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Mid/High-Potency Active Folate for Mood, Brain & Heart Health

Methylfolate Supplement 10 mg

Name: Methylfolate Supplement 10 mg
Brand: Methyl-Life® Supplements
SKU: methyl10-d1001
Price: 59 USD
Availability: InStock
Rating: 4.8 (26 reviews)

Methylfolate is critical for brain & nervous system health⁴. It supports DNA/RNA synthesis¹⁰, healthy homocysteine levels⁹, & proper fetal development during pregnancy⁸.

Supports Brain⁴ & Cardiovascular Function⁵
Bioactive L-Methylfolate For Healthy DNA¹⁰
3rd-Party Tested For Purity, Potency & Safety
90 Vegan, Non-GMO, Chewable Mint Tablets

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Supplement Facts

Serving Size: 1 Chewable Tablet

Servings Per Container: 90 servings per container

Amount Per Serving	% Daily Value
Folate 17,000 mcg DFE (10 mg L-Methylfolate from 14 mg of Cerebrofolate™)	4,250%

† Daily Value not established

Other Ingredients

Xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavor. Not a significant source of sugars.

Allergen & Safety Information

Does not contain: wheat, gluten, soy, dairy, tree nuts, animal products, or GMOs
No artificial ingredients or colorings
Sweetened with xylitol — do not give to pets

Suggested Use

Take 1-2 tablets after meals, or as directed by your healthcare practitioner.
May be chewed, dissolved in the mouth or swallowed.

How much should you take?

Every individual’s needs are different. Always consult your healthcare provider to determine the right dose for your specific needs.

Doctor-guided support

Visit our Dosage Information and Methylation Protocol pages to learn what some practitioners recommend, including step-by-step guidance for individuals with MTHFR gene variants.

Splitting tablets

Each chewable tablet is scored and can be split in half without a pill cutter. For best results, place your thumbs along the scored line with the tablet facing away from you, and press outward to snap. Watch the full demonstration in our tablet-splitting video.

Additional considerations

This supplement is designed to be taken daily or as recommended by your healthcare practitioner. In the absence of directions from your Healthcare Specialist, consider taking one to two tablets after meals. If you gain some relief from a single tablet, consider taking an additional tablet if you feel a second one may be beneficial.

Moderate-high dose Methylfolate Supplement for healthy methylation, homocysteine and natural mood support.

Bioactive folate uniquely formulated with the new & improved, internationally-branded nutrient Cerebrofolate™

L-methylfolate is the predominant form of folate circulating in the body and used for biological processes¹.

Studies show *15mg methylfolate + SSRI to be the most effective dose for improving depressive symptoms².

Methylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier³.

Support for brain function⁴
Supports cardiovascular health⁵
Support for healthy immune function⁶
Supports nerve function⁷
Support for preconception, pregnancy, and fetal health⁸
Involved in maintaining healthy homocysteine levels⁹
Essential nutrient required for healthy DNA and neurotransmitter synthesis¹⁰
Suitable for people with MTHFR mutations¹¹

A 2024 animal study found that high-dose methylfolate may protect against neurodevelopmental behaviours resulting from exposure to pyrethroid, a type of pesticide. Pyrethroid exposure disrupts folate metabolism in the brain and may contribute to behavioral disorders such as autism.

Methylfolate is the biologically active form of folate and can bypass disruptions to the breakdown of folate in the body, whether caused by MTHFR or by DPE exposure. In this study, high-dose supplementation with methylfolate dramatically reduced the behavioural disorders caused by folate issues, preventing deficits in the social, communication, cognitive, and locomotor areas of the brain that are linked to autism.¹⁹

Product details

Key ingredient: Folate 17,000 mcg DFE (10 mg L-Methylfolate from 14 mg of Cerebrofolate™)

Methylfolate Supplement 10 mg is a highly bioactive form of folate made with the purest L-methylfolate available¹².

Maximum absorption and bioavailability
No prescription required
Available in 2.5mg, 3mg+B12, 5mg, 7.5mg+B12, 10mg, 15mg, 15mg+B12
Rigorously tested for consistency, purity, safety, and potency

Why take a methylfolate supplement?

Folate is required for numerous critical functions of the brain and nervous system. It is essential for DNA/RNA synthesis, maintaining healthy homocysteine levels, and for proper fetal development during pregnancy.

