Cerebral folate deficiency (CFD) is a condition associated with low levels of a vital, transportable form of folate called 5-methyltetrahydrofolate (5-MTHF) in the cerebrospinal fluid (CSF) while folate levels are normal in other body (non-nervous) systems.
Symptoms of CFD usually reveal themselves at around four to six months of age, and while they may seem typical for infants, they are marked and intense in the presence of CFD.