L Methylfolate 15 mg - A Mood-Boosting Supplement
L Methylfolate 15 mg - A Mood-Boosting Supplement
L Methylfolate 15 mg - A Mood-Boosting Supplement
L Methylfolate 15 mg - A Mood-Boosting Supplement
L Methylfolate 15 mg - A Mood-Boosting Supplement
L Methylfolate 15 mg - A Mood-Boosting Supplement
L Methylfolate 15 mg - A Mood-Boosting Supplement
Gluten-Free Dairy-Free No Artificial Additives Vegan-Friendly Non-GMO BPA-Free Top 14 Allergen-Free Fish/Shellfish-Free
High-Potency Folate for Mood, Methylation & Brain Health

L Methylfolate 15 mg - A Mood-Boosting Supplement

Methyl-Life's® Methylfolate 15 mg provides a therapeutic-strength dose of bioactive L-Methylfolate (5-MTHF), specifically designed for individuals with increased folate needs or MTHFR genetic variants. This ultra-pure form of folate supports neurotransmitter production, mood balance, methylation, and homocysteine regulation with optimal absorption.
  • High-potency 15 mg L-Methylfolate, formulated for clinical-level support
  • Bioactive, ultra-pure Cerebrofolate® for superior stability and absorption
  • 3rd-Party Tested for Purity, Potency & Safety

Free Shipping on Orders Over $100

L-Methylfolate 15 mg is a therapeutic-strength dose of bioactive folate, formulated with ultra-pure Cerebrofolate® to provide advanced support for mood balance, brain chemistry and cognition, methylation, and homocysteine regulation.

  • Bioactive Folate That Crosses the Blood–Brain Barrier
    L-Methylfolate is the only biologically active form of folate capable of crossing the blood–brain barrier. At 15 mg, this higher potency delivers robust support for neurotransmitter synthesis, memory, and overall cognitive performance — especially in cases where moderate doses may not be sufficient.
  • Cardiovascular & Homocysteine Support
    Clinical-strength folate helps regulate homocysteine, a critical marker for cardiovascular and metabolic health. This 15 mg dose provides intensive methylation support, helping maintain vascular function and long-term cellular balance.
  • Optimized for MTHFR Gene Mutation Carriers
    This formula bypasses the impaired conversion pathway caused by common MTHFR polymorphisms (C677T and A1298C), delivering active folate directly. With up to 50% of the population affected by these variants, 15 mg L-Methylfolate is frequently chosen for advanced methylation protocols when lower doses are not sufficient.
  • Clinically Relevant Applications
    Because of its high potency, the 15 mg strength is often used under the guidance of a healthcare professional. Clinical research has shown that 15 mg/day of L-Methylfolate may be effective as adjunctive nutritional support in mood-related protocols (PMID: 23212058). It is also commonly considered for individuals requiring intensified methylation or neurological support.
Supplement Facts
Serving Size: 1 Chewable Tablet
Servings Per Container: 90 servings per container
Amount Per Serving % Daily Value
Folate 25,500 mcg DFE
(15 mg L-Methylfolate from 21 mg of Cerebrofolate®) 		6,376%
† Daily Value not established

*DFE = Dietary Folate Equivalents. 25,500 mcg DFE (15 mg L-Methylfolate from 21 mg of Cerebrofolate™

Other Ingredients

Xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavoring. Not a significant source of sugars.

Allergen & Safety Information

  • Does not contain: wheat, gluten, soy, dairy, tree nuts, animal products, or GMOs
  • No artificial ingredients or colorings
  • Sweetened with xylitol — do not give to pets

Suggested Use

Take 1 chewable tablet daily, or as directed by your healthcare practitioner.
May be chewed, dissolved in the mouth or swallowed.

How much should you take?

Every individual’s needs are different. The 15 mg dose is considered therapeutic-strength and is most often used under the guidance of a healthcare professional. This higher potency is frequently chosen in advanced protocols — including adjunctive nutritional support for mood, cognitive health, and intensive methylation needs. Always consult your healthcare provider to determine if this strength is appropriate for your situation.

Doctor-guided support

Visit our Dosage Information and Methylation Protocol pages to learn what some practitioners recommend, including step-by-step guidance for individuals with MTHFR gene variants.

