Kid-Friendly, MTHFR-Safe Multivitamin with Advanced Nutrient Support

Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children

Regular price $42.00

This professional-grade chewable is designed for individuals navigating MTHFR variants and other genetic challenges. Formulated as a cherry-berry flavored tablet, it provides a concentrated "methylation core" to help manage homocysteine levels and promote cognitive energy.

  • Bioactive Methylation Core: Features 800 mcg of L-methylfolate (1,360 mcg DFE) and 333 mcg of Vitamin B12 (as hydroxy B12) per serving to support healthy methylation pathways
  • Pure Cerebrofolate®: Utilizing a highly stable, research-backed form of 5-MTHF that has shown favorable purity and stability metrics in laboratory assessments
  • Homocysteine Management: Designed to help reduce homocysteine-a key biomarker for cardiovascular and neurological wellness
  • Active B6 (P5P) & Riboflavin (Vitamin B2): Includes the active form of Vitamin B6 and high-dose Riboflavin to support the complex enzymatic reactions required for cellular energy
  • Bioavailable Trace Minerals: Formulated with Albion® chelates and liposomal zinc to ensure reliable mineral absorption

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Methyl-Life® Methylated Multivitamin is a comprehensive, bioactive formula designed to promote methylation balance, enhance cognitive clarity  and support cardiovascular wellness through healthy homocysteine metabolism.

Why Active Folate and Vitamin B12 Matter

  • L-Methylfolate: This "ready-to-use" form of folate uniquely crosses the blood-brain barrier to support pathways linked to mood and neurotransmitter synthesis. By providing 800 mcg of L-methylfolate (1,360 mcg DFE), this formula provides effective nutritional support for those with genetic variants that may impair standard folic acid metabolism.
  • Active Vitamin B12: Featuring Hydroxy B12, this formula works synergistically to optimize methylation efficiency, neurological health and cellular energy metabolism. High-dose B12 is particularly effective for correcting insufficiencies that can lead to fatigue.

Cardiovascular & Homocysteine Support

By supplying essential methyl groups, L-Methylfolate helps maintain balanced homocysteine levels, which is a key marker for vascular integrity and metabolic wellness. Vitamin B12 facilitates the conversion of homocysteine to methionine, further promoting cardiovascular health and optimal circulation. While lowering homocysteine is a primary lab target, it is most effective when used to support overall heart-healthy lifestyles.

Optimized for MTHFR Gene Variant Carriers

Many individuals carry MTHFR gene variants (such as C677T and A1298C) that may reduce the efficiency of converting folic acid into its active form. Methyl-Life® delivers these nutrients in their fully active states, bypassing metabolic conversion barriers to support DNA synthesis, methylation activity and cellular function. This ensures your body receives the bioactive folate it needs regardless of genetic challenges.

Research-Driven Support

Our formula is grounded in biochemical science, providing concentrated doses of the "Methylation Core" to maintain cognitive performance, emotional wellbeing and neurological resilience.

  • Enhanced Absorption: Includes P5P (Active B6) and Riboflavin (Vitamin B2) to act as essential co-factors in the methylation cycle.
  • Bioavailable Delivery: Utilizes high-quality Cerebrofolate® for superior stability and Albion® minerals for reliable absorption.
  • Cognitive Add-ons: Features specialized nutrients like Citicoline and NADH to support cellular energy and brain health.
Supplement Facts
Serving Size: 4 Chewable Tablets
Servings Per Container: 30 servings per container
Amount Per Serving Daily Value
Calories 14
Total Carbohydrate 3 g
1%**
Total sugars 3 g
(including added sugars)
7%**
Vitamin A 200 mcg RAE (667 IU)
(as Retinyl Palmitate)
22%
Vitamin D 33 mcg (1,333 IU)
(as Cholecalciferol (D3))
165%
Vitamin E 8 mg (12 IU)
(as d-α-Tocopheryl Acid Succinate)
53%
Thiamin 1 mg
(Vitamin B1) (as Thiamin HCI)
83%
Riboflavin 6 mg
(Vitamin B2) (as Riboflavin 5 Sodium Phosphate)
462%
Niacin 14 mg NE
88%
Vitamin B6 3 mg
(as Pyridoxal 5 Phosphate)
176%
Folate 1,360 mcg
(800 mcg L-Methylfolate [from 1 mg of Cerebrofolate®])
340%
Vitamin B12 333 mcg
(as Hydroxocobalamin Acetate)
13,875%
Biotin 40 mcg
133%
Pantothenic Acid 5 mg
(as [Vitamin B5] D-Calcium Pantothenate)
100%
Iodine 56 mcg
(as Potassium Iodide)
37%
Zinc 12 mg
(as Liposomal Zinc Oxide)
109%
Selenium 67 mcg
(Selenium Glycinate (ALBION))
122%
Manganese 2 mg
(Manganese Bisglycinate Citrate (ALBION))
87%
Molybdenum 13 mcg
(Molybdenum Glycinate (ALBION))
29%
Artichoke 33 mg
(Leaf - Cynara scolymus L.) (Extract 5% Cynarin)
Citicoline Sodium 33 mg
Ubiquinol 10 mg
(CoQ10 Reduced Form)
Phosphatidylserine 7 mg
(Sunflower - Helianthus annuus)
Milk Thistle 33 mg
(Seed - Silybum marianum L.) (Extract 80% Silymarin)
Pantethine 14 mg
Para-Amino Benzoic Acid 7 mg
(PABA) (Vitamin B10)
Benfotiamine 16 mg
(Fat Soluble Vitamin B1)
NADH 1 mg
(Microencapsulated NADH)
Vitamin K2 68 mcg
(as Menaquinone-7)
† Daily Value not established.
** Percent Daily Values are based on a 2,000 calorie diet.
Manufactured: June 2025

