MTHFR, Fatigue and Supporting Nutrients

but some of us have more genetic complications that cause tiredness to become so severe we cannot fully function throughout a normal day. There are usually many reasons why this fatigue gets so debilitating. As the founder of Methyl-Life® I have suffered from fatigue's extreme complexities myself, and so will NOT pretend like it’s easy to solve with one or two magic bullets.

But surprisingly, being able to incorporate the right nutrients that may be missing from your daily intake (because of diet, genetics, medications, environment, malabsorption, disease states or other reasons) can significantly help the fatigue factor.

A suggested daily target might be somewhere between 1mg - 15mg of L-Methylfolate.

We base this on:

• Dr. Neil Rawlins’ general recommendations
• the wide range of symptoms the nervous system can manifest and 
• the tolerance challenges that some have due to sensitivity and detoxification clearance

You may only be able to take half or less of the suggested amount, but that may be just right for you personally. Some people respond quickly (within weeks) and others may take a full 4 months before they respond favorably to the therapeutic methylfolate dosing.

Consider getting your homocysteine levels checked by a healthcare practitioner. Lowering homocysteine levels may take additional nutrients and different dosing than what's suggested.

Start LOW with your initial dose and increase SLOWLY until you get to your targeted amount or reach tolerance.

Consider taking bioidentical B12 forms in conjunction with L-Methylfolate because they work synergistically together in the body on the methylation pathway and can amplify its benefits. Stay AWAY from cyanocobalamin in supplements and fortified foods! Methyl-Life® carries affordable, vegan versions of active B12 in a tasty sublingual tablet (some products even include L-Methylfolate).

Bioidentical Active B12 Forms:

• Hydroxocobalamin - harder to find, expensive, typically well-tolerated and used for pernicious anemia among other things
• Methylcobalamin - fairly available and found in some supplements. Note: it's not always well tolerated
• Adenosylcobalamin - harder to find, expensive, the most well-tolerated and often used in muscle recovery

B12 does NOT absorb well via the gut, so be sure to get a product that allows you to dissolve the B12 under your tongue. Sublingual transport is the best way to get B12 absorption (research has proven it's even better than B12 injections for increasing B12 sufficiency). If B12 blood serum levels test "high", consider Methyl-Life®'s Non-Methylated Multivitamin.

Learn more about the best bioidentical B12 forms to take.