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MTHFR, Gut Health and Supporting Nutrients

Methyl-Life® Product Help Guide

The Gut Microbiome plays a HUGE role...

in supporting nearly every system in our bodies. And yet, some of us face greater challenges than others which can severely impact our quality of life.


  • When the balance of the gut's microbes is disrupted, a condition known as dysbiosis can significantly affect overall health
  • Lifestyle factors are common contributors to dysbiosis (stress, diet, exercise, lack of laughter, trauma, belonging, etc.)
  • Research indicates that the MTHFR gene mutation may cause low folate levels, which can profoundly impact gut and immune health as well as overall well-being

Gut health has so many different contributing factors

Get one of our Free step-by-step Methylation Protocols

Consider getting your homocysteine levels checked by a healthcare practitioner. Lowering homocysteine levels may take additional nutrients and different dosing than what's suggested.


Start LOW with your initial dose and increase SLOWLY until you get to your targeted amount or reach tolerance.

Note about B12

Consider taking bioidentical B12 forms in conjunction with L-Methylfolate because they work synergistically together in the body on the methylation pathway and can amplify its benefits. Stay AWAY from cyanocobalamin in supplements and fortified foods! Methyl-Life® carries affordable, vegan versions of active B12 in a tasty sublingual tablet (some products even include L-Methylfolate).


Bioidentical Active B12 Forms:

  • Hydroxocobalamin - harder to find, expensive, typically well-tolerated and used for pernicious anemia among other things
  • Methylcobalamin - fairly available and found in some supplements. Note: it's not always well tolerated
  • Adenosylcobalamin - harder to find, expensive, the most well-tolerated and often used in muscle recovery


B12 does NOT absorb well via the gut, so be sure to get a product that allows you to dissolve the B12 under your tongue. Sublingual transport is the best way to get B12 absorption (research has proven it's even better than B12 injections for increasing B12 sufficiency). If B12 blood serum levels test "high", consider Methyl-Life®'s Non-Methylated Multivitamin.


Learn more about the best bioidentical B12 forms to take.

SENSITIVE PEOPLE who should go VERY SLOW when methylating

  • Children
  • Those sensitive to medications and supplements
  • Those significantly impacted by trauma
  • Those with chronic or complex illnesses (i.e. chronic fatigue, fibromyalgia, MS, Lyme, chemical sensitivities, etc.)

Quick Personal Note from Methyl-Life® Founder, Jamie Hope

"I had my serotonin level tested before starting a methylfolate and active B12 regimen. My result was 85, significantly low (normal range for the test was 125-185).


3 months later after taking 5 mg of L-Methylfolate and 5 mg of active B12 each day, I had my level tested again and it came back at 136 (significantly improved and within normal range).


Not only did I feel so much better (my mood was lifted), but my IBS symptoms began to melt away (much to my surprise). As I continued taking the nutrients over the next 6-9 months many things just got so much better. It really was quite an amazing transformation for me, a slow but steady healing. So don't underestimate the power of bioidentical methylfolate and B12 nutrients for not only mood improvement, but also repairing the gut.


Find your own sweet spot, where the amount of methylfolate you take makes you feel better.


It is worth noting that some people may never feel a big change like I did right away. Dr. Neil Rawlins says it may take some as many as 4 months (at a therapeutic dose - for some that is as much as 15 mg) to notice that they are actually feeling better.


Some people may just take methylfolate because it is recommended for them and reduces their homocysteine as well as disease risks (i.e. heart attack, miscarriage etc.) and helps clear toxins/metals/BPAs out of their system via glutathione boosting. These folks may not notice as much of a difference in how they 'feel', everyone's experience is unique."

Genetics
Nervous System Function (i.e. IBS, stress, neurotransmitter levels, etc.)
Conditions Preventing Absorption (i.e. leaky gut, celiac disease, ulcerative colitis/Crohn’s, etc.)
Immune System Function
Invaders Creating Infection (i.e. parasites, worms, amoebas, h. pylori, candida, SIBO, etc.)
Imbalance and Dysbiosis (i.e. bacteria, viruses, fungi, pathogens, etc.)