Methyl-Life® supplements typically retain their potency for 2-3 years. They should be stored in their original, tightly sealed containers in a cool, dry place away from heat, moisture, and direct sunlight.

Other Ingredients: Medium Chain Triglycerides (MCT), Xylitol (Xylisorb®), natural flavor, sodium stearyl fumarate (PRUV®), malic acid, citric acid anhydrous, xanthan gum, EMDEX®. Not a significant source of sugars.

Allergen & Safety Information

We prioritize purity and transparency to support those with sensitive systems or specific dietary requirements.

  • Free From Top 14 Allergens: Our formula contains no wheat, gluten, soy, dairy, tree nuts or animal products.
  • Clean Label Standards: Non-GMO and free from artificial ingredients, colorings or additives.
  • Pet Safety Warning: Contains Xylitol (Sweetened with xylitol), which is highly toxic to dogs and other pets. Store securely away from animals.
  • Medical Interaction Note: Includes Vitamin K2 (MK-7), which may interact with anticoagulant medications like Warfarin. If you are taking blood-thinning medication, consult your healthcare provider before use.
  • Zinc & Iodine Notice: If used for children, ensure the total daily intake from all sources does not exceed pediatric upper limits (UL), particularly for zinc.

Because every individual’s genetic makeup and "methylation tolerance" is unique, we recommend a "Start Low, Go Slow" approach to ensure your body acclimates comfortably to these high-potency bioactive nutrients. Visit our Dosage Information and Methylation Protocol pages to learn what some practitioners recommend, including step-by-step guidance for individuals with MTHFR gene variants.

Finding Your Ideal Serving

While the label serving is 1 to 4 tablets daily, your personal needs may vary based on your specific MTHFR variant (such as C677T or A1298C) and current nutrient status.

  • Step 1: The Introductory Dose (Days 1-7) Start with ½ to 1 chewable tablet daily. This allows you to monitor how your system responds to the concentrated B12 and active folate.
  • Step 2: Gradual Titration (Weeks 2-4) If you feel well, gradually increase by ½ tablet every 5-7 days until you reach the target dose recommended by your healthcare provider.
  • Step 3: Maintenance Most individuals find their "sweet spot" at 1-2 tablets daily for long-term support of homocysteine levels and cognitive energy.

Pro-Tips for Successful Dosing

  • Precision Splitting: Our tablets are designed to be easily split. Use a dedicated tablet splitter for the most accurate half-doses. Watch the full demonstration in our tablet-splitting video.
  • Timing Matters: For optimal absorption and to support natural daytime energy, take your serving in the morning or early afternoon with food.
  • Monitor for "Over-Methylation": If you experience temporary anxiety, restlessness or trouble sleeping, scale back your dose and consult your practitioner. This is often a sign your body is processing nutrients faster than your pathways can keep up.

