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High-Potency Folate for Mood, Methylation & Brain Health

L Methylfolate 15 mg - A Mood-Boosting Supplement

Name: L Methylfolate 15 mg - A Mood-Boosting Supplement
Brand: Methyl-Life® Supplements
SKU: m15-cerebro1001
Price: 76 USD
Availability: InStock
Rating: 4.8 (105 reviews)

Methyl-Life’s® L Methylfolate 15 mg is an active form of folate that can bypass the MTHFR mutation¹¹ for direct biochemical absorption & immediate use by the body.

Professional Strength - Ask Your Doctor
High-Dose L Methylfolate 15 Mg for Natural Mood Support²
3rd-Party Tested for Purity, Potency & Safety
90 Vegan, Non-GMO, Chewable Mint Tablets

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Supplement Facts

Serving Size: 1 Chewable Tablet

Servings Per Container: 90 servings per container

Amount Per Serving	% Daily Value
Folate 25,500 mcg DFE ((15 mg L-Methylfolate from 21 mg of Cerebrofolate™))	6,376%

† Daily Value not established

*DFE = Dietary Folate Equivalents. 25,500 mcg DFE (15 mg L-Methylfolate from 21 mg of Cerebrofolate™

Other Ingredients

Xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavoring. Not a significant source of sugars.

Allergen & Safety Information

Does not contain: wheat, gluten, soy, dairy, tree nuts, animal products, or GMOs
No artificial ingredients or colorings
Sweetened with xylitol — do not give to pets

Suggested Use

Take 1 chewable tablet daily, or as directed by your healthcare practitioner.
May be chewed, dissolved in the mouth or swallowed.

How much should you take?

Every individual’s needs are different. Always consult your healthcare provider to determine the right dose for your specific needs.

Doctor-guided support

Visit our Dosage Information and Methylation Protocol pages to learn what some practitioners recommend, including step-by-step guidance for individuals with MTHFR gene variants.

Splitting tablets

Each chewable tablet is scored and can be split in half without a pill cutter. For best results, place your thumbs along the scored line with the tablet facing away from you, and press outward to snap. Watch the full demonstration in our tablet-splitting video.

Additional considerations

This supplement is designed to be taken daily or as recommended by your healthcare practitioner. Some individuals start with lower doses and increase gradually, based on tolerance and need.

High dose L methylfolate 15 mg for healthy methylation, homocysteine and natural mood support.

Bioactive folate uniquely formulated with the new & improved, internationally-branded nutrient Cerebrofolate™⁰.

L-methylfolate is the predominant form of folate circulating in the body and used for biological processes¹.

Studies show *15mg methylfolate + SSRI to be the most effective dose for improving depressive symptoms².

L Methylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier³.

Support for brain function⁴
Supports cardiovascular health⁵
Support for healthy immune function⁶
Supports nerve function⁷
Support for preconception, pregnancy, and fetal health⁸
Involved in maintaining healthy homocysteine levels⁹
Essential nutrient required for healthy DNA and neurotransmitter synthesis¹⁰
Suitable for people with MTHFR mutations¹¹

A 2024 animal study found that high-dose methylfolate may protect against neurodevelopmental behaviours resulting from exposure to pyrethroid, a type of pesticide. Pyrethroid exposure disrupts folate metabolism in the brain and may contribute to behavioral disorders such as autism.

Methylfolate is the biologically active form of folate and can bypass disruptions to the breakdown of folate in the body, whether caused by MTHFR or by DPE exposure. In this study, high-dose supplementation with methylfolate dramatically reduced the behavioural disorders caused by folate issues, preventing deficits in the social, communication, cognitive, and locomotor areas of the brain that are linked to autism.²¹

Product details

Key ingredient: Folate 25,500 mcg DFE (15 mg L-Methylfolate from 21 mg of Cerebrofolate™)

L Methylfolate 15 mg is a highly bioactive form of folate made with the purest & most potent methylfolate available¹².

Maximum absorption and bioavailability
No prescription required
Available in 2.5mg, 3mg+B12, 5mg, 7.5mg+B12, 10mg, 15mg, 15mg+B12
Rigorously tested for consistency, purity, safety, and potency

Why take L Methylfolate?

Folate is required for numerous critical functions of the brain and nervous system. It is essential for DNA/RNA synthesis, maintaining healthy homocysteine levels, and for proper fetal development during pregnancy.

Folic acid is a synthetic form of folate. It can only be used by the body after it has been converted to active folate by an enzyme called methylenetetrahydrofolate reductase (MTHFR)¹³.

Who is affected by MTHFR mutations?

The MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants).

Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%). Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A>C polymorphism in Hispanics and Africans is 15%¹⁴. And these are just 2 of the well-documented polymorphisms out of over 70 MTHFR possible SNPs (single nucleotide polymorphisms) in the body.

An increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness¹⁵. MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses¹⁶.

For these people, L-methylfolate supplementation is shown to be the most effective way to provide this form of folate¹⁰.

Methyl-Life’s® L Methylfolate 15 mg is an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.

Why CEREBROFOLATE™?

Methyl-Life’s® L Methylfolate 15 mg is made with the new & improved, internationally-branded nutrient Cerebrofolate™, clinically tested as the world’s purest & most potent methylfolate (Cerebrofolate™ is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic®, Extrafolate®, Metafolin® & Magnafolate®²⁰).

Cerebrofolate™ is made with a form of methylfolate called L-5-MTHF-Ca, which is shown to be the most active form of folate in the plasma circulation. When compared with ordinary folate, L Methylfolate was found to be absorbed faster and utilized more quickly in the body¹⁷.

A recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation¹⁸.

Not only that, it has improved production processing methods which have increased its purity and potency to exceed the USP standards. So if you’re truly looking for professional strength, look no further, Cerebrofolate™ is the biochemically identical version of L-methylfolate that has been used in significant clinical studies to demonstrate mood elevation. Read more about Cerebrofolate's™ superiority¹⁹.

L Methylfolate 15 mg - A Mood-Boosting Supplement

$76

Traceable Ingredients You Can Trust

Every ingredient is sourced for purity, backed by clinical evidence, and rigorously tested for safety and bioavailability. Because in supplements, not all ingredients are created equal — and your body deserves only the most effective forms.

Supports Methylation, Mood & Cellular Health

L–5–Methyltetrahydrofolate Calcium (as Calcium – Cerebrofolate™)

Clinically tested and patented for superior purity, this bioactive form of folate bypasses genetic mutations (like MTHFR) and goes straight to work — supporting neurotransmitters, DNA repair, and a healthy mood balance.

Methyl-Life® L Methylfolate 15 mg - A Mood-Boosting Supplement contains no unnecessary excipients, synthetic colors, artificial preservatives, or common allergens. It is 100% free from gluten, soy, dairy, GMOs, animal-derived ingredients, and the EU’s top 14 allergens.

Every batch is third-party tested for purity, potency, and safety, manufactured in NSF-certified, cGMP-compliant facilities, and rigorously evaluated to ensure you’re getting clean, clinical-grade nutrients — nothing more, nothing less.

Frequently Asked Question

What is the right dosage for me?

Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.

What do doctors have to say about MTHFR and how to treat it?

Go to our A Doctor Explains resource and listen to Dr. Neil Rawlins’ video seminar on MTHFR and the effects of Methylfolate.

Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium the same thing?

Basically, yes. In the chemistry world, L stands for the “Left” isomer, which is the same as the “(6S)” isomer – the terms are synonyms (and this naming convention is used interchangeably by various companies in the industry). In the case of methylfolate, that L or (6S) isomer is the active isomer of 5-MTHF that the body can actually use (conversely, D or (6R) refers to the inactive isomer of 5-MTHF, which isn’t the exact form the human body needs). To learn more about the different types of 5 methylfolate, its history, potency levels and stability details, and to see how our L-Methylfolate proves to be the purest on the planet, visit our Methylfolate Types page.

How long does it take to experience the benefits of L Methylfolate 15 mg?

Individual responses may vary, but some users report noticing improvements in energy levels and overall well-being over just five weeks of starting L Methylfolate 15 mg supplementation.

Who can benefit from taking L Methylfolate 15 mg?

Individuals with MTHFR gene mutations, those requiring high doses of folate, and pregnant women seeking prenatal support may benefit from L Methylfolate 15 mg supplementation.

Is L Methylfolate 15 mg the only thing I should take if I have an MTHFR gene mutation?

No, actually our recommendation is to heavily consider Dr. Neil Rawlins’ full supplement protocol. You can learn more about his protocol by watching his video seminar.
You can also download one of four specific Methylation Protocols which guide you through the beginning nutrients to start. We recommend starting low and slowly titrating up to a dose that works well for you long term.
You'll find our MTHFR Newbies page is very helpful as well. It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.

How can I get more information on MTHFR?

You'll find our MTHFR Newbies page is very helpful. It's got some great tips for folks who haven't done much study on what to do if you have an MTHFR variant.

How can L Methylfolate 15 mg help with MTHFR mutations?

L Methylfolate 15 mg can be beneficial for individuals with MTHFR mutations because it provides a form of folate that is already methylated, bypassing the need for the MTHFR enzyme to convert it. This supports methylation processes in the body, which may be impaired in individuals with MTHFR mutations, and helps maintain optimal folate levels necessary for various biochemical reactions. It's important to consult with a healthcare professional for personalized advice on supplementation and managing MTHFR mutation.

