The 7 Best Vitamin B12 Supplements
Vitamin B12 is required for red blood cell production, energy metabolism, healthy DNA and neurotransmitter synthesis, optimal methylation, and many other processes.
Low B12 is common in vegetarians, the elderly and those with conditions affecting nutritional absorption.1 Deficiency can have severe consequences for almost every bodily system, and supplementation is highly recommended to restore healthy levels.
B12 supplements are readily available as capsules, tablets, oral sprays and liquids. However, not all forms of B12 are the same, and some supplements are more effective than others. The most common form of supplemental B12 is cyanocobalamin, which is synthetic (made in a lab). Research has shown that cyanocobalamin urinary excretion may be 3 times higher than that of methylcobalamin, and that methylcobalamin supplementation results in 13% more cobalamin being stored in the liver than cyanocobalamin.2
Here is a quick overview of the best vitamin B12 supplements for 2025 and how to choose the right product for your needs.