Moderate dose 5 methylfolate for healthy methylation, homocysteine and natural mood support.
Bioactive folate (5 mthf L-Methylfolate) uniquely formulated with the internationally-patented Magnafolate® PRO.
5 methylfolate is the predominant form of folate circulating in the body and used for biological processes1.
5 Methylfolate 5.6mg shown to slow cognitive decline in patients with dementia2.
5 Methylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier3.
- Support for brain function4
- Supports cardiovascular health5
- Support for healthy immune function6
- Supports nerve function7
- Support for preconception, pregnancy, and fetal health8
- Involved in maintaining healthy homocysteine levels9
- Essential nutrient required for healthy DNA and neurotransmitter synthesis10
- Suitable for people with MTHFR mutations11
Product details
Key ingredient: Folate 5,000 mcg (L-5-Methyltetrahydrofolate, Calcium as Magnafolate® PRO)
5 Methylfolate 5 mg is a highly bioactive form of folate made with the purest methylfolate available12.
- Maximum absorption and bioavailability
- No prescription required
- Available in 2.5mg, 3mg+B12, 5mg, 7.5mg+B12, 10mg, 15mg, 15mg+B12
- Rigorously tested for consistency, purity, safety, and potency
Why take methylfolate?
Folate is required for numerous critical functions of the brain and nervous system. It is essential for DNA/RNA synthesis, maintaining healthy homocysteine levels, and for proper fetal development during pregnancy.
Folic acid is a synthetic form of folate. It can only be used by the body after it has been converted to active folate by an enzyme called methylenetetrahydrofolate reductase (MTHFR)13.
Who is affected by MTHFR mutations?
The MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants). Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%). Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A>C polymorphism in Hispanics and Africans is 15%14.
An increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness15. MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses16.
For these people, L-methylfolate supplementation is shown to be the most effective way to provide this form of folate10.
Methyl-Life’s® Methylfolate is an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.
Why Magnafolate® PRO?
Methyl-Life’s® 5 Methylfolate 5 mg is made with the internationally-patented Magnafolate® PRO, clinically tested as the world’s purest methylfolate (Magnafolate® PRO is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic® and Extrafolate®).
Magnafolate® is made with a form of methylfolate called L-5-MTHF-Ca, which is shown to be the most active form of folate in the plasma circulation. When compared with ordinary folate, L-methylfolate was found to be absorbed faster and utilized more quickly in the body17.
A recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation18.
______________________________________
1 https://pubmed.ncbi.nlm.nih.gov/20608755/
2https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402301/
3https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687916/
4https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779227/
5https://www.ahajournals.org/doi/10.1161/hq0102.102190
6https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019735/
7https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867258/
8https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127769/
9https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832224/
10https://pubmed.ncbi.nlm.nih.gov/23212058/
11https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564482/
12https://cdn.shopify.com/s/files/1/0264/6369/9018/files/Methyl-Life_60-day_Methylfolate_Comparison.pdf?v=1595292111
13https://www.ncbi.nlm.nih.gov/books/NBK6561/
14https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530664/
15https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630484/
16https://www.ahajournals.org/doi/10.1161/01.CIR.0000165142.37711.E7
17https://pubmed.ncbi.nlm.nih.gov/24032278/
18https://i.trade-cloud.com.cn/upload/6405/file/20210929/english-version-magnafolate-enhancing-immunity_524485.pdf
Dosage
WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to some dosing options.
How to snap the tablet in half – See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.
Video
SUPPLEMENT FACTS
SUPPLEMENT FACTS | ||
Serving Size: 1 Chewable Tablet
|
||
Amount per Serving | % Daily Value | |
Folate | 9,667 mcg DFE | 2,417% |
(as L-5-Methyltetrahydrofolate, Calcium [equal to 7,300 mcg Magnafolate® PRO]) |
|
|
OTHER INGREDIENTS: xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavor (dextrose, silicon dioxide, natural flavor).
