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MTHFR, Pregnancy and the Right Nutrients

Methyl-Life® Product Help Guide

MTHFR Folate needs for those Pregnant

Recent studies suggest that mutations in the MTHFR gene elevate the risk of pregnancy complications, including recurrent miscarriages. This has led many women to question whether they can carry a pregnancy to term successfully.


Despite these challenges, women with MTHFR mutations can achieve successful pregnancies by ensuring adequate nutrient intake of the right nutrient forms, particularly bioidentical folate and B12 supplements.

A Note on Miscarriages

One customer who had 5 successive miscarriages finally switched from folic acid to Methyl-Life's® B-Methylated II product and was able to bring her baby girl to full term. She fully believes it’s because she stopped the high dose folic acid (which she could not convert in her body due to the MTHFR mutation) and chose Methyl-Life's® professional quality methylated folate instead. Our world class Cerebrofolate™ gets around the folate converting defects and delivers the most bioidentical folate your body needs.


However, if you are super sensitive, you may NOT tolerate:

  • the amount of methylfolate in that product or
  • the type of active B12 found in it (methylcobalamin)


So follow the protocol sheet you downloaded first and go slowly with that before you give the B-Methylated II product a try.  You may likely do best with our L Methylfolate 2.5 mg and Sublingual Hydroxy B12 product combination instead (MTHFR Key Actives).

Methylation nutrient combinations to consider

A suggested daily amount for Pregnancy support would be 1-4 mg of L-Methylfolate.


We base this on: 

  • the NeevoDHA prescription prenatal with L-Methylfolate 
  • Dr. Neil Rawlins’ pregnancy recommendations


NeevoDHA contains 1 mg of L-Methylfolate, just like Methyl-Life's® Chewable Methylated Multivitamin (Sweet 'n Tart Cherry Berry flavored).


NOTE: If you suffer from low mood, depression, postpartum (PPD) or other mental health challenges, consider reviewing our Mental Health and MTHFR protocol as it may be more suited to your specific needs.

SENSITIVE PEOPLE who should go VERY SLOW when methylating

  • Children
  • Those sensitive to medications and supplements
  • Those significantly impacted by trauma
  • Those with chronic or complex illnesses (i.e. chronic fatigue, fibromyalgia, MS, Lyme, chemical sensitivities, etc.)

Get one of our Free step-by-step Methylation Protocols

Consider getting your homocysteine levels checked by a healthcare practitioner. Lowering homocysteine levels may take additional nutrients and different dosing than what's suggested.


Start LOW with your initial dose and increase SLOWLY until you get to your targeted amount or reach tolerance.

Note about B12

Consider taking bioidentical B12 forms in conjunction with L-Methylfolate because they work synergistically together in the body on the methylation pathway and can amplify its benefits. Stay AWAY from cyanocobalamin in supplements and fortified foods! Methyl-Life® carries affordable, vegan versions of active B12 in a tasty sublingual tablet (some products even include L-Methylfolate).


Bioidentical Active B12 Forms:

  • Hydroxocobalamin - harder to find, expensive, typically well-tolerated and used for pernicious anemia among other things
  • Methylcobalamin - fairly available and found in some supplements. Note: it's not always well tolerated
  • Adenosylcobalamin - harder to find, expensive, the most well-tolerated and often used in muscle recovery


B12 does NOT absorb well via the gut, so be sure to get a product that allows you to dissolve the B12 under your tongue. Sublingual transport is the best way to get B12 absorption (research has proven it's even better than B12 injections for increasing B12 sufficiency). If B12 blood serum levels test "high", consider Methyl-Life®'s Non-Methylated Multivitamin.


Learn more about the best bioidentical B12 forms to take.

Quick Personal Note from Methyl-Life® Founder, Jamie Hope

"I had my serotonin level tested before starting a methylfolate and active B12 regimen. My result was 85, significantly low (normal range for the test was 125-185).


3 months later after taking 5 mg of L-Methylfolate and 5 mg of active B12 each day, I had my level tested again and it came back at 136 (significantly improved and within normal range).


Not only did I feel so much better (my mood was lifted), but my IBS symptoms began to melt away (much to my surprise). As I continued taking the nutrients over the next 6-9 months many things just got so much better. It really was quite an amazing transformation for me, a slow but steady healing. So don't underestimate the power of bioidentical methylfolate and B12 nutrients for not only mood improvement, but also repairing the gut.

Additional Resources

Methylation Protocol designed to Increase Methylation for Pregnancy and Fertility

Methylation Protocol designed to Increase Methylation for Sensitive Individuals

How MTHFR Affects Pregnancy

Pregnancy puts a higher demand on MTHFR

The MTHFR gene produces an enzyme essential for folate metabolism, which converts dietary folate into its active, bioidentical form, methylfolate. Individuals with MTHFR mutations must compensate through dietary folate intake, but pregnancy significantly increases the body’s folate demands. Consequently, women with MTHFR polymorphisms may face a higher likelihood of complications or birth defects due to insufficient methylfolate levels.

Pregnancy complications that can arise from MTHFR

Methylfolate plays a vital role in DNA synthesis and repair, gene regulation, and other critical processes that support cell division and embryo development. Impaired folate metabolism can also lead to elevated homocysteine levels, which have been associated with gestational diabetes and recurrent miscarriages.

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