Why L-Methylfolate + Vitamin B12 Matters

Methyl-Life® delivers a therapeutic-strength, bioactive dose of the body’s most usable folate form, L-Methylfolate (L-5-MTHF), combined with Active Vitamin B12. Unlike synthetic folic acid, which requires multiple enzymatic steps for conversion, this "ready-to-use" folate directly supports the methylation processes vital for cellular function, neurological clarity and healthy homocysteine metabolism to promote cardiovascular and metabolic wellness.

The concentrated strength provides effective support for individuals with moderate folate and B12 needs-including those with MTHFR gene polymorphisms seeking balanced methylation, cognitive performance and mood support. This formulation ensures optimal nutrient availability for daily wellness without exceeding standard therapeutic recommendations.

Scientifically Supported Benefits

Discover how this advanced supplement combines the most bioactive forms of folate and Vitamin B12 to support neurological clarity, cardiovascular balance and cellular vitality through key biochemical pathways.

  • Supports Emotional Balance and Wellbeing: L-Methylfolate provides essential methyl groups that help sustain neurochemical pathways linked to mood and resilience. When combined with Vitamin B12, this formula offers nutritional support for emotional wellness, particularly for individuals with higher folate needs or genetic variations influencing folate metabolism.
  • Promotes Cognitive Clarity and Brain Vitality: By contributing to DNA synthesis and methylation, this blend supports memory, learning and focus. The combination of active folate and Vitamin B12 helps maintain cognitive performance and long-term neurological wellness by addressing potential B-vitamin insufficiencies.
  • Supports Cardiovascular and Homocysteine Balance: Balanced homocysteine levels are closely tied to cardiovascular and metabolic wellness. L-Methylfolate, alongside Vitamin B12, supports the conversion of homocysteine to methionine, helping maintain vascular function and overall systemic wellness.
  • Facilitates Methylation and Cellular Energy: Folate and Vitamin B12 work together to provide methyl groups essential for gene regulation and energy metabolism. This synergy supports cellular detox pathways, metabolic efficiency and overall balance.
  • Supports Genetic and Metabolic Efficiency: For individuals with MTHFR polymorphisms, this formula delivers active, ready-to-use nutrients that bypass conversion steps, helping sustain methylation pathways and nutrient utilization.
  • Nourishes Neurological Wellness: Folate and Vitamin B12 play key roles in neurological performance, contributing to healthy signaling and structural support for long-term nervous system function.

Nutritional Relevance

What sets this product apart is its use of the comparison-study proven Cerebrofolate ®-a premium, ultra-pure form of L-Methylfolate known for its potency, purity and reliable absorption. Rigorous manufacturing standards ensure every batch meets high levels of stability and consistency, delivering a supplement free from unnecessary fillers or additives. This advanced formula supports methylation balance, cognitive clarity, cardiovascular wellness and overall cellular vitality, making it a valuable part of daily nutritional routines.

HOW WE HAVE HELPED OUR CUSTOMERS

Martha B.

Verified Buyer
04/26/2025
Excellent!

I take no other vitamin. I have suffered for years with MTHFR and finally figured it out. These vitamins help me so much! They taste great and dissolve easily. I definitely recommend!

HOW WE HAVE HELPED OUR CUSTOMERS

Kate

Verified Buyer
03/23/2024
Incredible results

My son was diagnosed with ADHD at a young age. We tried everything, even resorted to medication. This product has calmed his nervous system, and given him a clarity and calm he has never experienced with anything else. He is thinking clearly, able to complete tasks, and it has significantly reduced his impulsivity. 10/10 recommend this supplement.

HOW WE HAVE HELPED OUR CUSTOMERS

Roberta K.

Verified Buyer
11/04/2025
Real Experience

I was suffering from severe fatique. Was diagnosed with MTHFR gene mutation in 2017. Have tried all vitamins and minerals suggested including magnesium and B-12's, folate NAC, and glutathione. Did improve dramatically after being told I had this gene mutation and was prescribed the above (had special B-12 test to determine if I was metabolozing Vit B which of course I wasn't). However, my Vit B is high again and I tried the L-Methyfolate Active B12. I feel like I am on steroids. My brain is so much more alive and I am finally able to do some of my housework and outside job work that I was unable to do. Thanks for the recommendation.

HOW WE HAVE HELPED OUR CUSTOMERS

Sandy A.

Verified Buyer
03/31/2023
Such a relief

I started this Vitamin, 6 months after finding out I have the MTHFR and the COMT gene, my doc put me on a fu dose of L-methofolate and I came crashing down :( Thank god for my own research and finding out I had every symptom of being OVER methylated . I’m 100% better after starting this yummy vitamin that my body is craving each day. My long term circulation problems are no longer with me !! Thank you for this product. I will forever be grateful because I have my life back - finally !