Product Does NOT Contain: wheat, gluten, soy, dairy, tree nuts, animal products, GMO's. No artificial ingredients or colorings.
Research
FAQ'S
What is the right dosage for me?
Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.
Is 5 Methylfolate the only thing I should take if I have an MTHFR gene mutation?
What do doctors have to say about MTHFR and how to treat it?
How can I get more information on MTHFR?
Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium the same thing?
What is 5 Methylfolate 5 mg by Methyl-Life?
How does 5 Methylfolate 5 mg benefit health?
Can 5 Methylfolate 5 mg help with depression?
Who can benefit from taking 5 Methylfolate 5 mg?
How long does it take to experience the benefits of 5 Methylfolate 5 mg?
5 Methylfolate: 5-mthf L-Methylfolate 5 mg
- Bioactive 5 Methylfolate that crosses blood-brain barrier 3
- Supports Cardiovascular Function 5 & Brain Health 4
- 3rd-party tested for Purity, Potency & Safety
- 90 Vegan, Non-GMO, Chewable mint tablets
Methyl-Life's® 5 Methylfolate 5 mg, tailored for MTHFR genetic variants. Bioactive form of 5-mthf L-Methylfolate for optimal absorption & brain health support.
Dawn
I've been using this for several years now. Grateful for your company. So easy to use the sight etc.
hidden
Moderate dose 5 methylfolate for healthy methylation, homocysteine and natural mood support.
Bioactive folate (5 mthf L-Methylfolate) uniquely formulated with the internationally-patented Magnafolate® PRO.
5 methylfolate is the predominant form of folate circulating in the body and used for biological processes1.
5 Methylfolate 5.6mg shown to slow cognitive decline in patients with dementia2.
5 Methylfolate is the biologically activated form of folate and the only form that can cross the blood-brain barrier3.
- Support for brain function4
- Supports cardiovascular health5
- Support for healthy immune function6
- Supports nerve function7
- Support for preconception, pregnancy, and fetal health8
- Involved in maintaining healthy homocysteine levels9
- Essential nutrient required for healthy DNA and neurotransmitter synthesis10
- Suitable for people with MTHFR mutations11
Product details
Key ingredient: Folate 5,000 mcg (L-5-Methyltetrahydrofolate, Calcium as Magnafolate® PRO)
5 Methylfolate 5 mg is a highly bioactive form of folate made with the purest methylfolate available12.
- Maximum absorption and bioavailability
- No prescription required
- Available in 2.5mg, 3mg+B12, 5mg, 7.5mg+B12, 10mg, 15mg, 15mg+B12
- Rigorously tested for consistency, purity, safety, and potency
Why take methylfolate?
Folate is required for numerous critical functions of the brain and nervous system. It is essential for DNA/RNA synthesis, maintaining healthy homocysteine levels, and for proper fetal development during pregnancy.
Folic acid is a synthetic form of folate. It can only be used by the body after it has been converted to active folate by an enzyme called methylenetetrahydrofolate reductase (MTHFR)13.
Who is affected by MTHFR mutations?
The MTHFR mutation is much more common than many people realize (it’s estimated around 50% of the global population have at least 1 of 2 common variants). Approximately 25% of the global population are carriers of the MTHFR mutation C677T, with Hispanics making up the highest proportion (47%), East Asians (30%), South Asians (12%) and Africans (9%). Another 25% of the global population have the MTHFR mutation A1298C, which is highest in South East Asians (42%) and Europeans (31%). The frequency of the 1298A>C polymorphism in Hispanics and Africans is 15%14.
An increasing number of studies have shown links between those with MTHFR polymorphisms and an increased risk for high levels of homocysteine, depression, and reduced antidepressant effectiveness15. MTHFR is also linked to elevated homocysteine levels, which can cause serious vascular diseases, dementia, infertility, and other chronic illnesses16.
For these people, L-methylfolate supplementation is shown to be the most effective way to provide this form of folate10.
