NACET - The Next Evolution of NAC
N-Acetyl-L-Cysteine Ethyl Ester (NACET) is an advanced, highly absorbable form of NAC designed to support the body’s natural antioxidant systems at the cellular level.
NACET provides cysteine, a key building block the body uses to help maintain healthy glutathione (GSH) levels. Glutathione plays an essential role in protecting cells from oxidative stress and supporting overall cellular balance.
NACET supports:
- Elevated intracellular glutathione for powerful antioxidant protection
- Healthy liver function and other detoxification pathways
- Cellular protection against free radical damage
- Mitochondrial function and efficient energy metabolism
- Cognitive function and immune system defences
Evidence-Based Advantage: Research shows NACET raises intracellular glutathione concentrations more effectively than standard NAC, owing to its ability to cross cell membranes and the blood-brain barrier (PMC8234027).
NutriCloak™ Liposomal Minerals - Enhancing Cellular Function
This advanced mineral complex delivers liposomal magnesium, zinc, selenium, molybdenum and glycine: essential cofactors that power antioxidant enzyme systems, antioxidant capacity, and DNA repair. The NutriCloak™ liposomal delivery technology enhances mineral absorption and cellular bioavailability, ensuring optimal support where your body needs it most.
What This Supports:
- Glutathione peroxidase (GPx) activity: selenium-dependent enzyme required for for neutralizing harmful substances
- DNA synthesis, repair and stability: supported by zinc and magnesium
- Enzymatic detoxification: by providing essential coenzymes
- Optimal glutathione synthesis
- Enhanced mineral absorption & bioavailability - via NutriCloak™ liposomal delivery
Why It Matters
Oxidative stress can speed the aging process and impair cellular performance. By combining NACET’s highly absorbable antioxidant support with bioavailable liposomal minerals, this formula helps the body naturally:
- Neutralize free radicals
- Preserve cellular integrity and function
- Regenerate antioxidant systems
- Support detoxification pathways and energy production
Clinically Validated Benefits
Supported by clinical research, NACET and its key mineral cofactors (magnesium, zinc, selenium, molybdenum and glycine) are shown to:
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Increase Glutathione levels and Strengthen Antioxidant Defenses
NACET’s lipophilic structure allows it to efficiently cross cell membranes and increase intracellular levels of glutathione (GSH) - the body’s master antioxidant. Comparative studies show that NACET increases GSH concentrations significantly more than conventional N-acetylcysteine (NAC) by rapidly delivering cysteine inside cells. Higher glutathione levels help reduce damage to cells from harmful molecules and improve the body's ability to eliminate toxins (PMC7827200). -
Support Natural Detoxification Pathways
Glutathione is a central component of phase II liver detoxification and neutralization of reactive oxygen species (ROS) and toxins. By replenishing cysteine and boosting GSH levels, NACET supports liver detoxification and healthy function of the body’s cells. Essential mineral cofactors including selenium (required for glutathione peroxidase, GPx) and molybdenum further optimize the body’s detoxification systems (PMC11275037). -
Protect Mitochondrial Function and Energy Production
Oxidative stress impairs mitochondrial membranes and electron transport, leading to reduced adenosine triphosphate (ATP synthesis). NACET’s enhanced glutathione support helps preserve mitochondrial integrity, sustain ATP generation and mitigate fatigue linked to oxidative stress. Clinical trials demonstrate improved mitochondrial enzyme activity and reduced oxidative stress, validating NACET’s mechanistic advantage (PMC8719286). -
Support Cognitive and Neurological Health
Glutathione plays a vital role in neuronal protection and neurotransmitter regulation. Clinical studies involving NAC supplementation show improved cognitive performance and antioxidant capacity, along with reductions in oxidative stress and inflammation markers (PMC8234027). NACET’s superior ability to cross the blood–brain barrier may help protect the brain from damage caused by free radicals (PMC10376274). -
Strengthen Immune Function
Adequate intracellular glutathione is vital for immune cell function and oxidative stress control. Studies show that NAC can improve the immune response and reduce oxidative burden during infections or chronic stress. Liposomal forms of selenium and zinc cofactors enhance the body’s endogenous antioxidant enzymes (GPx, SOD, CAT), reinforcing immune system efficiency (PMID:32726657). -
Optimize Methylation and Cellular Repair
Efficient methylation and DNA repair processes depend on sufficient redox levels and the presence of critical mineral cofactors. Magnesium, zinc and molybdenum are integral to DNA repair and enzyme activity. Taken alongside NACET, these nutrients help maintain cellular integrity, DNA stability and efficient nutrient metabolism (PMC7575806).