The Top 6 Digestive Enzymes

Written By:

Katie Stone - Naturopath

Medical Reviewer:

Kari Asadorian - Bachelor of Science in Nursing

Edited By:

Jamie Hope - Founder of Methyl-Life

Updated On:

May 20, 2025

Why should I take digestive enzymes?

Enzyme deficiency
Symptoms such as bloating, gas, tummy pain, constipation and/or diarrhea may indicate that your body isn’t producing enough enzymes.
Food intolerances
Enzyme supplementation can be helpful for several digestive and malabsorption disorders, such as pancreatic insufficiency and lactose intolerance.²
Gastrointestinal conditions
Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) may also benefit from digestive enzyme supplements.

What are the best digestive enzyme supplements?

There are hundreds of digestive enzyme supplement products on the market today, but ingredients and efficacy can vary considerably. Plant, animal or microbial sources may all be used. For example, bromelain may be sourced from pineapple, while pancreatic enzymes such as ox bile may come from animals.

Here’s a summary of the best digestive enzymes supplements in 2025:

1. Enzymedica Digest Gold + ATPro

Price: $45 for 45 capsules ($1 per capsule)

Contents:

Enzyme blend: Maximum strength (high potency), broad-spectrum formula including trademarked Amylase Thera-blend®, Protease Thera-blend®, Cellulase Thera-blend®, Lipase Thera-blend® for digesting carbohydrates, protein, fat, fiber, and more. ATPro blend includes adenosine triphosphate, magnesium citrate, phytase, and CoQ10 to support cellular energy involved in digestion and nutrient absorption.

Benefits:

One of the most potent and comprehensive enzyme formulas on the market.
Designed for people with significant digestive issues or high enzyme needs
ATPro blend may improve energy production at the cellular level, enhancing enzyme activity
Gluten-free and non-GMO
Clean Label Project Certified, which indicates testing for contaminants like heavy metals and pesticides

Disadvantages:

Expensive (1 capsule per meal = $3 per day)

No added probiotics or prebiotics

May be more than necessary for those with only mild digestive issues

2. Methyl-Life® Chewable Digestive Enzymes

Price: $39 for 90 chewable tablets ($0.43 per tablet)

Contents:

Enzyme blend: Plant-based enzymes including diastase, cellulase, fungal protease, alpha-amylase, papain, bromelain, lactase, and more.

Benefits:

Comprehensive enzyme blend to support digestion of proteins, carbohydrates, fats, and fibers
Includes DPP-IV (dipeptidyl peptidase IV) for assisting with gluten & casein digestion
Wide range of enzymes for breaking down complex sugars, fibers, and plant compounds
Chewable form suitable for those who prefer an easy “after dinner mint” type of experience
NSF certified manufacturer, Non-GMO, Gluten & Allergen free

Disadvantages:

May not suit those who do not like mint flavor.

3. Zenwise Health Digestive Enzymes

Price: $25 for 60 capsules ($0.42 per capsule)

Contents:

Enzyme blend: Includes amylase, bromelain, lactase, lipase, and more

Probiotic Blend: Includes Lactobacillus and Bifidobacterium strains

Prebiotic: Apple pectin

Benefits:

Combines enzymes with both probiotics and a prebiotic for more comprehensive digestive support
Plant-based, so suitable for vegans and vegetarians
More affordable than other leading enzyme blend formulas
Suitable for maintaining everyday digestive function and potentially relieving mild issues

Disadvantages:

Enzyme potency is lower than Enzymedica.
May not be sufficient for people with very low enzyme production or severe digestive problems.

4. Physician’s CHOICE Digestive Enzymes

Price: $20 for 60 capsules ($0.33 per capsule)

Contents:

Enzyme blend includes lipase, amylase, cellulase, lactase, plus bromelain, protease, papain, peptidase, and others.

Probiotic blend: Three probiotic strains plus prebiotics.

Peppermint and ginger extracts.

Benefits:

Plant-based, broad-spectrum enzyme blend
Three Bacillus probiotic strains plus prebiotics from chicory and acacia fiber
Peppermint and ginger may help to ease bloating and indigestion after meals
Affordable

Disadvantages:

Fewer probiotic strains.
Probiotic count is not clearly stated.

5. NewRhythm Digestive Enzymes

Price: $20 for 60 capsules ($0.33 per capsule)

Contents:

Enzyme blend: Broad-spectrum blend including protease, amylase, lipase, lactase, cellulase, bromelain, and papain, along with probiotics and prebiotics. Plant-based.

Probiotic blend: Lactobacillus and Bifidobacterium strains (potency not stated)

Benefits:

Supports digestion and gut microbiome balance
Includes probiotics (30 billion CFU) and prebiotic XOS to support healthy microbiome
Targeted release technology to assist probiotic survival
Affordable
Vegan, non-GMO, plant-based, allergen-free

Disadvantages:

Moderate potency.
May not be suitable for someone with chronic/severe digestive issues.

6. Ancient Nutrition Digestive Enzymes

Price: $33.96 for 90 capsules ($0.37 per capsule)

Contents:

Enzyme blend: 10 essential digestive enzymes including cellulase, amylase, protease, lipase, bromelain, kiwifruit, xylanase.

Probiotic blend: Shelf-stable Bacillus coagulans (2 Billion CFU) (no refrigeration required)

Organic fermented herbal extracts (turkey tail, black pepper, ginger, turmeric, flax seed, and more.

Benefits:

Comprehensive enzyme blend to support digestion of all food groups
Probiotics and herbal extracts to support gut health and reduce inflammation
Affordable
Free from dairy, gluten, soy

Disadvantages

Low potency probiotics
Quantities of each enzyme/extract not stated