Moderate-high dose Methylfolate Supplement for healthy methylation, homocysteine and natural mood support.
Bioactive folate uniquely formulated with the new & improved, internationally-branded nutrient Cerebrofolate™
L-methylfolate is the predominant form of folate circulating in the body and used for biological processes1.
Studies show *15mg methylfolate + SSRI to be the most effective dose for improving depressive symptoms2.
Methylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier3.
- Support for brain function4
- Supports cardiovascular health5
- Support for healthy immune function6
- Supports nerve function7
- Support for preconception, pregnancy, and fetal health8
- Involved in maintaining healthy homocysteine levels9
- Essential nutrient required for healthy DNA and neurotransmitter synthesis10
- Suitable for people with MTHFR mutations11
A 2024 animal study found that high-dose methylfolate may protect against neurodevelopmental behaviours resulting from exposure to pyrethroid, a type of pesticide. Pyrethroid exposure disrupts folate metabolism in the brain and may contribute to behavioral disorders such as autism.
Methylfolate is the biologically active form of folate and can bypass disruptions to the breakdown of folate in the body, whether caused by MTHFR or by DPE exposure. In this study, high-dose supplementation with methylfolate dramatically reduced the behavioural disorders caused by folate issues, preventing deficits in the social, communication, cognitive, and locomotor areas of the brain that are linked to autism.19
Product details
Key ingredient: Folate 17,000 mcg DFE (10 mg L-Methylfolate from 14 mg of Cerebrofolate™)
Methylfolate Supplement 10 mg is a highly bioactive form of folate made with the purest L-methylfolate available12.
- Maximum absorption and bioavailability
- No prescription required
- Available in 2.5mg, 3mg+B12, 5mg, 7.5mg+B12, 10mg, 15mg, 15mg+B12
- Rigorously tested for consistency, purity, safety, and potency
Why take a methylfolate supplement?
Folate is required for numerous critical functions of the brain and nervous system. It is essential for DNA/RNA synthesis, maintaining healthy homocysteine levels, and for proper fetal development during pregnancy.
Folic acid is a synthetic form of folate. It can only be used by the body after it has been converted to active folate by an enzyme called methylenetetrahydrofolate reductase (MTHFR)13.
Who is affected by MTHFR mutations?
The MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants). Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%). Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A>C polymorphism in Hispanics and Africans is 15%14.
An increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness15. MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses16.
For these people, L-methylfolate supplementation is shown to be the most effective way to provide this form of folate10.
Methyl-Life’s® Methylfolate Supplement contains an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.
Why Magnafolate® PRO?
Methyl-Life’s® Methylfolate Supplement 10 mg is made with the internationally-patented Magnafolate® PRO, clinically tested as one of the purest methylfolate brands (Magnafolate® PRO is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic® and Extrafolate®).
Magnafolate® is made with a form of methylfolate called L-5-MTHF-Ca, which is shown to be the most active form of folate in the plasma circulation. When compared with ordinary folate, L-methylfolate was found to be absorbed faster and utilized more quickly in the body17.
A recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation18.
______________________________________
1 https://pubmed.ncbi.nlm.nih.gov/20608755/
2https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402301/
3https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687916/
4https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779227/
5https://www.ahajournals.org/doi/10.1161/hq0102.102190
6https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019735/
7https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867258/
8https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127769/
9https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832224/
10https://pubmed.ncbi.nlm.nih.gov/23212058/
11https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564482/
12https://cdn.shopify.com/s/files/1/0264/6369/9018/files/Methyl-Life_60-day_Methylfolate_Comparison.pdf?v=1595292111
13https://www.ncbi.nlm.nih.gov/books/NBK6561/
14https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530664/
15https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630484/
16https://www.ahajournals.org/doi/10.1161/01.CIR.0000165142.37711.E7
17https://pubmed.ncbi.nlm.nih.gov/24032278/
18https://i.trade-cloud.com.cn/upload/6405/file/20210929/english-version-magnafolate-enhancing-immunity_524485.pdf
19https://pmc.ncbi.nlm.nih.gov/articles/PMC11623627/
Dosage
WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to some dosing options.
How to snap the tablet in half – See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.
Video
SUPPLEMENT FACTS
| SUPPLEMENT FACTS | ||
|
Serving Size: 1 Chewable Tablet
|
||
| 90 servings per container | Amount per Serving | % Daily Value |
| Folate | 17,000 mcg DFE | 4,250% |
| (10 mg L-Methylfolate from 14 mg of Cerebrofolate™) |
|
|
FAQ'S
What is the right dosage for me?
Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.
Is a Methylfolate Supplement the only thing I should take if I have an MTHFR gene mutation?
What do doctors have to say about MTHFR and how to treat it?
How can I get more information on MTHFR?
Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium the same thing?