Why should I take L-methylfolate?

You may consider taking L-methylfolate if you have certain genetic variations affecting folate metabolism, are pregnant or planning to become pregnant, or have a medical condition that requires high doses of folate supplementation. L-Methylfolate can support various bodily functions, including DNA synthesis, neurotransmitter production, and cardiovascular health, making it beneficial for individuals with specific needs or seeking optimal folate levels.

How does L Methylfolate 15 mg benefit health?

L Methylfolate 15 mg supports DNA synthesis, neurotransmitter production, and cardiovascular health, making it beneficial for individuals with certain genetic variations or those seeking optimal folate levels.

The Science Behind

What Makes Methyl-Life® Methylfolate Different Folate

Clinically Formulated, Quality-Tested, and Designed for Real Absorption

Not all methylfolate is created equal. In this video, Methyl-Life® founder, Jamie Hope, explains what sets their L-Methylfolate apart — from the ultra-pure form of folate used, to the strict quality testing, to the small, clean tablet design that delivers more active ingredients in a tasty way with less filler.

What’s this video about?: The research, formulation and manufacturing differences that make Methyl-Life® 's L-Methylfolate a superior choice — especially for individuals with MTHFR mutations or sensitive systems.

The Science Behind

Understanding DFE Labeling for Methylfolate

What the New Numbers on Your Label Mean Now — and Why the Label Change Hasn’t Changed Your Dose

When it comes to folate supplements, labels can be misleading — not because the formulas are different, but because the rules have changed. In this video, Jamie from Methyl-Life® explains the FDA’s new requirement to use Dietary Folate Equivalents (DFE) and what that means for how folate is reported on supplement labels.

What’s this video about?: How the new FDA labeling standards affect folate supplements — and why your formula hasn’t changed, even if the number on the label looks much higher.

What Is Methylfolate — and Why It Matters

L-Methylfolate is the active form of folate, already converted and ready for use by the body — unlike synthetic folic acid, which must go through several enzymatic steps. This distinction is especially important for individuals with MTHFR gene variants, who often cannot convert folic acid efficiently.

Instead of building up unmetabolized folic acid in the bloodstream, L-Methylfolate delivers folate that is immediately bioavailable for methylation, neurotransmitter synthesis, DNA repair, detoxification and homocysteine reduction.

Reference: PubMed 20608755 – 5-MTHF is the predominant form of folate in circulation

What Sets Methyl-Life® Apart?

Study-proven Purest Form: Cerebrofolate™(coming soon)

Methyl-Life® uses Cerebrofolate™(coming soon), a patented crystalline calcium salt form of L-Methylfolate (L-5-MTHF-Ca). This advanced form offers:

Higher purity and stability than competing versions like Quatrefolic®
Superior metabolic compatibility for those with MTHFR gene variants
Enhanced absorption and proven reliability

Reference: Magnafolate® comparison report

Strength Options & Dosing Flexibility

Available in 2.5 mg, 5 mg, 10 mg and 15 mg, Methyl-Life® offers full dosing flexibility to support titration protocols. For example:

Start with 2.5 mg if you are new to methylfolate or sensitive to methyl donors
Easily split the 15 mg scored tablet into a 7.5 mg dose — cost-effective and precise

Reference: PubMed 23212058

Dosing Philosophy: Start Low, Increase Slowly

Jamie explains the importance of gradual titration — especially for individuals with mood issues or methylation impairments. Rapid increases can lead to irritability, fatigue or “overmethylation” symptoms in some users. Starting low and increasing over time allows the body to adapt.

Functional medicine practitioners often recommend beginning with lower doses and increasing based on symptoms and clinical goals.

Clean Ingredients + Small Tablet Design

Unlike large, filler-heavy tablets (such as Deplin), Methyl-Life®’s tablets are:

Small, chewable and tasty
Free from dyes, gluten, soy, dairy, GMOs and animal products
Designed to deliver 5 mg in a tablet smaller than a pinch of sugar

This product contains no unnecessary excipients or synthetic additives.

Every batch is third-party tested for:

Purity
Potency
Identity

Manufactured in an NSF-certified, cGMP-compliant facility, Methyl-Life® sets the standard for clinical-grade supplementation.

Why Pill Size Matters

Jamie explains that many pharmaceutical brands design large pills to enhance the placebo effect — assuming patients associate “big” with “strong.” But Methyl-Life® takes the opposite approach: smaller, cleaner, natural tablets packed with clinical efficacy and minimal filler.

This design delivers the same therapeutic dose with none of the fluff — maximizing absorption and minimizing unnecessary ingredients.

