Third-Party Tested
Every batch, not just some — verified for purity and potency.
Ultra-Pure Methylfolate
Formulated with the cleanest, most bioavailable L-Methylfolate.
NSF Certified & FDA Registered
Manufactured in a facility that exceeds quality standards.
Top 14 Allergen Free
Without any of the EU’s top 14 allergens — clean and worry-free supplementation.
Made in the USA
Ensuring trusted quality and ingredient traceability.
Shop by Category
MTHFR Supplements
Methyl-Life®’s MTHFR supplements contain the most potent over-the-counter L-Methylfolate combined with synergistic nutrients that support the body’s folate metabolism. This in turn aids healthy DNA/RNA replication, mood, energy, brain function, and other wellness processes.
Balance Your Body with MTHFR Support
L-Methylfolate
Methyl-Life®’s L-Methylfolate supplements contain the purest and most potent over-the-counter L-Methylfolate per USP standards. Choose therapeutic dosing when it comes to supporting your mood, cardiovascular function, pregnancy, mental clarity, and other health needs.
Boost Health with L-Methylfolate
B12 Supplements
Methyl-Life®’s B12 products contain 3 bioactive vegan B12 sublingual forms to improve absorption and sufficiency. Taking B12 alongside L-Methylfolate supports DNA synthesis, energy production, protein metabolism, nervous system function, and red blood cell health.
Methyl-B12
Methyl-Life®’s Methyl-B12 contains the most active bioidentical methylated B12 sublingual form. When taken with L-Methylfolate, these vegan nutrients support DNA synthesis, energy production, nerve health, red blood cells, and folate metabolism.
Power Up with Methyl-B12
Methylated Vitamins
Methyl-Life®’s methylated vitamins contain the most potent over-the-counter L-Methylfolate and methylated B vitamins to support neurotransmitter production, energy levels, detoxification, red blood cell health, and other vitality needs.
Energize with Methylated Vitamins
Superior Magnesium
Discover magnesium supplements with advanced bioavailability, formulated for efficient absorption and optimal effectiveness.
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Best Sellers
Supplements and Support
Your journey to better health starts here! Optimize your wellbeing with Methyl-Life®If you've been newly diagnosed with an MTHFR mutation or are just looking to take some concrete action that can better support your health and improve your quality of life, check out our 6 Helpful Steps for Treating MTHFR page for some ideal guidelines.
Dr. Neil Rawlins presents his 4-part video seminar on MTHFR, methylfolate and how to manage challenging genetic factors affecting folate metabolism, neurotransmitter production (i.e. serotonin, dopamine, etc.), methylation, homocysteine, detoxification and more.
Need personalized support? Our Naturopath can review your personal medical history, genetics and recent blood tests and provide either:
- An email response to one of your health issues OR
- A 60-minute online, real-time video consult addressing your top health concerns
What Makes Methyl-Life®’s Manufacturing Process Exceptional?
Made in the USA (NSF Certified Manufacturer)
All Methyl-Life® supplements are produced in an FDA-registered, cGMP-compliant facility, and we go a step further with NSF Certification, the gold standard for supplement quality.
Transparent + Traceable Ingredients
Each product comes with a Certificate of Analysis (COA). Want to verify? Just ask. We believe you deserve to know exactly what you're putting in your body.
Founder-Led Quality Commitment
Our founder, Jamie Hope, lives with the same methylation challenges as many of our customers. That’s why our motto is simple: “We take our own medicine.”
Third-Party Tested - Every. Single. Batch.
Unlike most brands that only spot-check, we third-party test every single batch for potency and purity, so you always get what the label promises.
Shop by Health Goal
Support Pregnancy & Fertility
Bioavailable folate and B12 to support your body’s natural rhythms during preconception and pregnancy - especially important if you're managing MTHFR.
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Support Cognition & Immune Health
Methylated folate and B12 to help support brain and immune system function - ideal for those navigating high-stress or wellness-focused lifestyles.
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Step-by-Step Nutrient Support for Kids
A simplified guide for parents managing MTHFR or methylation issues in children. These formulas offer age-appropriate support for mood, focus, immunity, and developmental wellness — backed by expert dosing insights.
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Cardiovascular & Nerve Health Support
These nutrients help regulate homocysteine, blood sugar metabolism, red blood cell production, and nerve signaling. A foundational choice for those managing cardiovascular risk, diabetes, anemia, or nerve-related issues.
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Explore Our Best Active B12 Supplements
Methyl-Life® offers methylcobalamin, hydroxocobalamin, and adenosylcobalamin — the most effective B12 forms for absorption and impact. Designed to bypass genetic blocks for optimal cellular support.
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Targeted Support for Gut Health
Methylation plays a vital role in gut lining integrity, immune regulation, and detox. These formulas promote optimal digestion, healthy flora, and support for those with MTHFR or gut-related fatigue.
Explore NowPopular reads from our experts
Let customers speak for us
Trusted Methylated Supplements Backed by Science & Personal Experience
Founded by Jamie Hope. Formulated for People Who Need Real Results.
At Methyl-Life®, we believe nutritional support should go beyond generic formulas and vague health promises. That’s why we specialize in methylated supplements — high-quality, bioavailable nutrients designed for those who need targeted support for methylation, mental health, cardiovascular health, pregnancy, energy levels, and more.
Our flagship products, including L-Methylfolate and methylated B vitamins, are meticulously formulated to deliver therapeutic-grade support for people with MTHFR gene mutations, nutrient absorption issues, or increased neurological, immune, or metabolic needs.
Why Methylation Matters
Methylation is a key biochemical process that affects everything from your mood and DNA to detoxification and cardiovascular health.
