
Best Bioidentical Active B12 Forms and Supplement Options
Methyl-Life® Product Help GuideNote about B12
Consider taking bioidentical B12 forms in conjunction with L-Methylfolate because they work synergistically together in the body on the methylation pathway and can amplify its benefits. Stay AWAY from cyanocobalamin in supplements and fortified foods! Methyl-Life® carries affordable, vegan versions of active B12 in a tasty sublingual tablet (some products even include L-Methylfolate).
Bioidentical Active B12 Forms:
- Hydroxocobalamin - harder to find, expensive, typically well-tolerated and used for pernicious anemia among other things
- Methylcobalamin - fairly available and found in some supplements. Note: it's not always well tolerated
- Adenosylcobalamin - harder to find, expensive, the most well-tolerated and often used in muscle recovery
B12 does NOT absorb well via the gut, so be sure to get a product that allows you to dissolve the B12 under your tongue. Sublingual transport is the best way to get B12 absorption (research has proven it's even better than B12 injections for increasing B12 sufficiency). If B12 blood serum levels test "high", consider Methyl-Life®'s Non-Methylated Multivitamin.
Learn more about the best bioidentical B12 forms to take.
Additional Resources
Quick Personal Note from Methyl-Life® Founder, Jamie Hope
"I had my serotonin level tested before starting a methylfolate and active B12 regimen. My result was 85, significantly low (normal range for the test was 125-185).
3 months later after taking 5 mg of L-Methylfolate and 5 mg of active B12 each day, I had my level tested again and it came back at 136 (significantly improved and within normal range).
Not only did I feel so much better (my mood was lifted), but my IBS symptoms began to melt away (much to my surprise). As I continued taking the nutrients over the next 6-9 months many things just got so much better. It really was quite an amazing transformation for me, a slow but steady healing. So don't underestimate the power of bioidentical methylfolate and B12 nutrients for not only mood improvement, but also repairing the gut.”
What if B12 serum levels are really high?
This often means your body is having trouble converting, transporting and absorbing B12 into the cells where it's needed for intracellular use.
And the high blood test result may also mean that you’re getting a form of B12 in your diet (or with vitamins) that is not converting well in your body for absorption (likely cyanocobalamin).
Ironically, this is called a “paradoxical B12 deficiency”. And it refers to a lack of iodine, selenium, and molybdenum which are the main reasons for not being able to activate B2. And B2 is important because it's highly correlated with B12 ... meaning if you are functionally deficient in B2, it is highly likely you will also have a B12 functional deficiency.
A few suggestions below are based on opinions from Research Studies, Naturopathic Doctors and Nutritionists ... Methyl-Life®'s Non-Methylated Multivitamin product satisfies the top 3 suggestions below and our Methylated Multivitamin 3-product pack covers 4 of the 6.
Best tests to determine B12 deficiency
- Methylmalonic Acid (MMA)
- Homocysteine
- Active B12 (Holotranscobalamin - holoTC)
If both the MMA and Homocysteine test results are high, then you may not be getting enough B12 intracellularly (even if your blood serum tests show B12 as high)
Recent research has been done across thousands of cases, comparing the results from intramuscular B12 injections vs. sublingual B12 treatment. The findings clearly indicated that the sublingual B12 treatment plans provided better sufficiency than the shots did. What's more ... taking a sublingual tablet is much faster, more convenient and less costly on both your wallet and time.
So if someone tells you a shot would be better, point them to the research findings, it's clear and conclusive: Sublingual B12 wins over the B12 injection treatment in the battle of B12 sufficiency.
SENSITIVE PEOPLE who should go VERY SLOW when methylating
- Children
- Those sensitive to medications and supplements
- Those significantly impacted by trauma
- Those with chronic or complex illnesses (i.e. chronic fatigue, fibromyalgia, MS, Lyme, chemical sensitivities, etc.)
Get one of our Free step-by-step Methylation Protocols
Consider getting your homocysteine levels checked by a healthcare practitioner. Lowering homocysteine levels may take additional nutrients and different dosing than what's suggested.
Start LOW with your initial dose and increase SLOWLY until you get to your targeted amount or reach tolerance.
Methylation Protocol designed to Increase Methylation for Sensitive Individuals
Methylation Protocol designed to Increase Methylation and B12 Supplementation
I know my specific COMT & VDR Taq gene details. Display the best suggested B12 form(s) for me based on that information.
Are B12 intramuscular injections best?
It’s worth noting that most doctors giving B12 shots are using the specific form cyanocobalamin, which is the cheap synthetic version that has cyanide in it. They typically give mega-doses (10-25 mg) to help those with significant B12 deficiency symptoms. However, this is not necessarily required. Cyanocobalamin has to go through a complex conversion process within the body in order to become active and many people cannot do these conversions well, so often much of the dose goes unused (even with a shot). A very few naturopaths or functional medicine doctors may be using methylcobalamin or hydroxocobalamin in an IV or shot scenario. These are considered two of the bioactive forms of B12, and they work well for many. However, be aware as methylcobalamin is typically the least well-tolerated of the 3 active forms.
For some overloading their system with a mega-dose shot of synthetic B12 can actually make them pretty sick because because they can’t clear or convert that form of B12 very well. This can be due to COMT, MTR or MTRR genetic mutations which help the body convert B12 into its active forms for use at the enzymatic and cellular level. When these conversions don't happen, then the body's blood stream is overloaded with a form of B12 it can't use or clear very quickly (hence you feel very bad afterwards). If you've had a BAD experience with B12 shots, it's most likely that you do not tolerate or convert cyanocobalamin well (see if you can verify what form of B12 was in the shot that made you react poorly, and then stay away from that specific form if you can).

What to do if B12 is needed?
Stay away from cyanocobalamin, it’s the cheap, synthetic version that has cyanide in it. Cyanocobalamin goes through a complex set of conversions within the body before it's absorbed and used (many can’t do these conversions well because of genetics i.e. MTR, MTRR, etc.). Spoiler ALERT: it's in many supplements and fortified foods.
Consider trying an active bioidentical form of B12. We recommend (along with many naturopaths and nutritionists who understand B12) you start with hydroxocobalamin. It’s generally well tolerated by most people. It’s more rare and expensive, but it works EXTREMELY well.
Be sure you are taking your B12 sublingually (dissolve it under your tongue). Recent studies prove sublingual B12 is more effective for improving B12 levels than intramuscular B12 shots. It turns out B12 does NOT absorb well via the gut, so don't buy a product you swallow thinking you're getting B12. Research says only 1-4% of B12 is absorbed via the gut.
Product Recommendations
Sublingual B12: well-tolerated, bioavailable Hydroxy B12 Tablets
$29.00
Methylcobalamin B12 Complete - Vitamin B12 5000 mcg
$32.00
Methylated Multivitamin 3-Product Pack - MTHFR Folate, Sublingual B12 + Cofactors
$96.00

Written By:
Jamie Hope - Founder of Methyl-Life
Medical Reviewer:
Kari Asadorian - Bachelor of Science in Nursing
Edited By:
Kari Asadorian - Bachelor of Science in NursingTable of Contents
Product Recommendations
Sublingual B12: well-tolerated, bioavailable Hydroxy B12 Tablets
$29.00
Methylcobalamin B12 Complete - Vitamin B12 5000 mcg
$32.00
Methylated Multivitamin 3-Product Pack - MTHFR Folate, Sublingual B12 + Cofactors
$96.00