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Bioactive Folate + B12 for Mood

L Methylfolate 7.5 mg + Vitamin B12 Tablets

Name: L Methylfolate 7.5 mg + Vitamin B12 Tablets
Brand: Methyl-Life® Supplements
SKU: methyl75-s1001
Price: 56 USD
Availability: InStock
Rating: 4.9 (126 reviews)

L Methylfolate 7.5 mg & Vitamin B12 Tablets for optimal absorption & uplifting your mood naturally². The most pure & potent L-Methylfolate to support brain function⁴.

Therapeutic, Professional Strength L Methylfolate
Bioactive, Sublingual Vitamin B12 Tablets
3rd-Party Tested for Purity, Potency & Safety
90 Vegan, Non-GMO, Chewable Mint Tablets

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3 months supply

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Supplement Facts

Serving Size: 1 Chewable Tablet

Servings Per Container: 90 servings per container

Amount Per Serving	% Daily Value
Folate 14,567 mcg DFE (as L-5-Methyltetrahydrofolate, Calcium [equal to 11,000 mcg Magnafolate® PRO])	3,642%
Vitamin B12 2,500 mcg (60% as Hydroxy B12) & (40% as Adenosylcobalamin)	104,167%

† Daily Value not established

Other Ingredients

Xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavoring (dextrose, silicon dioxide, natural flavor). Not a significant source of sugars.

Allergen & Safety Information

Does not contain: wheat, gluten, soy, dairy, tree nuts, animal products, or GMOs
No artificial ingredients or colorings
Sweetened with xylitol — do not give to pets

Suggested Use

Take 1 chewable tablet daily, or as directed by your healthcare practitioner. May be chewed, dissolved in the mouth or swallowed.

How much should you take?

Every individual’s needs are different. Always consult your healthcare provider to determine the right dose for your specific needs.

Doctor-guided support

Visit our Dosage Information and Methylation Protocol pages to learn what some practitioners recommend, including step-by-step guidance for individuals with MTHFR gene variants.

Splitting tablets

Each chewable tablet is scored and can be split in half without a pill cutter. For best results, place your thumbs along the scored line with the tablet facing away from you, and press outward to snap. Watch the full demonstration in our tablet-splitting video.

Additional considerations

This supplement is designed to be taken daily or as recommended by your healthcare practitioner. Some individuals start with lower doses and increase gradually, based on tolerance and need.

Dr. Amy Yasko (https://dramyyasko.com) recommends a specific form of B12 based on your genetics if you know the status of your COMT 158 and VDR Taq variants

Therapeutic mood-supporting dose of bioactive L Methylfolate 7.5 mg uniquely formulated with the internationally-patented Magnafolate® PRO and bioactive vitamin B12 forms (hydroxy B12 and adenosylcobalamin) to naturally support healthy mood, cognitive function, methylation and homocysteine support.

L methylfolate is the predominant form of folate circulating in the body and used for biological processes¹.

Studies show *15mg methylfolate + SSRI to be the most effective dose for improving depressive symptoms².

L Methylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier³.

Support for brain function⁴
Supports cardiovascular health⁵
Support for healthy immune function⁶
Supports nerve function⁷ and healthy myelin formation²²
Nervous system maintenance²¹
Support for preconception, pregnancy, and fetal health⁸
Involved in reducing²⁰ and maintaining healthy homocysteine levels⁹
Essential nutrient required for optimal DNA methylation¹⁹ and neurotransmitter synthesis¹⁰
Adjunctive support for serotonin selective reuptake inhibitors²³
Suitable for people with MTHFR mutations¹¹

Product details (90 chewable mint tablets per container)
Key ingredients:

Folate - 7,500 mcg (as L-5-Methyltetrahydrofolate, Calcium - Magnafolate® PRO)
Hydroxy B12 (Vitamin B12) - 1,500 mcg
Adenosylcobalamin (Vitamin B12) - 1,000 mcg

L Methylfolate 7.5mg is a highly bioactive form of folate made with the purest L-methylfolate available¹².

Maximum absorption and bioavailability
No prescription required
Available in 2.5mg, 3mg+B12, 5mg, 7.5mg+B12, 10mg, 15mg, 15mg+B12
Rigorously tested for consistency, purity, safety, and potency

Why take L Methylfolate 7.5 mg for Mood Support?

Synthesis of mood-enhancing neurotransmitters (serotonin, dopamine, and norepinephrine) is regulated by L methylfolate, a derivative of folate¹⁰. L Methylfolate 7.5 mg has demonstrated efficacy as an adjunctive treatment for individuals who have not responded optimally to antidepressant therapy².