Additional Resources

Review Methylfolate Dosage Details
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New to MTHFR?
Helpful Next Steps
Icon for New to MTHFR? <br> Helpful Next Steps
Potential Methylfolate Side Effects
Icon for Potential Methylfolate Side Effects

Methylation Protocol designed to Increase Methylation for Gut Health

Download Protocol

Methylation Protocol designed to Increase Methylation for Sensitive Individuals

DOWNLOAD PROTOCOL

A multi-pronged approach is needed for healing the gut

One important piece of the puzzle is ensuring your gut’s environment (microbiome) has enough of the ‘good guys’ so the bad guys aren’t taking over and wreaking havoc on your balance, absorption and basic processing functions. Some options to consider are:

Get the right nutrients to bring your body back into balance (think MTHFR replenishment through L-Methylfolate & B12 which work synergistically to make SAMe & serotonin for microbiome & immune health). Remember 90% of your body’s serotonin sits in your gut, so when you’re low, your belly is not usually happy (i.e. IBS)

Get the right enzymes which help break down your food into nutrient forms your body can properly digest, absorb and integrate for optimal downstream needs

Get the right prebiotics that the microbiome-enhancing strains you take can feed on (so the probiotics can repopulate and win the war against the “bad bugs”)

Get the right probiotics which target your specific challenges (i.e. strains that reduce low mood by positively affecting the GABA pathway)

Get the post biotics which help bring your body back into homeostasis faster (generating more of the positive benefits we take our probiotics for)

Work with your doctor as needed to treat specific pathogens, parasites and disease-related conditions

Methylfolate Ranges for Specific Health Conditions

If you’re targeting a particular condition, try a dosage level specific to that need. NOTE: L-Methylfolate crosses the blood-brain barrier, unlike folic acid.

Pregnancy/Fertility - target dosage is ~1-4 mg methylfolate per day

Diabetes/Cardiovascular Health - target dosage is ~3 mg methylfolate per day

Lowering Homocysteine levels - target dosage is ~3-7.5 mg methylfolate per day (NAC/NACET, TMG and Glutathione can also help with this)

ADD/ADHD/Focus and Attention - target dosage is ~1-5 mg methylfolate per day

Cognitive Health/Dementia/Alzheimer's - target dosage is ~5-6 mg methylfolate per day

Depression/Bipolar/Mental Health challenges - target dosage is ~7.5-15 mg methylfolate per day

Eye Health - target dosage is ~1 mg methylfolate per day

Product Recommendations

Chewable Digestive Enzymes

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Your Gut's Soothing Friend!
Methylation Supplements: L Methylfolate + B12 Sublingual

Methylation Supplements: L Methylfolate + B12 Sublingual
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METHYLATION SUPPLEMENTS AID COGNITION BY CROSSING BLOOD-BRAIN BARRIER
Gut Health 4 in 1: Full-Spectrum Microbiome Support

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POWERFUL ODOR - WORKS WELL, BUT IS STINKY!
Jamie Hope - Founder of Methyl-Life

Written By:

Jamie Hope - Founder of Methyl-Life
Kari Asadorian - Bachelor of Science in Nursing

Medical Reviewer:

Kari Asadorian - Bachelor of Science in Nursing
Kari Asadorian - Bachelor of Science in Nursing

Edited By:

Kari Asadorian - Bachelor of Science in Nursing

Table of Contents

Product Recommendations

Chewable Digestive Enzymes

Chewable Digestive Enzymes
(156)

$39.00

Your Gut's Soothing Friend!
Methylation Supplements: L Methylfolate + B12 Sublingual

Methylation Supplements: L Methylfolate + B12 Sublingual
(1)

$73.00

METHYLATION SUPPLEMENTS AID COGNITION BY CROSSING BLOOD-BRAIN BARRIER
Gut Health 4 in 1: Full-Spectrum Microbiome Support

Gut Health 4 in 1: Full-Spectrum Microbiome Support
(5)

$45.00

POWERFUL ODOR - WORKS WELL, BUT IS STINKY!