HOW WE HAVE HELPED OUR CUSTOMERS

Jennifer F.

Verified Buyer
04/17/2022
Very Effective Multi

I have taken countless multi vitamins and/or other types of supplements throughout the years and nothing has ever given me the results this multi does! I don’t know how I stumbled upon this, but it turned out to be a blessing! My anxiety is diminished, I am happier, my hair grows quicker and thicker, my skin glows, my energy soars, my mind is sharper! This stuff is the bomb.com! I never tout anything, but this I will make an exception for! I hope anyone trying this gets to experience the same great life changing results I have!

HOW WE HAVE HELPED OUR CUSTOMERS

Janet

Verified Buyer
09/12/2025
Real Experience

My physician recommended the methylated multivitamin and I have been very pleased with this chewable vitamin. The vitamin has a great taste, too.

Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children
$42

Updated Methylated Multi – Now with Even More Effective Support

At Methyl-Life®, we’re always working to improve our products so they can better support your health and well-being. Our latest Methylated Multi formula includes several carefully considered upgrades:

Upgraded Vitamin B5 - We’ve replaced some pantothenic acid with pantethine, a premium, bioactive form that offers improved absorption and supports cardiovascular and other key metabolic processes.

Chromium Removed - Following expert recommendations, we’ve eliminated chromium due to emerging concerns about potential metals toxicity.

Superior CoQ10 Form - We’ve replaced CoQ10 with ubiquinol, its most active and bioavailable form. This upgrade bypasses the genetic conversion step required for standard CoQ10, making it more effective for everyone.

Enhanced NADH - We’ve incorporated a more potent form of NADH to better support cellular energy production.

Binder Upgrade - We’ve replaced our xylitol-based binder with a new blend made from glucose monohydrate and polysaccharides which are essentially glucose and starch. This new binder offers an improved potency delivery system that is more aligned with out commitment to quality.

These refinements are part of our ongoing commitment to use the most effective and highest-quality ingredients available so you can feel confident you’re giving your body the very best.

Everything else you trust about the formula remains the same.

Full-spectrum methylated B vitamins, bioactive nutrient forms, and no compromises.

Traceable Ingredients You Can Trust

Every ingredient is sourced for purity, backed by clinical evidence, and rigorously tested for safety and bioavailability. Because in supplements, not all ingredients are created equal — and your body deserves only the most effective forms.

B12 for Brain & Nerve Health

B12 for Brain & Nerve Health

Adenosylcobalamin (Vitamin B12)

This mitochondria-targeted B12 powers your cells where energy is made — supporting memory, myelin formation, and neurological function. Perfect for those seeking deep cellular support.

Did You Know?

Adenosylcobalamin is one of the two metabolically active coenzyme forms of B12 and the only one directly used by mitochondria. It’s critical for the conversion of methylmalonyl-CoA to succinyl-CoA, a step essential in energy metabolism. In individuals with neurological conditions or degenerative diseases, this form has been associated with better nerve repair, protection against demyelination, and cognitive support PubMed.

Source: Adenosylcobalamin & Neurological Function – PMC7231506

B12 for Energy, Detox & Methylation

B12 for Energy, Detox & Methylation

Hydroxy B12 (Vitamin B12)

A highly absorbable B12 form ideal for people with methylation or absorption issues. Supports healthy energy levels, red blood cell formation, and detoxification without overstimulation.

Have You Heard?

Hydroxy B12 is a preferred B12 form in clinical settings because of its extended retention time and ability to convert efficiently into both active forms of B12: methylcobalamin and adenosylcobalamin. It also acts as a nitric oxide scavenger, supporting detoxification and cellular protection — especially valuable in individuals with oxidative stress or MTHFR-related impairments Clinical data.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235814/

Supports Methylation, Mood & Cellular Health

Supports Methylation, Mood & Cellular Health

L–5–Methyltetrahydrofolate Calcium (as Calcium – Cerebrofolate®)

The centerpiece of this formula is Cerebrofolate® — a next-generation, ultra-pure form of L-Methylfolate designed for unmatched purity, potency, and bioavailability. Unlike folic acid or less stable folate compounds, Cerebrofolate® is ready-to-use, bypassing the MTHFR enzymatic block to directly support neurological, cardiovascular, and methylation pathways.