Supplementing with 15mg L methylfolate alongside SSRIs may be effective in improving symptoms of depression²⁵. L Methylfolate is absorbed more efficiently than synthetic folic acid which must be converted to active folate by the enzyme methylenetetrahydrofolate reductase (MTHFR)¹³.

Hydroxy B12 and adenosylcobalamin are two naturally-occurring forms of B12 shown in clinical studies to improve vitamin B12 status. They are bioidentical to the form of B12 found in the human body and vastly superior to cyanocobalamin, a synthetic form of B12 that occurs only in trace amounts in the body²⁶.

Adenosylcobalamin is a cofactor for mitochondrial methylmalonyl-CoA mutase, which is required for the breakdown of several ketogenic amino acids and fatty acids²⁴. It is also a cofactor in enzymatic reactions required for the synthesis of DNA, myelin, and fatty acids, which are vital for cell division and growth²⁷.

Active B12 works closely alongside folate in converting homocysteine to methionine, which is necessary for nerve and brain health. B12’s complex metabolic pathway means that the only way to ensure proper uptake is by taking the most bioactive form of the vitamin²⁸.

Individuals with particular mutations [single nucleotide polymorphisms (SNPs)] affecting B12 assimilation may raise their B12 status more efficiently with one or more of the specific bioavailable forms of vitamin B12²⁶, hydroxy B12, methylcobalamin, or adenosylcobalamin.

Folate and B12 work together to produce S-adenosylmethionine (SAMe), a compound involved in immune function and mood. Studies show that bioactive B12 plays an important role in the treatment of mood disorders, particularly when combined with SSRIs²⁹.

Who is affected by MTHFR mutations?

The MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants). Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%). Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A>C polymorphism in Hispanics and Africans is 15%¹⁴.

An increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness¹⁵. MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses¹⁶.

For these people, L methylfolate supplementation is shown to be the most effective way to provide this form of folate¹⁰.

Methyl-Life’s® L Methylfolate is an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.

Why Magnafolate® PRO?

Methyl-Life’s® L Methylfolate 7.5mg+ Support Mood is made with the internationally-patented Magnafolate® PRO, clinically tested as one of the purest methylfolate brands (Magnafolate® PRO is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic® and Extrafolate®).

Magnafolate® is made with a form of L methylfolate called L-5-MTHF-Ca, which is shown to be the most active form of folate in the plasma circulation. When compared with ordinary folate, L methylfolate was found to be absorbed faster and utilized more quickly in the body¹⁷.

A recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation¹⁸.

L Methylfolate 7.5 mg + Vitamin B12 Tablets

$56

Traceable Ingredients You Can Trust

Every ingredient is sourced for purity, backed by clinical evidence, and rigorously tested for safety and bioavailability. Because in supplements, not all ingredients are created equal — and your body deserves only the most effective forms.

Supports Methylation, Mood & Cellular Health

L–5–Methyltetrahydrofolate Calcium (as Calcium – Cerebrofolate™)

Clinically tested and patented for superior purity, this bioactive form of folate bypasses genetic mutations (like MTHFR) and goes straight to work — supporting neurotransmitters, DNA repair, and a healthy mood balance.

B12 for Energy, Detox & Methylation

Hydroxy B12 (Vitamin B12)

A highly absorbable B12 form ideal for people with methylation or absorption issues. Supports healthy energy levels, red blood cell formation, and detoxification without overstimulation.

B12 for Brain & Nerve Health

Adenosylcobalamin (Vitamin B12)

This mitochondria-targeted B12 powers your cells where energy is made — supporting memory, myelin formation, and neurological function. Perfect for those seeking deep cellular support.

Methyl-Life® L Methylfolate 7.5 mg + Vitamin B12 Tablets contains no unnecessary excipients, synthetic colors, artificial preservatives, or common allergens. It is 100% free from gluten, soy, dairy, GMOs, animal-derived ingredients, and the EU’s top 14 allergens.

Every batch is third-party tested for purity, potency, and safety, manufactured in NSF-certified, cGMP-compliant facilities, and rigorously evaluated to ensure you’re getting clean, clinical-grade nutrients — nothing more, nothing less.

Frequently Asked Question

What is L Methylfolate 7.5 mg + Vitamin B12 Tablets?

