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MTHFR, Cognition and Immune System Supporting Nutrients

Methyl-Life® Product Help Guide

Pandemics & flus have changed our world

For a large majority of us, taking our health seriously and being proactive about how to keep ourselves free from illness has been a focus. That means ensuring our immune system is fully firing on all levels so we can fight off the hundreds of viruses, flus, pathogens and infections out there that can wreak havoc on our wellbeing.

PREGNANCY ALERT

If you're trying to conceive or are already pregnant, talk to your healthcare provider about this dosage level. You will need methylfolate for the baby so there's no question that the nutrient is required. It's the dosage amount you'll simply want to ensure your doctor is in agreement with based on your personal background and medical history. 


If you are a depressed mom-to-be or are experiencing postpartum depression (PPD), then you will likely fall into this 'higher dose' category range for L-methylfolate supplementation.

Note about B12

Consider taking bioidentical B12 forms in conjunction with L-Methylfolate because they work synergistically together in the body on the methylation pathway and can amplify its benefits. Stay AWAY from cyanocobalamin in supplements and fortified foods! Methyl-Life® carries affordable, vegan versions of active B12 in a tasty sublingual tablet (some products even include L-Methylfolate).


Bioidentical Active B12 Forms:

  • Hydroxocobalamin - harder to find, expensive, typically well-tolerated and used for pernicious anemia among other things
  • Methylcobalamin - fairly available and found in some supplements. Note: it's not always well tolerated
  • Adenosylcobalamin - harder to find, expensive, the most well-tolerated and often used in muscle recovery


B12 does NOT absorb well via the gut, so be sure to get a product that allows you to dissolve the B12 under your tongue. Sublingual transport is the best way to get B12 absorption (research has proven it's even better than B12 injections for increasing B12 sufficiency). If B12 blood serum levels test "high", consider Methyl-Life®'s Non-Methylated Multivitamin.


Learn more about the best bioidentical B12 forms to take.

Get one of our Free step-by-step Methylation Protocols

Consider getting your homocysteine levels checked by a healthcare practitioner. Lowering homocysteine levels may take additional nutrients and different dosing than what's suggested.


Start LOW with your initial dose and increase SLOWLY until you get to your targeted amount or reach tolerance.

Methylation nutrient combinations to consider

A suggested daily range for Cognition and Immune System support might be 5-6 mg of L-Methylfolate. We base this on the Cerefolin prescription product prescribed for dementia/Alzheimer’s helping to improve brain health and cognition levels (it contains 5.6 mg of L-Methylfolate and has clinical studies behind it).


You may only be able to take half or less of the suggested amount, but that may be just right for you personally. Some people respond quickly (within weeks) and others may take a full 4 months before they respond favorably to the therapeutic methylfolate dosing.

SENSITIVE PEOPLE who should go VERY SLOW when methylating

  • Children
  • Those sensitive to medications and supplements
  • Those significantly impacted by trauma
  • Those with chronic or complex illnesses (i.e. chronic fatigue, fibromyalgia, MS, Lyme, chemical sensitivities, etc.)

Quick Personal Note from Methyl-Life® Founder, Jamie Hope

"I had my serotonin level tested before starting a methylfolate and active B12 regimen. My result was 85, significantly low (normal range for the test was 125-185).


3 months later after taking 5 mg of L-Methylfolate and 5 mg of active B12 each day, I had my level tested again and it came back at 136 (significantly improved and within normal range).


Not only did I feel so much better (my mood was lifted), but my IBS symptoms began to melt away (much to my surprise). As I continued taking the nutrients over the next 6-9 months many things just got so much better. It really was quite an amazing transformation for me, a slow but steady healing. So don't underestimate the power of bioidentical methylfolate and B12 nutrients for not only mood improvement, but also repairing the gut.


Find your own sweet spot, where the amount of methylfolate you take makes you feel better.


It is worth noting that some people may never feel a big change like I did right away. Dr. Neil Rawlins says it may take some as many as 4 months (at a therapeutic dose - for some that is as much as 15 mg) to notice that they are actually feeling better.


Some people may just take methylfolate because it is recommended for them and reduces their homocysteine as well as disease risks (i.e. heart attack, miscarriage etc.) and helps clear toxins/metals/BPAs out of their system via glutathione boosting. These folks may not notice as much of a difference in how they 'feel', everyone's experience is unique."

Additional Resources

Review Methylfolate Dosage Details
Icon for Review Methylfolate Dosage Details
New to MTHFR?
Helpful Next Steps
Icon for New to MTHFR? <br> Helpful Next Steps
Potential Methylfolate Side Effects
Icon for Potential Methylfolate Side Effects

Methylation Protocol designed to Increase Methylation for Central Nervous System Health

Download Protocol

Methylation Protocol designed to Increase Methylation for Sensitive Individuals

DOWNLOAD PROTOCOL

L-Methylfolate plays an unexpected role in immune system health

Keeps Homocysteine Levels Down

When homocysteine goes above 10, it can be quite dangerous for our cardiovascular system and make us more prone to events like stroke, heart attack, etc., but beyond that, high homocysteine levels heavily impair our immune system from properly responding to invaders, disease and viral attacks. Taking L-methylfolate reduces homocysteine levels.

Can Protect Against Viral Replication

Another key point that may surprise you is that research has shown low folate levels leave open furin sites which specifically enable some viruses to replicate and advance to damage its host. This can be improved by supplementing with L-Methylfolate.

Methylfolate Ranges for Specific Health Conditions

If you’re targeting a particular condition, try a dosage level specific to that need. NOTE: L-Methylfolate crosses the blood-brain barrier, unlike folic acid.

Pregnancy/Fertility - target dosage is ~1-4 mg methylfolate per day

Diabetes/Cardiovascular Health - target dosage is ~3 mg methylfolate per day

Lowering Homocysteine levels - target dosage is ~3-7.5 mg methylfolate per day (NAC/NACET, TMG and Glutathione can also help with this)

ADD/ADHD/Focus and Attention - target dosage is ~1-5 mg methylfolate per day

Cognitive Health/Dementia/Alzheimer's - target dosage is ~5-6 mg methylfolate per day

Depression/Bipolar/Mental Health challenges - target dosage is ~7.5-15 mg methylfolate per day

Eye Health - target dosage is ~1 mg methylfolate per day

Jamie Hope - Founder of Methyl-Life

Written By:

Jamie Hope - Founder of Methyl-Life
Kari Asadorian - Bachelor of Science in Nursing

Medical Reviewer:

Kari Asadorian - Bachelor of Science in Nursing
Kari Asadorian - Bachelor of Science in Nursing

Edited By:

Kari Asadorian - Bachelor of Science in Nursing

Table of Contents

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