed around folic acid absorption. But Methyl-Life® uses methylfolate, which already comes in its active form and offers superior uptake — especially for those with MTHFR gene mutations.

This is supported by evidence showing that L-Methylfolate:

  • Crosses the blood–brain barrier for direct cognitive support2
  • Improves depressive symptoms when used at 15 mg/day in SSRI-resistant cases PubMed 23212058
  • Supports homocysteine metabolism to reduce cardiovascular and neurological risk PMC9832224

Why the DFE Conversion Matters Less Than the Form

DFE (Dietary Folate Equivalent) was designed around folic acid — a synthetic form that requires multiple conversion steps before it becomes usable by the body.

But Methyl-Life® uses L-methylfolate, which is already in its active form and offers superior absorption — especially for those with MTHFR gene mutations.

So while labeling has changed, nothing has changed in your supplement’s clinical or nutritional performance.

Recap: DFE Labeling Doesn’t Change the Dose

  • DFE stands for Dietary Folate Equivalent, a unit created to reflect folate’s usable potency based on absorption rates from whole foods
  • The formula is exactly the same — only the math calculation applied to the label has changed
  • Methyl-Life® continues to deliver clinically-studied L-Methylfolate at the same high-potency, now labeled to meet new DFE guidelines from the FDA

You do not need to recalculate your dose or change your usage.

Customer Reviews

Based on 37 reviews
86%
(32)
14%
(5)
0%
(0)
0%
(0)
0%
(0)
100.0
L
Lori

Really love this product! It really works with no side effects!

N
Nicole

I split the dose in half. Half when I wake up, half at lunch time. When I take it at lunch, I almost instantly feel anxious, jittery, paranoid, but sleepy all at the same time. I will continue to take half in the mornings, but even then I feel sleepy after taking it. I've done some research, but I'm on such a low dose, I don't think it's overmethylation. Any ideas?

J
John Berrier
"I could barely walk and reel me feet. Four days latter I could wear my new cowboy boots I bought...

"John Berrier
Plano, Texas 70 years old"

Thank you for sharing your inspiring progress! We’re so happy to hear about your improved mobility and that you could finally wear your cowboy boots again.

Wishing you continued health and comfort.

Best of Health to you.

P
Pat Rittenmeyer
"Excellent supplement"

"I've been taking II Methylated B for several years and am very pleased with it. I had tried other methylated B12 products and none of them come close to comparing to II Methylated B.
Plus I don't have to take 2 pills which is nice.

Great product and company.
Thank You
Gratefully,
Pat"

Hi Pat,
Thank you so much for your kind words and for being a loyal customer! We're thrilled to hear that II Methylated B has been working so well for you and that you appreciate the convenience of not having to take multiple pills. Your satisfaction means a lot to us. If you have any questions or need assistance in the future, feel free to reach out. Thank you again for your support!
Best of Health to you!

B
Brandi Stewart
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