MitoQ Product Description

You might have heard of Coenzyme Q10, a popular supplement that can help protect cardiovascular function and boost energy levels. CoQ10 is often recommended to people who have heart conditions as it’s been shown to support healthy mitochondrial function, slow the effects of aging, and also reduce the side effects of statins.

As good as that sounds, increasing your levels of CoQ10 isn’t as simple as taking any old supplement off the shelf. We’ll explain more about this below.

We’ll also tell you about a supplement that CAN increase your CoQ10 levels effectively and efficiently: MitoQ.

First, let’s have a quick biology lesson on the tiny organelles powering your body: mitochondria.

Our bodies are made up of trillions of cells. Inside each cell is the mitochondria, which are known as the “powerhouse” of a cell. These tiny organelles are like a digestive system within the cell itself. They take in nutrients, break them down, and use them to create molecules of energy for the cell known as ATP. ATP is the fuel that every one of our cells needs to keep us alive and functioning properly.

This biochemical process (and many others) that happen within the cell is called cellular respiration. Many of the reactions involved in cellular respiration happen in the mitochondria.

In short, mitochondria are the engines of the cell that maintain our energy levels.

Some cells have several thousand mitochondria while others have none. Your muscles require a lot of energy, so they have the most mitochondria, while neurons have much fewer.

If a cell isn’t getting enough energy to function properly, more mitochondria can be created. Sometimes mitochondria can grow larger or combine with other mitochondria. It all depends on what the cell needs.

Here’s a breakdown of the many roles of the mitochondria:

1. Converting the food you eat and the air you breathe into energy
2. Sending messages to other components within the cell
3. Regulating vital calcium levels
4. Producing and regulating body heat
5. Tailoring the cell to perform specific functions
6.  Controlling cell growth and cell self-destruction

In order for your body to perform at its best, your mitochondria also need to be performing at their best.

One of the most important roles of the mitochondria is to create adenosine triphosphate (ATP), the “fuel” for your cells. ATP is produced within the mitochondria by a metabolic system called the aerobic pathway. This involves combining the food you eat and the oxygen you breathe into energy that the cell can use. Your body requires a certain amount of oxygen, carbs and fats to produce energy via this pathway.

During physical activity, the aerobic pathway is the main form of energy production. It’s especially important for exercise that is longer in duration. ATP provides energy to your muscles by shuttling energy molecules within the cells.

The more effective mitochondria are at producing ATP, the better your athletic performance.

Coenzyme Q10 (COQ10) is a lipid-soluble, vitamin-like compound also known as Vitamin Q10, Ubiquinone, and Idebenone. It’s an essential component of the mitochondrial electron transport chain and an antioxidant in plasma membranes and lipoproteins.

CoQ10 is produced by the body and is present in almost every one of our cells. It’s primarily found within the mitochondria, where it plays a major role in the energy production of the cell by supporting the mitochondria during energy production. It’s also part of the body’s endogenous antioxidant system and very important in neutralizing free radicals.

Despite being vital for survival, CoQ10 is known as a ‘pseudovitamin’ which means it’s not classified as an essential vitamin. However, studies have shown that CoQ10has powerful benefits for our health and wellbeing, and a deficiency can be severely detrimental. Studies have found that people with chronic diseases tend to have lower levels of CoQ10 in their tissues and organs, which suggests that CoQ10 supplementation could alleviate aging symptoms and/or possibly prevent the onset of these diseases.

There is also evidence that supplementation with CoQ10 positively affects mitochondrial deficiency syndrome and the symptoms associated with aging, particularly cardiovascular disease and inflammation.

When the mitochondria create ATP, they produce both CoQ10 and free radicals as by-products. Efficient ATP production requires both healthy mitochondria and adequate stores of CoQ10.

However, as we get older, our body’s production of CoQ10 naturally declines. Diet and other lifestyle factors can also take a toll on our stores of CoQ10. This causes the mitochondria to function less efficiently and allows free radicals to run riot, which in turn can lead to further health issues.

While there are plenty of CoQ10 supplements on the market, increasing your body’s levels of this nutrient isn’t actually that simple. This is mainly because CoQ10 is a large fat-soluble molecule which is difficult for the body to absorb properly. The impermeable membrane of CoQ10 means that only a very small amount actually makes it inside our mitochondria. Even the active form of CoQ10 - ubiquinol - can be oxidized back into its inactive form, ubiquinone, very quickly.

But the mitochondria is exactly where you NEED CoQ10 the most!

MitoQ is another name for mitoquinone. Like CoQ10, MitoQ is an antioxidant which helps to scavenge free radicals in the body and neutralize them, preventing them from causing harm to delicate DNA.

The source of most free radicals is actually the mitochondria, and this is where MitoQ concentrates.

MitoQ was developed by two biochemists at Otago University in New Zealand. After experimenting with many different ways of achieving optimal absorption of CoQ10 in the body, they realized that the mitochondria’s negative charge could be used to attach a positively-charged ion to CoQ10. They were then able to create a unique formula that allows high levels of the MitoQ molecules to be drawn into the mitochondria quickly and efficiently.

While the recommended dose of CoQ10 is usually around 100 – 200 mg, MitoQ contains only a tenth of this amount - 10mg - and yet is still able to deliver a powerfully high amount of CoQ10.What’s more, MitoQ is recyclable! After neutralizing a free radical, MitoQ returns back to its active form. This means it can continue its scavenging and neutralizing of free radicals over and over again.

Studies show that mitochondrial function can be improved by targeting certain bioactive compounds in living cells . In fact, compounds that improve mitochondria in this way have been shown to have potential as anticancer drugs.

