Is There a Connection Between MTHFR and Eczema?

Is There a Connection Between MTHFR and Eczema?

As researchers continue to uncover more about the MTHFR gene, we are discovering more about the symptoms and side effects experienced by those with a mutation in the gene. While some of the most common symptoms include depression, digestive issues, cardiovascular complications and neurodegenerative diseases, eczema is one that often gets overlooked. 

If you’ve been struggling to find relief when dealing with eczema, it might be time to consider getting tested for an MTHFR mutation. There are ways to treat these mutations and supplement around them, which may help solve some of the eczema symptoms -- especially if your child is significantly suffering from eczema.

What Is Eczema?

Eczema is a condition where the skin becomes inflamed, itchy, and red. Over 30 million Americans suffer from one of the many forms of eczema, including dyshidrotic eczema, seborrheic dermatitis, atopic dermatitis, stasis dermatitis, nummular eczema, and contact dermatitis. 

Most cases of eczema will start in early childhood and will follow the person throughout their life, though there are ways to manage its severity. In some cases, it will completely disappear as a child grows older, while others can continue to experience it later in life.

The Eczema-MTHFR-Methylation Connection

Not all topical solutions and medical treatments will lead to relief. In some cases, you might be suffering from an issue that a topical solution can’t solve. Many people are starting to see a connection between eczema and a mutation in the MTHFR gene. 

The MTHFR gene is responsible for a biological process called methylation. When complications are experienced with the methylation process, your body will struggle to break down necessary enzymes, nutrients and compounds that your body needs to function. 

One of these compounds is histamine, which plays an essential role in immune responses. When our immune system is triggered, your cells will release histamine and you will experience the allergy-like symptoms that many are all-too-familiar with. 

The eczema-MTHFR-methylation connection exists because histamine reactions are often associated with itchy skin. If you have an MTHFR mutation that compromises your body’s ability to perform methylation, it could cause excess amounts of histamine to cause allergy-like symptoms. 

What Do the Studies Show?

While theories continue to point towards a connection, the study results have yet to match the theories. A large reason for this is due to a limited amount of testing being done, so more research is needed before making a strong case for or against the eczema-MTHFR-methylation connection. 

In one study, there was no significant evidence supporting an MTHFR mutation causing allergy symptoms to develop -- including eczema-related symptoms. But that doesn’t necessarily mean the connection doesn’t exist. More likely it means additional studies will need to be done in order to properly understand and prove the connection.

In the event that you’re also experiencing other symptoms that are associated with an MTHFR mutation, you may want to consider getting tested for it. If one or two variants are found, you’ll likely be directed to take L-Methylfolate (and potentially even an active B12 supplement) to boost your body’s methylation biopathway. 

Methyl-Life offers a variety of high-quality methylfolate products that could potentially affect your eczema symptoms. You can check out the 2.5 mg, 5 mg, 10 mg, and 15 mg chewable tablets at our online shop. It’s our mission to ensure our products contain the purest methylfolate on the planet, and we can prove it (our impurities register 3x lower than our closest competitor). So don’t compromise when it comes to your health. Contact us today with any questions, comments, or concerns!


Wang, Ting, et al. “Is Folate Status a Risk Factor for Asthma or Other Allergic Diseases?” Allergy, Asthma & Immunology Research, The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease, 14 July 2015,



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