L Methylfolate 7.5 mg + Vitamin B12 Tablets is a therapeutic supplement formulated to support healthy mood, cognitive function, methylation, and homocysteine levels. It contains bioactive L methylfolate as internationally-patented Magnafolate® PRO, and sublingual vitamin B12 tablet forms (hydroxy B12 and adenosylcobalamin)

How common is the MTHFR mutation?

The MTHFR mutation is more widespread than commonly realized, with approximately 50% of the global population estimated to have at least one of two common variants. Around 25% of the global population carries the MTHFR mutation C677T, with Hispanics having the highest proportion at 47%.

How is L Methylfolate 7.5 mg + Vitamin B12 Tablets different from other folate supplements?

It is uniquely formulated with Magnafolate® PRO, ensuring maximum absorption and bioavailability. Additionally, it contains active vitamin B12 sublingual tablet forms for comprehensive mood support.

How is the quality of L Methylfolate 7.5 mg + Vitamin B12 Tablets ensured?

Every single supplement batch undergoes rigorous 3rd-party testing for consistency, purity, safety, and potency to ensure maximum quality and efficacy.

My doctor said that because I have MTHFR, I should be taking methylcobalamin as my vitamin B12 form, why are you suggesting these other forms too?

One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxy B12, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true.

It’s important to realize that the MTHFR status does not necessarily determine the type of vitamin B12 tablets that are best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).

It seems there may be a general lack of education available to most doctors about the different forms of vitamin B12 tablets and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to your vitamin B12 tablets to see which you may tolerate best.

The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxy B12, and from there the hydroxy B12 has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.

What are the key benefits of L Methylfolate 7.5 mg + Vitamin B12 Tablets?

This supplement provides support for brain function, cardiovascular health, immune function, nerve function, nervous system maintenance, preconception, pregnancy, and fetal health. It also aids in reducing and maintaining healthy homocysteine levels, supports optimal DNA methylation, neurotransmitter synthesis, and can be adjunctive support for serotonin selective reuptake inhibitors.

Why is L-methylfolate important?

L-methylfolate is the biologically activated form of folate, which is essential for various biological processes, including crossing the blood-brain barrier, supporting brain function, and DNA methylation.

What if my blood serum B12 level test comes back as high, does that mean I don’t need B12?

The most important thing to realize is that blood tests for B12 are highly inaccurate at detecting actual cellular levels of B12 (meaning the B12 that’s available for the cells to use). Studies have shown that people can have high or normal B12 levels in the blood and actually show virtually no B12 in the spinal fluid, meaning the B12 is not being transported from the blood stream into the cells where it should be absorbed and used.

What does sublingual mean and why isn’t your product labeled as “sublingual”?

It’s a well-known fact that vitamin B12 does not absorb well through the gut, so taking B12 via sublingual or mouth absorption is best (holding it under the tongue or between the gums and cheek is most common). Consider some form of liquid or vitamin B12 tablets or lozenges that can be sucked on or dissolved in the mouth. Holding the vitamin B12 tablets in your mouth for at least 90 seconds is good and the longer you can leave it in your mouth, the better for sublingual absorption (as opposed to gut absorption).

Note: different manufacturers use different terms for tablets that are meant to dissolve sublingually in the mouth, but “sublingual” is considered a pharmaceutical term by the FDA, so dietary supplements are moving away from using that term. However, it doesn’t really matter what term you use (chewable tablet, lozenge, sublingual tablet, liquid, etc.) for maximum absorption the main idea is to hold it in your mouth for 90 seconds or more if you can (if you forget, don’t worry, since you’re taking the active form, your body will still get some benefit even if you swallow it whole).

Another way to absorb B12 is muscularly through shots, however, the research tells us that sublingual (or mouth) absorption is equally as effective as muscular absorption … and shots may cost significantly more money. Also, be aware with shots (many doctors still give cyanocobalamin shots) that though you may need higher doses of active B12s (like myself), you may not do well when given higher doses of cyanocobalamin in a shot because your body may not be able to do the conversions and you could have negative side effects.

I have my 23andme test results, how can I use those to know which form of vitamin B12 tablets I might best tolerate?

If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be hydroxy B12. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxy B12 (and this is why our methylation protocol suggests hydroxy B12 as the B12 form to begin with):

↦ Folks with multiple COMT mutations tend to do very well with hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems)

↦ Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation

↦ And Dr. Amy Yasko (https://dramyyasko.com) talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:

The Science Behind

Understanding DFE Labeling for Methylfolate

What the New Numbers on Your Label Mean Now — and Why the Label Change Hasn’t Changed Your Dose

When it comes to folate supplements, labels can be misleading — not because the formulas are different, but because the rules have changed. In this video, Jamie from Methyl-Life® explains the FDA’s new requirement to use Dietary Folate Equivalents (DFE) and what that means for how folate is reported on supplement labels.