Folic acid is a synthetic form of folate. It can only be used by the body after it has been converted to active folate by an enzyme called methylenetetrahydrofolate reductase (MTHFR)¹³.

Who is affected by MTHFR mutations?

The MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants). Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%). Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A>C polymorphism in Hispanics and Africans is 15%¹⁴.

An increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness¹⁵. MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses¹⁶.

For these people, L-methylfolate supplementation is shown to be the most effective way to provide this form of folate¹⁰.

Methyl-Life’s® Methylfolate Supplement contains an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.

Why Magnafolate® PRO?

Methyl-Life’s® Methylfolate Supplement 10 mg is made with the internationally-patented Magnafolate® PRO, clinically tested as one of the purest methylfolate brands (Magnafolate® PRO is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic® and Extrafolate®).

Magnafolate® is made with a form of methylfolate called L-5-MTHF-Ca, which is shown to be the most active form of folate in the plasma circulation. When compared with ordinary folate, L-methylfolate was found to be absorbed faster and utilized more quickly in the body¹⁷.

A recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation¹⁸.

Methylfolate Supplement 10 mg

$59

Traceable Ingredients You Can Trust

Every ingredient is sourced for purity, backed by clinical evidence, and rigorously tested for safety and bioavailability. Because in supplements, not all ingredients are created equal — and your body deserves only the most effective forms.

Supports Methylation, Mood & Cellular Health

L–5–Methyltetrahydrofolate Calcium (as Calcium – Cerebrofolate™)

Clinically tested and patented for superior purity, this bioactive form of folate bypasses genetic mutations (like MTHFR) and goes straight to work — supporting neurotransmitters, DNA repair, and a healthy mood balance.

Methyl-Life® Methylfolate Supplement 10 mg contains no unnecessary excipients, synthetic colors, artificial preservatives, or common allergens. It is 100% free from gluten, soy, dairy, GMOs, animal-derived ingredients, and the EU’s top 14 allergens.

Every batch is third-party tested for purity, potency, and safety, manufactured in NSF-certified, cGMP-compliant facilities, and rigorously evaluated to ensure you’re getting clean, clinical-grade nutrients — nothing more, nothing less.

Frequently Asked Question

What is the right dosage for me?

Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.

What do doctors have to say about MTHFR and how to treat it?

Go to our A Doctor Explains resource and listen to Dr. Neil Rawlins’ video seminar on MTHFR and the effects of Methylfolate.

Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium the same thing?

Basically, yes. In the chemistry world, L stands for the “Left” isomer, which is the same as the “(6S)” isomer – the terms are synonyms (and this naming convention is used interchangeably by various companies in the industry). In the case of methylfolate, that L or (6S) isomer is the active isomer of 5-MTHF that the body can actually use (conversely, D or (6R) refers to the inactive isomer of 5-MTHF, which isn’t the exact form the human body needs). To learn more about the different types of 5 methylfolate, its history, potency levels and stability details, and to see how our L-Methylfolate proves to be the purest on the planet, visit our Methylfolate Types page.

Is a Methylfolate Supplement the only thing I should take if I have an MTHFR gene mutation?

No, actually our recommendation is to heavily consider following Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching his video seminar.

You can also download one of specific Methylation Protocols which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term.

How can I get more information on MTHFR?

You'll find our MTHFR Newbies page is very helpful. It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.

The Science Behind

Understanding DFE Labeling for Methylfolate

What the New Numbers on Your Label Mean Now — and Why the Label Change Hasn’t Changed Your Dose

When it comes to folate supplements, labels can be misleading — not because the formulas are different, but because the rules have changed. In this video, Jamie from Methyl-Life® explains the FDA’s new requirement to use Dietary Folate Equivalents (DFE) and what that means for how folate is reported on supplement labels.

What’s this video about?: How the new FDA labeling standards affect folate supplements — and why your formula hasn’t changed, even if the number on the label looks much higher.

The Science Behind

What Makes Methyl-Life® Methylfolate Different Folate

Clinically Formulated, Quality-Tested, and Designed for Real Absorption

Not all methylfolate is created equal. In this video, Methyl-Life® founder, Jamie Hope, explains what sets their L-Methylfolate apart — from the ultra-pure form of folate used, to the strict quality testing, to the small, clean tablet design that delivers more active ingredients in a tasty way with less filler.

