CALMING Your Stress Naturally with the Best GABA Supplement - Methyl-Life® Supplements
CALMING Your Stress Naturally with the Best GABA Supplement - Methyl-Life® Supplements
CALMING Your Stress Naturally with the Best GABA Supplement - Methyl-Life® Supplements
CALMING Your Stress Naturally with the Best GABA Supplement - Methyl-Life® Supplements
CALMING Your Stress Naturally with the Best GABA Supplement - Methyl-Life® Supplements
CALMING Your Stress Naturally with the Best GABA Supplement
Gluten-Free Dairy-Free No Artificial Additives Vegan-Friendly Non-GMO BPA-Free Top 14 Allergen-Free
Promotes Resilience, Relaxation & Emotional Balance

CALMING Your Stress Naturally with the Best GABA Supplement

Manage anxiousness through natural nutrients that help both the mind & body chill out fast! GABA, together with Saffron, NAC, Phosphatidylserine, Zinc & Choline are a great combo for inviting a state of soothe & relax.
  • GABA + Saffron for natural mood and nervous system support
  • NACET, Zinc, and Phosphatidylserine to promote relaxation, detox, and focus
  • Choline to help fuel brain resilience and cognitive balance
  • 3rd-Party Tested for Purity, Potency & Safety

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  • Targeted Nutritional Support for Stress, Mood & Mental Clarity
    Methyl-Life’s® CALMING for Mind & Body Balance is a synergistic, fast-acting blend of clinically studied ingredients designed to help the mind and body relax, restore, and regain clarity. Whether you're dealing with everyday anxiousness, mental overstimulation, or an overactive stress response, this formula offers natural, non-habit-forming support without prescription interventions.
  • Neuro-Calming Nutrients for Mood & Emotional Regulation
    This targeted formula combines GABA, Saffron, and NACET — each studied for their role in supporting calmness, resilience, and emotional equilibrium. These ingredients help regulate neurotransmitters like GABA, dopamine, and serotonin, promoting a relaxed mental state and reducing overstimulation tied to elevated glutamate, cortisol and nervous system fatigue.
  • Supports a Healthy Stress Response & Cortisol Balance
    With Phosphatidylserine to support cognitive performance and cortisol regulation, and Choline + Zinc to nourish brain cell membranes and combat inflammation, CALMING supports mental focus and mood clarity even in high-pressure environments. This formula is ideal for those needing daily nervous system resilience or recovery from high mental load.
  • No Pharmaceutical Conversion Steps Required
    Unlike synthetic interventions, this formula relies on biologically active nutrients that the body can use right away. This makes CALMING a smart choice for those seeking a clean, well-tolerated option to support emotional balance and cognitive function — especially for individuals with genetic variants or sensitivities impacting neurotransmitter production.
Supplement Facts
Serving Size: 1
Servings Per Container: 60
Amount Per Serving % Daily Value
Zinc 11 mg
(encapsulated zinc oxide micro-release pellet) 		100%
NACET 60 mg
(N-Acetyl-L-Cysteine Ethyl Ester) 		†
Gamma Amino Butyric Acid 72 mg
(GABA) 		†
Citicoline 45 mg
(Sodium Citicoline) 		†
Phosphatidylserine 45 mg
 †
Saffron (Stigma) Extract 10 mg
(Crocus sativus, 3% Crocins) 		†
† Daily Value not established

Other Ingredients:
Vegetable capsule (hypromellose, purified water).
Free from unnecessary excipients, synthetic colorings, artificial preservatives, and flavorings.

Allergen & Safety Information

  • Does NOT contain: wheat, gluten, soy, dairy, tree nuts, animal products, GMOs, or artificial ingredients.
  • Free from the EU’s top 14 allergens.*
  • Manufactured in the USA in NSF-certified, cGMP-compliant facilities.
  • Every batch is third-party tested for purity, potency, and safety.

