L-Methylfolate 15mg+ B12

  • Purest Bioactive form of folate
  • Boost your mood
  • Pour cap contents under tongue for max B12 absorption
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Therapeutic high-dose of bioactive L-methylfolate uniquely formulated with the internationally-patented Magnafolate® PRO, active vitamin B12, and inositol to naturally support healthy mood, cognitive function, methylation and homocysteine support.

L-methylfolate is the predominant form of folate circulating in the body and used for biological processes1.

Studies show *15mg methylfolate + SSRI to be the most effective dose for improving depressive symptoms2.

Methylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier3.

  • Support for brain function4
  • Supports cardiovascular health5
  • Support for healthy immune function6
  • Supports nerve function7 and healthy myelin formation22
  • Nervous system maintenance21
  • Support for preconception, pregnancy, and fetal health8
  • Involved in reducing20 and maintaining healthy homocysteine levels9
  • Essential nutrient required for optimal DNA methylation19 and neurotransmitter synthesis10
  • Adjunctive support for serotonin selective reuptake inhibitors23
  • Suitable for people with MTHFR mutations11
Product details (30 capsule servings per container)
Key ingredients:  
  • Folate - 15,000 mcg (as L-5-Methyltetrahydrofolate, Calcium - Magnafolate® PRO)
  • Vitamin B12 - 1,000 mcg (as Hydroxocobalamin)
  • Inositol - 180 mg

Methylfolate 15mg+ Enhance Mood is a highly bioactive form of folate made with the purest methylfolate available12. 

  • Maximum absorption and bioavailability
  • No prescription required 
  • Available in 2.5mg, 3mg+B125mg, 7.5mg+B1210mg, 15mg, 15mg+B12 
  • Rigorously tested for consistency, purity, safety, and potency
  • Absolutely no fillers or additives of any kind

Why take Methylfolate 15mg+ Enhance Mood?

Synthesis of mood-enhancing neurotransmitters (serotonin, dopamine, and norepinephrine) is regulated by L-methylfolate, a derivative of folate10. Methylfolate has demonstrated efficacy as an adjunctive treatment for individuals who have not responded optimally to antidepressant therapy2.

Supplementing with 15mg methylfolate alongside SSRIs may be effective in improving symptoms of depression25. Methylfolate is absorbed more efficiently than synthetic folic acid which must be converted to active folate by the enzyme methylenetetrahydrofolate reductase (MTHFR)13.

Hydroxocobalamin works closely alongside folate in converting homocysteine to methionine to support mood and nervous system health. Individuals with MTHFR mutations may raise their nutrient status more efficiently with methylfolate11 and hydroxocobalamin26.

Inositol may be effective in treating disorders responsive to selective serotonin reuptake inhibitors, including depression, panic disorders, and obsessive-compulsive disorder24.

Methylfolate 15mg+ Enhance Mood is 100% free from all fillers and additives.

Who is affected by MTHFR mutations?

The MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants).  Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%).  Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A>C polymorphism in Hispanics and Africans is 15%14

An increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness15.  MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses16.

For these people, L-methylfolate supplementation is shown to be the most effective way to provide this form of folate10

Methyl-Life’s® Methylfolate is an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.

Why Magnafolate® PRO?

Methyl-Life’s® Methylfolate 15mg+ Enhance Mood is made with the internationally-patented Magnafolate® PRO, clinically tested as the world’s purest methylfolate (Magnafolate® PRO is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic® and Extrafolate®).

Magnafolate® is made with a form of methylfolate called L-5-MTHF-Ca, which is shown to be the most active form of folate in the plasma circulation. When compared with ordinary folate, L-methylfolate was found to be absorbed faster and utilized more quickly in the body17.

A recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation18



WARNING – How much is right for you to take?

Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step-by-step guide to some dosing options.

For optimal absorption, open the capsule and empty it under the tongue (hold it there and let it dissolve) – B12 is best absorbed via the mucous membrane in the mouth.

 Dr. Amy Yasko ( recommends a specific form of B12 based on your genetics if you know the status of your COMT 158 and VDR Taq variants. 

COMT V158M VDR Taq B12 Types That Should Be Tolerated
– – + + (TT) All 3 types of B12
– – + – (Tt) All 3 types of B12 with less Methylcobalamin
– – – – (tt) Hydroxocobalamin and Adenosylcobalamin
+ – + + All 3 types of B12 with less Methylcobalamin
+ – + – Hydroxocobalamin and Adenosylcobalamin
+ – – – Hydroxocobalamin and Adenosylcobalamin
+ + + + Hydroxocobalamin and Adenosylcobalamin
+ + + – Hydroxocobalamin and Adenosylcobalamin
+ + – – Mostly Hydroxocobalamin


SUGGESTED USEConsult with your healthcare practitioner before using this product. See for more recommendations. 