Splitting tablets

Each chewable tablet is scored and can be split in half without a pill cutter. For best results, place your thumbs along the scored line with the tablet facing away from you, and press outward to snap. Watch the full demonstration in our tablet-splitting video.

Additional considerations

This supplement is designed to be taken daily or as recommended by your healthcare practitioner. Some individuals start with lower doses and increase gradually, based on tolerance and need.

Why L-Methylfolate 15 mg Matters

L-Methylfolate is the only bioactive form of folate that can cross the blood–brain barrier, making it essential for neurotransmitter production, methylation, and homocysteine balance. At 15 mg, this clinical-strength dose is often chosen when moderate amounts are not sufficient — providing advanced nutritional support for mood, cognitive clarity, and cardiovascular health. It is particularly relevant for individuals with MTHFR gene variants or those requiring more intensive methylation support.

Key Scientific Findings

  • 15 mg/day L-Methylfolate has been clinically studied as an adjunctive nutrient alongside traditional mood protocols, showing improved outcomes compared to placebo or lower doses in certain populations.
  • Long-term research suggests continued use of 15 mg L-Methylfolate supports sustained emotional wellness and cognitive function, with a favorable safety profile over 12 months.
  • This high dose provides robust methylation support, helps regulate homocysteine metabolism, and contributes to overall neurological and vascular health — making it especially useful for those with folate metabolism challenges such as MTHFR C677T/A1298C variants.
  • Shown to support cognitive function and neurological health, including benefits observed in research on brain health.

Clinical Relevance

Clinical studies indicate that 15 mg L-Methylfolate may support mood balance, cognitive performance, and cardiovascular biomarkers, particularly in individuals whose needs go beyond standard folate supplementation. It is frequently recommended in practitioner-guided protocols for advanced methylation support.

  1. Papakostas GI, Shelton RC, Zajecka JM, et al. L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials. Am J Psychiatry. 2012;169(12):1267-1274. doi:10.1176/appi.ajp.2012.11071114

  2. Shelton RC, Sloan Manning J, Barrentine LW, Tipa EV. Assessing Effects of l-Methylfolate in Depression Management: Results of a Real-World Patient Experience Trial. Prim Care Companion CNS Disord. 2013;15(4):PCC.13m01520. doi:10.4088/PCC.13m01520
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402301/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687916/
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779227/
  6. https://www.ahajournals.org/doi/10.1161/hq0102.102190
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019735/
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867258/
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127769/
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832224/
  11. https://pubmed.ncbi.nlm.nih.gov/23212058/
  12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564482/
  13. https://methyl-life.com/blogs/methylfolate-facts/cerebrofolate-comparison
  14. https://www.ncbi.nlm.nih.gov/books/NBK6561/
  15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530664/
  16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630484/
  17. https://www.ahajournals.org/doi/10.1161/01.CIR.0000165142.37711.E7
  18. https://pubmed.ncbi.nlm.nih.gov/24032278/
  19. https://i.trade-cloud.com.cn/upload/6405/file/20210929/english-version-magnafolate-enhancing-immunity_524485.pdf
  20. https://methyl-life.com/pages/methylfolate-types
  21. https://ijbpas.com/archive/archive-single-pdf/6008
  22. https://pmc.ncbi.nlm.nih.gov/articles/PMC11623627/
HOW WE HAVE HELPED OUR CUSTOMERS

Stacy S.

Verified Buyer
02/04/2024
I love it because it's working

I've used other methylfolate products, but this one is by far the most effective. Very pleased.

HOW WE HAVE HELPED OUR CUSTOMERS

Carol M K.

Verified Buyer
06/09/2025
Excellent quality product

I really appreciate your product for its quality, flavor, and ability to be chewable. It's also a small pill and more economically priced than than the product that I have purchased on Amazon.

HOW WE HAVE HELPED OUR CUSTOMERS

Leon G.

Verified Buyer
10/01/2025
Great Product

Terrific product, with your subscription service I never run out. Very happy with your customer service and the informative emails you send with updates and suggestions.

HOW WE HAVE HELPED OUR CUSTOMERS

Wanda P.

Verified Buyer
12/05/2023
Excellent Product

I spent years taking Clinically-used form of active folate as the cost skyrocketed to the point that I needed to find a reliable just as good replacement. So thankful to have found Methyl-Life Methylfolate 15mg which is great! Works just as well as Clinically-used form of active folate if not better and I like the smaller chewable tabs. I also take the Methyl-Life B-12 2.5mg Supplement tabs too. I feel they go to work immediately! I trust the quality and research behind this great Company and their dedication to helping those with MTHFR!