Methylfolate Supplement 10 mg
Methylfolate is critical for brain & nervous system health4. It supports DNA/RNA synthesis10, healthy homocysteine levels9, & proper fetal development during pregnancy8.
Moderate-high dose Methylfolate Supplement for healthy methylation, homocysteine and natural mood support.
Bioactive folate uniquely formulated with the new & improved, internationally-branded nutrient Cerebrofolate™
L-methylfolate is the predominant form of folate circulating in the body and used for biological processes1.
Studies show *15mg methylfolate + SSRI to be the most effective dose for improving depressive symptoms2.
Methylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier3.
- Support for brain function4
- Supports cardiovascular health5
- Support for healthy immune function6
- Supports nerve function7
- Support for preconception, pregnancy, and fetal health8
- Involved in maintaining healthy homocysteine levels9
- Essential nutrient required for healthy DNA and neurotransmitter synthesis10
- Suitable for people with MTHFR mutations11
A 2024 animal study found that high-dose methylfolate may protect against neurodevelopmental behaviours resulting from exposure to pyrethroid, a type of pesticide. Pyrethroid exposure disrupts folate metabolism in the brain and may contribute to behavioral disorders such as autism.
Methylfolate is the biologically active form of folate and can bypass disruptions to the breakdown of folate in the body, whether caused by MTHFR or by DPE exposure. In this study, high-dose supplementation with methylfolate dramatically reduced the behavioural disorders caused by folate issues, preventing deficits in the social, communication, cognitive, and locomotor areas of the brain that are linked to autism.19
Product details
Key ingredient: Folate 17,000 mcg DFE (10 mg L-Methylfolate from 14 mg of Cerebrofolate™)
Methylfolate Supplement 10 mg is a highly bioactive form of folate made with the purest L-methylfolate available12.
- Maximum absorption and bioavailability
- No prescription required
- Available in 2.5mg, 3mg+B12, 5mg, 7.5mg+B12, 10mg, 15mg, 15mg+B12
- Rigorously tested for consistency, purity, safety, and potency
Why take a methylfolate supplement?
Folate is required for numerous critical functions of the brain and nervous system. It is essential for DNA/RNA synthesis, maintaining healthy homocysteine levels, and for proper fetal development during pregnancy.
Folic acid is a synthetic form of folate. It can only be used by the body after it has been converted to active folate by an enzyme called methylenetetrahydrofolate reductase (MTHFR)13.
Who is affected by MTHFR mutations?
The MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants). Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%). Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A>C polymorphism in Hispanics and Africans is 15%14.
An increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness15. MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses16.
For these people, L-methylfolate supplementation is shown to be the most effective way to provide this form of folate10.
Methyl-Life’s® Methylfolate Supplement contains an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.
Why Magnafolate® PRO?
Methyl-Life’s® Methylfolate Supplement 10 mg is made with the internationally-patented Magnafolate® PRO, clinically tested as one of the purest methylfolate brands (Magnafolate® PRO is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic® and Extrafolate®).
Magnafolate® is made with a form of methylfolate called L-5-MTHF-Ca, which is shown to be the most active form of folate in the plasma circulation. When compared with ordinary folate, L-methylfolate was found to be absorbed faster and utilized more quickly in the body17.
A recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation18.
______________________________________
1 https://pubmed.ncbi.nlm.nih.gov/20608755/
2https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402301/
3https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687916/
4https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779227/
5https://www.ahajournals.org/doi/10.1161/hq0102.102190
6https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019735/
7https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867258/
8https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127769/
9https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832224/
10https://pubmed.ncbi.nlm.nih.gov/23212058/
11https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564482/
12https://cdn.shopify.com/s/files/1/0264/6369/9018/files/Methyl-Life_60-day_Methylfolate_Comparison.pdf?v=1595292111
13https://www.ncbi.nlm.nih.gov/books/NBK6561/
14https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530664/
15https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630484/
16https://www.ahajournals.org/doi/10.1161/01.CIR.0000165142.37711.E7
17https://pubmed.ncbi.nlm.nih.gov/24032278/
18https://i.trade-cloud.com.cn/upload/6405/file/20210929/english-version-magnafolate-enhancing-immunity_524485.pdf
19https://pmc.ncbi.nlm.nih.gov/articles/PMC11623627/
Dosage
WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to some dosing options.
How to snap the tablet in half – See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.
Video
SUPPLEMENT FACTS
| SUPPLEMENT FACTS | ||
|
Serving Size: 1 Chewable Tablet
|
||
| 90 servings per container | Amount per Serving | % Daily Value |
| Folate | 17,000 mcg DFE | 4,250% |
| (10 mg L-Methylfolate from 14 mg of Cerebrofolate™) |
|
|
FAQ'S
What is the right dosage for me?
Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.
Is a Methylfolate Supplement the only thing I should take if I have an MTHFR gene mutation?
What do doctors have to say about MTHFR and how to treat it?
How can I get more information on MTHFR?
Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium the same thing?