In Summary

Feature	Methyl-Life® Methylfolate
Active form	Yes – L-5-MTHF-Ca (Cerebrofolate™ coming soon)
Doses available	2.5, 5, 10, 15 mg
Third-party tested	Yes – Purity, potency, identity
Manufacturing certification	NSF, cGMP-compliant, FDA registered & audited
Additives	None – clean and allergen-free
Recommended usage	Start low, titrate slowly
Competitive advantage	Superior bioavailability and purity

Why Folate Labels Now Use DFE

The FDA now requires that all folate-containing supplements list folate content in mcg DFE to account for how much folate is actually absorbed by the body, based on source.

Folic acid × 1.7 = mcg DFE
Methylfolate × 1.7 = mcg DFE

This change reflects differences in bioavailability. The folic acid nutrient, for example, has ~85% bioavailability when taken with food. However, natural food folate has only ~50% bioavailability. The DFE unit helps consumers understand how much “usable folate” they’re getting as if it were compared to eating folate from whole foods.

Example:

A supplement with 1,000 mcg folic acid will now be labeled as 1,700 mcg DFE.
A supplement with 15,000 mcg L-Methylfolate will now show 25,500 mcg DFE (or could show more, depending on the salt form used and its potency calculation).

NOTE: this is not an increase in the dosage amount — just new math to reflect usable folate content from the same formula.

Why This Matters for Methyl-Life® Users

Methyl-Life® uses L-5-Methyltetrahydrofolate (L-Methylfolate) — a bioactive form of folate that does not require MTHFR conversion. Even though it’s more effective and better absorbed than folic acid, the FDA still requires methylfolate products to use the same 1.7x multiplier for DFE.

So if your bottle used to say 15,000 mcg of L-Methylfolate, and now it says 25,000-30,000 mcg DFE, just know that neither the formula nor the dose has changed — only the math has. You're still receiving 15 mg of pure L-Methylfolate, now labeled using the updated DFE format.

Why the DFE Conversion Matters Less Than the Form

DFE was designed around folic acid absorption. But Methyl-Life® uses methylfolate, which already comes in its active form and offers superior uptake — especially for those with MTHFR gene mutations.

This is supported by evidence showing that L-Methylfolate:

Crosses the blood–brain barrier for direct cognitive support2
Improves depressive symptoms when used at 15 mg/day in SSRI-resistant cases PubMed 23212058
Supports homocysteine metabolism to reduce cardiovascular and neurological risk PMC9832224

Why the DFE Conversion Matters Less Than the Form

DFE (Dietary Folate Equivalent) was designed around folic acid — a synthetic form that requires multiple conversion steps before it becomes usable by the body.

But Methyl-Life® uses L-methylfolate, which is already in its active form and offers superior absorption — especially for those with MTHFR gene mutations.

So while labeling has changed, nothing has changed in your supplement’s clinical or nutritional performance.

Recap: DFE Labeling Doesn’t Change the Dose

DFE stands for Dietary Folate Equivalent, a unit created to reflect folate’s usable potency based on absorption rates from whole foods
The formula is exactly the same — only the math calculation applied to the label has changed
Methyl-Life® continues to deliver clinically-studied L-Methylfolate at the same high-potency, now labeled to meet new DFE guidelines from the FDA

You do not need to recalculate your dose or change your usage.

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Methyl-Life® 5 Methylfolate 5 mg – Clinically-Backed Support for Cognitive Health, Methylation & Mood Balance

Methyl-Life® 5 Methylfolate 5 mg delivers a moderate-strength dose of bioactive folate — also known as 5-MTHF or L-Methylfolate — the most absorbable form of folate for the body. Specially formulated for individuals with MTHFR gene variants, this supplement supports healthy methylation, cardiovascular function, brain health, and neurotransmitter production without relying on the body's ability to convert synthetic folic acid.

If you struggle with folate absorption, mental fatigue, mood imbalances, or elevated homocysteine levels, this supplement may help you experience the benefits of folate faster and more efficiently.

Understanding the MTHFR Mutation and Folate Deficiency

Many people dealing with fatigue, brain fog, or mood imbalances don’t realize a genetic mutation could be interfering with how their body processes folate. The MTHFR gene plays a crucial role in converting folic acid into L-Methylfolate, the active form the body actually uses.

When MTHFR is mutated, this conversion becomes impaired.

SUPPLEMENT FACTS
Serving Size: 1 Chewable Tablet
90 servings per container	Amount per Serving	% Daily Value
Folate	25,500 mcg DFE	6,376%
(15 mg L-Methylfolate from 21 mg of Cerebrofolate™)

L Methylfolate 15 mg - A Mood-Boosting Supplement

Traceable Ingredients You Can Trust

Supports Methylation, Mood & Cellular Health

Frequently Asked Question

The Science Behind

What Makes Methyl-Life® Methylfolate Different Folate

The Science Behind

Understanding DFE Labeling for Methylfolate

Customer Reviews