Non-Methylated Multivitamin with Cognitive Nutrients
Non-Methylated Multivitamin with Cognitive Nutrients
Non-Methylated Multivitamin with Cognitive Nutrients
Non-Methylated Multivitamin with Cognitive Nutrients
Non-Methylated Multivitamin with Cognitive Nutrients
Non-Methylated Multivitamin with Cognitive Nutrients
Non-Methylated Multivitamin with Cognitive Nutrients
Non-Methylated Multivitamin with Cognitive Nutrients
Gluten-Free Dairy-Free No Artificial Additives Fish/Shellfish-Free Vegan-Friendly Non-GMO BPA-Free Top 14 Allergen-Free
Manufactured: June 2025

Methyl-Life® supplements typically retain their potency for 2-3 years. They should be stored in their original, tightly sealed containers in a cool, dry place away from heat, moisture, and direct sunlight.
Energy + Cognitive Support, Designed for Sensitive Users

Non-Methylated Multivitamin with Cognitive Nutrients

$40.00

Methyl-Life’s® Non-Methylated Multivitamin is a daily multivitamin designed for individuals who want broad nutritional support without methylfolate or vitamin B12. It provides foundational vitamins and minerals while allowing sensitive users to personalize their routine by adding methylfolate and/or active B12 separately, in amounts that fit their individual needs.

This approach is especially helpful for those who do not tolerate methylated nutrients well or who prefer customized dosing as part of a more flexible methylation-support routine. By separating core nutrition from methylated components, this formula supports a calmer, more controlled daily experience.

This multivitamin pairs easily with Methyl-Life’s® methylfolate-only products, B12-only products, or other practitioner-recommended supplements that include methylfolate and/or vitamin B12.
  • Vitamins A, D3, E & bioactive K2 to support foundational daily nutrition
  • Artichoke extract & Milk Thistle to support the body’s natural nutrient-processing functions
  • Energy-supporting B vitamins with supportive cofactors, without methylated forms
  • 90 Caps / 45 Srvs - Non-GMO, Gluten-Free

Free Shipping on Orders Over $100

This specialized multivitamin was created for individuals who want comprehensive daily nutrient support without methylfolate or vitamin B12. It allows you to build a routine that feels more flexible and better tolerated, especially if methylated nutrients are not a good fit.

By keeping folate and B12 separate, this formula makes it easier to personalize your intake - whether you add them individually, follow a practitioner-guided protocol, or prefer to avoid methylated nutrients altogether.

Why a Multivitamin Without Folate or B12?

Many people using methylation-related supplements prefer the ability to adjust folate and B12 independently. This formula is designed to support that flexibility.

It provides a broad blend of vitamins, minerals and supportive nutrients while intentionally leaving folate and B12 out, so those can be added separately based on personal tolerance, goals, or professional guidance.

Comprehensive Nutrient Support for Energy and Well-Being

This formula includes a full complex of non-methylated, energy-supporting B vitamins, along with key cofactors that help support normal cellular energy production, thyroid-related nutrient use and metabolic balance.

It also incorporates:

  • Sucrosomial® and ALBION® minerals to support mineral uptake and utilization
  • Vitamins A, D3, E and bioactive K2 to support immune, bone and cellular health
  • PANMOL® NADH + MicroActive® CoQ10, included to support ATP-related energy processes
  • TMG, a methyl donor commonly used to support healthy homocysteine metabolism

Together, this nutrient profile makes the formula a foundational multivitamin option for individuals following methylation-focused routines - without adding folate or B12 directly.

Targeted Cognitive and Neurological Nutrients

To further support mental clarity and everyday cognitive function, this multivitamin includes two carefully selected nutrients:

  • Citicoline (soy-free) - a bioavailable choline source used to support focus, attention and cognitive processing
  • Phosphatidylserine (soy-free) - a phospholipid that supports memory, learning and stress-related balance

These nutrients were chosen to complement routines where neurological support is a priority, without relying on methylated forms.

Liver and Detox Support

Artichoke extract and Milk Thistle (standardized to silymarin) are included to support the body’s natural processes involved in nutrient handling, bile flow and overall liver function - systems that play a role in metabolic balance and methylation-related pathways.

Flexible Enough for Prenatal Use (With Add-Ons)

Because this formula contains no iron, vitamin C, folate, or vitamin B12, it can be paired with a clinician-recommended prenatal approach when additional nutrients are added separately.

Simply add:

  • Methylfolate, in an amount appropriate for individual needs
  • Active B12, such as a standalone B12 supplement

This flexibility allows for a more personalized prenatal routine, tailored to tolerance, nutritional goals and individual considerations.

