Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children
Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children
Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children
Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children
Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children
Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children
Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children
Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children
Gluten-Free Dairy-Free No Artificial Additives Fish/Shellfish-Free BPA-Free
Kid-Friendly, MTHFR-Safe Multivitamin with Advanced Nutrient Support

Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children

Methyl-Life's® Chewable Methylated Multivitamin is formulated with MTHFR-supporting nutrients. Methylfolate, methylcobalamin & cofactors. Boosts cognition & ATP energy!

Free Shipping on Orders Over $100

A delicious chewable Methylated Multivitamin with Cognitive & Energy promoting nutrients to support MTHFR and other genetic challenges.

Supplement Facts
Serving Size: 4 Chewable Tablets
Servings Per Container: 30 servings per container
Amount Per Serving % Daily Value
Calories 14
(--) 		--%
Total Carbohydrate 3 g
(--) 		1%
Total sugars 3 g
(including added sugars) 		7%
Vitamin A 200 mcg RAE (667 IU)
(as Retinyl Palmitate) 		22%
Vitamin D 33 mcg (1,333 IU)
(as Cholecalciferol (D3)) 		165%
Vitamin E 8 mg (12 IU)
(as d-α-Tocopheryl Acid Succinate) 		53%
Thiamin 1 mg
(Vitamin B1) (as Thiamin HCI) 		83%
Riboflavin 6 mg
(Vitamin B2) (as Riboflavin 5 Sodium Phosphate) 		462%
Niacin 14 mg NE
(--) 		88%
Vitamin B6 3 mg
(as Pyridoxal 5 Phosphate) 		176%
Folate 1,360 mcg
(800 mcg L-Methylfolate [from 1 mg of Cerebrofolate™]) 		340%
Vitamin B12 333 mcg
(as Hydroxocobalamin Acetate) 		13,875%
Biotin 40 mcg
(--) 		133%
Pantothenic Acid 5 mg
(as [Vitamin B5] D-Calcium Pantothenate) 		100%
Iodine 56 mcg
(as Potassium Iodide) 		37%
Zinc 12 mg
(as Liposomal Zinc Oxide) 		109%
Selenium 67 mcg
(Selenium Glycinate (ALBION)) 		122%
Manganese 2 mg
(Manganese Bisglycinate Citrate (ALBION)) 		87%
Molybdenum 13 mcg
(Molybdenum Glycinate (ALBION)) 		29%
Artichoke 33 mg
(Leaf - Cynara scolymus L.) (Extract 5% Cynarin) 		**%
Citicoline Sodium 33 mg
(--) 		**%
Ubiquinol 10 mg
(CoQ10 Reduced Form) 		**%
Phosphatidylserine 7 mg
(Sunflower - Helianthus annuus) 		**%
Milk Thistle 33 mg
(Seed - Silybum marianum L.) (Extract 80% Silymarin) 		**%
Pantethine 14 mg
(--) 		**%
Para-Amino Benzoic Acid 7 mg
(PABA) (Vitamin B10) 		**%
Benfotiamine 16 mg
(Fat Soluble Vitamin B1) 		**%
NADH 1 mg
(Microencapsulated NADH) 		**%
Vitamin K2 68 mcg
(as Menaquinone-7) 		**%
† Daily Value not established

Other Ingredients

Medium Chain Triglycerides (MCT), Xylitol (Xylisorb®), natural flavor, sodium stearyl fumarate (PRUV®), malic acid, citric acid anhydrous, xanthan gum, EMDEX®. Not a significant source of sugars.

Allergen & Safety Information

  • Does not contain: wheat, gluten, soy, dairy, tree nuts, animal products, or GMOs
  • No artificial ingredients or colorings
  • Sweetened with xylitol — do not give to pets

Suggested Use

Take 1-4 tablet(s) daily after meals, or as directed by your healthcare practitioner.
May be chewed, dissolved in the mouth or swallowed.

How much should you take?

Every individual’s needs are different. Always consult your healthcare provider to determine the right dose for your specific needs.

Doctor-guided support

Visit our Dosage Information and Methylation Protocol pages to learn what some practitioners recommend, including step-by-step guidance for individuals with MTHFR gene variants.

Splitting tablets

Each chewable tablet is scored and can be split in half without a pill cutter. For best results, place your thumbs along the scored line with the tablet facing away from you, and press outward to snap. Watch the full demonstration in our tablet-splitting video.

Additional considerations

This supplement is designed to be taken daily or as recommended by your healthcare practitioner. In the absence of directions from your Healthcare Specialist, consider taking one to two tablets after meals. If you gain some relief from a single tablet, consider taking an additional tablet if you feel a second one may be beneficial.