Cerebrofolate® delivers >80% free methylfolate, offering superior absorption and immediate usability compared to many other folate sources. Unlike synthetic folic acid, Cerebrofolate® does not contribute to unmetabolized folic acid accumulation, which has been associated with reduced immune efficiency and masking of B12 deficiency. L-Methylfolate supports much more than mood — it is vital for DNA synthesis and repair, detoxification, and healthy red blood cell formation. For those with MTHFR gene variants, Cerebrofolate® provides a direct pathway to active folate, helping maintain methylation efficiency and neurotransmitter support.

Backed by research: PMC3869616, PubMed 23212058, PMC5385290

Clinically tested and formulated for superior purity, this bioactive form of folate bypasses genetic mutations (like MTHFR) and goes straight to work — supporting neurotransmitters, DNA repair, and a healthy mood balance.

Did You Know?

L-Methylfolate is a biologically active form of folate that the body can readily use. It supports natural processes related to neurotransmitter synthesis, including those involving serotonin, dopamine, and more. It also plays a role in homocysteine metabolism and cellular function. For individuals seeking a form of folate that doesn't require complex conversion steps, L-Methylfolate may offer a more efficient nutritional option.* Source

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Methyl-Life® Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children contains no unnecessary excipients, synthetic colors, artificial preservatives, or common allergens. It is 100% free from gluten, soy, dairy, GMOs, animal-derived ingredients, and the EU’s top 14 allergens.

Every batch is third-party tested for purity, potency, and safety, manufactured in NSF-certified, cGMP-compliant facilities, and rigorously evaluated to ensure you’re getting clean, clinical-grade nutrients — nothing more, nothing less.

EU’s top 14 allergens

  • Cereals containing gluten - wheat (such as spelt and khorasan wheat), rye, barley, oats. Note: The cereal name, e.g., 'wheat', must be declared and highlighted, not 'gluten'.
  • Crustaceans, e.g., crabs, prawns, lobsters
  • Eggs
  • Fish
  • Peanuts
  • Soybeans
  • Milk
  • Nuts (almonds, hazelnuts, walnuts, cashews, pecan nuts, brazil nuts, pistachio nuts, macadamia/Queensland nut). Note: The name of the nut, e.g., 'almond', must be declared and highlighted, not 'nuts'.
  • Celery
  • Mustard
  • Sesame seeds
  • Sulphur dioxide and sulphites (at concentrations of more than 10 mg/kg or 10 mg/L in terms of total sulphur dioxide) – used as a preservative
  • Lupin 
  • Molluscs, e.g., mussels, oysters, squid, snails
Cognitive, Cardiovascular and Cellular Wellness

Comprehensive Methylation Support for Cognitive, Cardiovascular and Cellular Wellness

Methyl-Life® Chewable Methylated Multivitamin delivers a bioavailable dose of L-5-MTHF combined with high-potency active Vitamin B12. Designed to support methylation efficiency, cognitive clarity, emotional wellness and cardiovascular balance, this delicious cherry-berry chewable is ideal for individuals with MTHFR variants or those seeking a flexible, family-friendly option for genetic nutritional support.

Advanced Methylation Support for Cognitive, Cardiovascular and Cellular Wellness

This advanced formula provides 800 mcg of L-Methylfolate (1,360 mcg DFE) alongside 333 mcg of Hydroxy B12-a high-dose combination designed to optimize the methylation cycle. The product supports neurochemical pathways linked to focus and energy, contributes to balanced homocysteine metabolism for cardiovascular wellness, and promotes DNA methylation activity. Its chewable format allows for easy dose adjustments, making it particularly well-suited for both adults and children with unique metabolic needs.

It is particularly well-suited for individuals with MTHFR gene variants or those requiring concentrated folate and B12 support for neurological and cardiovascular wellness. Rigorous manufacturing standards and third-party testing ensure purity, stability and consistency in every batch, delivering a supplement free from unnecessary fillers.

Research Insights

  • Folate and Vitamin B12 supplementation is a proven method for reducing homocysteine levels, supporting long-term vascular and metabolic wellness.
  • L-Methylfolate is the bioactive form of folate that bypasses metabolic bottlenecks, ensuring immediate nutrient availability regardless of MTHFR status.
  • High-dose Vitamin B12 (333 mcg) provides critical support for individuals with absorption challenges, helping to maintain neurological health and cellular energy.
  • Comprehensive formulas containing the "methylation core" (B6, B12 and Folate) are essential for proper DNA synthesis and gene regulation.