What’s this video about?: The research, formulation and manufacturing differences that make Methyl-Life® 's L-Methylfolate a superior choice — especially for individuals with MTHFR mutations or sensitive systems.

Why Folate Labels Now Use DFE

The FDA now requires that all folate-containing supplements list folate content in mcg DFE to account for how much folate is actually absorbed by the body, based on source.

Folic acid × 1.7 = mcg DFE
Methylfolate × 1.7 = mcg DFE

This change reflects differences in bioavailability. The folic acid nutrient, for example, has ~85% bioavailability when taken with food. However, natural food folate has only ~50% bioavailability. The DFE unit helps consumers understand how much “usable folate” they’re getting as if it were compared to eating folate from whole foods.

Example:

A supplement with 1,000 mcg folic acid will now be labeled as 1,700 mcg DFE.
A supplement with 15,000 mcg L-Methylfolate will now show 25,500 mcg DFE (or could show more, depending on the salt form used and its potency calculation).

NOTE: this is not an increase in the dosage amount — just new math to reflect usable folate content from the same formula.

Why This Matters for Methyl-Life® Users

Methyl-Life® uses L-5-Methyltetrahydrofolate (L-Methylfolate) — a bioactive form of folate that does not require MTHFR conversion. Even though it’s more effective and better absorbed than folic acid, the FDA still requires methylfolate products to use the same 1.7x multiplier for DFE.

So if your bottle used to say 15,000 mcg of L-Methylfolate, and now it says 25,000-30,000 mcg DFE, just know that neither the formula nor the dose has changed — only the math has. You're still receiving 15 mg of pure L-Methylfolate, now labeled using the updated DFE format.

Why the DFE Conversion Matters Less Than the Form

DFE was designed around folic acid absorption. But Methyl-Life® uses methylfolate, which already comes in its active form and offers superior uptake — especially for those with MTHFR gene mutations.

This is supported by evidence showing that L-Methylfolate:

Crosses the blood–brain barrier for direct cognitive support2
Improves depressive symptoms when used at 15 mg/day in SSRI-resistant cases PubMed 23212058
Supports homocysteine metabolism to reduce cardiovascular and neurological risk PMC9832224

Why the DFE Conversion Matters Less Than the Form

DFE (Dietary Folate Equivalent) was designed around folic acid — a synthetic form that requires multiple conversion steps before it becomes usable by the body.

But Methyl-Life® uses L-methylfolate, which is already in its active form and offers superior absorption — especially for those with MTHFR gene mutations.

So while labeling has changed, nothing has changed in your supplement’s clinical or nutritional performance.

Recap: DFE Labeling Doesn’t Change the Dose

DFE stands for Dietary Folate Equivalent, a unit created to reflect folate’s usable potency based on absorption rates from whole foods
The formula is exactly the same — only the math calculation applied to the label has changed
Methyl-Life® continues to deliver clinically-studied L-Methylfolate at the same high-potency, now labeled to meet new DFE guidelines from the FDA

You do not need to recalculate your dose or change your usage.

What Is Methylfolate — and Why It Matters

L-Methylfolate is the active form of folate, already converted and ready for use by the body — unlike synthetic folic acid, which must go through several enzymatic steps. This distinction is especially important for individuals with MTHFR gene variants, who often cannot convert folic acid efficiently.

Instead of building up unmetabolized folic acid in the bloodstream, L-Methylfolate delivers folate that is immediately bioavailable for methylation, neurotransmitter synthesis, DNA repair, detoxification and homocysteine reduction.

Reference: PubMed 20608755 – 5-MTHF is the predominant form of folate in circulation

What Sets Methyl-Life® Apart?

Study-proven Purest Form: Cerebrofolate™(coming soon)

Methyl-Life® uses Cerebrofolate™(coming soon), a patented crystalline calcium salt form of L-Methylfolate (L-5-MTHF-Ca). This advanced form offers:

Higher purity and stability than competing versions like Quatrefolic®
Superior metabolic compatibility for those with MTHFR gene variants
Enhanced absorption and proven reliability

Reference: Magnafolate® comparison report

Strength Options & Dosing Flexibility

Available in 2.5 mg, 5 mg, 10 mg and 15 mg, Methyl-Life® offers full dosing flexibility to support titration protocols. For example:

Start with 2.5 mg if you are new to methylfolate or sensitive to methyl donors
Easily split the 15 mg scored tablet into a 7.5 mg dose — cost-effective and precise

Reference: PubMed 23212058

Dosing Philosophy: Start Low, Increase Slowly

Jamie explains the importance of gradual titration — especially for individuals with mood issues or methylation impairments. Rapid increases can lead to irritability, fatigue or “overmethylation” symptoms in some users. Starting low and increasing over time allows the body to adapt.