Suggested Use

Take 1 capsule as needed, ideally when feeling overwhelmed, overstimulated, or emotionally activated. For deeper relaxation, an additional capsule may be taken after assessing initial response. May be used daily or situationally depending on individual needs. Can promote rest, so consider trying it before bed. Always consult your healthcare provider before introducing new supplements into your routine.

How much should you take?

Every person’s stress threshold and nervous system sensitivity is different. CALMING for Mind & Body Balance is designed to be flexible — allowing individuals to take 1 capsule as needed, with the option to increase if additional calm is desired.

This dosage offers a balanced, moderate-strength serving of NACET along with gentle amounts of GABA and Saffron as well as supporting nutrients to help manage daily stress or more acute moments of emotional tension.

Doctor-Guided Support

We recommend speaking with your healthcare provider before adding new supplements to your routine — especially if you’re managing mood health, cognitive fatigue, or using prescription medications. CALMING can also be used as part of a broader nutritional resilience protocol for nervous system and mental wellness support.

Flexible Use for Stressful Moments or Daily Balance

Some individuals take 1 capsule situationally (e.g., during a stressful event, public speaking, emotional tension, trouble with sleep). Others incorporate it into their daily routine to maintain focus, calm, and mood clarity throughout the day. If needed, an additional capsule may be taken after assessing your personal response.

Additional Considerations

  • Best taken with water. Best taken with food.
  • For best evening results (e.g. to support restful sleep), consider combining with a highly bioavailable form of magnesium.
  • This supplement may promote mild drowsiness in sensitive individuals. Avoid driving or operating machinery until you know how it affects you.

Why CALMING for Mind & Body Balance Matters

In today’s high-pressure world, chronic stress can dysregulate the nervous system — impairing mood, sleep, focus, and even immune function. Methyl-Life’s® CALMING formula is built with science-backed nutrients that support the neurotransmitters responsible for resilience, calm, emotional clarity and that ‘chill factor’ we all want more of in this day and age.

Each ingredient was selected for its clinically studied role in modulating brain signaling pathways tied to stress response, inflammation, and mental balance — without relying on prescription-based interventions.

GABA, Saffron & Choline: Natural Mood and Neurotransmitter Balance Support

GABA is the brain’s primary calming neurotransmitter — responsible for slowing neural overactivity and helping the mind return to baseline during times of heightened stress. Supplementation with GABA may help buffer the effects of elevated glutamate and cortisol and promote a more relaxed, clear-headed state.
Reference: PMC7527439 – GABA supplementation and relaxation-related brain activity

Saffron, a spice-derived extract rich in crocins and safranal, has been shown in clinical studies to support mood and emotional resilience. It helps regulate serotonin, dopamine, and GABA levels, while reducing oxidative stress and inflammation in the brain.

Choline helps regulate brain glutamate levels by enhancing uptake and reducing excess release, supporting neuroprotection and promoting emotional balance and cognitive focus.
References:

  • PMC7882499 – Saffron extract and mood balance
  • PMC7573929 – Neuroprotective effects of saffron in mood and cognition
  • PMID15686962 – Neuroprotection and glutamate regulation by choline

NACET: Next-Gen Antioxidant Support for Brain and Detox Pathways

N-Acetylcysteine Ethyl Ester (NACET) is a highly bioavailable, lipophilic form of N-acetylcysteine (NAC) that efficiently crosses cell membranes and the blood–brain barrier. Once inside cells, NACET is converted to NAC and cysteine — precursors essential for producing glutathione, the body’s master antioxidant. Compared to NAC, which has low oral bioavailability (~3–6%), NACET offers dramatically improved absorption (around 60–80%) and greater intracellular delivery, particularly in brain tissue. This allows NACET to more effectively boost glutathione levels, help maintain balanced glutamate activity, modulate inflammatory responses, and protect neural cells from oxidative stress that can impact mood steadiness and mental performance.

While human clinical research on NACET is emerging, existing studies highlight its superior ability over NAC to enhance glutathione synthesis and antioxidant defenses at the cellular level — including in the brain. The extensive NAC research base supports the importance of glutathione restoration for oxidative balance, healthy neurotransmitter activity, and overall brain resilience, positioning NACET as a promising next-generation option for mind and body wellness.