HOW WE HAVE HELPED OUR CUSTOMERS

Emily C.

Verified Buyer
29/11/2020
After many years, we still love this product.

My daughter is on the spectrum and had the DNA testing for the methylation deficiency. She ended up missing the gene so we have been using Methyl-Life Methylfolate 15 for several years. We have definitely noticed an improvement in both her mood and sleeping while on the product compared to when she is out of tablets! We couldn’t be more pleased with Methyl-Life Methylfolate 15.

HOW WE HAVE HELPED OUR CUSTOMERS

Barry V.

Verified Buyer
12/10/2020
8 years and counting

My doctor recommended I start taking 7.5mg folate daily for heart health. He started me on Methylfolate, as it is the more active and natural form of folate and crosses the blood-brain barrier. I have been taking this product for 8 years now and in addition to the benefits for my heart like a risk reduction of me suffering from heart disease and stroke by about 20% by lowering homocysteine levels, I have more energy, leading to more productive workouts. I cant imagine not taking Methylfolate and I appreciate Methyl-Life for providing the best product for me.
L Methylfolate 15 mg - A Mood-Boosting Supplement
$76

Traceable Ingredients You Can Trust

Every ingredient is sourced for purity, backed by clinical evidence, and rigorously tested for safety and bioavailability. Because in supplements, not all ingredients are created equal — and your body deserves only the most effective forms.

Clinically Studied L-Methylfolate for Mood, Methylation & Brain Health

Clinically Studied L-Methylfolate for Mood, Methylation & Brain Health

L–5–Methyltetrahydrofolate, Calcium (as Cerebrofolate®)

The centerpiece of this formula is Cerebrofolate® — a next-generation, patented form of L-Methylfolate designed for unmatched purity, potency, and bioavailability. Unlike folic acid or less stable folate compounds, Cerebrofolate® is ready-to-use, bypassing the MTHFR enzymatic block to directly support neurological, cardiovascular, and methylation pathways.

Cerebrofolate® delivers >80% free methylfolate, offering superior absorption and immediate usability compared to many other folate sources. Unlike synthetic folic acid, Cerebrofolate® does not contribute to unmetabolized folic acid accumulation, which has been associated with reduced immune efficiency and masking of B12 deficiency. L-Methylfolate supports much more than mood — it is vital for DNA synthesis and repair, detoxification, and healthy red blood cell formation. For those with MTHFR gene variants, Cerebrofolate® provides a direct pathway to active folate, helping maintain methylation efficiency and neurotransmitter support.

Backed by research: PMC3869616, PubMed 23212058, PMC5385290

Methyl-Life® L Methylfolate 15 mg - A Mood-Boosting Supplement contains no unnecessary excipients, synthetic colors, artificial preservatives, or common allergens. It is 100% free from gluten, soy, dairy, GMOs, animal-derived ingredients, and the EU’s top 14 allergens.

Every batch is third-party tested for purity, potency, and safety, manufactured in NSF-certified, cGMP-compliant facilities, and rigorously evaluated to ensure you’re getting clean, clinical-grade nutrients — nothing more, nothing less.

EU’s top 14 allergens

  • Cereals containing gluten - wheat (such as spelt and khorasan wheat), rye, barley, oats. Note: The cereal name, e.g., 'wheat', must be declared and highlighted, not 'gluten'.
  • Crustaceans, e.g., crabs, prawns, lobsters
  • Eggs
  • Fish
  • Peanuts
  • Soybeans
  • Milk
  • Nuts (almonds, hazelnuts, walnuts, cashews, pecan nuts, brazil nuts, pistachio nuts, macadamia/Queensland nut). Note: The name of the nut, e.g., 'almond', must be declared and highlighted, not 'nuts'.
  • Celery
  • Mustard
  • Sesame seeds
  • Sulphur dioxide and sulphites (at concentrations of more than 10 mg/kg or 10 mg/L in terms of total sulphur dioxide) – used as a preservative
  • Lupin 
  • Molluscs, e.g., mussels, oysters, squid, snails
How This Formula Transforms Your Brain + Mood Health

Unlock Clinical-Grade Mood & Cognitive Support

Therapeutic-Strength Folate Supplement Powered by Cerebrofolate®. Formulated with an ultra-pure, clinically dosed 15 mg of L-5-methylfolate, this supplement provides advanced nutritional support for mood balance, cognitive clarity, and efficient methylation. It is ideally suited for individuals with MTHFR gene variants, elevated homocysteine, or increased folate needs related to neurological and cardiovascular function.