Superior Bioavailability of Active Nutrients

This formula combines the most bioactive and readily usable forms of key nutrients. It features Cerebrofolate®, a Type I crystalline calcium salt of L-5-MTHF that is engineered for superior stability and purity compared to standard amorphous forms. Paired with Hydroxocobalamin and liposomal minerals, this multivitamin provides nutrients in forms the body can efficiently recognize and absorb.

Research Insights

  • L-5-MTHF (Cerebrofolate®) is chemically identical to the body's natural folate and is proven to be more stable than generic alternatives.
  • Hydroxy B12 is an effective oral form of Vitamin B12 that can support systemic levels similarly to traditional injections in many contexts (PMC6494183).
  • Liposomal and chelated minerals (like Albion® Zinc and Selenium) are utilized for their enhanced absorption and gentleness on the digestive system.
  • Active folate crosses the blood-brain barrier to support neurotransmitter synthesis, a critical step for maintaining cognitive and emotional health (PMC10490031).
Simple blue icon of a pill capsule and tablet.

Why Choose the Chewable Multivitamin?

The Methyl-Life® Chewable Multivitamin offers a flexible and comprehensive alternative to high-dose single-nutrient tablets. It goes beyond standard folate supplementation by providing a full spectrum of active B-vitamins, minerals and synergistic "brain-boosters" like Citicoline and NADH in a convenient, tasty format. This level of support is ideal for those who carry MTHFR variants, which can impair the body’s ability to utilize standard folic acid.

Research Insights

  • Serum B12 testing can sometimes be misleading; maintaining high-potency intake ensures functional B12 status is supported across various metabolic markers.
  • Bioactive nutrients like P5P (active B6) and high-dose Riboflavin (vitamin B2) serve as essential cofactors to keep the methylation cycle moving efficiently.
  • For individuals sensitive to "over-methylation," the use of Hydroxy B12 provides a stable, non-methylated precursor that the body converts as needed.
  • Chewable delivery offers a practical solution for those with pill fatigue or difficulty swallowing, ensuring consistent daily support for nutrient-dependent pathways.

Supporting Neurological and Emotional Wellness

The combination of high-potency L-Methylfolate and Vitamin B12 provides foundational cofactors for neurochemical cycles that influence cognitive clarity, focus,and emotional resilience. By supporting efficient methylation, this formula also helps maintain healthy homocysteine levels, a factor associated with long-term neurological performance and brain health (PMC8000524).

Research Insights

  • Correcting B-vitamin insufficiencies is a primary strategy for supporting mental energy and reducing the risk of cognitive decline related to high homocysteine.
  • Synergistic ingredients like Citicoline and Phosphatidylserine are included to complement the B-vitamin core in supporting brain vitality (PMID:35889920).
  • Efficient methylation is linked to the production of glutathione, the body's master antioxidant, which is vital for cellular defense.
  • Bioactive folate and B12 play a role in maintaining the myelin sheath, which is essential for healthy nerve signaling and communication (PMC12566604).

Frequently Asked Question

Why is the Vitamin B12 dose so much higher than the Daily Value?
The 13,875% DV of Vitamin B12 (333 mcg) is designed for individuals who have difficulty absorbing B12 or those with higher metabolic demands due to MTHFR variants. While this looks like a large number, B12 has a very low toxicity profile and your body naturally excretes what it doesn't need. This high concentration ensures that even those with absorption challenges receive an effective dose.
I see Citicoline and Ubiquinol on the label-what do they do?
These are "synergistic add-ons" designed to support cellular energy and brain health. Citicoline supports neurotransmitter levels for focus, while Ubiquinol (the active form of CoQ10) provides antioxidant support for the mitochondria-the "powerhouses" of your cells.
Is this product safe for long-term use?
Yes, this multivitamin is formulated for daily, long-term support of nutritional status and homocysteine balance. However, because it contains potent doses of minerals like Zinc and Selenium, we recommend periodic blood testing with your doctor to ensure your levels stay within your personal "optimal zone".
How should I take this for the best results?
For maximum absorption, take your chewable tablets with a meal that contains a small amount of healthy fat. This helps your body utilize fat-soluble vitamins like A, D3, E and K2.
What is Cerebrofolate® and why is it used here?
Cerebrofolate® is a high-purity, Type I crystalline form of L-Methylfolate. Unlike standard folic acid, which many people cannot process efficiently, Cerebrofolate® is "body-ready". It is specifically chosen for its stability and its ability to directly support the methylation cycle and cross the blood-brain barrier.
Why use Hydroxocobalamin instead of Methylcobalamin?
Hydroxocobalamin is a unique "precursor" form of B12. It is often preferred for those who are sensitive to "methyl donors" or who experience jitters and anxiety from standard methyl-B12. Your body converts it into the active B12 forms it needs at its own pace.
Does this contain any artificial sweeteners or allergens?
No. This formula is sweetened with Xylitol, a tooth-friendly, low-glycemic sweetener. It is free from the Top 14 allergens, including gluten, dairy and soy. Note: Xylitol is toxic to dogs, so please keep this bottle away from pets.
Can this help with "Brain Fog"?
This formula provides the essential B-vitamins, NADH and Citicoline that support healthy neurological signaling and energy production. Supporting your methylation cycle is a foundational step in maintaining cognitive clarity and mental energy.

