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L-Methylfolate Methylated Vitamins MTHFR Supplements Methyl B12 B12 SupplementsPopular Picks
Best Sellers New ArrivalsL-Methylfolate
Methyl-Life®’s L-Methylfolate supplements deliver the purest, most potent OTC L-Methylfolate available, supporting mood, heart health, pregnancy, and mental clarity. They're ideal if you need high-dose L-Methylfolate based on genetic testing or medical advice and are already getting active B-12 from another source.
Potent, targeted methylation support for intensive health needs
Higher-Dose L-Methylfolate Therapeutic Formulations
High-potency products containing 15 mg or more of L-Methylfolate, often combined with methylated B12. These are designed for individuals with significant methylation requirements, confirmed by genetic testing or therapeutic recommendations, addressing conditions associated with folate deficiency.
- Professional Strength - Ask Your Doctor
- High-Dose L Methylfolate 15 Mg for Natural Mood Support²
- 3rd-Party Tested for Purity, Potency & Safety
- Bioactive L Methylfolate 15 Mg with Mood-Boosting Power2
- Vitamin B12 with Methyl for Neurotransmitter Synthesis10
- 3rd-Party Tested for Purity, Potency & Safety
Balanced dosing for elevated support of mood, cognition, and cardiovascular health
Medium-Dose L-Methylfolate Formulations
Supplements offering medium doses of L-Methylfolate (typically 7.5–10 mg), providing enhanced nutritional support for users with moderate methylation demands, mild genetic variants, or those transitioning to higher therapeutic dosing. Ideal for those needing stronger support than foundational levels.
- Therapeutic, Professional Strength L Methylfolate
- Bioactive, Sublingual Vitamin B12 Tablets
- 3rd-Party Tested for Purity, Potency & Safety
- Supports Brain4 & Cardiovascular Function5
- Bioactive L-Methylfolate For Healthy DNA10
- 3rd-Party Tested For Purity, Potency & Safety
Essential active folate for baseline support of methylation and wellness
Foundational & Low-Dose L-Methylfolate Supplements
Moderate and lower-dose L-Methylfolate formulations designed for daily nutritional support, mood regulation, cardiovascular health, and maintenance of methylation balance. Suitable for those beginning supplementation or requiring gentle folate support.
- Supports Healthy DNA Synthesis10
- Promotes Balanced Homocysteine Levels9
- 3rd-Party Tested for Purity, Potency & Safety
- Bioactive 5 Methylfolate That Crosses Blood-Brain Barrier 3
- Supports Cardiovascular Function 5 & Brain Health 4
- 3rd-Party Tested for Purity, Potency & Safety
- Bioactive L-Methylfolate 3 Mg & Methylated B12
- Great for Bypassing MTHFR Mutations
- 3rd-Party Tested for Purity, Potency & Safety
Methyl-Life® L-Methylfolate Supplements: Pure, Potent Active Folate for Targeted Methylation and Health Optimization
Methyl-Life® offers a premium selection of L-Methylfolate supplements that provide the purest and most potent active folate forms on the market, meeting USP standards for quality and efficacy. L-Methylfolate is the bioactive form of folate that bypasses common metabolic bottlenecks and genetic variants such as MTHFR mutations, making it essential for supporting numerous critical physiological processes, including mood regulation, cardiovascular health, cognitive function, pregnancy-related fetal development, and overall mental clarity.
These products are designed for individuals who require high doses of active L-Methylfolate, often guided by genetic testing or professional recommendations, and are typically combined with active forms of vitamin B12 either within the same formulation or through separate supplementation.
Why L-Methylfolate?
Unlike synthetic folic acid, L-Methylfolate is directly usable by the body without conversion, making it highly effective for promoting essential biochemical pathways:
- DNA and RNA synthesis – Vital for cell division, repair, and fetal development.
- Neurotransmitter synthesis – Includes serotonin, dopamine, and more, supporting mood balance and brain function.
- Homocysteine metabolism – Helps maintain healthy cardiovascular function by converting homocysteine to methionine
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Customer Support Hours (PST)
Monday-Friday (8:00 am - 7:00 pm)
support@methyl-life.com
Phone: (571) 308-2172
Methylation & Nutritional support for MTHFR since 2011.
Every batch is third-party tested for purity, potency, and safety, manufactured in NSF-certified, cGMP-compliant facilities, and rigorously evaluated to ensure you’re getting clean, clinical-grade nutrients — nothing more, nothing less.
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Let customers speak for us
from 1241 reviewsIt’s great so far
I really like CALMING. It helps me fall asleep and stay asleep. When I ran out, I noticed the difference. I will keep purchasing.
Sleeping so much bettersinceistartedtaking this.
Easy to order Good taste Multi vitamins in one Recommended by my doctor
Too soon to tell but feel less achy - is it a coincidence?
I'm taking these with Hydroxy B-12 (2.5mg) and the pain from diabetic neuropathy in my feet has decreased significantly. I am so pleased. I've been taking this regime for about 2 weeks.
thank you for the quick delivery of my order.
Everything is working very well.
Perfect combo for those with MTHFR . I love that I can adjust the dosage according to my needs.
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Gosh, methylfolate has saved my family. This is no joke. It gave us peace in our heads (essentially joy back into our lives - more patience as well since you are calmer), healthier lives with more immunity and a better functioning chemical processing body functioning on all cylinders now. It helps with moods - the peace I was talking about. If you’re searching for health, this is one key component that’s for sure. Note it will take awhile to notice a difference, but you will look back and see it.
These digestive enzymes work really well and have noticeably improved my digestion and food sensitivities. I experience much less bloating and discomfort after meals. They’re chewable and very effective, but strong, so it’s important to chew them as directed. When used correctly, they’re an excellent product and I will definitely repurchase.
Customized methylation... I love this product!
Great tasting easy to take.
Works well for my son and I.
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