What’s this video about?: How the new FDA labeling standards affect folate supplements — and why your formula hasn’t changed, even if the number on the label looks much higher.

The Science Behind

What Makes Methyl-Life® Methylfolate Different Folate

Clinically Formulated, Quality-Tested, and Designed for Real Absorption

Not all methylfolate is created equal. In this video, Methyl-Life® founder, Jamie Hope, explains what sets their L-Methylfolate apart — from the ultra-pure form of folate used, to the strict quality testing, to the small, clean tablet design that delivers more active ingredients in a tasty way with less filler.

What’s this video about?: The research, formulation and manufacturing differences that make Methyl-Life® 's L-Methylfolate a superior choice — especially for individuals with MTHFR mutations or sensitive systems.

Why Folate Labels Now Use DFE

The FDA now requires that all folate-containing supplements list folate content in mcg DFE to account for how much folate is actually absorbed by the body, based on source.

Folic acid × 1.7 = mcg DFE
Methylfolate × 1.7 = mcg DFE

This change reflects differences in bioavailability. The folic acid nutrient, for example, has ~85% bioavailability when taken with food. However, natural food folate has only ~50% bioavailability. The DFE unit helps consumers understand how much “usable folate” they’re getting as if it were compared to eating folate from whole foods.

Example:

A supplement with 1,000 mcg folic acid will now be labeled as 1,700 mcg DFE.
A supplement with 15,000 mcg L-Methylfolate will now show 25,500 mcg DFE (or could show more, depending on the salt form used and its potency calculation).

NOTE: this is not an increase in the dosage amount — just new math to reflect usable folate content from the same formula.

Why This Matters for Methyl-Life® Users

Methyl-Life® uses L-5-Methyltetrahydrofolate (L-Methylfolate) — a bioactive form of folate that does not require MTHFR conversion. Even though it’s more effective and better absorbed than folic acid, the FDA still requires methylfolate products to use the same 1.7x multiplier for DFE.

So if your bottle used to say 15,000 mcg of L-Methylfolate, and now it says 25,000-30,000 mcg DFE, just know that neither the formula nor the dose has changed — only the math has. You're still receiving 15 mg of pure L-Methylfolate, now labeled using the updated DFE format.

Why the DFE Conversion Matters Less Than the Form

DFE was designed around folic acid absorption. But Methyl-Life® uses methylfolate, which already comes in its active form and offers superior uptake — especially for those with MTHFR gene mutations.

This is supported by evidence showing that L-Methylfolate:

Crosses the blood–brain barrier for direct cognitive support2
Improves depressive symptoms when used at 15 mg/day in SSRI-resistant cases PubMed 23212058
Supports homocysteine metabolism to reduce cardiovascular and neurological risk PMC9832224

Why the DFE Conversion Matters Less Than the Form

DFE (Dietary Folate Equivalent) was designed around folic acid — a synthetic form that requires multiple conversion steps before it becomes usable by the body.

But Methyl-Life® uses L-methylfolate, which is already in its active form and offers superior absorption — especially for those with MTHFR gene mutations.

So while labeling has changed, nothing has changed in your supplement’s clinical or nutritional performance.

Recap: DFE Labeling Doesn’t Change the Dose

DFE stands for Dietary Folate Equivalent, a unit created to reflect folate’s usable potency based on absorption rates from whole foods
The formula is exactly the same — only the math calculation applied to the label has changed
Methyl-Life® continues to deliver clinically-studied L-Methylfolate at the same high-potency, now labeled to meet new DFE guidelines from the FDA

You do not need to recalculate your dose or change your usage.

What Is Methylfolate — and Why It Matters

L-Methylfolate is the active form of folate, already converted and ready for use by the body — unlike synthetic folic acid, which must go through several enzymatic steps. This distinction is especially important for individuals with MTHFR gene variants, who often cannot convert folic acid efficiently.

Instead of building up unmetabolized folic acid in the bloodstream, L-Methylfolate delivers folate that is immediately bioavailable for methylation, neurotransmitter synthesis, DNA repair, detoxification and homocysteine reduction.

Reference: PubMed 20608755 – 5-MTHF is the predominant form of folate in circulation

What Sets Methyl-Life® Apart?