Understanding DFE Labeling for Methylfolate

What the New Numbers on Your Label Mean - and Why They Haven’t Changed Your Dose

When it comes to folate supplements, labels can be misleading - not because the formulas are different, but because the rules have changed. In this video, Jamie from Methyl-Life® explains the FDA’s new requirement to use Dietary Folate Equivalents (DFE) and what that means for how folate is reported on supplement labels.

What’s this video about?: How the new FDA labeling standards affect folate supplements - and why your formula hasn’t changed, even if the number on the label looks much higher.

Methyl-Life® Methylated Multivitamin Review: Methylfolate, Methylcobalamin & More

Why the Methylated Multivitamin is designed to promote optimal methylation in the body, especially for those with MTHFR

Discover the benefits of Methyl-Life®’s Methylated Multivitamin with Jamie Hope, founder of Methyl-Life®. In this video, Jamie introduces a delicious chocolate raspberry chewable multivitamin, specially formulated for people with MTHFR and methylation challenges. Learn how this unique supplement supports optimal methylation, energy production, antioxidant levels, and neurotransmitter health with premium, bioactive ingredients.

Why Folate Labels Now Use DFE

The FDA now requires that all folate-containing supplements list folate content in mcg DFE to account for how much folate is actually absorbed by the body, based on food-based folate sources.

  • Folic acid × 1.7 = mcg DFE
  • Methylfolate × 1.7 = mcg DFE

This change reflects differences in bioavailability. Synthetic folic acid, for example, has ~85% bioavailability when taken with food. Natural, whole-food-based folate has ~50% bioavailability. The DFE unit helps consumers understand how much usable folate they’re getting compared to whole foods.

Example:

  • A supplement with 1,000 mcg folic acid will now be labeled as 1,700 mcg DFE.
  • A supplement with 15,000 mcg L-Methylfolate will now show 25,500 mcg DFE (or more, depending on the purity and form used).

But this is not an increase in the dose - just new math to reflect body-usable folate content.

Why This Matters for Methyl-Life® Users

Methyl-Life® uses L-5-Methyltetrahydrofolate (L-Methylfolate) - a bioactive form of folate that does not require MTHFR activity. Even though it’s more effective and better absorbed than folic acid, the FDA still requires methylfolate products to use the same 1.7 multiplier for DFE calculations.

So if your bottle used to say 15,000 mcg of L-Methylfolate and now it says 25,500 mcg DFE, the dose hasn’t changed - the math has. You're still receiving 15 mg of pure L-Methylfolate, now labeled using the updated DFE mcg format.

Why the DFE Conversion Matters Less Than the Form

DFE was designed around folic acid absorption. But Methyl-Life® uses methylfolate, which already comes in its active form and offers superior uptake - especially for those with MTHFR gene mutations.

This is supported by evidence showing that L-Methylfolate:

So while labeling has changed, nothing has changed in your supplement’s clinical performance.

Recap: DFE Labeling Doesn’t Change the Dose

  • DFE stands for Dietary Folate Equivalent, a unit created to reflect folate’s usable potency compared to whole-foods-based absorption levels
  • The formula is exactly the same - only the label has changed
  • Methyl-Life® continues to deliver clinically studied L-Methylfolate at the same high potency, now labeled to meet FDA guidelines
  • You do not need to recalculate your dose or change your usage