A delicious chewable Methylated Multivitamin with Cognitive & Energy promoting nutrients to support MTHFR and other genetic challenges

Methyl-Life’s® Methylated Multivitamin! It's a Sweet 'n Tart Cherry Berry flavored chewable that tastes even better than before (your kids will love it). It holds many of the needed ingredients for methylation to occur optimally in the body. It’s been specially formulated with L-Methylfolate and Active B12 to:

  • Promote glutathione, your body’s strongest antioxidant
  • Boost serotonin, an important neurotransmitter
  • Reduce harmful homocysteine levels in the body
  • Support fertility, pregnancy and fetal health
  • Help repair the myelin sheath for nerve health
  • Support RNA/DNA build blocks
  • Support your thyroid and liver

This formula is BOASTING the PUREST proven L-Methylfolate on the planet, Magnafolate® PRO. This form of L-Methylfolate, is more identical to the pharmaceutical version of methylfolate, AND it tested 3 times more pure in a recent study. Our formula is Gluten, Dairy and Soy free. This multivitamin also contains:

  • The energy-supporting B vitamins along with their co-factors supporting the thyroid
  • Patented Sucrosome® minerals
  • Vitamins A, D3, E and bioactive K2
  • A new ATP energy formula (NADH + CoQ10)
  • TMG is built in for lowering homocysteine levels in the body
  • A specialized, soy-free form of choline that crosses the blood brain barrier for improved cognitive health
  • And another brain health nutrient, soy-free Phosphatidylserine which contains essential phospholipids supporting healthy cognition
  • Artichoke extract and Milk Thistle to support the liver

The Methylated Multi may reduce homocysteine levels in the body. It can be taken along with other Methyl-Life® products that have methylfolate in them (if one wishes to intake higher methylfolate doses). Methyl-Life’s® Methylated Multivitamin is one of the best formulas you’ll find out in the market today. You may find this multi can also act as a nice prenatal without iron or Vitamin C, as well as a great kid’s multi-vitamin(though you’ll want to consider adjusting the number of tablets given as a serving if you take it for these other purposes).
Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children
$42

Traceable Ingredients You Can Trust

Every ingredient is sourced for purity, backed by clinical evidence, and rigorously tested for safety and bioavailability. Because in supplements, not all ingredients are created equal — and your body deserves only the most effective forms.

B12 for Brain & Nerve Health

B12 for Brain & Nerve Health

Adenosylcobalamin (Vitamin B12)

This mitochondria-targeted B12 powers your cells where energy is made — supporting memory, myelin formation, and neurological function. Perfect for those seeking deep cellular support.

Did You Know?

Adenosylcobalamin is one of the two metabolically active coenzyme forms of B12 and the only one directly used by mitochondria. It’s critical for the conversion of methylmalonyl-CoA to succinyl-CoA, a step essential in energy metabolism. In individuals with neurological conditions or degenerative diseases, this form has been associated with better nerve repair, protection against demyelination, and cognitive support. PubMed

Source: Adenosylcobalamin & Neurological Function – PMC7231506

B12 for Energy, Detox & Methylation

B12 for Energy, Detox & Methylation

Hydroxy B12 (Vitamin B12)

A highly absorbable B12 form ideal for people with methylation or absorption issues. Supports healthy energy levels, red blood cell formation, and detoxification without overstimulation.

Have You Heard?

Hydroxy B12 is a preferred B12 form in clinical settings because of its extended retention time and ability to convert efficiently into both active forms of B12: methylcobalamin and adenosylcobalamin. It also acts as a nitric oxide scavenger, supporting detoxification and cellular protection — especially valuable in individuals with oxidative stress or MTHFR-related impairments. Clinical data

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235814/

Supports Methylation, Mood & Cellular Health

Supports Methylation, Mood & Cellular Health

L–5–Methyltetrahydrofolate Calcium (as Calcium – Cerebrofolate™)

Clinically tested and patented for superior purity, this bioactive form of folate bypasses genetic mutations (like MTHFR) and goes straight to work — supporting neurotransmitters, DNA repair, and a healthy mood balance.

Backed by research:

Clinically tested and patented for superior purity, this bioactive form of folate bypasses genetic mutations (like MTHFR) and goes straight to work — supporting neurotransmitters, DNA repair, and a healthy mood balance.

Did You Know?

L-Methylfolate is a biologically active form of folate that the body can readily use. It supports natural processes related to neurotransmitter synthesis, including those involving serotonin, dopamine, and norepinephrine. It also plays a role in homocysteine metabolism and cellular function. For individuals seeking a form of folate that doesn't require complex conversion steps, L-Methylfolate may offer a more efficient nutritional option.* Source

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Methyl-Life® Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children contains no unnecessary excipients, synthetic colors, artificial preservatives, or common allergens. It is 100% free from gluten, soy, dairy, GMOs, animal-derived ingredients, and the EU’s top 14 allergens.

