Sublingual B12 Tablets (as Hydroxy B12 - the rare bioavailable scavenger)
Methyl-Life’s® Sublingual B12 Hydroxy form B12 Tablets contain a rarer (but biologically active) form of B12. Bioactive just means that the B12 has already been converted into a form that your body’s methionine pathway can use immediately. The B12 does not need to be converted by your genes/enzymes in order to be available for use. B12 conversion can be a problem for people with MTR and MTRR gene mutations. Also, individuals with COMT defects can be at higher risk for accumulating too much peroxynitrites which builds up in their bodies, causing stiffness and muscle pain or “brain fog” and cardiovascular problems.
Think of hydroxy B12 as a scavenger that can “mop up” the peroxynitrites in the body and convert them back into methionine. This can be helpful for those suffering from Chronic Fatigue or Fibromyalgia.
Hydroxy B12 also helps the body:
- Detoxify
- Manufacture myelin sheath
- Promote neurotransmitters (for healthy brain function)
- Protects against anemia
- And much more
The small, sublingual form of Methyl-Life’s® Sublingual Hydroxy B12 tablets provides for maximum B12 absorption through the mucous membranes in the mouth. Did you know that recent research shows that taking B12 in a sublingual oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots? It's usually much more convenient and affordable as well - https://pubmed.ncbi.nlm.nih.gov/30632091
Methyl-Life’s® Sublingual Hydroxy B12 Tablets (bottle of 90 servings) are some of the most cost-effective versions of Hydroxy B12 available over-the-counter today. Read more information about the best forms of B12 to take.
Dosage
WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to one dosing option. Learn more about B12 and the best active forms to take.
Dr. Amy Yasko (https://dramyyasko.com) recommends a specific form of B12 based on your genetics if you know the status of your COMT 158 and VDR Taq variants.
| COMT V158M | VDR Taq | B12 Types That Should Be Tolerated |
|---|---|---|
| – – | + + (TT) | All 3 types of B12 |
| – – | + – (Tt) | All 3 types of B12 with less Methylcobalamin |
| – – | – – (tt) | Hydroxy B12 and Adenosylcobalamin |
| + – | + + | All 3 types of B12 with less Methylcobalamin |
| + – | + – | Hydroxy B12 and Adenosylcobalamin |
| + – | – – | Hydroxy B12 and Adenosylcobalamin |
| + + | + + | Hydroxy B12 and Adenosylcobalamin |
| + + | + – | Hydroxy B12 and Adenosylcobalamin |
| + + | – – | Mostly Hydroxy B12 |
How to snap the tablet in half – See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.
Video
SUPPLEMENT FACTS
Suggested Use: Consult with your healthcare practitioner before using this product. See methyl-life.com/dosage for more recommendations.
Bite tablet into pieces, and hold under tongue before ingesting.
KEEP THIS PRODUCT AWAY FROM PETS (contains xylitol).
| SUPPLEMENT FACTS | ||
|
Serving Size: 1 Chewable Tablet
|
||
| 90 servings per container | Amount per Serving | % Daily Value |
| Vitamin B12 (as Hydroxy B12 Acetate) | 2,500 mcg | 104,167% |
OTHER INGREDIENTS: xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavor (dextrose, silicon dioxide, natural flavor).
Not a significant source of total sugars.
Product Does NOT Contain: wheat, gluten, soy, dairy, tree nuts, animal products, GMOs. No artificial ingredients or colorings.
FAQ'S
What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?
The most important thing to realize is that blood tests for B12 are highly inaccurate at detecting actual cellular levels of B12 (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used.
What can you do if you have high B12 blood test results? Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).
What does sublingual mean and why isn’t your product labeled as “sublingual”?
My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too?
One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (Hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true.
It’s important to realize that the MTHFR status does not necessarily determine the type of B12 that’s best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).
It seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.
The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into Hydroxy B12, and from there the Hydroxy B12 has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.
I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?
