Get Methyl-Life’s® Methylation Supplements bundle with L Methylfolate and B12 Sublingual, 2 foundational products for neuro-protection.
This active-nutrients package contains 2 chewable products targeting improved cognition and brain health:
- The purest bioactive L Methylfolate for direct biopathway absorption and use by the body
- The rare but well-tolerated B12 Sublingual form, Hydroxy B12
Check out the details below regarding each product included in the bundle to learn more:
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- L Methylfolate - Stable & pure form of L Methylfolate (5 mg chewable tablet) for full absorption
- B12 Sublingual - Bioactive form at 2.5 mg of Hydroxy B12 per chewable tablet
Did you know that recent research shows that taking B12 in a sublingual oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots? It's usually much more convenient and affordable as well - https://pubmed.ncbi.nlm.nih.gov/30632091.
Dosage
WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to some dosing options.
How to snap the tablet in half – See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.
Research
FAQ'S
What is the right dosage for me?
Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.
What is the Methyl-Life® Brain Protect Bundle?
What do doctors have to say about MTHFR and how to treat it?
How can I get more information on MTHFR?
Which products are included in the bundle?
L Methylfolate 5: This product features the most stable and pure form of L Methylfolate available for purchase, with a dosage of 5 mg per tablet.
B12 Sublingual: This is the rare but highly tolerated form, Hydroxy B12, providing 2.5 mg of active B12 per tablet.
What are the benefits of Hydroxy B12 Sublingual for the brain?
Hydroxy B12 Sublingual is known for its neuroprotective properties and its ability to support healthy nerve function. With a dosage of 2.5 mg per tablet, it complements the cognitive support provided by L Methylfolate.
What can you do if you have high B12 blood test results? Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 Sublingual form in that’s most likely best for you).
Who can benefit from using the Methyl-Life® Brain Protect Bundle?
How should the products in the bundle be consumed?
Both L Methylfolate 5 mg and B12 Sublingual 2.5 mg are chewable tablets, making them convenient for daily consumption. Follow the recommended dosage instructions provided with each product or consult a healthcare professional for personalized guidance.
I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?
If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 Sublingual forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 Sublingual for folks seems to be hydroxy B12 Sublingual. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxy B12 (and this is why our methylation protocol suggests hydroxy B12 as the B12 sublingual form to begin with):
- Folks with multiple COMT mutations tend to do very well with hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)
- Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation
- And Dr. Amy Yasko(https://dramyyasko.com/)talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:
| COMT V158M | VDR Taq | B12 Types That Should Be Tolerated |
|---|---|---|
| – – | + + (TT) | All 3 types of B12 |
| – – | + – (Tt) | All 3 types of B12 with less Methylcobalamin |
| – – | – – (tt) | Hydroxy B12 and Adenosylcobalamin |
| + – | + + | All 3 types of B12 with less Methylcobalamin |
| + – | + – | Hydroxy B12 and Adenosylcobalamin |
| + – | – – | Hydroxy B12 and Adenosylcobalamin |
| + + | + + | Hydroxy B12 and Adenosylcobalamin |
| + + | + – | Hydroxy B12 and Adenosylcobalamin |
| + + | – – | Mostly Hydroxy B12 |