Every batch is third-party tested for purity, potency, and safety, manufactured in NSF-certified, cGMP-compliant facilities, and rigorously evaluated to ensure you’re getting clean, clinical-grade nutrients — nothing more, nothing less.

EU’s top 14 allergens

  • Cereals containing gluten - wheat (such as spelt and khorasan wheat), rye, barley, oats. Note: The cereal name, e.g., 'wheat', must be declared and highlighted, not 'gluten'.
  • Crustaceans, e.g., crabs, prawns, lobsters
  • Eggs
  • Fish
  • Peanuts
  • Soybeans
  • Milk
  • Nuts (almonds, hazelnuts, walnuts, cashews, pecan nuts, brazil nuts, pistachio nuts, macadamia/Queensland nut). Note: The name of the nut, e.g., 'almond', must be declared and highlighted, not 'nuts'.
  • Celery
  • Mustard
  • Sesame seeds
  • Sulphur dioxide and sulphites (at concentrations of more than 10 mg/kg or 10 mg/L in terms of total sulphur dioxide) – used as a preservative
  • Lupin 
  • Molluscs, e.g., mussels, oysters, squid, snails

Frequently Asked Question

The Chewable Methylated Multivitamin is a comprehensive multivitamin formula containing L-Methylfolate and Active B12, specifically designed to support individuals with MTHFR mutations, pregnant women, and children.
The Methylated Multi may help reduce homocysteine levels in the body, contributing to overall health and well-being. It can also be safely taken alongside other Methyl-Life® products containing methylfolate for those seeking higher doses of methylfolate.
Methyl-Life’s® Methylated Multivitamin stands out as an exceptional formula in the market today, offering comprehensive nutritional support with its methylated ingredients. It can serve as an excellent prenatal option without iron or Vitamin C and is also suitable as a high-quality multivitamin for children, although serving sizes may need adjustment for these specific purposes.
The suggested use for this product is to chew 1-4 tablets daily with food for optimal absorption. It is recommended to follow the dosage instructions provided by your healthcare professional.
One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true.

It’s important to realize that the MTHFR status does not necessarily determine the type of B12 that’s best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).

It seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.

The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxy B12, and from there the hydroxy B12 has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.
This multivitamin provides essential nutrients in a chewable form, making it convenient for individuals with MTHFR mutations, pregnant women, and children to meet their nutritional needs. With L-Methylfolate and Active B12, it offers optimal support for methylation and overall health during pregnancy and childhood.
Check out our Help for MTHFR Newbies page.
The most important thing to realize is that blood tests for B12 are highly inaccurate at detecting actual cellular levels of B12 (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used.
It’s a well-known fact that B12 does not absorb well through the gut, so taking B12 via sublingual or mouth absorption is best (holding it under the tongue or between the gums and cheek is most common). Consider some form of liquid or tablet/lozenge that can be sucked on or dissolved in the mouth. Holding the B12 in your mouth for at least 90 seconds is good and the longer you can leave it in your mouth, the better for sublingual absorption (as opposed to gut absorption).

Note: different manufacturers use different terms for tablets that are meant to dissolve sublingually in the mouth, but “sublingual” is considered a pharmaceutical term by the FDA, so dietary supplements are moving away from using that term. However, it doesn’t really matter what term you use (chewable tablet, lozenge, sublingual tablet, liquid, etc.) for maximum absorption the main idea is to hold it in your mouth for 90 seconds or more if you can (if you forget, don’t worry, since you’re taking the active form, your body will still get some benefit even if you swallow it whole).

Another way to absorb B12 is muscularly through shots, however, the research tells us that sublingual (or mouth) absorption is equally as effective as muscular absorption … and shots may cost significantly more money. Also, be aware with shots (many doctors still give cyanocobalamin shots) that though you may need higher doses of active B12s (like myself), you may not do well when given higher doses of cyanocobalamin in a shot because your body may not be able to do the conversions and you could have negative side effects.
If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxy B12 (and this is why our methylation protocol suggests hydroxy B12 as the B12 form to begin with):

↦ Folks with multiple COMT mutations tend to do very well with hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)

↦ Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation.

↦ And Dr. Amy Yasko (https://dramyyasko.com) talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:

The Science Behind

Understanding DFE Labeling for Methylfolate

What the New Numbers on Your Label Mean Now — and Why the Label Change Hasn’t Changed Your Dose

When it comes to folate supplements, labels can be misleading — not because the formulas are different, but because the rules have changed. In this video, Jamie from Methyl-Life® explains the FDA’s new requirement to use Dietary Folate Equivalents (DFE) and what that means for how folate is reported on supplement labels.