References:

  • Superior antioxidant and pharmacokinetic properties of NACET compared to NAC, including brain glutathione boosting (PMC7827200)
  • NACET’s rapid cellular uptake and enhanced bioavailability compared to NAC (PubMed 23000913)
  • Review of NAC in oxidative stress and brain health support (PMC9095537)
  • NAC’s role in regulating brain neurotransmitter balance (PubMed 40414419)

Phosphatidylserine, Zinc & Choline: Cognitive Resilience Blend

  • Phosphatidylserine supports cortisol regulation and enhances cognitive processing under stress.
    Reference: https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-13-121
  • Zinc is essential for neurotransmitter activity and emotional stability, especially under chronic mental load.
    Reference: PMC9855948
  • Choline helps build acetylcholine, a neurotransmitter essential for focus, learning, and nervous system resilience. Research shows that choline supports anxiety reduction, cognitive clarity, and stress regulation by contributing to neural plasticity, neurotransmitter balance, and possibly lowering glutamate levels.
    Reference: PMC7601330, PMC3327365
  • Choline helps build acetylcholine, a neurotransmitter tied to focus, learning, and nervous system resilience.
    Reference: PMC7601330

Built for the Whole Mind-Body Stress Axis

Unlike isolated mood supplements, CALMING for Mind & Body Balance works across multiple systems — calming neural hyperactivity (via balancing glutamate with GABA and Saffron), enhancing neurotransmitter production (via Phosphatidylserine and Choline), and buffering oxidative stress (via NACET and Zinc). It is a comprehensive nutritional protocol designed for individuals navigating daily stress, mood imbalance, or focus fatigue — and seeking clean, science-backed support.

NAC/NACET’s Neurotransmitter Support

NAC and NACET help maintain balanced glutamate signaling, supporting a calm and focused state. NACET’s advanced bioavailability allows for enhanced brain delivery, where it can boost glutathione levels — the brain’s master antioxidant — to protect cells from oxidative stress. Zinc further supports these pathways by aiding antioxidant activity and contributing to healthy neurotransmitter regulation, helping to sustain overall mental and emotional balance.

  1. Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review. Front Neurosci. 2020;14:923. Published 2020 Sep 17. doi:10.3389/fnins.2020.00923
  2. Jackson PA, Forster J, Khan J, et al. Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial. Front Nutr. 2021;7:606124. Published 2021 Feb 1. doi:10.3389/fnut.2020.606124
  3. Bian Y, Zhao C, Lee SM. Neuroprotective Potency of Saffron Against Neuropsychiatric Diseases, Neurodegenerative Diseases, and Other Brain Disorders: From Bench to Bedside. Front Pharmacol. 2020;11:579052. Published 2020 Oct 6. doi:10.3389/fphar.2020.579052
  4. Chakraborty S, Shankaranarayana Rao BS, Tripathi SJ. The neuroprotective effects of N-acetylcysteine in psychiatric and neurodegenerative disorders: From modulation of glutamatergic transmission to restoration of synaptic plasticity. Neuropharmacology. Published online May 23, 2025. doi:10.1016/j.neuropharm.2025.110527
  5. Bradlow RCJ, Berk M, Kalivas PW, Back SE, Kanaan RA. The Potential of N-Acetyl-L-Cysteine (NAC) in the Treatment of Psychiatric Disorders. CNS Drugs. 2022;36(5):451-482. doi:10.1007/s40263-022-00907-3
  6. Cope EC, Levenson CW. Role of zinc in the development and treatment of mood disorders. Curr Opin Clin Nutr Metab Care. 2010;13(6):685-689. doi:10.1097/MCO.0b013e32833df61a
  7. Jasielski P, Piędel F, Piwek M, Rocka A, Petit V, Rejdak K. Application of Citicoline in Neurological Disorders: A Systematic Review. Nutrients. 2020;12(10):3113. Published 2020 Oct 12. doi:10.3390/nu12103113
  8. Li Z, Liu Y, Wei R, Yong VW, Xue M. The Important Role of Zinc in Neurological Diseases. Biomolecules. 2022;13(1):28. Published 2022 Dec 23. doi:10.3390/biom13010028
  9. Starks MA, Starks SL, Kingsley M, Purpura M, Jäger R. The effects of phosphatidylserine on endocrine response to moderate intensity exercise. J Int Soc Sports Nutr. 2008;5:11. Published 2008 Jul 28. doi:10.1186/1550-2783-5-11
  10. Dean O, Giorlando F, Berk M. N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. J Psychiatry Neurosci. 2011;36(2):78-86. doi:10.1503/jpn.100057
  11. Black MM. The evidence linking zinc deficiency with children's cognitive and motor functioning. J Nutr. 2003;133(5 Suppl 1):1473S-6S. doi:10.1093/jn/133.5.1473S
  12. Hurtado O, Moro MA, Cárdenas A, et al. Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. Neurobiol Dis. 2005;18(2):336-345. doi:10.1016/j.nbd.2004.10.006