Supports Neurotransmitter Balance

15 mg of L-Methylfolate supports the body’s natural production of serotonin and dopamine — neurotransmitters essential for mood regulation, motivation, memory, and focus. L-Methylfolate functions as a key cofactor in the methylation cycle, helping replenish methyl groups required for neurotransmitter synthesis.

For individuals with MTHFR gene polymorphisms, who may have difficulty converting folic acid into its active form, this supplement provides bioavailable folate that directly supports neurotransmitter pathways and contributes to overall brain health.

Research Insights: 

  • A pivotal randomized controlled trial reported that 15 mg/day of L-Methylfolate, when used alongside standard mood protocols, enhanced outcomes in individuals who had not responded fully to other approaches (PubMed 23212058).
  • Observational research indicates that adding L-Methylfolate (7.5–15 mg) to existing regimens may support emotional balance and social functioning in those with folate insufficiency (PMC3869616).

Case-level findings suggest that higher-dose L-Methylfolate alone may provide notable support for individuals requiring advanced folate supplementation (PMC7572139).

Crosses the Blood–Brain Barrier for Central Nervous System Support

Unlike synthetic folic acid, L-Methylfolate is the only form of folate that can cross the blood–brain barrier in its active state, ensuring efficient delivery to neurons. This direct transport supports cognitive processes, healthy neurotransmission, and nerve protection — all of which are critical for long-term brain health.

Research Backing:

  • L-Methylfolate plays a role in the body’s natural methylation and enzymatic processes, supporting healthy neurotransmitter pathways that influence mood balance and overall neurological function (PMC8573752).
  • Clinical evidence shows that 15 mg/day of L-Methylfolate, when used alongside standard protocols, is associated with improved central nervous system outcomes, suggesting effective brain penetration (PubMed 23212058).
  • Research confirms that folate is actively transported across the blood–brain barrier to help maintain brain folate balance, which is essential for neurological support (PMC5385290).

Fuels Methylation & DNA Repair

Cerebrofolate® delivers the most bioactive form of folate, essential for methylation — a core biochemical process that regulates gene expression, cellular detoxification, DNA synthesis, and energy metabolism. Proper methylation helps maintain cellular health, immune resilience, and neurological performance.

When folate intake is insufficient, methylation can slow, which may affect DNA repair capacity and overall cellular balance. Supplementing with bioavailable L-Methylfolate ensures the body has access to active methyl groups needed to keep these pathways functioning optimally.

Scientific Support

  • L-Methylfolate provides methyl groups required for the conversion of homocysteine to methionine, supporting the formation of S-adenosylmethionine (SAM) — the universal methyl donor for DNA methylation and repair (PMC3262611).
  • Clinical studies highlight L-Methylfolate’s role in promoting healthy methylation and balanced homocysteine metabolism, which are both important for cardiovascular and neurological health (PMC9832224, PubMed 23212058).

Frequently Asked Question

Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.
You'll find our MTHFR Newbies page page is very helpful. It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.
Basically, yes. In the chemistry world, L stands for the “Left” isomer, which is the same as the “(6S)” isomer – the terms are synonyms (and this naming convention is used interchangeably by various companies in the industry). In the case of methylfolate, that L or (6S) isomer is the active isomer of 5-MTHF that the body can actually use (conversely, D or (6R) refers to the inactive isomer of 5-MTHF, which isn’t the exact form the human body needs). To learn more about the different types of 5 methylfolate, its history, potency levels and stability details, and to see how our L-Methylfolate proves to be the purest on the planet, visit our Methylfolate Types page.
This higher-potency dose offers advanced support for mood, cognitive health, and cardiovascular function. It is frequently chosen by individuals who require more intensive folate supplementation due to genetic variations (such as MTHFR) or elevated folate needs.