Functional medicine practitioners often recommend beginning with lower doses and increasing based on symptoms and clinical goals.

Clean Ingredients + Small Tablet Design

Unlike large, filler-heavy tablets (such as Deplin), Methyl-Life®’s tablets are:

Small, chewable and tasty
Free from dyes, gluten, soy, dairy, GMOs and animal products
Designed to deliver 5 mg in a tablet smaller than a pinch of sugar

This product contains no unnecessary excipients or synthetic additives.

Every batch is third-party tested for:

Purity
Potency
Identity

Manufactured in an NSF-certified, cGMP-compliant facility, Methyl-Life® sets the standard for clinical-grade supplementation.

Why Pill Size Matters

Jamie explains that many pharmaceutical brands design large pills to enhance the placebo effect — assuming patients associate “big” with “strong.” But Methyl-Life® takes the opposite approach: smaller, cleaner, natural tablets packed with clinical efficacy and minimal filler.

This design delivers the same therapeutic dose with none of the fluff — maximizing absorption and minimizing unnecessary ingredients.

In Summary

Feature	Methyl-Life® Methylfolate
Active form	Yes – L-5-MTHF-Ca (Cerebrofolate™ coming soon)
Doses available	2.5, 5, 10, 15 mg
Third-party tested	Yes – Purity, potency, identity
Manufacturing certification	NSF, cGMP-compliant, FDA registered & audited
Additives	None – clean and allergen-free
Recommended usage	Start low, titrate slowly
Competitive advantage	Superior bioavailability and purity

best product for those who cant absorb b vitamins via normal methods

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"Test"

"Test"

"These didn’t work for me"

"The product itself is fine, but I would like to share my experience that may help others. I have the double MTHFR gene mutation. Everything I read said to take these supplements. When I began taking them, my anxiety went through the roof!!! I was angry and anxious. I read about over methylation and I was experiencing this (even on a lower dose). Sometimes people don’t react well to methyl supplements. So just listen to your body. If you experience these side effects, you may want to consider Folinic acid. I hope Methyl Life will make a Folinic acid supplement."

We're glad you tried our supplements and took the time to write a review. You're absolutely right, not everyone responds well to methylated forms of nutrients, especially when it's the first thing they try. Have you taken any NAC by chance? This is often a good thing to try, it will definitely help benefit those who are overmethylating - and for many taking it along with the methylated forms can really be beneficial (and potentially even allow them to tolerate some of the methyl forms). Folinic acid does not get around the MTHFR mutation, so for that reason Dr. Neil Rawlins does not suggest it as best if you have an MTHFR mutation, however, it can work in conjunction with methylfolate for some (I know Autism Speaks was doing a trial with it). Folinic acid is technically Leucovorin and so can be classified as a drug to treat cancer in some cases, we are still researching how possible it is for us to leverage it in our products legally. And it's worth noting that Dr. Neil Rawlins suggests methylfolate instead of Leucovorin in many cases. Again, thank you for taking the time to leave us feedback. We hope you are finding some great options for improving your health needs.

"it's a great product but the s"

"it's a great product but the shipping options are terrible. I actually ran out because the usps is the only shipping option and they temporarily lost my most recent package. There needs to be other shipping options."

Thank you for your feedback, we are always looking into improving our operations and will take this into consideration.

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SUPPLEMENT FACTS
Serving Size: 1 Chewable Tablet
90 servings per container	Amount per Serving	% Daily Value
Folate	17,000 mcg DFE	4,250%
(10 mg L-Methylfolate from 14 mg of Cerebrofolate™)

Methylfolate Supplement 10 mg

Traceable Ingredients You Can Trust

Supports Methylation, Mood & Cellular Health

Frequently Asked Question

The Science Behind

Understanding DFE Labeling for Methylfolate

The Science Behind

What Makes Methyl-Life® Methylfolate Different Folate

Customer Reviews