Supplement Facts
Serving Size: 2 Veggie Capsules
Servings Per Container: 45 servings per container
Amount Per Serving Daily Value
Vitamin A 300 mcg RAE (1,000 IU)
(as Retinyl Palmitate)
33%
Vitamin D 50 mcg (2,000 IU)
(as Cholecalciferol [D3])
250%
Vitamin E 12 mg
(as d-α-Tocopheryl Acid Succinate)
80%
Thiamin 1 mg
(Vitamin B1) (as Thiamin HCI)
83%
Vitamin B2 8 mg
(as Riboflavin 5 Sodium Phosphate)
615%
Niacin 20 mg NE
125%
Vitamin B6 5 mg
(as Pyridoxal 5 Phosphate)
294%
Biotin 60 mcg
200%
Pantothenic Acid 22 mg
(as B5 - D-Calcium Pantothenate)
440%
Iodine 100 mcg
(as Potassium Iodide)
67%
Zinc 15 mg
(as sustained release micropellet)
136%
Selenium 100 mcg
(as Sucrosomial Selenium (UltraSel®))
182%
Manganese 3 mg
(Manganese Bisglycinate Citrate)
130%
Molybdenum 35 mcg
(Molybdenum Glycinate (ALBION))
78%
Artichoke 50 mg
(Leaf) Extract 5% Cynarin)
†
Citicoline Sodium 50 mg
†
Ubiquinol 10 mg
(CoQ10 Reduced Form)
†
Phosphatidylserine 50 mg
(Sunflower - Helianthus annuus)
†
Milk Thistle 50 mg
((Seed) Extract 80% Silymarin)
†
Trimethylglycine 50 mg
(TMG)
†
Pantethine 50% 14 mg
†
Para-Aminobenzoic Acid 10 mg
(PABA) (Vitamin B10)
†
Benfotiamine 20 mg
(Fat Soluble Vitamin B1)
†
NADH 1 mg
(Microencapulated NADH)
†
Vitamin K2 80 mcg
(as Menaquinone-7)
†
† Daily Value not established.
Manufactured: June 2025

Methyl-Life® supplements typically retain their potency for 2-3 years. They should be stored in their original, tightly sealed containers in a cool, dry place away from heat, moisture, and direct sunlight.

Other Ingredients

L-Leuciine, capsule (hypermellose, purified water).

Allergen & Safety Information

  • Does not contain: wheat, gluten, soy, dairy, tree nuts, animal products, or GMOs
  • No artificial ingredients or colorings
  • Sweetened with xylitol — do not give to pets
  • Suitable for individuals avoiding common allergens and those sensitive to methylated nutrients, since this product contains zero folate and zero B12 by design.

Suggested Use

Take 1-2 capsule(s) daily after meals or as directed by your healthcare practitioner. May be chewed, dissolved in the mouth or swallowed.

How much should you take?

Everyone’s needs are different. Always consult your healthcare provider to help determine the amount that best fits your individual routine.

The recommended serving for this multivitamin is:

→ 1-2 capsules daily, taken after meals
 (or as directed by your healthcare practitioner)

Because this formula intentionally excludes methylfolate and vitamin B12, it gives you the flexibility to:

  • Pair it with your own practitioner-recommended methylfolate or B12 amount
  • Avoid overstimulation if you are sensitive to active or methylated forms
  • Build a personalized routine while still receiving comprehensive vitamin, mineral and cognitive support

Always consult your healthcare provider to determine the ideal amount for your individual needs.

Doctor-Guided Support

Visit our Dosage Information and Methylation Protocol pages to learn how some practitioners approach multivitamin and folate/B12 combinations, including step-by-step guidance often used for individuals with MTHFR gene variants.

These resources explain how practitioners commonly structure multivitamin routines and how intake may be adjusted over time based on tolerance and response.

Additional considerations

Some individuals prefer to:

  • Start with 1 capsule per day
  • In the absence of specific guidance from a healthcare professional, consider taking one to two capsules after meals. If you feel comfortable with one capsule, an additional capsule may be added if desired.
  • Adjust timing based on energy sensitivity (morning use is common)

As with any multivitamin routine, consistency matters. Take daily unless your clinician recommends a different schedule.

Why a Non-Methylated Multivitamin Matters

Many individuals using methylation-focused supplements prefer a high-quality multivitamin without folate or vitamin B12, allowing more precise and individualized control of these nutrients. This formula was developed in response to clinicians and customers seeking foundational nutritional support for energy, cognition, thyroid-related nutrient use and homocysteine pathways - without adding additional methyl donors.