If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be Hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of Hydroxy B12 (and this is why our methylation protocol suggests Hydroxy B12 as the B12 form to begin with):
- Folks with multiple COMT mutations tend to do very well with Hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)
- Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation
- And Dr. Amy Yasko talks (https://dramyyasko.com) about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:
| COMT V158M | VDR Taq | B12 Types That Should Be Tolerated |
|---|---|---|
| – – | + + (TT) | All 3 types of B12 |
| – – | + – (Tt) | All 3 types of B12 with less Methylcobalamin |
| – – | – – (tt) | Hydroxy B12 and Adenosylcobalamin |
| + – | + + | All 3 types of B12 with less Methylcobalamin |
| + – | + – | Hydroxy B12 and Adenosylcobalamin |
| + – | – – | Hydroxy B12 and Adenosylcobalamin |
| + + | + + | Hydroxy B12 and Adenosylcobalamin |
| + + | + – | Hydroxy B12 and Adenosylcobalamin |
| + + | – – | Mostly Hydroxy B12 |
What is Hydroxy B12?
Hydroxy B12 is a bioavailable form of vitamin B12 known for its excellent tolerability, commonly used in supplements like chewables to support energy production, nervous system health, and red blood cell formation.
How does Hydroxy B12 differ from other forms of vitamin B12?
Hydroxy B12 is considered one of the most well-tolerated forms of vitamin B12, offering sustained release and potentially longer-lasting benefits compared to other forms like cyanocobalamin.
How does Hydroxy B12 benefit the body beyond supporting B12 levels?
Hydroxy B12 offers additional advantages by aiding in detoxification, manufacturing the myelin sheath for nerve protection, promoting neurotransmitter production crucial for healthy brain function, protecting against anemia, and providing numerous other benefits essential for overall health and well-being.
Why choose Methyl-Life’s® Sublingual Hydroxy B12 Tablets?
Methyl-Life’s® Sublingual Hydroxy B12 Tablets offer exceptional value, providing one of the most cost-effective options for Hydroxy B12 supplementation available over-the-counter. For further guidance on selecting the best forms of B12, explore additional information to make informed decisions about your supplement choices.
How should I use Methyl-Life’s® Sublingual Hydroxy B12 Tablets?
Before use, it's advisable to consult with your healthcare practitioner. For dosage recommendations and further guidance, visit methyl-life.com/dosage. When taking the tablets, bite them into pieces and hold them under your tongue before swallowing for optimal absorption.
Sublingual B12: well-tolerated, bioavailable Hydroxy B12 Tablets
Did you know Sublingual B12 is more effective for treating B12 deficiencies than intramuscular shots? Try Methyl-Life®'s Sublingual B12 for extreme absorption.
Sublingual B12 Tablets (as Hydroxy B12 - the rare bioavailable scavenger)
Methyl-Life’s® Sublingual B12 Hydroxy form B12 Tablets contain a rarer (but biologically active) form of B12. Bioactive just means that the B12 has already been converted into a form that your body’s methionine pathway can use immediately. The B12 does not need to be converted by your genes/enzymes in order to be available for use. B12 conversion can be a problem for people with MTR and MTRR gene mutations. Also, individuals with COMT defects can be at higher risk for accumulating too much peroxynitrites which builds up in their bodies, causing stiffness and muscle pain or “brain fog” and cardiovascular problems.
Think of hydroxy B12 as a scavenger that can “mop up” the peroxynitrites in the body and convert them back into methionine. This can be helpful for those suffering from Chronic Fatigue or Fibromyalgia.
Hydroxy B12 also helps the body:
- Detoxify
- Manufacture myelin sheath
- Promote neurotransmitters (for healthy brain function)
- Protects against anemia
- And much more
The small, sublingual form of Methyl-Life’s® Sublingual Hydroxy B12 tablets provides for maximum B12 absorption through the mucous membranes in the mouth. Did you know that recent research shows that taking B12 in a sublingual oral form is more effective for treating B12 deficiencies than actually getting B12 intramuscular shots? It's usually much more convenient and affordable as well - https://pubmed.ncbi.nlm.nih.gov/30632091
Methyl-Life’s® Sublingual Hydroxy B12 Tablets (bottle of 90 servings) are some of the most cost-effective versions of Hydroxy B12 available over-the-counter today. Read more information about the best forms of B12 to take.
Dosage
WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to one dosing option. Learn more about B12 and the best active forms to take.