Because mitochondria play a role in many critical cell processes, the targeting of mitochondrial function may help to protect, repair or kill cells where necessary, which in turn may be a key tool in the treatment of certain DNA-related diseases.

The health of our mitochondria is vital not only to our daily function but to our long-term health. Mitochondria provide energy to the most important and hardest-working cells in the body, particularly those in the heart, liver, and brain.

Due to its poor bioavailability, CoQ10 must be taken with fats or oils. However, MitoQ is water-soluble, which allows it to be absorbed quickly and easily. It also has a positive charge. Mitochondria have a negative charge, so they actively draw MitoQ in. No specific food required!

MitoQ’s size, charge, and water solubility means it can reach peak concentration far more quickly than CoQ10. It passes quickly and easily through biological membranes including the blood-brain barrier.

Over 400 peer review research papers have now been published on the benefits of MitoQ. It has shown potential in improving numerous health conditions including seven of the top ten most costly to human life.

MitoQ is believed to help improve your overall health and wellbeing by...

• Improving and sustaining energy production
• Supporting healthy blood pressure
• Maintaining healthy blood sugar and cholesterol levels
• Supporting muscle and joint function
• Supporting overall fitness and recovery from physical exercise
• Maintaining the health of the liver and kidneys function for normal metabolic operation
• Supporting brain and nervous system function for better mental clarity and alertness
• Improving immune system function and potentially reducing allergic responses
• Reducing the effects of oxidative stress from environmental and lifestyle factors

Physical performance is crucial to athletes, and there is substantial evidence that CoQ10 can help. CoQ10 plays a central role in energy production and maintenance, so it makes sense that supplementation can boost performance.

Training promotes an increase in the number of mitochondria in the heart and muscles. The more energy your body requires, the faster CoQ10 is used up. Even highly-trained athletes can end up with suboptimal amounts of CoQ10 because of the huge demand during exercise.

Studies involving athletes and non-athletes have shown mixed results regarding the effect of CoQ10 on physical performance. One study found that CoQ10 helped to increase the time spent exercising, which suggests it may be beneficial for both trained and untrained individuals.

Although some foods do contain CoQ10, it would be almost impossible to obtain the levels required to provide therapeutic benefits through food. Supplementation with MitoQ not only ensures a high dose of CoQ10, but it ensures that dose is delivered right where it’s needed: into the mitochondria.

Statins are often prescribed by doctors to those with high levels of ‘bad’ cholesterol (LDL). Statins are drugs that block a substance your body needs to make cholesterol, which helps to lower your LDL levels.

However, statins can cause a number of negative side effects such as headaches, nausea, weakness or fatigue, digestive issues (constipation, diarrhea, indigestion or gas) muscle pain, sleeping problems, and a low blood platelet count.

Although CoQ10 has been shown to help reduce these side effects, statins also decrease your body’s levels of active CoQ10. Reduced levels of CoQ10 cause the side effects of statins to increase, along with other associated health risks.

Maintaining the health of your mitochondria is crucial in minimizing the negative side effects of statins. While supplementing with a CoQ10 is recommended, it’s also not well-absorbed. MitoQ is a more efficient means of boosting your body’s levels of CoQ10 so that you can mitigate the oxidative damage caused by statins.

Liver health

• A study involving 30 patients with chronic hepatitis C showed that MitoQ helped to reduce liver enzymes including plasma ALT and aspartate aminotransferase. This suggested that MitoQ may help to decrease necroinflammation in the liver of these patients
• A study involving rats found that MitoQ helped to reduce free radicals and HIF1α, which helped to alleviate alcohol-associated mitochondrial reactive oxygen species (ROS) and several downstream effects of ROS/RNS (reactive nitrogen species) production .
• MitoQ was shown to prevent liver fibrosis caused by free radicals in mice, which led researchers to suggest it could be an effective therapeutic strategy for liver fibrosis in humans .

• A meta-analysis of 27 animal studies analyzed the effects of MitoQ on aging-related biomarkers. The researchers concluded that it produced a significant reduction in nitrotyrosine concentration (an indicator of cell damage and inflammation), and that it may be of some benefit in alleviating oxidative stress related to aging.  
• In human cells, MitoQ was found to be 800 times stronger than idebenone (another CoQ10 analog) at preventing cell death caused by free radicals. This led researchers to suggest that mitochondria-targeted antioxidants such as MitoQ are effective in preventing cell death due to endogenous oxidative damage, and that it may have therapeutic potential in treating disorders caused by mitochondrial oxidative damage .

A review of preclinical trials suggested that MitoQ may be effective antioxidant therapies against the damage caused by enhanced reactive species generation, and may prevent mitochondrial DNA damage from UV better than resveratrol, curcumin, or NAC.

Several studies involving rats showed that MitoQ helped to reduce free radicals caused by cocaine or chemotherapy use, thus preventing heart failure, preserving energy production, and reducing inflammation (TNF-alpha).

Studies with mice showed that MitoQ helped to prevent inflammation caused by low oxygen and also reverse the age-related increase in endothelial susceptibility to acute mitochondrial damage.

When administered to mice with Alzheimer’s disease, MitoQ appeared to prevent further cognitive decline, nerve loss, injury from free radicals, as well as the build-up of amyloid-beta plaques. The researchers suggested that mitochondria play a major role in neurodegeneration and that mitochondria-targeted therapeutics may be highly beneficial in treating diseases involving oxidative stress and metabolic failure.

You can learn more about the science behind MitoQ and its many benefits in the MitoQ ebook or by watching the video shown in the product’s Description tab.

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As with any health supplement, we strongly advise consulting a qualified healthcare professional before taking MitoQ.