By removing folate and vitamin B12 entirely, this multivitamin allows for more personalized approaches to:

  • Methylation support
  • MTHFR-related nutrient sensitivity
  • Customized folate and B12 intake
  • Avoidance of excessive methyl donor exposure
  • Stacking with prescription-based or standalone folate/B12 supplements

For individuals who are sensitive to methylated nutrients or who follow practitioner-guided protocols, this “clean base” approach is often preferred.

Key Scientific Foundations Behind This Formula

B-Vitamins for Energy and Cellular Metabolism

Non-methylated B vitamins - including thiamine (B1), riboflavin (B2), pyridoxine (B6), niacin and pantothenic acid - support essential biochemical pathways involved in:

  • Cellular energy production (ATP-related processes)
  • Carbohydrate, lipid and protein metabolism
  • Thyroid- and adrenal-related nutrient utilization
  • Red blood cell formation

These forms provide broad metabolic support without contributing additional methyl donors (PMC8839250).

Sucrosomial® and ALBION® Minerals for Enhanced Absorption

Sucrosomial® selenium and ALBION® mineral chelates are widely studied for their ability to support:

  • High bioavailability
  • Improved gastrointestinal tolerability
  • Efficient cellular uptake

Minerals such as zinc, selenium, iodine and manganese play important roles in immune-related nutrient use, thyroid hormone metabolism, enzyme activity and antioxidant defense.

PANMOL® NADH + MicroActive® CoQ10 for ATP and Mitochondrial Support

This formulation includes a complementary combination selected to support mitochondrial energy-related processes:

  • PANMOL® NADH serves as a contributor to ATP-related pathways
  • MicroActive® CoQ10 is included for enhanced absorption and sustained cellular utilization

Together, these ingredients support consistent cellular energy processes without the use of stimulants (PMC8399248).

TMG (Trimethylglycine) and Homocysteine Metabolism

TMG, also known as betaine, is well studied for its role in supporting:

  • Healthy homocysteine metabolism
  • Methylation-related pathways
  • Liver-related metabolic processes

TMG is included because it supports these pathways independently of folate or vitamin B12, offering greater flexibility in protocol design (PMC8224793).

Cognitive and Neurological Support from Citicoline and Phosphatidylserine

Two extensively researched cognitive-support nutrients are included:

  • Citicoline (CDP-Choline) to support attention, focus and cognitive processing
  • Phosphatidylserine to support memory, learning and cellular communication within the brain

Both ingredients are soy-free, improving accessibility for individuals with common allergen sensitivities (PMC4562749).

Liver-Supportive Extracts: Artichoke and Milk Thistle

These botanicals are commonly used to support:

  • Healthy bile flow
  • Antioxidant activity
  • Normal hepatic detoxification pathways

Standardized milk thistle (80% silymarin) has a long history of use in clinically oriented liver-support formulations (PMC8856812).

Clinical Relevance

This multivitamin is designed for individuals who:

  • Require a high-quality, fully active multivitamin without folate or vitamin B12
  • Experience sensitivity to methylated nutrients
  • Use prescription-based or supplemental folate/B12 and prefer a “clean” multivitamin base
  • Follow practitioner-guided methylation or MTHFR-related routines
  • Desire cognitive and energy support without overstimulating ingredients

Although this multivitamin does not contain folate or vitamin B12, its combination of clinically recognized nutrients supports foundational systems involved in energy metabolism, cognitive function, homocysteine-related pathways, thyroid-related nutrient use and liver function.

HOW WE HAVE HELPED OUR CUSTOMERS

Dibs

Verified Buyer
05/08/2025
Real Experience

I like them. I like that it's small capsules. Seems to be a good blend of nutrients. I'm moving more and more toward a carnivore diet so may not need them too much longer, but still taking them for a while to be sure.

HOW WE HAVE HELPED OUR CUSTOMERS

Tatiana D.

Verified Buyer
05/15/2025
Real Experience

Methylated vitamins are the best. After one month I feel rejuvenated and fool of energy. Highly recommended. Customer service is fantastic. Accelerates communication, quick replacement and returns.

HOW WE HAVE HELPED OUR CUSTOMERS

Sharon P.

Verified Buyer
11/11/2024
Increased the daily dose per my doctors recommendation

I began taking 2 capsules of this multivitamin daily about a year ago, shortly after I was diagnosed with compound heterozygous mthfr. I read a review that this multi helped with sleep. I have a life long history of insomnia, so I decided to give it a try. It definitely helped my nightly melatonin to be more effective. Additionally, I cannot tolerate methylated forms of folate and B12 due to my homozygous (slow) COMT, so this formula allows me to customize my dosages of folinic acid and adenosyl hydroxo B12. Recently, based on lab results, my functional medicine doctor suggested I try 3 caps daily. Much to my surprise, I began sleeping soundly through the night... No melatonin needed! I hope methyl life never stops making this multivitamin. It's perfect for me.