Traceable Ingredients You Can Trust

Every ingredient is sourced for purity, backed by clinical evidence, and rigorously tested for safety and bioavailability. Because in supplements, not all ingredients are created equal — and your body deserves only the most effective forms.

GABA (Gamma-Aminobutyric Acid)

A naturally occurring neurotransmitter that slows neural activity and helps the brain transition from a state of overdrive to a state of calm. GABA supports mental stillness, emotional balance, and parasympathetic nervous system activation.

Backed by Research: GABA supplementation has been linked to reduced stress-related brain activity and improvements in relaxation and cognition.

Reference:PMC7527439

Saffron (Crocus sativus L., 3% Crocins)

A potent botanical extract with decades of research supporting its role in emotional health. Saffron may help regulate serotonin and dopamine levels, enhance mood resilience, and reduce oxidative stress in the brain.

Backed by Research: Saffron has been clinically studied in mood-related protocols and is well-tolerated as a natural support compound.

References:PMC7573929, PMC7882499

N-Acetylcysteine Ethyl Ester (NACET) / N-Acetyl Cysteine (NAC)

NACET is a highly bioavailable, next-generation form of NAC that delivers cysteine efficiently into cells and crosses the blood–brain barrier. This advanced delivery enables superior intracellular glutathione production — the brain’s master antioxidant — which plays a role in detoxification, oxidative stress balance, and maintaining healthy glutamate signaling. By supporting these key pathways, NACET contributes to calmness, cognitive clarity, and overall mood resilience, especially in high-demand or high-stress situations.

While much of the scientific literature focuses on NAC, NACET builds upon that foundation with enhanced absorption and brain penetration, making it a promising upgrade for those seeking targeted neurological and stress-support benefits.

Backed by Research: NACET achieves 60–80% bioavailability compared to NAC’s 3–6%, enabling more effective delivery to the brain and restoration of glutathione. NACET increases intracellular glutathione levels by up to 250% and crosses the blood–brain barrier, supporting neuroprotection and healthy glutamate balance. Extensive NAC research highlights its role in oxidative stress balance and mood support in the context of nervous system health.

References:PubMed 23000913, PMC7827200, PMC9095537

Phosphatidylserine

A phospholipid that protects brain cell membranes, enhances cognitive performance, and helps regulate cortisol — the body’s primary stress hormone.

Backed by Research: Phosphatidylserine supplementation has been shown to reduce cortisol response and improve performance under pressure.

Reference: PMC2503954

Choline

An essential nutrient involved in synthesizing acetylcholine, a neurotransmitter tied to memory, focus, and nervous system integrity.

Backed by Research: Choline has been shown to support executive function and long-term brain health.

Reference:PMC7601330

Zinc (as micro-encapulated Zinc)

An essential mineral for neurological health, antioxidant activity, and neurotransmitter function. Zinc plays a key role in regulating stress, immunity, and cognition.