Methyl-Life’s® Methylfolate is an active form of folate that can bypass the MTHFR mutation. It is already in its metabolized form, which means it can be readily absorbed and utilized in the body for many biochemical reactions.
Why Magnafolate® PRO?
Methyl-Life’s® 5 Methylfolate 5 mg is made with the internationally-patented Magnafolate® PRO, clinically tested as the world’s purest methylfolate (Magnafolate® PRO is shown to have significantly greater purity, stability and potency when compared to competing brands Quatrefolic® and Extrafolate®).
Magnafolate® is made with a form of methylfolate called L-5-MTHF-Ca, which is shown to be the most active form of folate in the plasma circulation. When compared with ordinary folate, L-methylfolate was found to be absorbed faster and utilized more quickly in the body17.
A recent study found that L-5-MTHF-Ca significantly boosted immune function over just five weeks of supplementation18.
______________________________________
1 https://pubmed.ncbi.nlm.nih.gov/20608755/
2https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402301/
3https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687916/
4https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779227/
5https://www.ahajournals.org/doi/10.1161/hq0102.102190
6https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019735/
7https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867258/
8https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127769/
9https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832224/
10https://pubmed.ncbi.nlm.nih.gov/23212058/
11https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564482/
12https://cdn.shopify.com/s/files/1/0264/6369/9018/files/Methyl-Life_60-day_Methylfolate_Comparison.pdf?v=1595292111
13https://www.ncbi.nlm.nih.gov/books/NBK6561/
14https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530664/
15https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630484/
16https://www.ahajournals.org/doi/10.1161/01.CIR.0000165142.37711.E7
17https://pubmed.ncbi.nlm.nih.gov/24032278/
18https://i.trade-cloud.com.cn/upload/6405/file/20210929/english-version-magnafolate-enhancing-immunity_524485.pdf
Dosage
WARNING – How much is right for you to take? Talk to your doctor about what’s best for you. Before you purchase check out our dosage information to learn more about what some doctors recommend. And review our suggested methylation protocol as a potential step by step guide to some dosing options.
How to snap the tablet in half – See how its done via video. First find the half hash line and face it away from yourself (with the back of the tablet facing your chest/stomach), then put both of your thumbs next to each other along the line (as if there were one on the back of the tablet). You want the half hash line facing away from you (not on the side of the tablet where your thumbs are). And then you should be able to break it in half along that line every time by simply applying pressure to snap it outwards, by pushing your thumbs away from you. This approach works far better than using a pill cutter, which seems to cause the tablet to crumble much more.
Video
SUPPLEMENT FACTS
SUPPLEMENT FACTS | ||
Serving Size: 1 Chewable Tablet
|
||
Amount per Serving | % Daily Value | |
Folate | 9,667 mcg DFE | 2,417% |
(as L-5-Methyltetrahydrofolate, Calcium [equal to 7,300 mcg Magnafolate® PRO]) |
|
|
OTHER INGREDIENTS: xylitol (Xylisorb®), microcrystalline cellulose (Microcel®), stearic acid, silicon dioxide, natural mint flavor (dextrose, silicon dioxide, natural flavor).
Product Does NOT Contain: wheat, gluten, soy, dairy, tree nuts, animal products, GMO's. No artificial ingredients or colorings.
Research
FAQ'S
What is the right dosage for me?
Check out our Dosage page to learn what some doctors are saying. And consider reviewing our Methylation Protocol page as one example of how someone could start taking the active methylation nutrients.
Is 5 Methylfolate the only thing I should take if I have an MTHFR gene mutation?
What do doctors have to say about MTHFR and how to treat it?
How can I get more information on MTHFR?
Is L-Methylfolate and (6S)-5-Methyltetrahydrofolate, Calcium the same thing?
What is 5 Methylfolate 5 mg by Methyl-Life?
How does 5 Methylfolate 5 mg benefit health?
Can 5 Methylfolate 5 mg help with depression?
Who can benefit from taking 5 Methylfolate 5 mg?
How long does it take to experience the benefits of 5 Methylfolate 5 mg?