HOW WE HAVE HELPED OUR CUSTOMERS

Heidi D.

Verified Buyer
07/21/2024
Great formulation

I'm really liking these non-methylated vitamins. I've been purchasing the methylated multi for quite a while and decided to give these other ones a try and then tweak my methylfolate dosage, in addition to asking my husband to start taking these capsules. First off, there has been zero digestive upset with these. That's a win. Second, my husband takes these with zero complaints. Another win. I have to make the observation that Methyl Life makes great products and has great formulations. Been a customer for a number of years and don't plan to change.

HOW WE HAVE HELPED OUR CUSTOMERS

Crystal MN

Verified Buyer
08/29/2023
Best multivitamin I've tried

This is the only multivitamin that I've noticed a difference between when I'm taking it and when I'm out of it. I noticeably feel better taking it. {Your pee will also be more yellow due to the riboflavin/b2)

HOW WE HAVE HELPED OUR CUSTOMERS

Michael M.

Verified Buyer
10/09/2025
Real Experience

Also can't believe how healthy my hair is. It's growing so fast, and male pattern baldness has seemed to slow.I'm feeling great. I love taking this daily in the morning.
Non-Methylated Multivitamin with Cognitive Nutrients
$40

Updated Non-Methylated Multi - Now with Even More Effective Support

At Methyl-Life®, we’re always working to improve our products so they can better support your health and well-being. Our latest Non-Methylated Multi formula includes several carefully considered upgrades:

Upgraded Vitamin B5 - We’ve replaced some pantothenic acid with pantethine, a premium, bioactive form that offers improved absorption and supports cardiovascular and other key metabolic processes.

Chromium Removed - Following expert recommendations, we’ve eliminated chromium due to emerging concerns about potential metals toxicity.

Superior CoQ10 Form - We’ve replaced CoQ10 with ubiquinol, its most active and bioavailable form. This upgrade bypasses the genetic conversion step required for standard CoQ10, making it more effective for everyone.

Enhanced NADH - We’ve incorporated a more potent form of NADH to better support cellular energy production.

These refinements are part of our ongoing commitment to use the most effective and highest-quality ingredients available so you can feel confident you’re giving your body the very best.

Traceable Ingredients You Can Trust

Every ingredient is sourced for purity, backed by clinical evidence, and rigorously tested for safety and bioavailability. Because in supplements, not all ingredients are created equal — and your body deserves only the most effective forms.

Cognitive Clarity and Brain Energy Support

Citicoline (CDP-Choline)

Citicoline is included to support focus, mental clarity and brain energy, without relying on stimulants or methylated nutrients.

It provides a form of choline the brain uses to help maintain healthy brain cell structure and communication. This makes it a practical option for individuals who want clear thinking and cognitive support as part of a flexible, non-methylated routine.

LEARN MORE: Did You Know?

  • Citicoline has been shown to support attention, processing speed and memory performance by enhancing phospholipid turnover and brain energy pathways (PMC10389840).
  • Research suggests Citicoline helps maintain neuronal membrane integrity, supporting mental clarity during cognitive demand (PMC4562749).

Backed by research: PMC10389840, PMC4562749

Memory, Learning and Stress Support

Phosphatidylserine (Sunflower-Derived)

Phosphatidylserine is included to support memory, learning and calm, focused thinking, especially during periods of mental demand.

It helps support how brain cells communicate and respond to everyday stress, which plays a role in mental clarity and emotional balance. Using a sunflower-derived, soy-free form makes this ingredient easier to tolerate for individuals with common sensitivities.

LEARN MORE: Did You Know?

  • Studies show PS supports memory recall, executive function and mental accuracy, particularly under stress (PMC10195946).
  • PS contributes to cell signaling, membrane fluidity and cognitive resilience, supporting  long-term brain health (PMC9382310).

Backed by research: PMC10195946, PMC9382310

Mitochondrial Energy and Cellular Vitality

PANMOL® NADH

PANMOL® NADH is included to support natural cellular energy and mental stamina, without relying on stimulants.

It helps support how the body produces and maintains energy at the cellular level, contributing to steady vitality and metabolic efficiency throughout the day. This makes it a good fit for individuals who want consistent energy support that feels balanced rather than intense.

LEARN MORE: Did You Know?

  • NADH is a direct participant in mitochondrial ATP synthesis, supporting natural energy production at the cellular level (PMC7112453).
  • Research indicates NADH may help maintain healthy mitochondrial function and support metabolic resilience during periods of increased demand (PMC12177089).