Backed by Research: Zinc deficiency is associated with increased mood instability and reduced brain resilience.

Reference:36671413

Methyl-Life® CALMING Your Stress Naturally with the Best GABA Supplement contains no unnecessary excipients, synthetic colors, artificial preservatives, or common allergens. It is 100% free from gluten, soy, dairy, GMOs, animal-derived ingredients, and the EU’s top 14 allergens.

Every batch is third-party tested for purity, potency, and safety, manufactured in NSF-certified, cGMP-compliant facilities, and rigorously evaluated to ensure you’re getting clean, clinical-grade nutrients — nothing more, nothing less.

EU’s top 14 allergens

  • Cereals containing gluten - wheat (such as spelt and khorasan wheat), rye, barley, oats. Note: The cereal name, e.g., 'wheat', must be declared and highlighted, not 'gluten'.
  • Crustaceans, e.g., crabs, prawns, lobsters
  • Eggs
  • Fish
  • Peanuts
  • Soybeans
  • Milk
  • Nuts (almonds, hazelnuts, walnuts, cashews, pecan nuts, brazil nuts, pistachio nuts, macadamia/Queensland nut). Note: The name of the nut, e.g., 'almond', must be declared and highlighted, not 'nuts'.
  • Celery
  • Mustard
  • Sesame seeds
  • Sulphur dioxide and sulphites (at concentrations of more than 10 mg/kg or 10 mg/L in terms of total sulphur dioxide) – used as a preservative
  • Lupin 
  • Molluscs, e.g., mussels, oysters, squid, snails
How This Formula Transforms Your Brain + Mood Health

A clinical-strength, multi-nutrient formula combining GABA, Saffron, NACET, and Phosphatidylserine — designed to promote emotional balance, mental clarity, and nervous system resilience without pharmaceuticals. Ideal for individuals experiencing overstimulation, elevated stress response, persistent mood imbalances, or sleep disturbances.

Emotional Clarity & Nervous System Balance

CALMING provides the body with direct precursors and cofactors that help regulate the neurotransmitters responsible for stress adaptation — including GABA to balance glutamate, serotonin, and dopamine. Unlike conventional sedatives, this formula promotes clarity and ease without blunt-force sedation or dependency.

GABA is the brain’s primary inhibitory neurotransmitter, responsible for calming overactive signaling. Saffron supports the natural production and modulation of mood-related chemicals and has shown promise in supporting emotional wellness, especially during high-stress periods.

Backed by Research:

  • GABA supplementation has been linked to measurable improvements in parasympathetic nervous system activity and relaxation markers (PMC7527439)
  • Clinical studies show saffron can help maintain healthy mood and reduce stress-related symptoms by supporting GABA, serotonin, and dopamine levels (PMC7882499)

NACET enhances glutamate balance and promotes antioxidant activity, both essential for emotional stability and stress regulation (PMC9095537)

Advanced Antioxidant & Neuroinflammation Defense

NACET (N-Acetylcysteine Ethyl Ester) is a next-generation form of NAC designed for exceptional absorption and delivery to the brain. Unlike standard NAC, NACET efficiently crosses cell membranes and the blood–brain barrier, allowing it to rapidly increase glutathione — the body’s master antioxidant — inside brain cells. This powerful support helps protect neurons from oxidative stress, assists in regulating glutamate activity, and promotes a balanced, more resilient stress response.

With far greater bioavailability than NAC, NACET delivers robust antioxidant defense where it’s needed most. By replenishing glutathione levels, it supports detoxification pathways, helps maintain a healthy redox balance, and reduces the oxidative burden that can contribute to mental fatigue. Its ability to modulate glutamate adds another layer of support for calm mood regulation and cognitive clarity.

