Therapeutic high-dose of bioactive L Methylfolate 15mg uniquely formulated with the internationally-patented Magnafolate® PRO and Vitamin B12 with Methyl, as well as inositol to naturally support healthy mood, cognitive function, methylation and homocysteine support.
L-methylfolate is the predominant form of folate circulating in the body and used for biological processes1.
Studies show *L methylfolate 15mg + SSRI to be the most effective dose for improving depressive symptoms2.
L Methylfolate 15 mg is the biologically activated form of folate and the only form that can cross the blood-brain barrier3.
- Support for brain function4
- Supports cardiovascular health5
- Support for healthy immune function6
- Supports nerve function7 and healthy myelin formation22
- Nervous system maintenance21
- Support for preconception, pregnancy, and fetal health8
- Involved in reducing20 and maintaining healthy homocysteine levels9
- Essential nutrient required for optimal DNA methylation19 and neurotransmitter synthesis10
- Adjunctive support for serotonin selective reuptake inhibitors23
- Suitable for people with MTHFR mutations11
Key ingredients:
- Folate - 15,000 mcg (as L-5-Methyltetrahydrofolate, Calcium - Magnafolate® PRO)
- Vitamin B12 - 1,000 mcg (as Hydroxy B12)
- Inositol - 180 mg
L Methylfolate 15mg + Vitamin B12 with Methyl is a highly bioactive form of folate made with the purest L methylfolate available12.
- Maximum absorption and bioavailability
- No prescription required
- Available in 2.5mg, 3mg+B12, 5mg, 7.5mg+B12, 10mg, 15mg, 15mg+B12
- Rigorously tested for consistency, purity, safety, and potency
- Absolutely no fillers or additives of any kind
Why take L Methylfolate 15mg + Vitamin B12 with Methyl?
Synthesis of mood-enhancing neurotransmitters (serotonin, dopamine, and norepinephrine) is regulated by L methylfolate, a derivative of folate10. L Methylfolate has demonstrated efficacy as an adjunctive treatment for individuals who have not responded optimally to antidepressant therapy2.
Supplementing with 15mg L methylfolate alongside SSRIs may be effective in improving symptoms of depression25. L Methylfolate is absorbed more efficiently than synthetic folic acid which must be converted to active folate by the enzyme methylenetetrahydrofolate reductase (MTHFR)13.
Hydroxy B12 works closely alongside folate in converting homocysteine to methionine to support mood and nervous system health. Individuals with MTHFR mutations may raise their nutrient status more efficiently with methylfolate11 and Hydroxy B1226.
Inositol may be effective in treating disorders responsive to selective serotonin reuptake inhibitors, including depression, panic disorders, and obsessive-compulsive disorder24.
L Methylfolate 15mg + Vitamin B12 with Methyl is 100% free from all fillers and additives.
Who is affected by MTHFR mutations?
The MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants). Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%). Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A>C polymorphism in Hispanics and Africans is 15%14.
An increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness15. MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses16.
For these people, L Methylfolate supplementation is shown to be the most effective way to provide this form of folate10.
Methyl-Life’s® L Methylfolate 15mg is an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.
Why Magnafolate® PRO?
Methyl-Life’s® L Methylfolate 15mg + Vitamin B12 with Methyl is made with the internationally-patented Magnafolate® PRO, clinically tested as the one of the purest L methylfolate brands (Magnafolate® PRO is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic® and Extrafolate®).
Magnafolate® is made with a form of L Methylfolate called L-5-MTHF-Ca, which is shown to be the most active form of folate in the plasma circulation. When compared with ordinary folate, L methylfolate was found to be absorbed faster and utilized more quickly in the body17.
A recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation18.
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1 https://pubmed.ncbi.nlm.nih.gov/20608755/
2https://pubmed.ncbi.nlm.nih.gov/23212058/
3https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687916/
4https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779227/
5https://www.ahajournals.org/doi/10.1161/hq0102.102190
6https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019735/
7https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867258/
8https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127769/
9https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832224/
10https://pubmed.ncbi.nlm.nih.gov/19193337/
11https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564482/
12https://cdn.shopify.com/s/files/1/0264/6369/9018/files/Methyl-Life_60-day_Methylfolate_Comparison.pdf?v=1595292111
13https://www.ncbi.nlm.nih.gov/books/NBK6561/
14https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630484
15https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530664/
16https://www.ahajournals.org/doi/10.1161/01.CIR.0000165142.37711.E7
17https://pubmed.ncbi.nlm.nih.gov/24032278/
18https://i.trade-cloud.com.cn/upload/6405/file/20210929/english-version-magnafolate-enhancing-immunity_524485.pdf
19https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262611/
20https://www.ahajournals.org/doi/full/10.1161/01.atv.18.3.356
21https://www.ncbi.nlm.nih.gov/books/NBK557632/#
22https://pubmed.ncbi.nlm.nih.gov/15896807/
23https://www.sciencedirect.com/science/article/abs/pii/S0924977X97004094?via%3Dihub
24https://pubmed.ncbi.nlm.nih.gov/8780431/
25https://www.tandfonline.com/doi/full/10.1080/24750573.2018.1552401
26https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312744/
CofA
CERTIFICATE OF ANALYSIS
Dosage
WARNING – How much is right for you to take?
Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step-by-step guide to some dosing options.
For optimal absorption, open the capsule and empty it under the tongue (hold it there and let it dissolve) – B12 is best absorbed via the mucous membrane in the mouth.
Dr. Amy Yasko (https://dramyyasko.com) recommends a specific form of B12 based on your genetics if you know the status of your COMT 158 and VDR Taq variants.
| COMT V158M | VDR Taq | B12 Types That Should Be Tolerated |
|---|---|---|
| – – | + + (TT) | All 3 types of B12 |
| – – | + – (Tt) | All 3 types of B12 with less vitamin B12 with methyl |
| – – | – – (tt) | Hydroxy B12 and Adenosylcobalamin |
| + – | + + | All 3 types of B12 with less vitamin B12 with methyl |
| + – | + – | Hydroxy B12 and Adenosylcobalamin |
| + – | – – | Hydroxy B12 and Adenosylcobalamin |
| + + | + + | Hydroxy B12 and Adenosylcobalamin |
| + + | + – | Hydroxy B12 and Adenosylcobalamin |
| + + | – – | Mostly Hydroxy B12 |
Video
SUPPLEMENT FACTS
| SUPPLEMENT FACTS | ||
|
Serving Size: 1 Veggie Capsule
|
||
| 30 servings per container | Amount per Serving | % Daily Value |
| Folate (as L-5-Methyltetrahydrofolate, Calcium [equal to 20,000 mcg of Magnafolate PRO®]) | 26,883 mcg DFE | 6,721% (Total) |
| Vitamin B12 (as Hydroxy B12) | 1,000 mcg | 41,667% (Total) |
| Inositol | 180 mg | ** |
PRODUCT CONTAINS NO: wheat, gluten, soy, dairy, egg, fish/shellfish, corn, yeast, nuts, starch, ingredients of animal origin, caffeine, artificial colorings, preservatives or artificial flavoring, bisphenol-A (BPA), or phthalate.
Research
FAQ'S
What is the right dosage for me?
Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.
What is L Methylfolate 15mg + Vitamin B12 with Methyl?
What are the benefits of L Methylfolate 15mg + Vitamin B12 with Methyl?
How can I get more information on MTHFR?
What is the Therapeutic high-dose of bioactive L-methylfolate?
What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?
The most important thing to realize is that blood tests for B12 are highly inaccurate at detecting actual cellular levels of B12 (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used.
What is L Methylfolate 15mg + Enhance Mood?
Methylfolate 15mg+ Enhance Mood is a highly bioactive form of folate made with the purest methylfolate available.
What are the key features of L Methylfolate 15mg + Enhance Mood?
My doctor said that because I have MTHFR, I should be taking vitamin B12 with methyl as my B12 form, why are you suggesting these other forms too?
One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, vitamin B12 with methyl or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called vitamin B12 with methyl, but that is simply NOT true.
It’s important to realize that the MTHFR status does not necessarily determine the type of B12 that’s best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that L methylfolate and vitamin B12 with methyl work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate L methylfolate well you’ll also need, want or tolerate vitamin B12 with methyl well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).
It seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.
The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxy B12, and from there the hydroxy B12 has to be converted into both adenosylcobalamin and vitamin B12 with methyl. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.
I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?
If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be Hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of Hydroxy B12 (and this is why our methylation protocol suggests Hydroxy B12 as the B12 form to begin with):
- Folks with multiple COMT mutations tend to do very well with Hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)
- Folks with MTR & MTRR mutations may do well with vitamin B12 with methyl & adenosylcobalamin supplementation
- And Dr. Amy Yasko (https://dramyyasko.com) talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:
| COMT V158M | VDR Taq | B12 Types That Should Be Tolerated |
|---|---|---|
| – – | + + (TT) | All 3 types of B12 |
| – – | + – (Tt) | All 3 types of B12 with less vitamin B12 with methyl |
| – – | – – (tt) | Hydroxy B12 and Adenosylcobalamin |
| + – | + + | All 3 types of B12 with less vitamin B12 with methyl |
| + – | + – | Hydroxy B12 and Adenosylcobalamin |
| + – | – – | Hydroxy B12 and Adenosylcobalamin |
| + + | + + | Hydroxy B12 and Adenosylcobalamin |
| + + | + – | Hydroxy B12 and Adenosylcobalamin |
| + + | – – | Mostly Hydroxy B12 |