Backed by research: PMC7112453, PMC12177089

Enhanced Bioavailability for Steady Energy

MicroActive® CoQ10

MicroActive® CoQ10 is included to support steady cellular energy and overall mitochondrial health, using a form designed for improved absorption and gradual release.

CoQ10 plays an important role in how cells produce and manage energy, while also supporting antioxidant activity. Using a sustained-release form helps provide more consistent energy support throughout the day, rather than sharp peaks or drops.

LEARN MORE: Did You Know?

  • MicroActive® CoQ10 has demonstrated enhanced bioavailability, allowing higher tissue uptake compared to standard forms (PMC7146408).
  • CoQ10 supports steady ATP production, helping maintain natural vitality throughout the day.

Backed by research: PMC7146408

Antioxidant and Thyroid Support

Sucrosomial® Selenium (UltraSel®)

Sucrosomial® Selenium is included to support thyroid-related nutrient function, antioxidant balance and immune support, using a form designed for gentle digestion and reliable absorption.

Its protective delivery system helps selenium pass through the digestive system more comfortably, making it easier for the body to utilize. This allows for consistent selenium support without the harshness sometimes associated with traditional mineral forms.

LEARN MORE: Did You Know?

  • Sucrosomial® technology enhances intestinal uptake and bioavailability, making selenium easier to absorb (PMC6316120).
  • Selenium is essential for antioxidant enzymes that protect cells against oxidative stress (PMC5981252).

Backed by research: PMC6316120, PMC5981252

Superior Absorption & Metabolic Support

ALBION® Chelated Minerals

ALBION® chelated minerals are included to support reliable mineral absorption and everyday metabolic function, using forms designed to be gentle on digestion.

By binding minerals such as zinc, manganese and molybdenum to amino acids, these chelates help the body utilize minerals more efficiently. This supports a wide range of daily processes related to metabolism, enzyme activity and cellular function, without harsh or poorly absorbed forms.

LEARN MORE: Did You Know?

  • Chelated minerals demonstrate greater absorption and improved tolerance compared to non-chelated forms (PMC10993154).
  • Zinc and manganese are involved in enzyme activation, antioxidant defenses and cellular repair pathways.

Backed by research: PMC10993154

Liver and Detoxification Support

Milk Thistle (80% Silymarin)

Milk Thistle is included to support liver function and the body’s natural detoxification processes, using a standardized extract for consistency and reliability.

Silymarin helps support the liver’s ability to handle everyday metabolic demands and provides antioxidant support that contributes to overall cellular protection. It also supports healthy bile flow, which plays a role in digestion and nutrient processing.

LEARN MORE: Did You Know?

  • Silymarin has been shown to support liver cell resilience and antioxidant capacity (PMC11404857).
  • Milk Thistle contributes to healthy detoxification, helping the liver process nutrients more efficiently.

Backed by research: PMC11404857

Digestive & Bile Flow Support

Artichoke Extract (5% Cynarin)

Artichoke extract is included to support comfortable digestion and healthy bile flow, which play a role in how the body processes nutrients from food.

By supporting bile production and movement, artichoke extract helps promote efficient nutrient breakdown and metabolic balance. It works alongside Milk Thistle to provide gentle, complementary support for liver-related digestive processes.

LEARN MORE: Did You Know?

  • Artichoke extract has demonstrated benefits for bile secretion and digestive comfort (PMID:26310198).
  • Research highlights its supportive role in liver enzyme activity and antioxidant pathways.

Backed by research: PMC3931154

Methylation Flexibility Without Folate or B12

Trimethylglycine (TMG)

TMG is included to support balanced methylation activity and healthy homocysteine pathways, without relying on folate or vitamin B12.

It helps support methylation-related processes and liver function while allowing you to fully customize folate and B12 intake separately. This makes it especially useful for individuals who want methylation support without committing to fixed or combined nutrient doses.

LEARN MORE: Did You Know?

  • TMG supports the body’s natural methylation cycle by contributing methyl groups needed for homocysteine metabolism (PMC8224793).
  • Research shows TMG may help maintain nutritional methylation balance without overstimulating sensitive individuals.

Backed by research: PMC8224793

Methyl-Life® Non-Methylated Multivitamin with Cognitive Nutrients contains no unnecessary excipients, synthetic colors, artificial preservatives, or common allergens. It is 100% free from gluten, soy, dairy, GMOs, animal-derived ingredients, and the EU’s top 14 allergens.

Every batch is third-party tested for purity, potency, and safety, manufactured in NSF-certified, cGMP-compliant facilities, and rigorously evaluated to ensure you’re getting clean, clinical-grade nutrients — nothing more, nothing less.

