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Mood Elevating Bundle - L-Methylfolate 15 mg + 3 Active B12s 5 mg - 3 month supply - Chewables

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Get Methyl-Life’s® most popular bundle targeting Mood Improvement - 2 key nutrients at professional strength. You'll notice a difference in your therapeutic healing process.  

This methylation package contains the bioactive nutrients:

    • The purest L-Methylfolate (as shown in a recent study)
    • All 3 active forms of B12 (as Methylcobalamin, Hydroxocobalamin, & Adenosylcobalamin)
Check out the details below regarding each specific product included in the bundle using the links below:
    • Methylfolate 15 - Most stable & pure L-Methylfolate (15 mg) you can purchase
    • B12 Complete - A power-packed 5 mg of 3 different Active B12s per tablet

WARNING  How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to some dosing options.

How to snap the tablet in half  See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more. 



Methylfolate 15 What is the right dosage for me?

Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.


Methylfolate 15 What is included in the Mood Elevating Bundle?

The Mood Elevating Bundle consists of L-Methylfolate 15 mg and 3 Active B12s 5 mg. This bundle provides a 3-month supply of chewable tablets.

Methylfolate 15 What do doctors have to say about MTHFR and how to treat it?

Go to A Doctor Explains and listen to Dr. Neil Rawlins’ 51-minute seminar on MTHFR and the effects of Methylfolate.

Methylfolate 15 How can the Mood Elevating Bundle benefit me?

This bundle is designed to support mood elevation and overall well-being. L-Methylfolate and Active B12s work synergistically to promote healthy mood balance. With a 3-month supply of chewable tablets, it offers convenience and ease of use.

Methylfolate 15 What does this methylation package contain?

This methylation package includes the following bioactive nutrients:

The purest L-Methylfolate, as demonstrated in a recent study.
All three active forms of B12, including Methylcobalamin, Hydroxocobalamin, and Adenosylcobalamin.


Vitamin B 12 (as Hydroxocobalamin) How can these nutrients benefit me?

These bioactive nutrients are essential for supporting optimal methylation processes in the body, which play a crucial role in various physiological functions. L-Methylfolate and the active forms of B12 work together synergistically to promote overall health and well-being.


Vitamin B 12 (as Hydroxocobalamin) What can you do if you have high B12 blood test results? Dr. Amy Yasko and Nutritionist Cynthia Smith both suggest you can consider taking low dose lithium orotate (Cynthia Smith suggests approximately 4.6 mg pulsed a couple times a week before adding the B12 form in that’s most likely best for you).


Vitamin B 12 (as Hydroxocobalamin) How does L-Methylfolate adjunctive therapy benefit individuals with SSRI-resistant major depression?

How does L-Methylfolate adjunctive therapy benefit individuals with SSRI-resistant major depression?

Vitamin B 12 (as Hydroxocobalamin) My doctor said that because I have MTHFR, I should be taking methylcobalamin as my B12 form, why are you suggesting these other forms too?

One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12. There are 3 different types of B12 that are considered very beneficial to the body (hydroxocobalamin, methylcobalamin or adenosylcobalamin). Many automatically think that if you have an MTHFR defect, then you need the form of B12 called methylcobalamin, but that is simply NOT true.

It’s important to realize that the MTHFR status does not necessarily determine the type of B12 that’s best for you, instead it’s the status of genes like COMT, MTR, MTRR as well as VDR Taq. It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc. are currently saying right now).

It seems there may be a general lack of education available to most doctors about the different forms of B12 and what those forms are as well as how they get converted within the body and what each is most beneficial for (not to mention which set of genes or genetic mutations could benefit most from which B12 type). So do your homework when it comes to B12 to see which you may tolerate best.

The most common form of B12 that you’ll find everywhere is cyanocobalamin and it is not very active or beneficial to the body because the absorption rate is fairly low, that’s because the body has to convert it first into hydroxocobalamin, and from there the hydroxocobalamin has to be converted into both adenosylcobalamin and methylcobalamin. But if the body has genetic mutations then these conversions don’t happen well at all and the effect is the body does not get the absorption or use of the nutrient.


Vitamin B 12 (as Hydroxocobalamin) I have my 23andme test results, how can I use those to know which form of B12 I might best tolerate?

If you have your 23andme genetic test results, you can use those to help guide you as you try the specific B12 forms to see how they do for you. You’ll notice below that, according to Dr. Amy Yasko, the most well tolerated active form of B12 for folks seems to be hydroxocobalamin. Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of hydroxocobalamin (and this is why our methylation protocol suggests hydroxocobalamin as the B12 form to begin with):

    • Folks with multiple COMT mutations tend to do very well with hydroxocobalamin (it helps mop up excess peroxynitrites which can cause problems)
    • Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation
    • And Dr. Amy Yasko (https://dramyyasko.com) talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12: 

COMT V158M VDR Taq B12 Types That Should Be Tolerated
– – + + (TT) All 3 types of B12
– – + – (Tt) All 3 types of B12 with less Methylcobalamin
– – – – (tt) Hydroxocobalamin and Adenosylcobalamin
+ – + + All 3 types of B12 with less Methylcobalamin
+ – + – Hydroxocobalamin and Adenosylcobalamin
+ – – – Hydroxocobalamin and Adenosylcobalamin
+ + + + Hydroxocobalamin and Adenosylcobalamin
+ + + – Hydroxocobalamin and Adenosylcobalamin
+ + – – Mostly Hydroxocobalamin

Please Note

Before purchasing any of our products, Methyl-Life® recommends that you talk with a healthcare professional if you have any questions. Methyl-Life® cannot be held liable for adverse reactions or negative side effects that you think are the result of one of our products.

If you have not used Methyl-Life® products before, please consider ordering one bottle to start before making larger orders. We also recommend you read through our dosage and methylation protocol pages and consider starting with a lower dose product to ensure you tolerate the ingredients well before increasing your strength to a higher dose product.

It is also important to speak with your healthcare professional before purchasing. Methyl-Life® prefers not to accept returns for large orders. If you return three unopened bottles from a 4-pack purchase, you will receive a full refund minus the cost of one bottle charged at full price.

Within 45 days of your order, you can return any unopened item shipped to you by Methyl-Life® (as long as all seals are intact). Just let us know you plan to return the product by emailing us at: support@methyl-life.com or using the Contact Us form (please include the tracking information so we can be on the lookout for the package).

It will be your responsibility and cost to ensure the return parcel gets to Methyl-Life® (ship to: P.O. Box 33606, Seattle, WA 98133). We suggest you get a tracking number and consider insuring the package. After we receive your returned item, we will process your full refund within 10 business days and send you an email indicating your refund has been complete. Be aware that depending upon your institution, this may not be reflected in your account status for a few days.

If you have received the wrong item or your product has been damaged or is somehow defective, please email us at: support@methyl-life.com with detailed information or use the Contact Us form and our Customer Service Manager will address your concern(s) right away. Please do not throw any items away unless or until you are directed to do so.



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