Study-proven Purest Form: Cerebrofolate™(coming soon)

Methyl-Life® uses Cerebrofolate™(coming soon), a patented crystalline calcium salt form of L-Methylfolate (L-5-MTHF-Ca). This advanced form offers:

Higher purity and stability than competing versions like Quatrefolic®
Superior metabolic compatibility for those with MTHFR gene variants
Enhanced absorption and proven reliability

Reference: Magnafolate® comparison report

Strength Options & Dosing Flexibility

Available in 2.5 mg, 5 mg, 10 mg and 15 mg, Methyl-Life® offers full dosing flexibility to support titration protocols. For example:

Start with 2.5 mg if you are new to methylfolate or sensitive to methyl donors
Easily split the 15 mg scored tablet into a 7.5 mg dose — cost-effective and precise

Reference: PubMed 23212058

Dosing Philosophy: Start Low, Increase Slowly

Jamie explains the importance of gradual titration — especially for individuals with mood issues or methylation impairments. Rapid increases can lead to irritability, fatigue or “overmethylation” symptoms in some users. Starting low and increasing over time allows the body to adapt.

Functional medicine practitioners often recommend beginning with lower doses and increasing based on symptoms and clinical goals.

Clean Ingredients + Small Tablet Design

Unlike large, filler-heavy tablets (such as Deplin), Methyl-Life®’s tablets are:

Small, chewable and tasty
Free from dyes, gluten, soy, dairy, GMOs and animal products
Designed to deliver 5 mg in a tablet smaller than a pinch of sugar

This product contains no unnecessary excipients or synthetic additives.

Every batch is third-party tested for:

Purity
Potency
Identity

Manufactured in an NSF-certified, cGMP-compliant facility, Methyl-Life® sets the standard for clinical-grade supplementation.

Why Pill Size Matters

Jamie explains that many pharmaceutical brands design large pills to enhance the placebo effect — assuming patients associate “big” with “strong.” But Methyl-Life® takes the opposite approach: smaller, cleaner, natural tablets packed with clinical efficacy and minimal filler.

This design delivers the same therapeutic dose with none of the fluff — maximizing absorption and minimizing unnecessary ingredients.

In Summary

Feature	Methyl-Life® Methylfolate
Active form	Yes – L-5-MTHF-Ca (Cerebrofolate™ coming soon)
Doses available	2.5, 5, 10, 15 mg
Third-party tested	Yes – Purity, potency, identity
Manufacturing certification	NSF, cGMP-compliant, FDA registered & audited
Additives	None – clean and allergen-free
Recommended usage	Start low, titrate slowly
Competitive advantage	Superior bioavailability and purity

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"Definitely feel much more energetic and it helps me sleep at night. I am definitely going to keep using. This is the first supplement that has helped with both."

Thank you so much for your feedback! We're thrilled to hear that you're feeling more energetic and enjoying better sleep. It's great to know that our supplement has made such a positive impact for you. We appreciate your support and are excited that you'll continue using it!
If you ever have any questions, don't hesitate to reach out.
Best of Health to you!

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COMT V158M	VDR Taq	B12 Types That Should Be Tolerated
– –	+ + (TT)	All 3 types of B12
– –	+ – (Tt)	All 3 types of B12 with less Methylcobalamin
– –	– – (tt)	Hydroxy B12 and Adenosylcobalamin
+ –	+ +	All 3 types of B12 with less Methylcobalamin
+ –	+ –	Hydroxy B12 and Adenosylcobalamin
+ –	– –	Hydroxy B12 and Adenosylcobalamin
+ +	+ +	Hydroxy B12 and Adenosylcobalamin
+ +	+ –	Hydroxy B12 and Adenosylcobalamin
+ +	– –	Mostly Hydroxy B12

COMT V158M	VDR Taq	B12 Types That Should Be Tolerated
– –	+ + (TT)	All 3 types of B12
– –	+ – (Tt)	All 3 types of B12 with less Methylcobalamin
– –	– – (tt)	Hydroxy B12 and Adenosylcobalamin
+ –	+ +	All 3 types of B12 with less Methylcobalamin
+ –	+ –	Hydroxy B12 and Adenosylcobalamin
+ –	– –	Hydroxy B12 and Adenosylcobalamin
+ +	+ +	Hydroxy B12 and Adenosylcobalamin
+ +	+ –	Hydroxy B12 and Adenosylcobalamin
+ +	– –	Mostly Hydroxy B12

L Methylfolate 7.5 mg + Vitamin B12 Tablets

Traceable Ingredients You Can Trust