EU’s top 14 allergens

  • Cereals containing gluten - wheat (such as spelt and khorasan wheat), rye, barley, oats. Note: The cereal name, e.g., 'wheat', must be declared and highlighted, not 'gluten'.
  • Crustaceans, e.g., crabs, prawns, lobsters
  • Eggs
  • Fish
  • Peanuts
  • Soybeans
  • Milk
  • Nuts (almonds, hazelnuts, walnuts, cashews, pecan nuts, brazil nuts, pistachio nuts, macadamia/Queensland nut). Note: The name of the nut, e.g., 'almond', must be declared and highlighted, not 'nuts'.
  • Celery
  • Mustard
  • Sesame seeds
  • Sulphur dioxide and sulphites (at concentrations of more than 10 mg/kg or 10 mg/L in terms of total sulphur dioxide) – used as a preservative
  • Lupin 
  • Molluscs, e.g., mussels, oysters, squid, snails
A Research-Informed Multivitamin Without Folate or Vitamin B12 - Formulated for Precision

Unlock Advanced Cognitive, Energy & Methylation-Support Flexibility

This multivitamin is designed for people who want complete daily nutrition without folate or vitamin B12 included. It gives you the flexibility to support your health while keeping full control over how and when those nutrients are added.

For individuals following methylation-focused routines, folate and B12 often need to be adjusted carefully. By leaving both out entirely, this formula acts as a clean, neutral foundation - supporting energy, mental clarity and nutrient balance without interfering with personalized protocols or overwhelming sensitive systems.

It’s a practical option for people who want support without guesswork.

This formula is well suited for individuals who:

  • Are fine-tuning methylation or B-vitamin intake with professional guidance
  • Prefer a multivitamin that won’t conflict with customized folate or B12 dosing
  • Feel better using flexible, non-methylated approaches
  • Want daily support for mental performance, energy metabolism and overall nutrient coverage

Supports Cognitive, Cellular & Neuro-Metabolic Balance

This formula combines carefully selected nutrients that support everyday brain function, cellular health and steady energy - without adding methyl donors.

  • Citicoline helps support mental focus and brain cell structure
  • Phosphatidylserine supports healthy cell signaling and stress-related balance
  • PANMOL® NADH and MicroActive® CoQ10 support natural cellular energy production
  • Non-methylated B vitamins help support metabolic processes tied to energy and neurological function

Together, these ingredients are chosen to support clear thinking, consistent energy and comfortable daily use, especially for individuals who prefer non-stimulating formulas.

Research Insights: 

  • Human studies show that Citicoline supports attention, mental processing speed and healthy phospholipid metabolism in the brain (PMC10389840).
  • Phosphatidylserine has been associated with supporting memory scores, executive function and stress-related cognitive performance across multiple age groups (PMC4220811).
  • Research on NADH suggests it plays a supportive role in mitochondrial ATP generation and cellular energy metabolism , especially when paired with CoQ10 (PMC8399248).
  • CoQ10, particularly in enhanced-absorption forms, has demonstrated benefits for mitochondrial function, cellular energy output and antioxidant capacity in human tissues (PMC8066821).

Promotes Cognitive Performance & Neuro-Structural Support

This multivitamin includes citicoline and phosphatidylserine, two well-studied nutrients chosen to support clear thinking, focus and everyday cognitive performance.

These nutrients help support the structure and function of brain cells, which plays a role in attention, memory and information processing. By supporting how brain cells communicate and maintain integrity, they contribute to mental clarity without overstimulation.

Importantly, this cognitive support is delivered without adding methyl donors, making it well suited for individuals who prefer flexible, non-methylated approaches.

Scientific Support

  • Citicoline has demonstrated benefits for attention, learning and cognitive processing speed, supporting healthy brain energy metabolism (PMC4562749).
  • Phosphatidylserine supports memory, cognitive performance and stress-related mental clarity, particularly in individuals experiencing cognitive demand (PMC10195946).
  • Choline-based nutrients contribute to phospholipid synthesis and neuronal membrane health, supporting long-term cognitive resilience (PMC7352907).

Optimizes Cellular Energy and ATP Production

This formula is designed to support steady, everyday energy at the cellular level, without relying on stimulants or methylated B vitamins.

It combines PANMOL® NADH, MicroActive® CoQ10 and non-methylated B vitamins to support the body’s natural energy-producing processes - helping cells efficiently generate and use energy throughout the day.

Instead of pushing energy quickly, these nutrients work together to support balanced, sustained energy output, which is especially helpful for individuals who are sensitive to overstimulation or prefer a calmer metabolic response.

The result is consistent cellular energy support that fits well into flexible, non-methylated routines and precision-based protocols.