What’s this video about?: How the new FDA labeling standards affect folate supplements — and why your formula hasn’t changed, even if the number on the label looks much higher.

Methyl-Life® Methylated Multivitamin Review: Methylfolate, Methylcobalamin & More

Why the Methylated Multivitamin is designed to promote optimal methylation in the body, especially for those with MTHFR

Discover the benefits of Methyl-Life®’s Methylated Multivitamin with Jamie Hope, founder of Methyl-Life®. In this video, Jamie introduces a delicious chocolate raspberry chewable multivitamin, specially formulated for people with MTHFR and methylation challenges. Learn how this unique supplement supports optimal methylation, energy production, antioxidant levels, and neurotransmitter health with premium, bioactive ingredients.

Why Folate Labels Now Use DFE

The FDA now requires that all folate-containing supplements list folate content in mcg DFE to account for how much folate is actually absorbed by the body, based on source.

  • Folic acid × 1.7 = mcg DFE
  • Methylfolate × 1.7 = mcg DFE

This change reflects differences in bioavailability. The folic acid nutrient, for example, has ~85% bioavailability when taken with food. However, natural food folate has only ~50% bioavailability. The DFE unit helps consumers understand how much “usable folate” they’re getting as if it were compared to eating folate from whole foods.

Example:

  • A supplement with 1,000 mcg folic acid will now be labeled as 1,700 mcg DFE.
  • A supplement with 15,000 mcg L-Methylfolate will now show 25,500 mcg DFE (or could show more, depending on the salt form used and its potency calculation).

NOTE:  this is not an increase in the dosage amount — just new math to reflect usable folate content from the same formula.

Why This Matters for Methyl-Life® Users

Methyl-Life® uses L-5-Methyltetrahydrofolate (L-Methylfolate) — a bioactive form of folate that does not require MTHFR conversion. Even though it’s more effective and better absorbed than folic acid, the FDA still requires methylfolate products to use the same 1.7x multiplier for DFE.

So if your bottle used to say 15,000 mcg of L-Methylfolate, and now it says 25,000-30,000 mcg DFE, just know that neither the formula nor the dose has changed — only the math has. You're still receiving 15 mg of pure L-Methylfolate, now labeled using the updated DFE format.

Why the DFE Conversion Matters Less Than the Form

DFE was designed around folic acid absorption. But Methyl-Life® uses methylfolate, which already comes in its active form and offers superior uptake — especially for those with MTHFR gene mutations.

This is supported by evidence showing that L-Methylfolate:

  • Crosses the blood–brain barrier for direct cognitive support2
  • Improves depressive symptoms when used at 15 mg/day in SSRI-resistant cases PubMed 23212058
  • Supports homocysteine metabolism to reduce cardiovascular and neurological risk PMC9832224

Why the DFE Conversion Matters Less Than the Form

DFE (Dietary Folate Equivalent) was designed around folic acid — a synthetic form that requires multiple conversion steps before it becomes usable by the body.

But Methyl-Life® uses L-methylfolate, which is already in its active form and offers superior absorption — especially for those with MTHFR gene mutations.

So while labeling has changed, nothing has changed in your supplement’s clinical or nutritional performance.

Recap: DFE Labeling Doesn’t Change the Dose

  • DFE stands for Dietary Folate Equivalent, a unit created to reflect folate’s usable potency based on absorption rates from whole foods
  • The formula is exactly the same — only the math calculation applied to the label has changed
  • Methyl-Life® continues to deliver clinically-studied L-Methylfolate at the same high-potency, now labeled to meet new DFE guidelines from the FDA

You do not need to recalculate your dose or change your usage.

Customer Reviews

Based on 82 reviews
65%
(53)
15%
(12)
5%
(4)
4%
(3)
12%
(10)
84.6
J
Julianne

This makes a huge difference for my nerve issues due to fibromyalgia and depression.

User picture
M
Matt

Good product but very expensive

M
Mike

I like the chewable multivitamin. It's easier to swallow.

M
Melissa

I love the vitamin. I even enjoyed the old flavor. The new flavor is nasty and tastes like chemicals. Please switch back to the old flavor.

A
Anonymous

I was dealing with chronic fatigue for years. Within a week of starting this product I noticed a moderate to significant increase in energy and focus. I would highly recommend this product to anyone.

The only reason I did not give a five star review is because of the Xylitol content. I, like many customers, have a beloved canine member of my family. I would hope that in the future this company considers replacing this extremely toxic and dangerous compound to a different alternative sweetener (stevia, monk fruit extract, erythritol, etc.).

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