Backed by Research:

  • NACET raises glutathione levels significantly more than standard NAC and crosses the blood–brain barrier to target central nervous system oxidative stress (PMID30114478)
  • A 2022 review highlights NAC and related compounds as promising for supporting resilience under prolonged psychological strain (PMC9095537)

Research shows NACET’s enhanced intracellular action helps maintain redox balance and supports healthy cognitive performance under stress (PMC7827200)

Cognitive Focus & Cortisol Regulation

With phosphatidylserine and choline as foundational ingredients, CALMING supports a balanced stress response and helps promote a composed mental state. Phosphatidylserine plays a role in maintaining healthy hypothalamic-pituitary-adrenal (HPA) axis activity, which is involved in regulating cortisol levels and supporting emotional steadiness during challenging situations. This balance can help you feel more centered and better equipped to handle daily demands.

At the same time, choline supports the integrity of brain cell membranes and is a key nutrient for acetylcholine production — a neurotransmitter essential for mental clarity, focus, and cognitive adaptability, particularly during periods of stress.

Human studies suggest that phosphatidylserine can help maintain healthy cortisol responses to both physical and mental stressors, supporting mood and overall resilience. Choline complements this by supporting neurotransmitter activity and sustaining cognitive performance under pressure, helping to keep the mind sharp and adaptive.

Backed by Research:

  • Phosphatidylserine supports balanced cortisol responses by promoting healthy HPA axis function (PMC2503954)

Choline supports cognitive performance during stress, aiding focus, working memory, and processing speed (PMC7601330)

Built for Fast Relief + Long-Term Resilience

CALMING for Mind & Body Balance is more than a short-term stress remedy — it’s a multi-pathway solution. By nourishing the nervous system, modulating neurotransmitters, and reducing inflammation, this formula builds lasting resilience without the side effects associated with conventional interventions.

Frequently asked question

GABA (Gamma-Aminobutyric Acid) is a naturally occurring neurotransmitter that plays a key role in calming overactive brain signaling. Supplementing with GABA may support a more balanced emotional state by helping to reduce feelings of overstimulation and mental tension. It promotes a relaxed, focused state without sedation.
Reference: PMC7527439
N-Acetyl-L-cysteine ethyl ester (NACET) is a highly bioavailable, lipid-soluble form of N-acetylcysteine (NAC) that can efficiently cross cell membranes and the blood–brain barrier. Research indicates that NACET not only delivers NAC and cysteine into cells, but also significantly increases intracellular glutathione (GSH) levels in brain tissue. Glutathione is a key antioxidant that helps protect neural cells from oxidative stress, supports natural detoxification processes, and plays a role in regulating neurotransmitters such as glutamate — all of which are important for maintaining healthy brain function and emotional balance.
References: PMC10215789, PMC7827200
Zinc is essential for more than 300 enzymatic reactions in the body, many of which influence cognitive function, stress response, and emotional balance. Low zinc status has been linked to increased mental fatigue and reduced ability to adapt to everyday stressors. Adequate zinc intake may help support mental clarity and promote mood stability.

Zinc also plays a critical role in antioxidant defense. It acts as a cofactor for enzymes involved in glutathione synthesis — the body’s primary cellular antioxidant — and research suggests zinc can help stimulate glutathione production. Because supporting glutathione with NACET may increase the body’s demand for certain minerals during detoxification and antioxidant activity, replenishing zinc can help sustain resilience, cellular protection, and overall metabolic balance during times of oxidative stress.
References: PMC9917832, PMC3137935
Yes. This formula is suitable for both daily use and situational support. You can take one capsule per day to help maintain consistent mood balance and stress resilience, or use it as needed during periods of heightened stress or occasional sleep difficulties.