Scientific Support

  • NADH has been shown to contribute to mitochondrial ATP synthesis, supporting natural cellular energy output and metabolic resilience (PMC7112453).
  • CoQ10 supplementation is associated with improved mitochondrial efficiency and antioxidant activity, helping sustain healthy energy production at the cellular level (PMC8389239).
  • B-vitamins play essential roles in macronutrient metabolism and mitochondrial enzyme function, supporting sustained energy without overstimulation (PMID:16765926).

Supports Mineral Absorption, Thyroid Function and Antioxidant Defense

This formula includes highly absorbable mineral forms selected to support consistent nutrient uptake and everyday balance, even when dietary intake isn’t perfect.

Sucrosomial® selenium (UltraSel®) and ALBION® chelated minerals are chosen for their gentle digestion and reliable absorption. Minerals such as selenium, zinc and iodine help support antioxidant activity, immune-related processes and normal thyroid function - all without harsh forms that can be difficult to tolerate.

By focusing on bioavailable, well-tolerated minerals, this multivitamin helps support balanced micronutrient status as part of a flexible, daily routine.

Scientific Support

  • Sucrosomial® Selenium has shown higher bioavailability and improved tolerability compared to traditional forms, supporting antioxidant and metabolic pathways (PMC12430616).
  • Zinc and selenium are essential cofactors for antioxidant enzymes, contributing to cellular defense and immune function (PMC11939285).
  • Chelated minerals exhibit enhanced absorption and greater physiological availability, supporting overall micronutrient status (PMID:39988216).

Frequently Asked Question

What makes this multivitamin different from standard multivitamins?
This formula is designed for individuals who want a high-quality multivitamin without folate or vitamin B12. Most standard multivitamins include these nutrients automatically, which can make personalization difficult for sensitive users.

By leaving folate and B12 out entirely, this multivitamin allows you to customize your intake separately, based on tolerance or practitioner guidance. It also includes supportive energy and cognitive nutrients such as citicoline, phosphatidylserine, PANMOL® NADH, MicroActive® CoQ10 and Sucrosomial® / ALBION® minerals, which are not commonly combined in conventional multivitamins.
Who is this multivitamin best suited for?
This product is a good fit for individuals who:
  • Want a high-quality multivitamin without folate or vitamin B12
  • Prefer to add methylfolate or B12 separately
  • Are sensitive to methylated nutrients
  • Follow practitioner-guided methylation or MTHFR-related routines
  • Use prescription or standalone folate/B12 supplements
  • Want energy, cognitive, thyroid-related nutrient support and liver support without stimulants
It is also suitable for those looking for a comprehensive daily vitamin and mineral foundation with added cognitive and energy-related cofactors.
Is this multivitamin appropriate for people with MTHFR gene variants?
This multivitamin is often chosen by individuals who want to manage methylation-related intake carefully, including those with MTHFR gene variants.
By excluding folate and vitamin B12, it allows users to:
  • Avoid unintentional intake of methylated nutrients
  • Add precise amounts of methylfolate or B12 separately
  • Follow practitioner-guided routines without additional methyl donors from the multivitamin
It provides foundational nutrient support while allowing greater flexibility.
Does this formula support energy and cognitive function?
Yes. While it does not contain folate or vitamin B12, it includes several well-studied nutrients associated with energy-related and cognitive processes, including:
  • PANMOL® NADH and MicroActive® CoQ10 to support ATP-related energy pathways
  • Citicoline (CDP-Choline) to support focus and cognitive processing
  • Phosphatidylserine to support memory and learning
  • Non-methylated B vitamins to support normal metabolic and cellular energy processes
Together, these nutrients support steady, non-stimulant energy and everyday cognitive function.
What brand-name ingredients are included in this formula?
This multivitamin includes several research-backed, branded ingredients, selected for quality and tolerability, including:
  • PANMOL® NADH for cellular energy support
  • MicroActive® CoQ10 for enhanced absorption
  • Sucrosomial® Selenium (UltraSel®) for efficient mineral delivery
  • ALBION® mineral chelates for improved absorption and gastrointestinal comfort
  • Citicoline (soy-free) for cognitive support
  • Phosphatidylserine (soy-free, sunflower-derived) for memory and mental performance
These ingredients are included for their purity, stability and bioavailability.
How should I take this multivitamin? Do I need to take it after meals?
For general use:

→ Take 1-2 capsules daily after meals

Taking the capsules after meals helps support comfortable digestion and nutrient utilization. If you are new to this product or sensitive to supplements, starting with a lower amount may be preferred.
Why is this formula made without folate or vitamin B12?
Many people following methylation-focused routines prefer to control folate and B12 intake independently. When these nutrients are included in a multivitamin, adjusting amounts can be challenging - especially for those who are sensitive to methylated forms.