This strength may be most appropriate for:

  • Individuals with MTHFR gene variants impacting folate metabolism
  • Those seeking advanced methylation or homocysteine regulation
  • People requiring adjunctive nutritional support for mood balance
  • Individuals who have not achieved sufficient results with lower doses (2.5–10 mg)
No, actually our recommendation is to heavily consider following Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching his video seminar. You can also download one of specific Methylation Protocols which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term.
Go to our A Doctor Explains resource and listen to Dr. Neil Rawlins’ video seminar on MTHFR and the effects of Methylfolate.
L-Methylfolate 15 mg by Methyl-Life® is a therapeutic-strength L-5-methylfolate supplement, providing the most bioavailable form of folate to fuel methylation pathways in the body. It plays a critical role in neurotransmitter production, DNA synthesis, and homocysteine balance.
Research has shown that 15 mg/day of L-Methylfolate has been clinically studied as adjunctive nutritional support in mood-related protocols. At this range, it may help regulate neurotransmitter activity, particularly in populations with folate metabolism challenges. Because of its clinical strength, it should be used under healthcare professional guidance.
Response time varies. Some individuals notice improvements in clarity, energy, or mood relatively quickly, while others may take several weeks (or even months) of consistent use. Since this is a therapeutic-strength dose, it is best used with ongoing practitioner guidance to ensure proper integration into your health plan.

Clinically Studied, Backed by Real Science

L-Methylfolate is one of the most extensively studied forms of folate, with research exploring its role in mood balance, homocysteine metabolism, and neurological health. Unlike synthetic folic acid, the bioactive form of folate is directly usable by the body, making it particularly relevant for individuals with MTHFR genetic variants or increased folate requirements. Clinical research continues to demonstrate the value of L-Methylfolate, especially at clinically effective dosages such as 15 mg.

Research Spotlight: Adjunctive Support for Mood

Research Highlights the Role of High-Dose L-Methylfolate in Supporting Emotional Wellbeing

A significant number of individuals on standard SSRI protocols do not achieve full benefits. Research indicates that adding 15 mg of L-Methylfolate may provide additional mood and neurotransmitter support, particularly in those with low folate status or MTHFR gene variants that affect folate metabolism. L-Methylfolate’s role in neurotransmitter synthesis and methylation pathways makes it uniquely positioned compared to synthetic folic acid, which requires enzymatic conversion.

Evidence-Based Insight: A landmark double-blind, placebo-controlled study reported that individuals taking 15 mg/day of L-Methylfolate as an adjunct to SSRIs experienced greater improvements in mood-related outcomes compared to those taking SSRIs with placebo (PubMed 23212058).

Read the Study - PMC3869616

What Makes Methyl-Life® Methylfolate Different Folate

Clinically Formulated, Quality-Tested, and Designed for Real Absorption

Not all methylfolate is created equal. In this video, Methyl-Life® founder, Jamie Hope, explains what sets their L-Methylfolate apart — from the ultra-pure form of folate used, to the strict quality testing, to the small, clean tablet design that delivers more active ingredients in a tasty way with less filler.

What’s this video about? The research, formulation and manufacturing differences that make Methyl-Life® 's L-Methylfolate a superior choice — especially for individuals with MTHFR mutations or those needing the precision-based activity of bioidentical folate.

What Is Methylfolate — and Why It Matters

L-Methylfolate is the active form of folate, already converted and ready for use by the body — unlike synthetic folic acid, which must go through several enzymatic steps. This distinction is especially important for individuals with MTHFR gene variants, who often cannot convert folic acid efficiently.

Instead of building up unmetabolized folic acid in the bloodstream, L-Methylfolate delivers folate that is immediately bioavailable for methylation, neurotransmitter synthesis, DNA repair, detoxification and homocysteine reduction.

Reference: PubMed 20608755 – 5-MTHF is the predominant form of folate in circulation

What Sets Methyl-Life® Apart?

Study-proven Purest Form:  Cerebrofolate®

Methyl-Life® uses Cerebrofolate®, a Type I crystalline calcium salt form of L-Methylfolate (L-5-MTHF-Ca). This advanced form offers:

  • Higher purity and stability than competing versions like Quatrefolic®
  • Superior metabolic compatibility for those with MTHFR gene variants
  • Enhanced absorption and proven reliability
  • Least impurities degradation over time compared to leading brands

Reference: Magnafolate® comparison report

Strength Options & Dosing Flexibility

Available in 2.5 mg, 5 mg, 10 mg and 15 mg, Methyl-Life® offers full dosing flexibility to support titration protocols. For example:

  • Start with 2.5 mg if you are new to methylfolate or sensitive to methyl donors
  • Easily split the 15 mg scored tablet into a 7.5 mg dose — cost-effective and precise
  • Research indicates that 15 mg/day of L-methylfolate has been studied as an adjunct to standard mood support protocols.