Notably, ingredients such as GABA and saffron have been studied for their role in supporting healthy sleep patterns. Standardized saffron extract has been shown in clinical trials to improve sleep quality and reduce insomnia severity in adults with sleep challenges — with benefits reported as early as one week into supplementation. Research suggests saffron’s active compounds may help regulate neurotransmitters involved in sleep and relaxation, including GABA, serotonin, and dopamine, while GABA itself can promote a sense of calm conducive to restful sleep.
References: jcsm.8376, PMC8145009
Saffron has been clinically studied for its ability to support mood balance, sleep quality, and resilience to emotional stress. Its active compounds, crocin and safranal, help regulate key neurotransmitters like serotonin and dopamine, which play a role in emotional regulation.
References: PMC7882499, PMC7573929
Phosphatidylserine supports healthy cortisol levels and may help improve focus, memory, and mood during times of mental stress. It plays a structural role in brain cell membranes and assists in neurotransmitter signaling.
Reference: PMC2503954
Choline is an essential nutrient that plays a central role in brain health. It is needed for producing acetylcholine — a neurotransmitter involved in memory, learning, and attention — and for maintaining the structure of cell membranes through its contribution to phosphatidylcholine. Choline also supports phosphatidylcholine synthesis, mitochondrial function, and healthy brain energy metabolism.

In addition to these benefits, research shows that certain forms of choline can help lower excess glutamate levels in the brain — supporting a balanced excitatory–inhibitory neurotransmitter environment and protecting neurons from overstimulation. This makes choline particularly valuable for promoting cognitive function, mood stability, and long-term nervous system resilience.
References: PMC10389840, PMC6683073, PMC7878037
Some individuals may experience a mild calming or sleep-promoting effect, especially when taken at night or alongside magnesium. However, it is not designed to be sedative and should not cause heavy drowsiness in most users.

Clinically Studied, Backed by Real Science

Methyl-Life® CALMING for Mind & Body Balance is rooted in clinical research — not trends. From neurotransmitter modulation and antioxidant defense to cortisol regulation and cognitive clarity, every claim we make is grounded in evidence. Below are the science-backed reasons why this formula works across multiple biological systems to promote calm, clarity, and stress resilience.

Reduces Mental Tension Through GABA Signaling

GABA plays a central role in calming neural overactivity and helping the brain shift from sympathetic (fight-or-flight) to parasympathetic (rest-and-digest) dominance. Supplementing with GABA may support a more balanced emotional state and improved focus in overstimulated individuals.

Evidence-Based Insight: In a randomized, double-blind trial, oral GABA supplementation was shown to reduce alpha brain wave activity associated with anxiety and promote faster recovery from mental stress.

Read the study – PMC7527439

Customer Reviews

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D
Derek Jansen
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J
Joy Jacobson

"I am still trying to calm my mind down for sleep since insomnia is kicking my butt. Just working out a good timing for taking this supplement yet it has been helping me thus far."

Thank you so much for sharing your experience! We're really glad to hear the supplement has been helping, even as you work out the best timing for it. Insomnia can be incredibly challenging, and you're not alone, many of our customers are on a similar journey. If you ever need personalized suggestions or support, our Customer Care team is here and happy to help!

Wishing you continued progress and restful nights ahead

Methyl-Life® CALMING for Mind & Body Balance – Clinical-Strength Nutritional Support for Emotional Wellness, Resilience & Mental Clarity

CALMING for Mind & Body Balance delivers a targeted blend of research-backed nutrients — including GABA, Saffron, NACET, Phosphatidylserine, Choline, and Zinc — to help support your body’s ability to handle emotional stress, regulate mood, and promote nervous system balance. This formula is ideal for those seeking a clean, non-sedative alternative to conventional mood-balancing interventions or those recovering from burnout, anxious tension, or chronic overstimulation.

If you experience difficulty winding down at the end of the day, struggle with overthinking, or feel emotionally “wired but tired,” this advanced formula is designed to help regulate the systems most affected by stress: your brain, your hormones, and your nervous system.

Understanding the Connection Between Stress, Neurotransmitters & Resilience
Many individuals today experience nervous system dysregulation due to environmental, emotional, or biological stressors — all of which can impair neurotransmitter balance. GABA, the brain’s chief inhibitory neurotransmitter, helps counterbalance excessive excitatory signaling (like glutamate), which can lead to anxiousness, irritability, and racing thoughts when left unchecked. Choline has also been shown to help lower excess glutamate, further supporting a balanced excitatory–inhibitory state and protecting brain cells from overactivation.