Serving Size: 1 Veggie Capsule
30 servings per container Amount per Serving % Daily Value
Folate (as L-5-Methyltetrahydrofolate, Calcium [equal to 20,000 mcg of Magnafolate PRO®]) 26,883 mcg DFE 6,721% (Total)
Vitamin B12 (as Hydroxocobalamin) 1,000 mcg 41,667% (Total)
Inositol 180 mg **

OTHER INGREDIENTS:  Capsule (water, hypromellose).

PRODUCT CONTAINS NO:  wheat, gluten, soy, dairy, egg, fish/shellfish, corn, yeast, nuts, starch, ingredients of animal origin, caffeine, artificial colorings, preservatives or artificial flavoring, bisphenol-A (BPA), or phthalate.

Methylfolate 15 What is the right dosage for me?

Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.

Methylfolate 15 What is L-Methylfolate 15mg+ B12?

L-Methylfolate 15mg+ B12 is a supplement that combines L-Methylfolate, the active form of folate, with vitamin B12.

Methylfolate 15What are the benefits of L-Methylfolate 15mg+ B12?

This supplement provides a high dose of L-Methylfolate along with vitamin B12, which supports methylation processes in the body. It may be beneficial for individuals with specific health concerns or nutritional needs requiring higher levels of these nutrients.

Methylfolate 15 How can I get more information on MTHFR?

check out our Help for MTHFR Newbies page.

Methylfolate 15 What is the Therapeutic high-dose of bioactive L-methylfolate?

The Therapeutic high-dose of bioactive L-methylfolate is a supplement uniquely formulated with the internationally-patented Magnafolate® PRO, active vitamin B12, and inositol.

Vitamin B 12 (as Hydroxocobalamin) What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?

The most important thing to realize is that blood tests for B12 are highly inaccurate at detecting actual cellular levels of B12 (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used.

Vitamin B 12 (as Hydroxocobalamin) What is Methylfolate 15mg+ Enhance Mood?

Methylfolate 15mg+ Enhance Mood is a highly bioactive form of folate made with the purest methylfolate available.

Vitamin B 12 (as Hydroxocobalamin) What are the key features of Methylfolate 15mg+ Enhance Mood?

This supplement offers maximum absorption and bioavailability, does not require a prescription, and is available in various strengths ranging from 2.5mg to 15mg+B12. It undergoes rigorous testing for consistency, purity, safety, and potency and contains absolutely no fillers or additives of any kind.

Vitamin B 12 (as Hydroxocobalamin) My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too?

One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxocobalamin, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true.

It’s important to realize that the MTHFR status does not necessarily determine the type of B12 that’s best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).

It seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.

The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxocobalamin, and from there the hydroxocobalamin has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.

Vitamin B 12 (as Hydroxocobalamin) I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?

If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be hydroxocobalamin. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxocobalamin (and this is why our methylation protocol suggests hydroxocobalamin as the B12 form to begin with):

    • Folks with multiple COMT mutations tend to do very well with hydroxocobalamin (it helps mop up excess peroxynitrites which can cause problems)
    • Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation
    • And Dr. Amy Yasko ( talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:


COMT V158M VDR Taq B12 Types That Should Be Tolerated
– – + + (TT) All 3 types of B12
– – + – (Tt) All 3 types of B12 with less Methylcobalamin
– – – – (tt) Hydroxocobalamin and Adenosylcobalamin
+ – + + All 3 types of B12 with less Methylcobalamin
+ – + – Hydroxocobalamin and Adenosylcobalamin
+ – – – Hydroxocobalamin and Adenosylcobalamin
+ + + + Hydroxocobalamin and Adenosylcobalamin
+ + + – Hydroxocobalamin and Adenosylcobalamin
+ + – – Mostly Hydroxocobalamin

Please Note:

Before purchasing any of our products, Methyl-Life® recommends that you talk with a healthcare professional if you have any questions. Methyl-Life® cannot be held liable for adverse reactions or negative side effects that you think are the result of one of our products.

If you have not used Methyl-Life® products before, please consider ordering one bottle to start before making larger orders. We also recommend you read through our dosage and methylation protocol pages and consider starting with a lower dose product to ensure you tolerate the ingredients well before increasing your strength to a higher dose product.

It is also important to speak with your healthcare professional before purchasing. Methyl-Life® prefers not to accept returns for large orders. If you return three unopened bottles from a 4-pack purchase, you will receive a full refund minus the cost of one bottle charged at full price.

Within 45 days of your order, you can return any unopened item shipped to you by Methyl-Life® (as long as all seals are intact). Just let us know you plan to return the product by emailing us at: or using the Contact Us form (please include the tracking information so we can be on the lookout for the package).

It will be your responsibility and cost to ensure the return parcel gets to Methyl-Life® (ship to: P.O. Box 33606, Seattle, WA 98133). We suggest you get a tracking number and consider insuring the package. After we receive your returned item, we will process your full refund within 10 business days and send you an email indicating your refund has been complete. Be aware that depending upon your institution, this may not be reflected in your account status for a few days.

If you have received the wrong item or your product has been damaged or is somehow defective, please email us at: with detailed information or use the Contact Us form and our Customer Service Manager will address your concern(s) right away. Please do not throw any items away unless or until you are directed to do so.



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