By excluding folate and vitamin B12 entirely, this multivitamin serves as a clean, neutral base that can be paired with targeted amounts of methylfolate or B12, without the risk of unintentionally stacking doses.
Can I take this multivitamin with my own methylfolate or B12 supplement?
Yes. This multivitamin was intentionally designed to be used alongside customized folate or B12 supplementation.

Because it contains no folate and no vitamin B12, you can take the specific amount recommended by your practitioner - whether low, moderate, or higher - without overlap from the multivitamin itself. This makes it well suited for individuals adjusting intake based on personal tolerance.
Can this product be helpful if I’m sensitive to methylated nutrients?
Many people report discomfort when taking multivitamins that include methylated forms of folate or B12. This formula avoids that issue by providing a non-methylated, non-stimulating base.
You can start with a lower amount, adjust gradually and add methylated nutrients separately only if and when they feel well tolerated.
Can this be used as a prenatal multivitamin?
This product may be used as part of a prenatal approach for individuals who need a multivitamin without iron, vitamin C, folate, or vitamin B12.
Because these nutrients are intentionally excluded, they would need to be added separately, such as:
  • A clinician-recommended amount of methylfolate
  • An active form of vitamin B12
  • Iron and vitamin C, if appropriate
Always consult a healthcare provider before using any supplement during pregnancy.
Which allergens or additives does this multivitamin avoid?
This formula avoids many common allergens and unnecessary additives. It contains no:
  • Wheat or gluten
    • Soy
  • Dairy
  • Tree nuts
  • Animal-derived ingredients
  • Artificial colors or artificial ingredients
  • GMOs
It is encapsulated in a vegetable-based (hypromellose) capsule and includes only essential excipients.
Can I start with one capsule instead of the full dose?
Yes. Many individuals prefer to to assess tolerance.
You may increase to 2 capsules daily once you feel comfortable or if advised by your healthcare provider.

Clinically Studied, Backed by Real Science

The ingredients in Methyl-Life®’s Non-Methylated Multivitamin are supported by clinical research examining their roles in everyday cognitive function, cellular energy processes and metabolic balance.

By combining bioavailable, well-studied nutrients - without folate or vitamin B12 - this formula provides a science-informed foundation that supports key physiological pathways while allowing full flexibility around methylation-related intake.

Many of the nutrients included, such as citicoline, phosphatidylserine, NADH, CoQ10 and chelated minerals, have been examined in human studies for their associations with mental performance, cellular energy support and overall resilience.

Cognitive Processing and Mental Performance

Supporting Brain Cell Structure for Focus and Memory

Clear thinking and focus depend on healthy brain cells and how well they communicate with each other. When brain cells are well supported, it’s easier to stay attentive, process information and remember details during the day.

Nutrients that help maintain brain cell structure and communication are commonly associated with better focus, memory and mental efficiency, especially during periods of increased mental demand.

Evidence-Based Insight:

A clinical review reported that nutritional support for brain cell structure and related metabolic processes was associated with improvements in cognitive performance and sustained mental clarity in human studies (PMC5476966).

📄 Read the Study – PMC5476966

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Methyl-Life® Supplement Collection Overview

Methyl-Life® offers a premium line of methylation support supplements designed for diverse wellness needs, with a focus on individuals managing MTHFR genetic variations. This curated collection features L-Methylfolate formulas, advanced B vitamins, digestive support, and synergistic nutrient protocols—all developed to promote lasting energy, cognitive clarity, immune resilience, and overall vitality.

Pure L-Methylfolate: Superior Folate for Cellular Wellness

At the core of the collection are L-Methylfolate supplements, recognized for their purity, potency, and bioavailability. L-Methylfolate is the bioactive form of folate, supporting:

  • Mood balance and mental clarity
  • Cognitive and memory function
  • Cardiovascular and circulatory wellness
  • Prenatal and maternal health

Made with USP-grade ingredients and often featuring patented forms such as Magnafolate® PRO or Cerebrofolate®, these supplements provide consistent quality and superior absorption compared to standard folic acid.

Complete B Vitamin Solutions

Methyl-Life® also delivers comprehensive B12 solutions, featuring methylcobalamin, hydroxy B12, and adenosylcobalamin—three active forms of vitamin B12 known for high absorption and neurological benefits.

Highlights include:

  • Sublingual delivery for better absorption
  • Support for nerve health and energy production
  • Enhanced focus and overall vitality

These diverse forms allow for customizable approaches based on unique needs, including those who face digestive or genetic absorption challenges