Dr. Amy Yasko (https://dramyyasko.com) recommends a specific form of B12 based on your genetics if you know the status of your COMT 158 and VDR Taq variants.
| COMT V158M | VDR Taq | B12 Types That Should Be Tolerated |
|---|---|---|
| – – | + + (TT) | All 3 types of B12 |
| – – | + – (Tt) | All 3 types of B12 with less Methylcobalamin |
| – – | – – (tt) | Hydroxy B12 and Adenosylcobalamin |
| + – | + + | All 3 types of B12 with less Methylcobalamin |
| + – | + – | Hydroxy B12 and Adenosylcobalamin |
| + – | – – | Hydroxy B12 and Adenosylcobalamin |
| + + | + + | Hydroxy B12 and Adenosylcobalamin |
| + + | + – | Hydroxy B12 and Adenosylcobalamin |
| + + | – – | Mostly Hydroxy B12 |
How to snap the tablet in half – See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.
Video
SUPPLEMENT FACTS
Suggested Use: Consult with your healthcare practitioner before using this product. See methyl-life.com/dosage for more recommendations.
Bite tablet into pieces, and hold under tongue before ingesting.
KEEP THIS PRODUCT AWAY FROM PETS (contains xylitol).
| SUPPLEMENT FACTS | ||
|
Serving Size: 1 Chewable Tablet
|
||
| 90 servings per container | Amount per Serving | % Daily Value |
| Vitamin B12 (as Hydroxy B12 Acetate) | 2,500 mcg | 104,167% |
OTHER INGREDIENTS: xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavor (dextrose, silicon dioxide, natural flavor).
Not a significant source of total sugars.
Product Does NOT Contain: wheat, gluten, soy, dairy, tree nuts, animal products, GMOs. No artificial ingredients or colorings.
FAQ'S
What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?
The most important thing to realize is that blood tests for B12 are highly inaccurate at detecting actual cellular levels of B12 (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used.
What can you do if you have high B12 blood test results? Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).
What does sublingual mean and why isn’t your product labeled as “sublingual”?
My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too?
One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (Hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true.
It’s important to realize that the MTHFR status does not necessarily determine the type of B12 that’s best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).
It seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.
The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into Hydroxy B12, and from there the Hydroxy B12 has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.
I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?
If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be Hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of Hydroxy B12 (and this is why our methylation protocol suggests Hydroxy B12 as the B12 form to begin with):
- Folks with multiple COMT mutations tend to do very well with Hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)
- Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation
- And Dr. Amy Yasko talks (https://dramyyasko.com) about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:
| COMT V158M | VDR Taq | B12 Types That Should Be Tolerated |
|---|---|---|
| – – | + + (TT) | All 3 types of B12 |
| – – | + – (Tt) | All 3 types of B12 with less Methylcobalamin |
| – – | – – (tt) | Hydroxy B12 and Adenosylcobalamin |
| + – | + + | All 3 types of B12 with less Methylcobalamin |
| + – | + – | Hydroxy B12 and Adenosylcobalamin |
| + – | – – | Hydroxy B12 and Adenosylcobalamin |
| + + | + + | Hydroxy B12 and Adenosylcobalamin |
| + + | + – | Hydroxy B12 and Adenosylcobalamin |
| + + | – – | Mostly Hydroxy B12 |
What is Hydroxy B12?
Hydroxy B12 is a bioavailable form of vitamin B12 known for its excellent tolerability, commonly used in supplements like chewables to support energy production, nervous system health, and red blood cell formation.
How does Hydroxy B12 differ from other forms of vitamin B12?
Hydroxy B12 is considered one of the most well-tolerated forms of vitamin B12, offering sustained release and potentially longer-lasting benefits compared to other forms like cyanocobalamin.
How does Hydroxy B12 benefit the body beyond supporting B12 levels?
Hydroxy B12 offers additional advantages by aiding in detoxification, manufacturing the myelin sheath for nerve protection, promoting neurotransmitter production crucial for healthy brain function, protecting against anemia, and providing numerous other benefits essential for overall health and well-being.
Why choose Methyl-Life’s® Sublingual Hydroxy B12 Tablets?
Methyl-Life’s® Sublingual Hydroxy B12 Tablets offer exceptional value, providing one of the most cost-effective options for Hydroxy B12 supplementation available over-the-counter. For further guidance on selecting the best forms of B12, explore additional information to make informed decisions about your supplement choices.
How should I use Methyl-Life’s® Sublingual Hydroxy B12 Tablets?
Before use, it's advisable to consult with your healthcare practitioner. For dosage recommendations and further guidance, visit methyl-life.com/dosage. When taking the tablets, bite them into pieces and hold them under your tongue before swallowing for optimal absorption.