Reference: PubMed 23212058

Dosing Philosophy: Start Low, Increase Slowly

Jamie explains the importance of gradual titration — especially for sensitive individuals with mood issues or methylation impairments. Rapid increases can lead to irritability, fatigue or “overmethylation” symptoms in some users. Starting low and increasing over time allows the body to adapt.

Functional medicine and naturopathic practitioners often recommend beginning with lower doses and increasing based on symptoms and clinical goals.

4. Clean Ingredients + Small Tablet Design

Unlike large, filler-heavy tablets (such as Deplin®), Methyl-Life®’s tablets are:

  • Small, chewable and on-the-go easy
  • Free from dyes, gluten, soy, dairy, GMOs and animal products
  • Designed to deliver 15 mg in a tablet that tastes like a fresh hint of mint

This product contains no unnecessary excipients or synthetic additives.

Every batch is third-party tested for:

  • Purity
  • Potency
  • Identity

Manufactured in an NSF-certified, cGMP-compliant facility registered with the FDA, Methyl-Life® sets the standard for clinical-grade supplementation.

Why Pill Size Matters

Jamie explains that many pharmaceutical brands design large pills to enhance the placebo effect — assuming patients associate “big” with “strong” and bright colors with “effectiveness” levels. But Methyl-Life® takes the opposite approach: smaller, cleaner, natural tablets packed with clinical efficacy and no dyes or unnecessary fillers.

This design delivers the same therapeutic dose with none of the fluff — maximizing absorption and minimizing unnecessary ingredients your body doesn’t need.

In Summary

Feature Methyl-Life®’s Cerebrofolate®
Active form Bioidentical L-5-MTHF as Cerebrofolate®
Doses available 2.5 mg, 5 mg, 10 mg, 15 mg
Third-party tested Yes – Purity, Potency, Identity
Manufacturing certification NSF-certified, cGMP-compliant, FDA registered & audited
Additives None – clean and allergen-free
Recommended usage Start low, titrate slowly
Competitive advantage Superior bioavailability and purity

Customer Reviews

Based on 110 reviews
87%
(96)
10%
(11)
1%
(1)
2%
(2)
0%
(0)
81.3
92.9
A
Anonymous

I definitely think it gas helped! Thank you

P
Patty Roberts Temples

I think this is a great product & will continue to order from your company

c
cyberdoc

A very good and easy to use product at a fairprice. The best source I have found To Date for this medical food.

N
Nicole Paige

I feel much better. My mood is lifted.

G
Gregg Pauletti

It tastes chalky. Would rather have a capsule version that must be swallowed.

Load More

Related Articles

Popular reads from our experts

Methyl-Life® L-Methylfolate 15 mg – Potent, Clinical-Strength Support for Mood, Cognition & Cardiovascular Health

Methyl-Life® L-Methyfolate 15 mg delivers a high-strength dose of bioactive folate — also known as 5-MTHF or L-Methylfolate — the most absorbable and effective form of folate for the body. Specially formulated for individuals with MTHFR gene variants or elevated folate requirements, this advanced supplement supports essential methylation processes, neurotransmitter production, cardiovascular function, and brain health without relying on the body’s ability to convert synthetic folic acid.

If you experience ongoing mood challenges, cognitive changes, or elevated homocysteine, Methyl-Life® L-Methyfolate 15 mg provides advanced folate support designed to promote mental clarity, emotional balance, and overall wellness.

Understanding the MTHFR Mutation and Folate Deficiency

Many people dealing with fatigue, low mood, brain fog, or cardiovascular concerns are unaware that a genetic variation in the MTHFR enzyme could be limiting their ability to convert folic acid into its active, usable form. The MTHFR gene is essential in the metabolic pathway that converts synthetic folic acid into bioactive L-Methylfolate (5-MTHF).

Variants like C677T or A1298C can reduce the enzyme’s function by 40–80%, causing unmetabolized folic acid accumulation while lowering the body’s access to functional folate